{"id":"https://openalex.org/W4384297451","doi":"https://doi.org/10.1530/erc-23-0009","title":"Detection and yield of thyroid cancer surveillance in adults with PTEN hamartoma tumour syndrome","display_name":"Detection and yield of thyroid cancer surveillance in adults with PTEN hamartoma tumour syndrome","publication_year":2023,"publication_date":"2023-07-14","ids":{"openalex":"https://openalex.org/W4384297451","doi":"https://doi.org/10.1530/erc-23-0009","pmid":"https://pubmed.ncbi.nlm.nih.gov/37451289"},"language":"en","primary_location":{"id":"doi:10.1530/erc-23-0009","doi":"https://doi.org/10.1530/erc-23-0009","is_oa":false,"landing_page_url":"https://doi.org/10.1530/erc-23-0009","pdf_url":null,"source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059875436","display_name":"Meggie M.C.M. Drissen","orcid":"https://orcid.org/0000-0002-5742-8011","observed_orcids":["https://orcid.org/0000-0002-5742-8011"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Meggie M C M Drissen","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5742-8011","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041770166","display_name":"Janet R. Vos","orcid":"https://orcid.org/0000-0001-8802-7002","observed_orcids":["https://orcid.org/0000-0001-8802-7002"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Janet R Vos","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083660817","display_name":"Romana Teodora Netea-Maier","orcid":"https://orcid.org/0000-0002-9603-0460","observed_orcids":["https://orcid.org/0000-0002-9603-0460"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Romana T Netea-Maier","raw_affiliation_strings":["Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042300545","display_name":"Martin Gotthardt","orcid":"https://orcid.org/0000-0002-6537-7744","observed_orcids":["https://orcid.org/0000-0002-6537-7744"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin Gotthardt","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014697573","display_name":"Nicoline Hoogerbrugge","orcid":"https://orcid.org/0000-0003-2393-8141","observed_orcids":["https://orcid.org/0000-0003-2393-8141"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nicoline Hoogerbrugge","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-2393-8141","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":null,"apc_paid":null,"fwci":1.8299,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.86459713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"30","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12631","display_name":"Head and Neck Anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten-hamartoma-tumor-syndrome","display_name":"PTEN hamartoma tumor syndrome","score":0.9480000138282776},{"id":"https://openalex.org/keywords/thyroid-cancer-surveillance","display_name":"thyroid cancer surveillance","score":0.984000027179718},{"id":"https://openalex.org/keywords/thyroid-ultrasound","display_name":"thyroid ultrasound","score":0.9179999828338623},{"id":"https://openalex.org/keywords/thyroid-nodules","display_name":"thyroid nodules","score":0.6940000057220459},{"id":"https://openalex.org/keywords/thyroid-cancer-detection","display_name":"thyroid cancer detection","score":0.5389999747276306},{"id":"https://openalex.org/keywords/surveillance-interval","display_name":"surveillance interval","score":0.7590000033378601},{"id":"https://openalex.org/keywords/thyroid-adenoma","display_name":"thyroid adenoma","score":0.7110000252723694},{"id":"https://openalex.org/keywords/thyroidectomy","display_name":"thyroidectomy","score":0.6019999980926514},{"id":"https://openalex.org/keywords/thyroiditis","display_name":"thyroiditis","score":0.3959999978542328},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8720343112945557},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6492007970809937},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.526472806930542},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5093187093734741},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5087834000587463},{"id":"https://openalex.org/C2777074255","wikidata":"https://www.wikidata.org/wiki/Q1351681","display_name":"Thyroidectomy","level":3,"score":0.4900699853897095},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.46929341554641724},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.43954506516456604},{"id":"https://openalex.org/C2780846426","wikidata":"https://www.wikidata.org/wiki/Q1138188","display_name":"Cowden syndrome","level":5,"score":0.43399155139923096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4175286889076233},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41528576612472534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006223","descriptor_name":"Hamartoma Syndrome, Multiple","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016606","descriptor_name":"Thyroid Nodule","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1530/erc-23-0009","doi":"https://doi.org/10.1530/erc-23-0009","is_oa":false,"landing_page_url":"https://doi.org/10.1530/erc-23-0009","pdf_url":null,"source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},{"id":"pmid:37451289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37451289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-related cancer","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/295820","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/295820","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6399999856948853}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1997649361","https://openalex.org/W1999130958","https://openalex.org/W2014715513","https://openalex.org/W2026864697","https://openalex.org/W2033744064","https://openalex.org/W2065298297","https://openalex.org/W2083451078","https://openalex.org/W2093392185","https://openalex.org/W2110389495","https://openalex.org/W2130504509","https://openalex.org/W2131118854","https://openalex.org/W2142139981","https://openalex.org/W2145150141","https://openalex.org/W2164389238","https://openalex.org/W2165516672","https://openalex.org/W2315678220","https://openalex.org/W2603963723","https://openalex.org/W2742257046","https://openalex.org/W2761380258","https://openalex.org/W2766712571","https://openalex.org/W2902457052","https://openalex.org/W2903120058","https://openalex.org/W2951540166","https://openalex.org/W2953480225","https://openalex.org/W2954321320","https://openalex.org/W2969748831","https://openalex.org/W3001128754","https://openalex.org/W3007405360","https://openalex.org/W3011219490","https://openalex.org/W3034228166","https://openalex.org/W3046180298","https://openalex.org/W3096174017","https://openalex.org/W3117391800","https://openalex.org/W3156109060","https://openalex.org/W3183903577","https://openalex.org/W4210440720","https://openalex.org/W4232874382","https://openalex.org/W4233923946","https://openalex.org/W4235019056","https://openalex.org/W4239504322","https://openalex.org/W4244947133","https://openalex.org/W4247556390","https://openalex.org/W4248604478","https://openalex.org/W4250780993","https://openalex.org/W4253344037","https://openalex.org/W4255645971","https://openalex.org/W4283644264","https://openalex.org/W4297964791","https://openalex.org/W4306771297","https://openalex.org/W4392731388"],"related_works":["https://openalex.org/W4283644264","https://openalex.org/W4401431835","https://openalex.org/W3156109060","https://openalex.org/W3046180298","https://openalex.org/W4297850695","https://openalex.org/W3023819583","https://openalex.org/W3117391800","https://openalex.org/W2779321067","https://openalex.org/W4317797603","https://openalex.org/W2050758777"],"abstract_inverted_index":{"Thyroid":[0],"cancer":[1,20],"surveillance":[2],"(TCS)":[3],"with":[4,41,90,100,188,196,220],"ultrasound":[5],"(US)":[6],"is":[7],"advised":[8],"for":[9],"PTEN":[10],"hamartoma":[11],"tumour":[12],"syndrome":[13],"(PHTS)":[14],"patients":[15,46,74,119,151,164],"due":[16],"to":[17,32,52,242],"increased":[18],"thyroid":[19,110,147,157],"(TC)":[21],"risk.":[22],"However,":[23],"data":[24,78],"supporting":[25],"TCS":[26,40,63,87,95,226],"guidelines":[27],"are":[28,248],"scarce.":[29],"We":[30],"aimed":[31],"assess":[33],"the":[34,54,62,221,232,236],"detection":[35,106,179],"and":[36,51,75,81,93,112,145,154,177,191,201,211,230],"yield":[37,84],"of":[38,56,107],"annual":[39,86,101,241],"US":[42,59,99,186,194,239],"in":[43,130,140,149,161,173,184,192,208],"adult":[44,72],"PHTS":[45,73],"without":[47],"a":[48,57,135,146],"TC":[49,139],"history":[50],"evaluate":[53],"impact":[55],"reduced":[58],"interval":[60,102],"on":[61],"yield.":[64],"A":[65],"retrospective":[66],"cohort":[67],"study":[68],"was":[69,88,128,171],"conducted,":[70],"including":[71],"medical":[76],"record":[77],"between":[79],"2005":[80],"2021.":[82],"The":[83],"from":[85,240],"compared":[89],"hypothetical":[91],"biennial":[92,189,243],"triennial":[94,197],"after":[96,235],"two":[97,150,238],"initial":[98,237],"by":[103],"counting":[104],"delayed":[105,183],"nodular":[108],"growth,":[109],"adenoma,":[111],"TC.":[113],"During":[114],"279":[115],"follow-up":[116,233],"years,":[117],"84":[118],"(median":[120,165],"age":[121,166,228],"40":[122],"years)":[123],"underwent":[124],"349":[125],"US.":[126],"Thyroidectomy":[127],"performed":[129],"6/84":[131],"(7%)":[132],"patients,":[133,176,214],"revealing":[134],"minimally":[136],"invasive":[137],"follicular":[138],"one":[141],"patient":[142],"aged":[143,152],"22":[144],"adenoma":[148],"21":[153],"53.":[155],"Multiple":[156],"nodules":[158],"were":[159,206],"diagnosed":[160],"73/84":[162],"(87%)":[163],"36":[167],"years).":[168],"Nodular":[169],"growth":[170],"detected":[172],"9/56":[174],"(16%)":[175],"its":[178],"would":[180],"have":[181],"been":[182],"4-7%":[185],"rounds":[187,195],"TCS,":[190],"2-6%":[193],"TCS.":[198],"US-based":[199],"thyroiditis":[200],"indeterminate":[202],"non-malignant":[203],"lymph":[204],"nodes":[205],"found":[207],"8/74":[209],"(11%)":[210],"7/72":[212],"(10%)":[213],"respectively.":[215],"Following":[216],"our":[217],"findings":[218,247],"combined":[219],"literature,":[222],"we":[223],"propose":[224],"starting":[225],"before":[227],"18":[229],"reducing":[231],"frequency":[234],"if":[244],"no":[245],"suspicious":[246],"detected.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-15T00:00:00"}
