{"id":"https://openalex.org/W4384155251","doi":"https://doi.org/10.1038/s41467-023-39772-z","title":"Extending the dynamic range of biomarker quantification through molecular equalization","display_name":"Extending the dynamic range of biomarker quantification through molecular equalization","publication_year":2023,"publication_date":"2023-07-13","ids":{"openalex":"https://openalex.org/W4384155251","doi":"https://doi.org/10.1038/s41467-023-39772-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/37443317","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10344875"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-39772-z","doi":"https://doi.org/10.1038/s41467-023-39772-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-39772-z","pdf_url":"https://www.nature.com/articles/s41467-023-39772-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-39772-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037539542","display_name":"Sharon S. Newman","orcid":"https://orcid.org/0000-0001-5432-173X","observed_orcids":["https://orcid.org/0000-0001-5432-173X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon S. Newman","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA","Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":"https://orcid.org/0000-0001-5432-173X","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070976556","display_name":"Brandon D. Wilson","orcid":"https://orcid.org/0000-0002-8867-4848","observed_orcids":["https://orcid.org/0000-0002-8867-4848"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon D. Wilson","raw_affiliation_strings":["Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA","Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-8867-4848","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049989498","display_name":"Dan Mamerow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Mamerow","raw_affiliation_strings":["Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA","Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043343366","display_name":"Benjamin C. Wollant","orcid":"https://orcid.org/0000-0002-9354-7421","observed_orcids":["https://orcid.org/0000-0002-9354-7421"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin C. Wollant","raw_affiliation_strings":["Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060684894","display_name":"Hnin Yin Yin Nyein","orcid":"https://orcid.org/0000-0002-5692-6182","observed_orcids":["https://orcid.org/0000-0002-5692-6182"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hnin Nyein","raw_affiliation_strings":["Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035416695","display_name":"Yael Rosenberg\u2010Hasson","orcid":"https://orcid.org/0000-0002-3284-5732","observed_orcids":["https://orcid.org/0000-0002-3284-5732"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yael Rosenberg-Hasson","raw_affiliation_strings":["Institute for Immunity, Transplantation, and Infection, School of Medicine, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunity, Transplantation, and Infection, School of Medicine, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068399737","display_name":"Holden Terry Maecker","orcid":"https://orcid.org/0000-0003-0795-9946","observed_orcids":["https://orcid.org/0000-0003-0795-9946","https://orcid.org/0000-0001-5389-0906"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holden T. Maecker","raw_affiliation_strings":["Institute for Immunity, Transplantation, and Infection, School of Medicine, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":"https://orcid.org/0000-0003-0795-9946","affiliations":[{"raw_affiliation_string":"Institute for Immunity, Transplantation, and Infection, School of Medicine, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110637876","display_name":"Michael S. Eisenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Eisenstein","raw_affiliation_strings":["Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA","Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020581130","display_name":"Hyongsok Tom Soh","orcid":"https://orcid.org/0000-0001-9443-857X","observed_orcids":["https://orcid.org/0000-0001-9443-857X","https://orcid.org/0000-0001-9432-4011"]},"institutions":[{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. Tom Soh","raw_affiliation_strings":["Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA. tsoh@stanford.edu","Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA. tsoh@stanford.edu","Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA. tsoh@stanford.edu","Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":"https://orcid.org/0000-0001-9443-857X","affiliations":[{"raw_affiliation_string":"Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA. tsoh@stanford.edu","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA. tsoh@stanford.edu","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA. tsoh@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020581130"],"corresponding_institution_ids":["https://openalex.org/I4210100286","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":1.7429,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85374589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"4192","last_page":"4192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.1356000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamic-range-enhancement","display_name":"dynamic range extension","score":0.7379999756813049},{"id":"https://openalex.org/keywords/proximity-ligation-assay","display_name":"proximity ligation assay","score":0.8799999952316284},{"id":"https://openalex.org/keywords/plasma-proteome","display_name":"plasma proteome","score":0.6859999895095825},{"id":"https://openalex.org/keywords/sample-splitting","display_name":"sample splitting","score":0.49799999594688416},{"id":"https://openalex.org/keywords/femtomolar-detection","display_name":"femtomolar detection","score":0.6420000195503235},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.7379030585289001},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.6432809233665466},{"id":"https://openalex.org/C87133666","wikidata":"https://www.wikidata.org/wiki/Q1161699","display_name":"Dynamic range","level":2,"score":0.6216303706169128},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5188973546028137},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47881489992141724},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.46429571509361267},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.4287247657775879},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.37223684787750244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28118717670440674},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20395714044570923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1384933888912201},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07809600234031677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-023-39772-z","doi":"https://doi.org/10.1038/s41467-023-39772-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-39772-z","pdf_url":"https://www.nature.com/articles/s41467-023-39772-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2023.02.07.527534","doi":"https://doi.org/10.1101/2023.02.07.527534","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.02.07.527534","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/02/08/2023.02.07.527534.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10344875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10344875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10344875/pdf/41467_2023_Article_39772.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37443317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37443317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39772-z","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-39772-z","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e3aeff914b4d4f3aad121a3da02109c1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e3aeff914b4d4f3aad121a3da02109c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-39772-z","doi":"https://doi.org/10.1038/s41467-023-39772-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-39772-z","pdf_url":"https://www.nature.com/articles/s41467-023-39772-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1816894442","display_name":null,"funder_award_id":"CR-0000579","funder_id":"https://openalex.org/F4320306705","funder_display_name":"Genentech Foundation for Biomedical Sciences"},{"id":"https://openalex.org/G971451555","display_name":"Workshop:  Spin Electronics for the 21st Century","funder_award_id":"0000579","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306705","display_name":"Genentech Foundation for Biomedical Sciences","ror":"https://ror.org/011qkaj49"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384155251.pdf","grobid_xml":"https://content.openalex.org/works/W4384155251.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W336832692","https://openalex.org/W987420839","https://openalex.org/W1543776368","https://openalex.org/W1967501266","https://openalex.org/W1975290591","https://openalex.org/W1984096033","https://openalex.org/W2020474446","https://openalex.org/W2033692444","https://openalex.org/W2041677964","https://openalex.org/W2050271637","https://openalex.org/W2053003735","https://openalex.org/W2092598739","https://openalex.org/W2092956762","https://openalex.org/W2098556604","https://openalex.org/W2104841504","https://openalex.org/W2128381684","https://openalex.org/W2137166024","https://openalex.org/W2142706826","https://openalex.org/W2148304424","https://openalex.org/W2172116519","https://openalex.org/W2233603983","https://openalex.org/W2253972942","https://openalex.org/W2346272251","https://openalex.org/W2508169637","https://openalex.org/W2522699003","https://openalex.org/W2782941307","https://openalex.org/W2952048284","https://openalex.org/W3016940372","https://openalex.org/W3021659033","https://openalex.org/W3026163675","https://openalex.org/W6894270897"],"related_works":["https://openalex.org/W2113766156","https://openalex.org/W2410363375","https://openalex.org/W7095986826","https://openalex.org/W4413974939","https://openalex.org/W2312970873","https://openalex.org/W7155033969","https://openalex.org/W1992396342","https://openalex.org/W2755414940","https://openalex.org/W2010084870","https://openalex.org/W3204471759"],"abstract_inverted_index":{"Precision":[0],"medicine":[1],"requires":[2],"highly":[3,189],"scalable":[4],"methods":[5,20,55],"of":[6,28,34,42,52,84,92,117,123,139,164,172,184],"multiplexed":[7,93,111,190],"biomarker":[8],"quantification":[9,116,138],"that":[10,77],"can":[11,78,87],"accurately":[12],"describe":[13,96],"patient":[14],"physiology.":[15],"Unfortunately,":[16],"contemporary":[17],"molecular":[18],"detection":[19,183],"are":[21],"generally":[22],"limited":[23],"to":[24,63,130,149,179],"a":[25,98,110,120,131,158,167,188],"dynamic":[26,40,159],"range":[27,41,122,160],"sensitivity":[29],"spanning":[30,119,145,161],"just":[31],"3-4":[32],"orders":[33,51,163],"magnitude,":[35],"whereas":[36],"the":[37,43,73,82,90,103,177],"actual":[38],"physiological":[39],"human":[44,174],"plasma":[45],"proteome":[46],"spans":[47],"more":[48],"than":[49],"10":[50],"magnitude.":[53],"Current":[54],"rely":[56],"on":[57],"sample":[58,171],"splitting":[59],"and":[60,75,135],"differential":[61],"dilution":[62,86],"compensate":[64],"for":[65,101],"this":[66,153],"mismatch,":[67],"but":[68],"such":[69],"measures":[70],"greatly":[71,88],"limit":[72],"reproducibility":[74],"scalability":[76],"be":[79],"achieved-in":[80],"particular,":[81],"effects":[83],"non-linear":[85],"confound":[89],"analysis":[91],"assays.":[94],"We":[95,125],"here":[97],"two-pronged":[99],"strategy":[100,129],"equalizing":[102],"signal":[104],"generated":[105],"by":[106],"each":[107],"analyte":[108],"in":[109,166,187],"panel,":[112],"thereby":[113],"enabling":[114],"simultaneous":[115,137],"targets":[118],"wide":[121],"concentrations.":[124],"apply":[126],"our":[127],"'EVROS'":[128],"proximity":[132],"ligation":[133],"assay":[134],"demonstrate":[136],"four":[140],"analytes":[141,186],"present":[142],"at":[143],"concentrations":[144],"from":[146],"low":[147],"femtomolar":[148],"mid-nanomolar":[150],"levels.":[151],"In":[152],"initial":[154],"demonstration,":[155],"we":[156],"achieve":[157,180],"seven":[162],"magnitude":[165],"single":[168],"5":[169],"\u00b5l":[170],"undiluted":[173],"serum,":[175],"highlighting":[176],"opportunity":[178],"sensitive,":[181],"accurate":[182],"diverse":[185],"fashion.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-07-14T00:00:00"}
