{"id":"https://openalex.org/W4384070538","doi":"https://doi.org/10.1101/2023.07.09.548214","title":"Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch","display_name":"Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch","publication_year":2023,"publication_date":"2023-07-10","ids":{"openalex":"https://openalex.org/W4384070538","doi":"https://doi.org/10.1101/2023.07.09.548214"},"language":"en","primary_location":{"id":"doi:10.1101/2023.07.09.548214","doi":"https://doi.org/10.1101/2023.07.09.548214","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.09.548214","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/10/2023.07.09.548214.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/10/2023.07.09.548214.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069453450","display_name":"Andrew Crowther","orcid":"https://orcid.org/0000-0001-9269-6188","observed_orcids":["https://orcid.org/0000-0001-9269-6188"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Crowther","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":"https://orcid.org/0000-0001-9269-6188","affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022507193","display_name":"Sakeen W. Kashem","orcid":"https://orcid.org/0000-0002-2594-2884","observed_orcids":["https://orcid.org/0000-0002-2594-2884"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210143381","display_name":"San Francisco VA Health Care System","ror":"https://ror.org/04g9q2h37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sakeen W. Kashem","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Dermatology, University of California San Francisco, San Francisco, CA 94158, USA","Division of Dermatology, San Francisco Veteran\u2019s Administration Healthcare System, San Francisco, CA 94121, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Dermatology, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Division of Dermatology, San Francisco Veteran\u2019s Administration Healthcare System, San Francisco, CA 94121, USA","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I4210143381"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002497102","display_name":"Madison E. Jewell","orcid":"https://orcid.org/0009-0004-8337-1583","observed_orcids":["https://orcid.org/0009-0004-8337-1583"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madison E. Jewell","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102534154","display_name":"Henry Le Chang","orcid":"https://orcid.org/0009-0003-2064-1198","observed_orcids":["https://orcid.org/0009-0003-2064-1198"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Le Chang","raw_affiliation_strings":["Department of Anatomy University of California -San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy University of California -San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102860018","display_name":"M. Casillas","orcid":"https://orcid.org/0000-0002-8028-4634","observed_orcids":["https://orcid.org/0000-0002-8028-4634"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariela Rosa Casillas","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":"https://orcid.org/0000-0002-8028-4634","affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011681307","display_name":"\u00c9lora Midavaine","orcid":"https://orcid.org/0000-0002-0364-8975","observed_orcids":["https://orcid.org/0000-0002-0364-8975"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"\u00c9lora Midavaine","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000488476","display_name":"Sian Rodriguez-Rosado","orcid":"https://orcid.org/0009-0001-0440-1974","observed_orcids":["https://orcid.org/0009-0001-0440-1974"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sian Rodriguez","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084440429","display_name":"Jo\u00e3o M. Br\u00e1z","orcid":"https://orcid.org/0000-0001-8955-0735","observed_orcids":["https://orcid.org/0000-0001-8955-0735"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joao M. Braz","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032853383","display_name":"Artur Kania","orcid":"https://orcid.org/0000-0002-5209-2520","observed_orcids":["https://orcid.org/0000-0002-5209-2520"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Artur Kania","raw_affiliation_strings":["Institut de Recherches Cliniques de Montr\u00e9al (IRCM), Montreal, Qc, H2W 1R7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Cliniques de Montr\u00e9al (IRCM), Montreal, Qc, H2W 1R7","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007740596","display_name":"Allan I. Basbaum","orcid":"https://orcid.org/0000-0002-1710-6333","observed_orcids":["https://orcid.org/0000-0002-1710-6333"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan I. Basbaum","raw_affiliation_strings":["Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anatomy, University of California San Francisco, San Francisco, CA 9458, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007740596"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.40139999985694885,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.40139999985694885,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.3206000030040741,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.24009999632835388,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetracycline-transactivator","display_name":"tetracycline transactivator","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuropathic-itch","display_name":"neuropathic itch","score":0.7549999952316284},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/primary-afferent-neurons","display_name":"primary afferent neurons","score":0.9110000133514404},{"id":"https://openalex.org/keywords/scratching-behavior","display_name":"scratching behavior","score":0.6809999942779541},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.6010000109672546},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.7229999899864197},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dreadd","display_name":"DREADD","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gi-signaling","display_name":"Gi signaling","score":0.6779999732971191},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.7020000219345093},{"id":"https://openalex.org/keywords/conditional-gene-expression","display_name":"conditional gene expression","score":0.6000000238418579},{"id":"https://openalex.org/keywords/phox2b","display_name":"PHOX2B","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2780196728","wikidata":"https://www.wikidata.org/wiki/Q1413166","display_name":"Scratching","level":2,"score":0.784369707107544},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.6418731808662415},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.5976572036743164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5920256972312927},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5428904891014099},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.4588618278503418},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4347926676273346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4273435175418854},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3586573004722595},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3470924496650696},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2933637499809265},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2170383632183075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18283623456954956},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.16271507740020752},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1280725598335266},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2023.07.09.548214","doi":"https://doi.org/10.1101/2023.07.09.548214","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.09.548214","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/10/2023.07.09.548214.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2023.07.09.548214","doi":"https://doi.org/10.1101/2023.07.09.548214","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.09.548214","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/10/2023.07.09.548214.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1004233763","display_name":null,"funder_award_id":"NSR35097306","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1365006173","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"2034836","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2289634171","display_name":"A genetic analysis of the development of nociceptive topognosis.","funder_award_id":"162225_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G2546462022","display_name":"A genetic analysis of the development of nociceptive topognosis.","funder_award_id":"159839_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4960690329","display_name":null,"funder_award_id":"PJT- 153053","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8587513942","display_name":null,"funder_award_id":"and PJT-159839","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G9000320434","display_name":null,"funder_award_id":"MOP-77556","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320315389","display_name":"Open Philanthropy Project","ror":"https://ror.org/004d1k391"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384070538.pdf","grobid_xml":"https://content.openalex.org/works/W4384070538.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W36053009","https://openalex.org/W1492722920","https://openalex.org/W1748482670","https://openalex.org/W1956941772","https://openalex.org/W1977347668","https://openalex.org/W1989100246","https://openalex.org/W1992840415","https://openalex.org/W1993592741","https://openalex.org/W1993960807","https://openalex.org/W2003583687","https://openalex.org/W2045026834","https://openalex.org/W2060484288","https://openalex.org/W2065323160","https://openalex.org/W2072653944","https://openalex.org/W2079978524","https://openalex.org/W2086991865","https://openalex.org/W2090429649","https://openalex.org/W2096881442","https://openalex.org/W2098533907","https://openalex.org/W2101889725","https://openalex.org/W2158259619","https://openalex.org/W2177347011","https://openalex.org/W2529059282","https://openalex.org/W2549478702","https://openalex.org/W2589186092","https://openalex.org/W2753125068","https://openalex.org/W2761382264","https://openalex.org/W2773803332","https://openalex.org/W2782605743","https://openalex.org/W2802576439","https://openalex.org/W2807235788","https://openalex.org/W2904533595","https://openalex.org/W2938522726","https://openalex.org/W2952059832","https://openalex.org/W2979638528","https://openalex.org/W3012445391","https://openalex.org/W3048685979","https://openalex.org/W3109914580","https://openalex.org/W3128292268","https://openalex.org/W3132360936","https://openalex.org/W3200769092","https://openalex.org/W3204107460","https://openalex.org/W4317757285","https://openalex.org/W4385460202","https://openalex.org/W4404252574"],"related_works":["https://openalex.org/W4411207568","https://openalex.org/W4392281564","https://openalex.org/W2001461732","https://openalex.org/W3161184956","https://openalex.org/W2904926540","https://openalex.org/W4416023279","https://openalex.org/W2103106877","https://openalex.org/W2791294509","https://openalex.org/W7075293366","https://openalex.org/W2980923998"],"abstract_inverted_index":{"Abstract":[0],"Mouse":[1],"models":[2],"that":[3,63,82,208,219],"combine":[4],"tetracycline-controlled":[5],"gene":[6],"expression":[7,17,151],"systems":[8],"and":[9,22,35,78,189],"conditional":[10],"genetic":[11],"activation":[12,230],"can":[13,38,83],"tightly":[14],"regulate":[15],"transgene":[16],"in":[18,56,154,182],"discrete":[19],"cell":[20],"types":[21],"tissues.":[23],"However,":[24],"the":[25,68,87,97,114,122,133,139,159,172,186,200,220],"commonly":[26],"used":[27],"Tet-Off":[28],"variant,":[29],"tetracycline":[30],"transactivator":[31],"(tTA),":[32],"when":[33],"overexpressed":[34],"fully":[36],"active,":[37],"lead":[39],"to":[40,103,113,207],"developmental":[41],"lethality,":[42],"disease,":[43],"or":[44],"more":[45],"subtle":[46],"behavioral":[47],"phenotypes.":[48],"Here":[49],"we":[50,99],"describe":[51],"a":[52,59,203,237],"profound":[53],"itch":[54,222],"phenotype":[55,102],"mice":[57,73,117],"expressing":[58],"genetically":[60],"encoded":[61],"tTA":[62,72,88,119],"is":[64],"conditionally":[65],"activated":[66,120],"within":[67,121,132],"Phox2a":[69,115],"lineage.":[70],"Phox2a;":[71],"develop":[74],"intense,":[75],"localized":[76,187,228],"scratching":[77,140,188,201],"regional":[79],"skin":[80,155,163,190],"lesions":[81,164],"be":[84],"controlled":[85],"by":[86,210],"inhibitor,":[89],"doxycycline.":[90],"As":[91],"gabapentin,":[92],"but":[93,145,234],"not":[94,109,137,146,225],"morphine,":[95],"relieved":[96],"scratching,":[98],"consider":[100],"this":[101],"result":[104],"from":[105,227,236],"chronic":[106],"neuropathic":[107,221],"itch,":[108],"pain.":[110],"In":[111,142],"contrast":[112],"lineage,":[116,124],"with":[118,202],"Phox2b":[123],"which":[125,157,162,176],"has":[126],"many":[127],"similar":[128],"areas":[129],"of":[130,171,194,231,241],"recombination":[131],"nervous":[134],"system,":[135],"did":[136],"recapitulate":[138],"phenotype.":[141],"Phox2a-Cre":[143],"mice,":[144],"Phox2b-Cre,":[147],"intense":[148],"Cre-dependent":[149],"reporter":[150],"was":[152],"found":[153],"keratinocytes":[156],"formed":[158],"area":[160],"at":[161],"developed.":[165],"Most":[166],"interestingly,":[167],"repeated":[168],"topical":[169],"application":[170],"DREADD":[173],"agonist,":[174],"CNO,":[175],"chronically":[177],"induced":[178],"G":[179,211],"i":[180,212],"signaling":[181],"Phox2a-keratinocytes,":[183],"completely":[184],"reversed":[185],"lesions.":[191],"Furthermore,":[192],"ablation":[193],"TRPV1-expressing,":[195],"primary":[196],"afferent":[197],"neurons":[198],"reduced":[199],"time":[204],"course":[205],"comparable":[206],"produced":[209],"-DREADD":[213],"inhibition.":[214],"These":[215],"temporal":[216],"properties":[217],"suggest":[218],"condition":[223],"arises":[224],"only":[226],"keratinocyte":[229],"peripheral":[232],"nerves":[233],"also":[235],"persistent,":[238],"gabapentin-sensitive":[239],"state":[240],"central":[242],"sensitization.":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-13T00:00:00"}
