{"id":"https://openalex.org/W4384295901","doi":"https://doi.org/10.1016/j.jid.2023.02.006","title":"Spatial Cancer Systems Biology Resolves Heterotypic Interactions and Identifies Disruption of Spatial Hierarchy as a Pathological Driver Event","display_name":"Spatial Cancer Systems Biology Resolves Heterotypic Interactions and Identifies Disruption of Spatial Hierarchy as a Pathological Driver Event","publication_year":2023,"publication_date":"2023-07-14","ids":{"openalex":"https://openalex.org/W4384295901","doi":"https://doi.org/10.1016/j.jid.2023.02.006","pmid":"https://pubmed.ncbi.nlm.nih.gov/36911273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10002759"},"language":"en","primary_location":{"id":"doi:10.1016/j.jid.2023.02.006","doi":"https://doi.org/10.1016/j.jid.2023.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2023.02.006","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jid.2023.02.006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047057665","display_name":"Fabian V. Filipp","orcid":"https://orcid.org/0000-0001-9889-5727","observed_orcids":["https://orcid.org/0000-0001-9889-5727"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Fabian V. Filipp","raw_affiliation_strings":["Cancer Systems Biology, Institute of Diabetes and Cancer, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen, Germany; School of Life Sciences Weihenstephan, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany; Institute for Advanced Study, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany; Metaflux, San Diego, California, USA. Electronic address: fabian.filipp@helmholtz-muenchen.de","Cancer Systems Biology, Institute of Diabetes and Cancer, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen, Germany","Institute for Advanced Study, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany","Metaflux, San Diego, California, USA","School of Life Sciences Weihenstephan, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9889-5727","affiliations":[{"raw_affiliation_string":"Cancer Systems Biology, Institute of Diabetes and Cancer, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen, Germany; School of Life Sciences Weihenstephan, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany; Institute for Advanced Study, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany; Metaflux, San Diego, California, USA. Electronic address: fabian.filipp@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"]},{"raw_affiliation_string":"Cancer Systems Biology, Institute of Diabetes and Cancer, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Institute for Advanced Study, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Metaflux, San Diego, California, USA","institution_ids":[]},{"raw_affiliation_string":"School of Life Sciences Weihenstephan, Technical University M\u00fcnchen, Maximus-von-Imhof-Forum 3, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047057665"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.1775,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.37884667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"143","issue":"8","first_page":"1342","last_page":"1347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/planar-cell-polarity","display_name":"planar cell polarity","score":0.972000002861023},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8180000185966492},{"id":"https://openalex.org/keywords/epithelial-organization","display_name":"epithelial organization","score":0.7820000052452087},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/cancer-drivers","display_name":"cancer drivers","score":0.5519999861717224},{"id":"https://openalex.org/keywords/cancer-systems-biology","display_name":"cancer systems biology","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.7139123678207397},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.6172592043876648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5012617111206055},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4668273329734802},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4445030689239502},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.440141886472702},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33498960733413696},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.33353227376937866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22579285502433777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21752789616584778},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19858121871948242},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.11367276310920715},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06924250721931458},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.1016/j.jid.2023.02.006","doi":"https://doi.org/10.1016/j.jid.2023.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2023.02.006","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.03.01.530706","doi":"https://doi.org/10.1101/2023.03.01.530706","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.03.01.530706","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/19/2023.03.01.530706.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:36911273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36911273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ArXiv","raw_type":"Preprint"},{"id":"pmid:36993709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36993709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37455062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37455062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of investigative dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:2303.00933","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2303.00933","pdf_url":"https://arxiv.org/pdf/2303.00933","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10002759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10002759","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10002759/pdf/nihpp-2303.00933v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ArXiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10054974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10054974","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10054974/pdf/nihpp-2023.03.01.530706v2.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"doi:10.48550/arxiv.2303.00933","doi":"https://doi.org/10.48550/arxiv.2303.00933","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2303.00933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1016/j.jid.2023.02.006","doi":"https://doi.org/10.1016/j.jid.2023.02.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2023.02.006","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G263743809","display_name":"Tumor pyruvate kinase as key regulator of cancer metabolism","funder_award_id":"R00CA154887","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3339627588","display_name":null,"funder_award_id":"CA-154887","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4516132404","display_name":"Tumor pyruvate kinase as key regulator of cancer metabolism","funder_award_id":"K99CA154887","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000093710","display_name":null,"funder_award_id":"CA154887","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310706","display_name":"Bundesverband der Deutschen Industrie","ror":"https://ror.org/00xb58j90"},{"id":"https://openalex.org/F4320320873","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57"},{"id":"https://openalex.org/F4320328348","display_name":"Bayerisch-Kalifornischen Hochschulzentrum","ror":"https://ror.org/010k8ya28"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1997074238","https://openalex.org/W2917625314","https://openalex.org/W2987478814","https://openalex.org/W3124296497","https://openalex.org/W4224994977","https://openalex.org/W4284893339","https://openalex.org/W4296701485","https://openalex.org/W4308559041","https://openalex.org/W4311306094","https://openalex.org/W4317757307"],"related_works":["https://openalex.org/W4412700591","https://openalex.org/W2765676808","https://openalex.org/W2171204703","https://openalex.org/W7097901672","https://openalex.org/W2930419027","https://openalex.org/W2779861385","https://openalex.org/W3042151980","https://openalex.org/W4415651584","https://openalex.org/W2137518600","https://openalex.org/W4406014103"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-07-15T00:00:00"}
