{"id":"https://openalex.org/W4383957252","doi":"https://doi.org/10.1155/2023/4878774","title":"Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis","display_name":"Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4383957252","doi":"https://doi.org/10.1155/2023/4878774","pmid":"https://pubmed.ncbi.nlm.nih.gov/37469991","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10353900"},"language":"en","primary_location":{"id":"doi:10.1155/2023/4878774","doi":"https://doi.org/10.1155/2023/4878774","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/4878774","pdf_url":"https://downloads.hindawi.com/journals/bmri/2023/4878774.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2023/4878774.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083735281","display_name":"John P. Vanden Heuvel","orcid":"https://orcid.org/0000-0002-3350-2037","observed_orcids":["https://orcid.org/0000-0002-3350-2037"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Vanden Heuvel","raw_affiliation_strings":["Asymmetric Therapeutics LLC, 141 Main St., P.O. Box J, Unadilla, NY 13849, USA","Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA","Indigo Biosciences, Inc., 3006 Research Drive, State College, PA 16801, USA"],"raw_orcid":"https://orcid.org/0000-0002-3350-2037","affiliations":[{"raw_affiliation_string":"Asymmetric Therapeutics LLC, 141 Main St., P.O. Box J, Unadilla, NY 13849, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Indigo Biosciences, Inc., 3006 Research Drive, State College, PA 16801, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049129235","display_name":"Shuling Zhou","orcid":"https://orcid.org/0000-0001-5984-7415","observed_orcids":["https://orcid.org/0000-0001-5984-7415","https://orcid.org/0000-0003-3408-9501"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuling Zhou","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087679575","display_name":"Anisha B. Patel","orcid":"https://orcid.org/0000-0002-5372-784X","observed_orcids":["https://orcid.org/0000-0002-5372-784X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anisha B. Patel","raw_affiliation_strings":["Asymmetric Therapeutics LLC, 141 Main St., P.O. Box J, Unadilla, NY 13849, USA","Department of Dermatology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-5372-784X","affiliations":[{"raw_affiliation_string":"Asymmetric Therapeutics LLC, 141 Main St., P.O. Box J, Unadilla, NY 13849, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001860622","display_name":"Harry N. Kamerow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095634","display_name":"Mount Nittany Medical Center","ror":"https://ror.org/00nw7tq55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095634"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry N. Kamerow","raw_affiliation_strings":["Mount Nittany Medical Center, 1850 East Park Avenue, State College, PA 16803, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Nittany Medical Center, 1850 East Park Avenue, State College, PA 16803, USA","institution_ids":["https://openalex.org/I4210095634"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Baran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095634","display_name":"Mount Nittany Medical Center","ror":"https://ror.org/00nw7tq55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095634"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Baran","raw_affiliation_strings":["Mount Nittany Medical Center, 1850 East Park Avenue, State College, PA 16803, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Nittany Medical Center, 1850 East Park Avenue, State College, PA 16803, USA","institution_ids":["https://openalex.org/I4210095634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012445238","display_name":"John P Ford","orcid":"https://orcid.org/0000-0001-5151-4157","observed_orcids":["https://orcid.org/0000-0001-5151-4157"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John P. Ford","raw_affiliation_strings":["Asymmetric Therapeutics LLC, 141 Main St., P.O. Box J, Unadilla, NY 13849, USA"],"raw_orcid":"https://orcid.org/0000-0001-5151-4157","affiliations":[{"raw_affiliation_string":"Asymmetric Therapeutics LLC, 141 Main St., P.O. Box J, Unadilla, NY 13849, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012445238"],"corresponding_institution_ids":[],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0984,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.30469415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"2023","issue":"1","first_page":"4878774","last_page":"4878774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":1.0},{"id":"https://openalex.org/keywords/topical-therapy","display_name":"topical treatment","score":0.8799999952316284},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/xanthine-oxidase-inhibition","display_name":"xanthine oxidase inhibition","score":0.7749999761581421},{"id":"https://openalex.org/keywords/oxypurinol","display_name":"oxypurinol","score":0.8650000095367432},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9229999780654907},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.8529999852180481},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oncostatin-m","display_name":"oncostatin M","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/il-1alpha","display_name":"IL-1\u03b1","score":0.6850000023841858},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.578000009059906},{"id":"https://openalex.org/keywords/skin-thickness","display_name":"skin thickness","score":0.656000018119812},{"id":"https://openalex.org/keywords/inflammatory-skin-diseases","display_name":"inflammatory skin diseases","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7611507177352905},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.7442141771316528},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.7257957458496094},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6241101026535034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6179731488227844},{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.5407713651657104},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46100613474845886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32446908950805664},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28859591484069824},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25671350955963135},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2427365481853485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20926791429519653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0943635106086731},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1155/2023/4878774","doi":"https://doi.org/10.1155/2023/4878774","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/4878774","pdf_url":"https://downloads.hindawi.com/journals/bmri/2023/4878774.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10353900","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10353900","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10353900/pdf/BMRI2023-4878774.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Res Int","raw_type":"Text"},{"id":"pmid:37469991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37469991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed research international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1155/2023/4878774","doi":"https://doi.org/10.1155/2023/4878774","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/4878774","pdf_url":"https://downloads.hindawi.com/journals/bmri/2023/4878774.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4192716958","display_name":null,"funder_award_id":"1010021","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383957252.pdf","grobid_xml":"https://content.openalex.org/works/W4383957252.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1499259204","https://openalex.org/W1720483047","https://openalex.org/W1983280412","https://openalex.org/W2005057655","https://openalex.org/W2013900474","https://openalex.org/W2038583425","https://openalex.org/W2051641690","https://openalex.org/W2058426885","https://openalex.org/W2061037198","https://openalex.org/W2071629773","https://openalex.org/W2071759610","https://openalex.org/W2074492117","https://openalex.org/W2126526169","https://openalex.org/W2197645752","https://openalex.org/W2208802314","https://openalex.org/W2337217181","https://openalex.org/W2626378503","https://openalex.org/W2745016857","https://openalex.org/W2748620435","https://openalex.org/W2785547592","https://openalex.org/W2954800457","https://openalex.org/W3093443335","https://openalex.org/W3093603374","https://openalex.org/W3093765038","https://openalex.org/W3128954319","https://openalex.org/W3132811301","https://openalex.org/W3180911120","https://openalex.org/W3207661545","https://openalex.org/W4281290093"],"related_works":["https://openalex.org/W2005057655","https://openalex.org/W4367601096","https://openalex.org/W2426842211","https://openalex.org/W1968961618","https://openalex.org/W4290770436","https://openalex.org/W2013900474","https://openalex.org/W2936142673","https://openalex.org/W7152089684","https://openalex.org/W3161368388","https://openalex.org/W2886325973"],"abstract_inverted_index":{"Although":[0],"the":[1,9,48,126,184,195,208,211,232,236,272],"management":[2],"options":[3],"for":[4,21,45,93,155],"psoriasis":[5],"have":[6,255],"progressed":[7],"with":[8,23,57,140,219,259],"use":[10],"of":[11,31,84,186,194,200,207,210,227,235,274],"systemic":[12],"agents,":[13],"there":[14],"are":[15],"few":[16],"efficacious":[17],"nonsteroidal":[18,269],"topical":[19,250],"therapies":[20,270],"patients":[22],"limited":[24],"or":[25],"lower":[26],"grade":[27],"disease.":[28],"The":[29,82,168,224],"effects":[30],"allopurinol":[32],"(Allo)":[33],"and":[34,67,79,86,95,117,144,148,151,157,164,173,189,221,252,262],"glutathione":[35],"(GSH)":[36],"were":[37,55,138],"examined":[38],"in":[39,42,71,121,149,183,205,271],"two":[40],"different":[41],"vitro":[43],"models":[44],"psoriasis.":[46,285],"In":[47,125],"first":[49],"model,":[50,128],"human":[51,130],"immortalized":[52],"keratinocytes":[53],"(HaCaT)":[54],"treated":[56,139],"M5":[58],"cocktail":[59],"(IL\u201017A,":[60],"IL\u201022,":[61],"oncostatin":[62],"M,":[63],"IL\u20101":[64],"\u03b1":[65,69],",":[66],"TNF\u2010":[68],")":[70],"four":[72],"interventional":[73],"groups":[74],"(control,":[75],"Allo,":[76],"oxypurinol":[77],"(Oxy),":[78],"methotrexate":[80],"(MTX)).":[81],"number":[83],"live":[85],"dead":[87],"cells":[88,137],"was":[89,175,217],"determined":[90],"after":[91],"treatment":[92,273],"48":[94],"72":[96],"hrs.":[97],"Allo":[98,143,172,220,230,241,251],"decreased":[99],"cell":[100,106,281],"proliferation":[101,282],"(total":[102],"cells)":[103],"without":[104],"increasing":[105],"death":[107],"compared":[108],"to":[109,171,177,202,229],"both":[110,187],"its":[111],"xanthine":[112],"oxidase":[113],"inhibiting":[114],"metabolite":[115],"Oxy":[116],"a":[118,129,178,256,264],"standard":[119,179],"agent":[120,181],"clinical":[122],"use,":[123],"MTX.":[124],"second":[127],"psoriatic":[131],"skin":[132,276],"equivalent":[133,176],"(PSE)":[134],"culture":[135],"system,":[136],"vehicle":[141],"control,":[142],"GSH":[145,174,222,228,253],"(as":[146],"monotherapies":[147],"combination),":[150],"vitamin":[152],"D":[153],"(VitD)":[154],"2":[156],"6":[158,198],"days":[159,199],"followed":[160],"by":[161,240,279],"histological":[162],"analysis":[163],"altered":[165],"gene":[166],"expression.":[167],"combined":[169],"exposure":[170,201,226,242],"antipsoriasis":[180],"VitD":[182,203],"inhibition":[185],"proliferative":[188],"replicative":[190],"markers.":[191],"Histologic":[192],"examination":[193],"tissue":[196,215],"at":[197],"resulted":[204],"loss":[206],"integrity":[209,216],"squamous/epithelial":[212],"continuity":[213],"whereas":[214],"preserved":[218],"exposure.":[223],"additional":[225],"reversed":[231],"increased":[233,280],"thickness":[234],"dermis":[237],"layer":[238],"caused":[239],"alone.":[243],"Taken":[244],"together,":[245],"this":[246],"data":[247],"shows":[248],"that":[249],"may":[254],"synergistic":[257],"effect":[258],"low":[260],"toxicity":[261],"constitute":[263],"therapeutic":[265],"advantage":[266],"over":[267],"current":[268],"inflammatory":[275],"conditions":[277],"marked":[278],"such":[283],"as":[284]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-07-12T00:00:00"}