{"id":"https://openalex.org/W4384282944","doi":"https://doi.org/10.1371/journal.pone.0288615","title":"Comparison of the clinical characteristics and clinical outcomes of culture-positive septic shock and culture-negative septic shock among pediatric patients","display_name":"Comparison of the clinical characteristics and clinical outcomes of culture-positive septic shock and culture-negative septic shock among pediatric patients","publication_year":2023,"publication_date":"2023-07-14","ids":{"openalex":"https://openalex.org/W4384282944","doi":"https://doi.org/10.1371/journal.pone.0288615","pmid":"https://pubmed.ncbi.nlm.nih.gov/37450547","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10348532"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0288615","doi":"https://doi.org/10.1371/journal.pone.0288615","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0288615","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288615&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4384282944"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288615&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102714757","display_name":"Da Hyun Kim","orcid":"https://orcid.org/0000-0002-8588-7848","observed_orcids":["https://orcid.org/0000-0002-8588-7848"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Da Hyun Kim","raw_affiliation_strings":["Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027802125","display_name":"Seong Jong Park","orcid":"https://orcid.org/0000-0003-0250-2381","observed_orcids":["https://orcid.org/0000-0003-0250-2381"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Jong Park","raw_affiliation_strings":["Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089112198","display_name":"Won Kyoung Jhang","orcid":"https://orcid.org/0000-0003-2309-0494","observed_orcids":["https://orcid.org/0000-0003-2309-0494"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Won Kyoung Jhang","raw_affiliation_strings":["Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-2309-0494","affiliations":[{"raw_affiliation_string":"Division of Pediatric Critical Care Medicine, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089112198"],"corresponding_institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"],"apc_list":{"value":1805,"currency":"USD","value_usd":1805},"apc_paid":{"value":1805,"currency":"USD","value_usd":1805},"fwci":0.8766,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69844329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"18","issue":"7","first_page":"e0288615","last_page":"e0288615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pediatric-sepsis","display_name":"pediatric sepsis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5580000281333923},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.8190000057220459},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/renal-replacement-therapy","display_name":"renal replacement therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/vasopressor-support","display_name":"vasopressor therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/inotropic-support","display_name":"inotropic support","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.9000058174133301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8584089279174805},{"id":"https://openalex.org/C2778939556","wikidata":"https://www.wikidata.org/wiki/Q17146605","display_name":"Pediatric intensive care unit","level":2,"score":0.7220304012298584},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.6297403573989868},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.46620452404022217},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.46185457706451416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3916756510734558},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36385083198547363},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3334888219833374},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.3126789927482605}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pone.0288615","doi":"https://doi.org/10.1371/journal.pone.0288615","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0288615","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288615&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10348532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10348532","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10348532/pdf/pone.0288615.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:37450547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37450547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0288615","doi":"https://doi.org/10.1371/journal.pone.0288615","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0288615","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288615&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384282944.pdf","grobid_xml":"https://content.openalex.org/works/W4384282944.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1966076267","https://openalex.org/W1967992144","https://openalex.org/W2019349925","https://openalex.org/W2019778131","https://openalex.org/W2027831139","https://openalex.org/W2041461587","https://openalex.org/W2062328478","https://openalex.org/W2084445380","https://openalex.org/W2095497639","https://openalex.org/W2139557348","https://openalex.org/W2142343447","https://openalex.org/W2145577370","https://openalex.org/W2320604007","https://openalex.org/W2520212960","https://openalex.org/W2560253519","https://openalex.org/W2594150871","https://openalex.org/W2745212246","https://openalex.org/W2778781692","https://openalex.org/W2804205468","https://openalex.org/W2805372352","https://openalex.org/W2942993836","https://openalex.org/W2998853022","https://openalex.org/W3005429114","https://openalex.org/W3014991516","https://openalex.org/W3049554052","https://openalex.org/W3081371243","https://openalex.org/W3107496746","https://openalex.org/W3131139258","https://openalex.org/W3192388297","https://openalex.org/W3207810491","https://openalex.org/W4206897319","https://openalex.org/W4240164237","https://openalex.org/W4254674135","https://openalex.org/W4281861370","https://openalex.org/W4304890291"],"related_works":["https://openalex.org/W4401402767","https://openalex.org/W4206693385","https://openalex.org/W4295904368","https://openalex.org/W4386319685","https://openalex.org/W7220642316","https://openalex.org/W3107496746","https://openalex.org/W4313235930","https://openalex.org/W2778781692","https://openalex.org/W3160460162","https://openalex.org/W3131139258"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Among":[1,193,225,244],"pediatric":[2,41,60,226],"patients":[3,61,117,199],"with":[4,81,203,221,249],"septic":[5,8,35,70],"shock,":[6],"culture-negative":[7],"shock":[9,36,71],"(CNSS)":[10],"is":[11],"common":[12],"but":[13],"there":[14],"have":[15],"been":[16],"limited":[17],"data":[18],"on":[19,90],"its":[20],"clinical":[21,28,31,169,240],"characteristics":[22,29],"and":[23,30,38,75,86,104,137,158,178,185,190,215,231,242],"prognosis.":[24,254],"We":[25],"compared":[26],"the":[27,66,91,96,155,159,173,186,194,228,245],"outcomes":[32,170],"between":[33,72,154],"culture-positive":[34],"(CPSS)":[37],"CNSS":[39,124,160,232],"in":[40,168,239],"patients.":[42],"DESIGN:":[43],"Retrospective":[44],"single-center":[45],"study.":[46],"SETTING:":[47],"Pediatric":[48],"intensive":[49],"care":[50],"unit":[51],"(PICU)":[52],"of":[53,93,115,134,188,212],"a":[54],"tertiary":[55],"referral":[56],"hospital.":[57],"PATIENTS:":[58],"All":[59],"who":[62,88,200],"were":[63,130,150,201],"admitted":[64],"to":[65,69,95],"PICU":[67,182],"due":[68],"January":[73],"2010":[74],"November":[76],"2021,":[77],"except":[78],"for":[79,175],"those":[80,87,219,248],"fungal":[82],"or":[83],"viral":[84],"infections":[85],"expired":[89],"day":[92],"admittance":[94],"PICU.":[97],"The":[98,132,162],"primary":[99],"outcome":[100],"was":[101],"30-day":[102,135,213],"mortality":[103,136,139,141,146,214,217],"in-hospital":[105,138,145,216],"mortality.":[106,243],"INTERVENTIONS:":[107],"None.":[108],"MEASUREMENTS":[109],"AND":[110],"MAIN":[111],"RESULTS:":[112],"A":[113],"total":[114],"294":[116],"(CPSS":[118],"group,":[119,125,196,247],"n":[120,126],"=":[121,127],"185":[122],"[62.9%];":[123],"109":[128],"[37.1%])":[129],"included.":[131],"rates":[133,211],"(30-day":[140],"22.7%":[142],"vs":[143,148],"22%,":[144],"29.7%":[147],"25.7%)":[149],"not":[151,235],"significantly":[152,209],"different":[153],"CPSS":[156,195,229,246],"group":[157,230,233],"group.":[161],"two":[163],"groups":[164],"showed":[165],"comparable":[166],"results":[167],"such":[171],"as":[172],"requirement":[174],"mechanical":[176],"ventilator":[177],"renal":[179],"replacement":[180],"therapy,":[181],"stay":[183],"duration,":[184],"duration":[187],"MV":[189],"vasopressor/inotrope":[191],"support.":[192],"98":[197],"(53%)":[198],"infected":[202,220],"multi-drug":[204],"resistance":[205],"(MDR)":[206],"bacteria":[207,251],"had":[208,252],"higher":[210],"than":[218],"non-MDR":[222],"bacteria.":[223],"CONCLUSIONS:":[224],"patients,":[227],"did":[234],"show":[236],"significant":[237],"differences":[238],"features":[241],"MDR":[250],"poorer":[253]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-07-15T00:00:00"}
