{"id":"https://openalex.org/W4383752915","doi":"https://doi.org/10.1073/pnas.2221118120","title":"Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii","display_name":"Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii","publication_year":2023,"publication_date":"2023-07-10","ids":{"openalex":"https://openalex.org/W4383752915","doi":"https://doi.org/10.1073/pnas.2221118120","pmid":"https://pubmed.ncbi.nlm.nih.gov/37428915","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10629562"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2221118120","doi":"https://doi.org/10.1073/pnas.2221118120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2221118120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2221118120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023910888","display_name":"Rebeca Carballar\u2010Lejaraz\u00fa","orcid":"https://orcid.org/0000-0002-9338-8774","observed_orcids":["https://orcid.org/0000-0002-9338-8774"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebeca Carballar-Lejaraz\u00fa","raw_affiliation_strings":["Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058550119","display_name":"Yuemei Dong","orcid":"https://orcid.org/0000-0002-7902-2899","observed_orcids":["https://orcid.org/0000-0002-7902-2899"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuemei Dong","raw_affiliation_strings":["W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038171896","display_name":"Thai Binh Pham","orcid":"https://orcid.org/0000-0001-7661-0495","observed_orcids":["https://orcid.org/0000-0001-7661-0495"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thai Binh Pham","raw_affiliation_strings":["Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061953795","display_name":"Taylor Tushar","orcid":"https://orcid.org/0000-0001-6982-3249","observed_orcids":["https://orcid.org/0000-0001-6982-3249"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Tushar","raw_affiliation_strings":["Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025"],"raw_orcid":"https://orcid.org/0000-0001-6982-3249","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043310039","display_name":"Rodrigo M. Corder","orcid":"https://orcid.org/0000-0002-8929-2200","observed_orcids":["https://orcid.org/0000-0002-8929-2200"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo M. Corder","raw_affiliation_strings":["Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720"],"raw_orcid":"https://orcid.org/0000-0002-8929-2200","affiliations":[{"raw_affiliation_string":"Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072041969","display_name":"Agastya Mondal","orcid":"https://orcid.org/0000-0002-3369-987X","observed_orcids":["https://orcid.org/0000-0002-3369-987X"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agastya Mondal","raw_affiliation_strings":["Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720"],"raw_orcid":"https://orcid.org/0000-0002-3369-987X","affiliations":[{"raw_affiliation_string":"Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052650113","display_name":"H\u00e9ctor M. S\u00e1nchez C.","orcid":"https://orcid.org/0000-0001-7378-8853","observed_orcids":["https://orcid.org/0000-0001-7378-8853"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H\u00e9ctor M. S\u00e1nchez C.","raw_affiliation_strings":["Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720"],"raw_orcid":"https://orcid.org/0000-0001-7378-8853","affiliations":[{"raw_affiliation_string":"Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hsu-Feng Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsu-Feng Lee","raw_affiliation_strings":["Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063129753","display_name":"John Macky Marshall","orcid":"https://orcid.org/0000-0003-0603-7341","observed_orcids":["https://orcid.org/0000-0003-0603-7341"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Marshall","raw_affiliation_strings":["Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720"],"raw_orcid":"https://orcid.org/0000-0003-0603-7341","affiliations":[{"raw_affiliation_string":"Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075932475","display_name":"George Dimopoulos","orcid":"https://orcid.org/0000-0001-6755-8111","observed_orcids":["https://orcid.org/0000-0001-6755-8111"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Dimopoulos","raw_affiliation_strings":["W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205"],"raw_orcid":"https://orcid.org/0000-0001-6755-8111","affiliations":[{"raw_affiliation_string":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039756363","display_name":"Anthony Amade James","orcid":"https://orcid.org/0000-0001-5577-3308","observed_orcids":["https://orcid.org/0000-0001-5577-3308"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony A. James","raw_affiliation_strings":["Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025","Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697-3900"],"raw_orcid":"https://orcid.org/0000-0001-5577-3308","affiliations":[{"raw_affiliation_string":"Department of Microbiology & Molecular Genetics, University of California, Irvine, CA 92697-4025","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697-3900","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039756363"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":20.971,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.99797914,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"120","issue":"29","first_page":"e2221118120","last_page":"e2221118120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-drive","display_name":"gene drive","score":0.9739999771118164},{"id":"https://openalex.org/keywords/population-modification","display_name":"population modification","score":0.8600000143051147},{"id":"https://openalex.org/keywords/malaria-vector-control","display_name":"malaria vector control","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anopheles-gambiae","display_name":"Anopheles gambiae","score":0.996999979019165},{"id":"https://openalex.org/keywords/anopheles-coluzzii","display_name":"Anopheles coluzzii","score":1.0},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ookinetes","display_name":"ookinetes","score":0.7229999899864197},{"id":"https://openalex.org/keywords/sporozoites","display_name":"sporozoites","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transmission-threshold","display_name":"transmission threshold","score":0.5299999713897705},{"id":"https://openalex.org/keywords/fitness-cost","display_name":"fitness cost","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2776802408","wikidata":"https://www.wikidata.org/wiki/Q135237","display_name":"Anopheles gambiae","level":3,"score":0.9473639726638794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8480418920516968},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.8039137125015259},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6818804740905762},{"id":"https://openalex.org/C2781375639","wikidata":"https://www.wikidata.org/wiki/Q158597","display_name":"Anopheles","level":3,"score":0.671139121055603},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5979064106941223},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5870715379714966},{"id":"https://openalex.org/C2778060650","wikidata":"https://www.wikidata.org/wiki/Q22964789","display_name":"Gene drive","level":4,"score":0.5134747624397278},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49395328760147095},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4670141339302063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4656537175178528},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.44082844257354736},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19785717129707336},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.10381317138671875},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072138","descriptor_name":"Mosquito Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000852","descriptor_name":"Anopheles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000852","descriptor_name":"Anopheles","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D034101","descriptor_name":"Sporozoites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2221118120","doi":"https://doi.org/10.1073/pnas.2221118120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2221118120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10629562","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10629562","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10629562/pdf/pnas.202221118.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:37428915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37428915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8vc6n49z","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8vc6n49z","pdf_url":"https://escholarship.org/content/qt8vc6n49z/qt8vc6n49z.pdf?t=rzuf3j","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 29","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2221118120","doi":"https://doi.org/10.1073/pnas.2221118120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2221118120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5078157272","display_name":"University of California, Berkeley - to use computational modeling to inform gene drive development","funder_award_id":"INV-017683","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G5248914246","display_name":"University of California, Irvine - to develop and characterize population modification strains of gene drive mosquitoes","funder_award_id":"INV-043645","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G9000877618","display_name":"Impact of gene-drive systems for population modification on malaria vector mosquitoes","funder_award_id":"R01AI170692","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F208254070","display_name":"University of California Malaria Initiative","ror":null},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320315694","display_name":"Bloomberg Philanthropies","ror":"https://ror.org/01sv5vd96"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383752915.pdf","grobid_xml":"https://content.openalex.org/works/W4383752915.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W658624297","https://openalex.org/W1534179616","https://openalex.org/W1729017034","https://openalex.org/W1985606005","https://openalex.org/W1992286851","https://openalex.org/W2010614468","https://openalex.org/W2014240398","https://openalex.org/W2017380332","https://openalex.org/W2038776617","https://openalex.org/W2048023924","https://openalex.org/W2050517636","https://openalex.org/W2053027067","https://openalex.org/W2066245205","https://openalex.org/W2068017695","https://openalex.org/W2074255178","https://openalex.org/W2076658183","https://openalex.org/W2076721712","https://openalex.org/W2084250742","https://openalex.org/W2090791625","https://openalex.org/W2103247762","https://openalex.org/W2104950321","https://openalex.org/W2112400573","https://openalex.org/W2120579606","https://openalex.org/W2122182808","https://openalex.org/W2131400772","https://openalex.org/W2180866616","https://openalex.org/W2314236847","https://openalex.org/W2419022643","https://openalex.org/W2517063877","https://openalex.org/W2529599078","https://openalex.org/W2562896996","https://openalex.org/W2766764213","https://openalex.org/W2794019234","https://openalex.org/W2805197529","https://openalex.org/W2806605174","https://openalex.org/W2894635702","https://openalex.org/W2980731483","https://openalex.org/W2994719674","https://openalex.org/W3006331632","https://openalex.org/W3012007369","https://openalex.org/W3024066723","https://openalex.org/W3031020728","https://openalex.org/W3034248695","https://openalex.org/W3039236671","https://openalex.org/W3042390851","https://openalex.org/W3080198030","https://openalex.org/W3083990309","https://openalex.org/W3092862378","https://openalex.org/W3094669925","https://openalex.org/W3124276390","https://openalex.org/W3160468589","https://openalex.org/W3182916335","https://openalex.org/W4205501921","https://openalex.org/W4214514365","https://openalex.org/W4225631538","https://openalex.org/W4280558310","https://openalex.org/W4281755185","https://openalex.org/W4288038562","https://openalex.org/W4296706284","https://openalex.org/W4308104141","https://openalex.org/W4313463380"],"related_works":["https://openalex.org/W7133359866","https://openalex.org/W7167495107","https://openalex.org/W2180866616","https://openalex.org/W4296706284","https://openalex.org/W7203915729","https://openalex.org/W3080198030","https://openalex.org/W3094669925","https://openalex.org/W2190054909","https://openalex.org/W4413425556","https://openalex.org/W7162189852"],"abstract_inverted_index":{"Proposed":[0],"genetic":[1],"approaches":[2],"for":[3,156,191,230,253],"reducing":[4,160],"human":[5,157],"malaria":[6,73,161,231],"include":[7],"population":[8],"modification,":[9],"which":[10],"introduces":[11],"genes":[12,37,58],"into":[13],"vector":[14],"mosquitoes":[15,74],"to":[16,33,38,52,90,153,168,175,197,221],"reduce":[17],"or":[18,247],"prevent":[19],"parasite":[20,66,124,206,244],"transmission.":[21],"We":[22],"demonstrate":[23],"the":[24,71,209,218],"potential":[25],"of":[26,134,181,211,236],"Cas9/guide":[27],"RNA":[28],"(gRNA)\u2013based":[29],"gene-drive":[30,49,83,107,198],"systems":[31,84],"linked":[32],"dual":[34,53],"antiparasite":[35],"effector":[36,57,119],"spread":[39],"rapidly":[40],"through":[41],"mosquito":[42],"populations.":[43],"Two":[44],"strains":[45,226,249],"have":[46],"an":[47,139],"autonomous":[48],"system":[50,199],"coupled":[51],"anti-":[54],"Plasmodium":[55],"falciparum":[56],"comprising":[59],"single-chain":[60],"variable":[61],"fragment":[62],"monoclonal":[63],"antibodies":[64],"targeting":[65],"ookinetes":[67],"and":[68,78,126,183,208,241],"sporozoites":[69],"in":[70,95,138,163,257],"African":[72],"Anopheles":[75,79],"gambiae":[76],"(AgTP13)":[77],"coluzzii":[80],"(AcTP13).":[81],"The":[82,118],"achieved":[85],"full":[86],"introduction":[87],"within":[88,170,186],"3":[89,187],"6":[91],"mo":[92,177],"after":[93,178],"release":[94],"small":[96],"cage":[97],"trials.":[98],"Life-table":[99],"analyses":[100],"revealed":[101],"no":[102],"fitness":[103,200],"loads":[104],"affecting":[105],"AcTP13":[106],"dynamics":[108],"but":[109],"AgTP13":[110],"males":[111],"were":[112],"less":[113],"competitive":[114],"than":[115],"wild":[116],"types.":[117],"molecules":[120],"reduced":[121,223],"significantly":[122],"both":[123],"prevalence":[125],"infection":[127,158,203],"intensities.":[128],"These":[129,246],"data":[130],"supported":[131],"transmission":[132,238],"modeling":[133],"conceptual":[135],"field":[136,255],"releases":[137],"island":[140],"setting":[141],"that":[142],"shows":[143],"meaningful":[144],"epidemiological":[145],"impacts":[146],"at":[147],"different":[148],"sporozoite":[149,193,237],"threshold":[150,239],"levels":[151],"(2.5":[152],"10":[154],"k)":[155],"by":[159,166,184],"incidence":[162],"optimal":[164],"simulations":[165],"50":[167],"90%":[169],"as":[171,173],"few":[172],"1":[174],"2":[176],"a":[179,258],"series":[180],"releases,":[182],"\u226590%":[185],"mo.":[188],"Modeling":[189],"outcomes":[190],"low":[192],"thresholds":[194],"are":[195,250],"sensitive":[196],"loads,":[201],"gametocytemia":[202],"intensities":[204],"during":[205],"challenges,":[207],"formation":[210],"potentially":[212],"drive-resistant":[213],"genome":[214],"target":[215],"sites,":[216],"extending":[217],"predicted":[219],"times":[220],"achieve":[222],"incidence.":[224],"TP13-based":[225],"could":[227],"be":[228],"effective":[229],"control":[232],"strategies":[233],"following":[234],"validation":[235],"numbers":[240],"testing":[242],"field-derived":[243],"strains.":[245],"similar":[248],"viable":[251],"candidates":[252],"future":[254],"trials":[256],"malaria-endemic":[259],"region.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":31},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-11T00:00:00"}