{"id":"https://openalex.org/W4383710074","doi":"https://doi.org/10.1177/00368504231182834","title":"Fibrin Sealant TISSEEL Lyo as a haemostatic agent in vascular surgery: Results of randomized, controlled, patient-blinded, multicentre clinical study in the Russian population","display_name":"Fibrin Sealant TISSEEL Lyo as a haemostatic agent in vascular surgery: Results of randomized, controlled, patient-blinded, multicentre clinical study in the Russian population","publication_year":2023,"publication_date":"2023-07-01","ids":{"openalex":"https://openalex.org/W4383710074","doi":"https://doi.org/10.1177/00368504231182834","pmid":"https://pubmed.ncbi.nlm.nih.gov/37427979","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10358634"},"language":"en","primary_location":{"id":"doi:10.1177/00368504231182834","doi":"https://doi.org/10.1177/00368504231182834","is_oa":true,"landing_page_url":"https://doi.org/10.1177/00368504231182834","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/00368504231182834","source":{"id":"https://openalex.org/S9683234","display_name":"Science Progress","issn_l":"0036-8504","issn":["0036-8504","2047-7163"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Progress","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/00368504231182834","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035923563","display_name":"Andrey A. Karpenko","orcid":"https://orcid.org/0000-0002-8064-1857","observed_orcids":["https://orcid.org/0000-0002-8064-1857","https://orcid.org/0000-0001-6914-334X"]},"institutions":[{"id":"https://openalex.org/I4210150189","display_name":"Meshalkin National Medical Research Center","ror":"https://ror.org/04jm2zr28","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210150189"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey A Karpenko","raw_affiliation_strings":["National Research Center Named after Academician E.N. Meshalkin, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center Named after Academician E.N. Meshalkin, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210150189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058045533","display_name":"Alexey V. Cheban","orcid":"https://orcid.org/0000-0002-6094-4607","observed_orcids":["https://orcid.org/0000-0002-6094-4607"]},"institutions":[{"id":"https://openalex.org/I4210150189","display_name":"Meshalkin National Medical Research Center","ror":"https://ror.org/04jm2zr28","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210150189"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexey V Cheban","raw_affiliation_strings":["National Research Center Named after Academician E.N. Meshalkin, Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-6094-4607","affiliations":[{"raw_affiliation_string":"National Research Center Named after Academician E.N. Meshalkin, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210150189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068876303","display_name":"Artem A. Rabtsun","orcid":"https://orcid.org/0000-0003-2803-5937","observed_orcids":["https://orcid.org/0000-0003-2803-5937"]},"institutions":[{"id":"https://openalex.org/I4210150189","display_name":"Meshalkin National Medical Research Center","ror":"https://ror.org/04jm2zr28","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210150189"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Artem A Rabtsun","raw_affiliation_strings":["National Research Center Named after Academician E.N. Meshalkin, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center Named after Academician E.N. Meshalkin, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210150189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038348332","display_name":"\u0421\u043e\u043a\u0443\u0440\u0435\u043d\u043a\u043e \u0413\u0435\u0440\u043c\u0430\u043d \u042e\u0440\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-2556-0576","observed_orcids":["https://orcid.org/0000-0003-2556-0576"]},"institutions":[{"id":"https://openalex.org/I4210166077","display_name":"Nikiforov Russian Center of Emergency and Radiation Medicine","ror":"https://ror.org/05wd4ca48","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210166077"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"German Y Sokurenko","raw_affiliation_strings":["A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, St-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, St-Petersburg, Russia","institution_ids":["https://openalex.org/I4210166077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029613612","display_name":"K.A. Andreychuk","orcid":"https://orcid.org/0000-0001-5705-0234","observed_orcids":["https://orcid.org/0000-0001-5705-0234"]},"institutions":[{"id":"https://openalex.org/I4210166077","display_name":"Nikiforov Russian Center of Emergency and Radiation Medicine","ror":"https://ror.org/05wd4ca48","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210166077"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin A Andreychuk","raw_affiliation_strings":["A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, St-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, St-Petersburg, Russia","institution_ids":["https://openalex.org/I4210166077"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Igor N Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor N Kim","raw_affiliation_strings":["State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112956344","display_name":"Valentin A Volf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valentin A Volf","raw_affiliation_strings":["State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104141224","display_name":"Maksim R Kuznetsov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]},{"id":"https://openalex.org/I4210133425","display_name":"City Clinical Hospital","ror":"https://ror.org/02zyvys51","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210133425"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maksim R Kuznetsov","raw_affiliation_strings":["City Clinical Hospital Named after S. S. Yudin, Moscow, Russia","Institute of Cluster Oncology Named after L. L. Levshin of the Sechenov University, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City Clinical Hospital Named after S. S. Yudin, Moscow, Russia","institution_ids":["https://openalex.org/I4210133425"]},{"raw_affiliation_string":"Institute of Cluster Oncology Named after L. L. Levshin of the Sechenov University, Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031871036","display_name":"\u041f\u0440\u043e\u0441\u0442\u043e\u0432 \u0418\u0433\u043e\u0440\u044c \u0418\u0433\u043e\u0440\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-7853-6775","observed_orcids":["https://orcid.org/0000-0002-7853-6775"]},"institutions":[{"id":"https://openalex.org/I16478408","display_name":"Rostov State Medical University","ror":"https://ror.org/046a1ah60","country_code":"RU","type":"education","lineage":["https://openalex.org/I16478408"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Igor I Prostov","raw_affiliation_strings":["Rostov State Medical University, Rostov-on-Don, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rostov State Medical University, Rostov-on-Don, Russia","institution_ids":["https://openalex.org/I16478408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112956342","display_name":"N. G. Sapronova","orcid":"https://orcid.org/0000-0001-9650-848X","observed_orcids":["https://orcid.org/0000-0001-9650-848X"]},"institutions":[{"id":"https://openalex.org/I16478408","display_name":"Rostov State Medical University","ror":"https://ror.org/046a1ah60","country_code":"RU","type":"education","lineage":["https://openalex.org/I16478408"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia G Sapronova","raw_affiliation_strings":["Rostov State Medical University, Rostov-on-Don, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rostov State Medical University, Rostov-on-Don, Russia","institution_ids":["https://openalex.org/I16478408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067014602","display_name":"Nina D. MZHAVANADZE","orcid":"https://orcid.org/0000-0001-5437-1112","observed_orcids":["https://orcid.org/0000-0001-5437-1112"]},"institutions":[{"id":"https://openalex.org/I4210141419","display_name":"Ryazan State Medical University named after Academician I.P. Pavlov","ror":"https://ror.org/04nvcbr70","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210141419"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nina D Mzhavanadze","raw_affiliation_strings":["Ryazan State Medical University Named after Academician I.P. Pavlov, Ryazan, Russia"],"raw_orcid":"https://orcid.org/0000-0001-5437-1112","affiliations":[{"raw_affiliation_string":"Ryazan State Medical University Named after Academician I.P. Pavlov, Ryazan, Russia","institution_ids":["https://openalex.org/I4210141419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054187526","display_name":"\u041a\u0430\u043c\u0430\u0435\u0432 \u0410\u043b\u0435\u043a\u0441\u0435\u0439 \u0410\u043d\u0434\u0440\u0435\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-3979-1271","observed_orcids":["https://orcid.org/0000-0002-3979-1271"]},"institutions":[{"id":"https://openalex.org/I4210141419","display_name":"Ryazan State Medical University named after Academician I.P. Pavlov","ror":"https://ror.org/04nvcbr70","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210141419"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey A Kamaev","raw_affiliation_strings":["Ryazan State Medical University Named after Academician I.P. Pavlov, Ryazan, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ryazan State Medical University Named after Academician I.P. Pavlov, Ryazan, Russia","institution_ids":["https://openalex.org/I4210141419"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019530034","display_name":"Igor Aleksandrovich Suchkov","orcid":"https://orcid.org/0000-0002-1292-5452","observed_orcids":["https://orcid.org/0000-0002-1292-5452"]},"institutions":[{"id":"https://openalex.org/I4210141419","display_name":"Ryazan State Medical University named after Academician I.P. Pavlov","ror":"https://ror.org/04nvcbr70","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210141419"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Igor A Suchkov","raw_affiliation_strings":["Ryazan State Medical University Named after Academician I.P. Pavlov, Ryazan, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1292-5452","affiliations":[{"raw_affiliation_string":"Ryazan State Medical University Named after Academician I.P. Pavlov, Ryazan, Russia","institution_ids":["https://openalex.org/I4210141419"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058045533"],"corresponding_institution_ids":["https://openalex.org/I4210150189"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.7705,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69840185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"106","issue":"3","first_page":"368504231182834","last_page":"368504231182834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrin-glue","display_name":"fibrin glue","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hemostatic-agents","display_name":"hemostatic agents","score":0.8299999833106995},{"id":"https://openalex.org/keywords/vascular-surgery","display_name":"vascular surgery","score":0.7720000147819519},{"id":"https://openalex.org/keywords/manual-compression","display_name":"manual compression","score":0.7390000224113464},{"id":"https://openalex.org/keywords/expanded-polytetrafluoroethylene-graft","display_name":"expanded polytetrafluoroethylene graft","score":0.8809999823570251},{"id":"https://openalex.org/keywords/peripheral-vascular-surgery","display_name":"peripheral vascular surgery","score":0.8009999990463257},{"id":"https://openalex.org/keywords/rebleeding","display_name":"rebleeding","score":0.7739999890327454},{"id":"https://openalex.org/keywords/surgical-site-infection","display_name":"surgical site infection","score":0.7519999742507935},{"id":"https://openalex.org/keywords/graft-occlusion","display_name":"graft occlusion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/intraoperative-bleeding","display_name":"intraoperative bleeding","score":0.6690000295639038},{"id":"https://openalex.org/keywords/russian-patients","display_name":"Russian patients","score":0.48899999260902405},{"id":"https://openalex.org/keywords/efficacy-and-safety-comparison","display_name":"comparative efficacy and safety","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9609957933425903},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.7804803848266602},{"id":"https://openalex.org/C2909810335","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostatics","level":3,"score":0.5744835734367371},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.5521537065505981},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5311521291732788},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5155231952667236},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.497576504945755},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.49247846007347107},{"id":"https://openalex.org/C2777327002","wikidata":"https://www.wikidata.org/wiki/Q2865760","display_name":"Fibrous joint","level":2,"score":0.4815819263458252},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44418615102767944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09289783239364624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072836","descriptor_name":"Surgical Wound","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000072836","descriptor_name":"Surgical Wound","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014656","descriptor_name":"Vascular Surgical Procedures","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015718","descriptor_name":"Fibrin Tissue Adhesive","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016063","descriptor_name":"Blood Loss, Surgical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/00368504231182834","doi":"https://doi.org/10.1177/00368504231182834","is_oa":true,"landing_page_url":"https://doi.org/10.1177/00368504231182834","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/00368504231182834","source":{"id":"https://openalex.org/S9683234","display_name":"Science Progress","issn_l":"0036-8504","issn":["0036-8504","2047-7163"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Progress","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10358634","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10358634","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10358634/pdf/10.1177_00368504231182834.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Prog","raw_type":"Text"},{"id":"pmid:37427979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37427979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science progress","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:doaj.org/article:64a2039e14d54fc2a2c4d3e0d365a166","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/64a2039e14d54fc2a2c4d3e0d365a166","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science Progress, Vol 106 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/00368504231182834","doi":"https://doi.org/10.1177/00368504231182834","is_oa":true,"landing_page_url":"https://doi.org/10.1177/00368504231182834","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/00368504231182834","source":{"id":"https://openalex.org/S9683234","display_name":"Science Progress","issn_l":"0036-8504","issn":["0036-8504","2047-7163"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Progress","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383710074.pdf","grobid_xml":"https://content.openalex.org/works/W4383710074.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W598267038","https://openalex.org/W1989044247","https://openalex.org/W2005625497","https://openalex.org/W2009345386","https://openalex.org/W2026922206","https://openalex.org/W2027685298","https://openalex.org/W2027739067","https://openalex.org/W2032096047","https://openalex.org/W2074947227","https://openalex.org/W2078373882","https://openalex.org/W2100932347","https://openalex.org/W2103258742","https://openalex.org/W2122822472","https://openalex.org/W2416183346","https://openalex.org/W2555574214","https://openalex.org/W2571455808","https://openalex.org/W2664381089","https://openalex.org/W2770162756","https://openalex.org/W2782208222","https://openalex.org/W2889122693"],"related_works":["https://openalex.org/W2664381089","https://openalex.org/W2925249600","https://openalex.org/W2005625497","https://openalex.org/W2015420963","https://openalex.org/W2009345386","https://openalex.org/W3112334436","https://openalex.org/W115405857","https://openalex.org/W2151107725","https://openalex.org/W4250456223","https://openalex.org/W2895891446"],"abstract_inverted_index":{"Background:":[0],"This":[1],"phase":[2],"III,":[3],"controlled,":[4],"patient-blinded,":[5],"multicentre":[6],"study":[7,124,165],"in":[8,38,44,229,233,239,243,254,298,301,325,347],"two":[9],"parallel,":[10],"equal-sized":[11],"treatment":[12,83,117,161],"groups":[13],"compared":[14],"the":[15,97,107,123,131,134,142,164,174,180,234,244,259,302,328],"efficacy":[16,104,139],"and":[17,58,84,154,186,200,238,277,318,337,358,361],"safety":[18],"of":[19,109,133,144,173,182,193,206,267],"TISSEEL":[20,75,235,255,312,333],"Lyo,":[21],"fibrin":[22],"sealant":[23],"versus":[24,286],"Manual":[25],"Compression":[26],"(MC)":[27],"with":[28,74,184],"surgical":[29,64,135,175,197],"gauze":[30],"pads":[31],"for":[32],"use":[33],"as":[34,89,177,179,343],"a":[35,344],"haemostatic":[36,345],"agent":[37,346],"patients":[39,110,145,183,208,212,232,242,253,326],"who":[40,51],"underwent":[41],"vascular":[42,54,348],"surgery":[43,349],"Russia.":[45],"Methods:":[46],"Adult":[47],"patients,":[48],"both":[49],"genders,":[50],"received":[52],"peripheral":[53],"expanded":[55],"polytetrafluoroethylene":[56],"conduits":[57],"had":[59,85,290,335,362],"suture":[60,125,166],"line":[61],"bleeding":[62,80,94],"after":[63,116,160],"haemostasis":[65,112,147,226,260,269],"were":[66,69,209,213,323],"enrolled.":[67],"Patients":[68],"randomized":[70],"to":[71,86,96,311,316,321,341,364],"be":[72,87,365],"treated":[73],"Lyo":[76,236,256,334],"or":[77,92],"MC.":[78,287],"The":[79,102,137],"needed":[81],"additional":[82],"assessed":[88],"grade":[90],"1":[91],"2":[93],"according":[95],"Validated":[98],"Intraoperative":[99],"Bleeding":[100],"scale.":[101],"primary":[103],"endpoint":[105],"was":[106,128,169,227,295],"proportion":[108,143,181],"achieving":[111,146,268],"at":[113,122,148,163,261,350],"4":[114,120,225],"min":[115,150,156,360],"application":[118,162],"(T":[119,151,157],")":[121,153,159],"line,":[126,167],"which":[127,168],"maintained":[129,170],"until":[130,171],"closure":[132,172],"wound.":[136],"secondary":[138],"endpoints":[140],"included":[141,191],"6":[149,152,263,357],"10":[155,158,279,359],"wound,":[176],"well":[178],"intraoperative":[185,291],"postoperative":[187],"rebleeding.":[188,292],"Safety":[189],"outcomes":[190],"incidence":[192],"adverse":[194],"events":[195],"(AEs),":[196],"site":[198],"infections":[199],"graft":[201],"occlusions.":[202],"Results:":[203],"A":[204],"total":[205],"110":[207],"screened;":[210],"104":[211],"randomized:":[214],"(TISSEEL":[215],"Lyo:":[216],"51":[217],"[49%]":[218],"patients;":[219],"MC:":[220],"53":[221],"[51%]":[222],"patients).":[223],"T":[224,262,278],"achieved":[228,258],"43":[230],"(84.3%)":[231],"group":[237,246,257],"11":[240],"(20.8%)":[241],"MC":[245,303,342],"(":[247],"p":[248],"<":[249],"0.001).":[250],"Significantly":[251],"more":[252],"(relative":[264],"risk":[265],"(RR)":[266],"1.74":[270],"[95%":[271,282],"confidence":[272],"interval":[273],"(CI)":[274],"1.37;":[275],"2.35])":[276],"(RR":[280],"1.18":[281],"CI":[283],"1.05;":[284],"1.38])":[285],"No":[288,305],"one":[289,299],"Postoperative":[293],"rebleeding":[294],"reported":[296,324],"only":[297],"patient":[300],"group.":[304],"treatment-emergent":[306],"serious":[307],"AEs":[308],"(TESAEs)":[309],"related":[310],"Lyo/MC,":[313],"TESAEs":[314,319],"leading":[315,320],"withdrawal":[317],"death":[322],"during":[327],"study.":[329],"Conclusions:":[330],"Data":[331],"demonstrated":[332],"clinically":[336],"statistically":[338],"significant":[339],"superiority":[340],"all":[351],"measured":[352],"time":[353],"points":[354],"including":[355],"4,":[356],"proven":[363],"safe.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-11T00:00:00"}