{"id":"https://openalex.org/W4383671822","doi":"https://doi.org/10.1016/j.clineuro.2023.107885","title":"A prospective observational longitudinal study with a two-year follow-up of multiple sclerosis patients on Cladribine","display_name":"A prospective observational longitudinal study with a two-year follow-up of multiple sclerosis patients on Cladribine","publication_year":2023,"publication_date":"2023-07-09","ids":{"openalex":"https://openalex.org/W4383671822","doi":"https://doi.org/10.1016/j.clineuro.2023.107885","pmid":"https://pubmed.ncbi.nlm.nih.gov/37459794"},"language":"en","primary_location":{"id":"doi:10.1016/j.clineuro.2023.107885","doi":"https://doi.org/10.1016/j.clineuro.2023.107885","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clineuro.2023.107885","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112134649","display_name":"Jasem Yousef Al-Hashel","orcid":"https://orcid.org/0000-0001-6371-7381","observed_orcids":["https://orcid.org/0000-0001-6371-7381"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]},{"id":"https://openalex.org/I4210150512","display_name":"Ibn Sina Hospital","ror":"https://ror.org/05359he25","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I4210150512"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Jasem Al-Hashel","raw_affiliation_strings":["Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait; Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address: dralhasel@hotmail.com","Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait","Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait; Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address: dralhasel@hotmail.com","institution_ids":["https://openalex.org/I36721946","https://openalex.org/I4210150512"]},{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait","institution_ids":["https://openalex.org/I4210150512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000026859","display_name":"Samar Farouk Ahmed","orcid":"https://orcid.org/0000-0002-9026-9219","observed_orcids":["https://orcid.org/0000-0002-9026-9219"]},"institutions":[{"id":"https://openalex.org/I4210150512","display_name":"Ibn Sina Hospital","ror":"https://ror.org/05359he25","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I4210150512"]},{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG","KW"],"is_corresponding":false,"raw_author_name":"Samar Farouk Ahmed","raw_affiliation_strings":["Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait; Department of Neurology and Psychiatry, Minia University, P.O. Box 61519, Minia 61111, Egypt","Department of Neurology and Psychiatry, Minia University, P.O. Box 61519, Minia 61111, Egypt","Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait; Department of Neurology and Psychiatry, Minia University, P.O. Box 61519, Minia 61111, Egypt","institution_ids":["https://openalex.org/I4210150512","https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Neurology and Psychiatry, Minia University, P.O. Box 61519, Minia 61111, Egypt","institution_ids":["https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait","institution_ids":["https://openalex.org/I4210150512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025338838","display_name":"Malak AlMojel","orcid":"https://orcid.org/0000-0001-7736-3270","observed_orcids":["https://orcid.org/0000-0001-7736-3270"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Malak AlMojel","raw_affiliation_strings":["Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049456235","display_name":"Raed Alroughani","orcid":"https://orcid.org/0000-0001-5436-5804","observed_orcids":["https://orcid.org/0000-0001-5436-5804","https://orcid.org/0000-0002-7111-0480"]},"institutions":[{"id":"https://openalex.org/I2803040547","display_name":"Amiri Hospital","ror":"https://ror.org/04y2hdd14","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I2803040547"]},{"id":"https://openalex.org/I4210150512","display_name":"Ibn Sina Hospital","ror":"https://ror.org/05359he25","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I4210150512"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Raed Alroughani","raw_affiliation_strings":["Division of Neurology, Amiri Hospital, Arabian Gulf Street, Sharq 13041, Kuwait; MS Clinic, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait","Division of Neurology, Amiri Hospital, Arabian Gulf Street, Sharq 13041, Kuwait","MS Clinic, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Amiri Hospital, Arabian Gulf Street, Sharq 13041, Kuwait; MS Clinic, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait","institution_ids":["https://openalex.org/I2803040547","https://openalex.org/I4210150512"]},{"raw_affiliation_string":"Division of Neurology, Amiri Hospital, Arabian Gulf Street, Sharq 13041, Kuwait","institution_ids":["https://openalex.org/I2803040547"]},{"raw_affiliation_string":"MS Clinic, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait","institution_ids":["https://openalex.org/I4210150512"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5112134649"],"corresponding_institution_ids":["https://openalex.org/I36721946","https://openalex.org/I4210150512"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":1.109,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74418374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"232","issue":null,"first_page":"107885","last_page":"107885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cladribine","display_name":"cladribine","score":0.7710000276565552},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/relapse-rate","display_name":"relapse rate","score":0.8840000033378601},{"id":"https://openalex.org/keywords/disability-progression","display_name":"disability progression","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mri-lesion-activity","display_name":"MRI lesion activity","score":0.5979999899864197},{"id":"https://openalex.org/keywords/gadolinium-enhancement","display_name":"gadolinium enhancement","score":0.859000027179718},{"id":"https://openalex.org/keywords/neda-3","display_name":"NEDA-3","score":0.8199999928474426},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.6769999861717224},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8299999833106995},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7450000047683716},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.7929999828338623},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.6669999957084656},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.414000004529953},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9621332883834839},{"id":"https://openalex.org/C2779200787","wikidata":"https://www.wikidata.org/wiki/Q414030","display_name":"Cladribine","level":2,"score":0.9427380561828613},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.7185735702514648},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7084202170372009},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6826278567314148},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5145558714866638},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4814121723175049},{"id":"https://openalex.org/C2780892749","wikidata":"https://www.wikidata.org/wiki/Q929518","display_name":"Expanded Disability Status Scale","level":3,"score":0.47372832894325256},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45114490389823914},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.42745134234428406},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2757464051246643},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07107600569725037}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017338","descriptor_name":"Cladribine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.clineuro.2023.107885","doi":"https://doi.org/10.1016/j.clineuro.2023.107885","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clineuro.2023.107885","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},{"id":"pmid:37459794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37459794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neurology and neurosurgery","raw_type":"Observational Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W121485390","https://openalex.org/W1966849321","https://openalex.org/W1968558564","https://openalex.org/W1974000699","https://openalex.org/W1981220317","https://openalex.org/W2009177607","https://openalex.org/W2112165124","https://openalex.org/W2122545833","https://openalex.org/W2123021165","https://openalex.org/W2128361812","https://openalex.org/W2139204856","https://openalex.org/W2163089957","https://openalex.org/W2549644306","https://openalex.org/W2591887102","https://openalex.org/W2729106139","https://openalex.org/W2751578374","https://openalex.org/W2777074421","https://openalex.org/W2790446387","https://openalex.org/W2833295077","https://openalex.org/W2869377759","https://openalex.org/W2914770914","https://openalex.org/W2943207554","https://openalex.org/W2981958753","https://openalex.org/W2998137352","https://openalex.org/W3036791033","https://openalex.org/W3160836548","https://openalex.org/W4238626963","https://openalex.org/W4247467891","https://openalex.org/W6740663098","https://openalex.org/W6820275139","https://openalex.org/W6829085919"],"related_works":["https://openalex.org/W4367296164","https://openalex.org/W4363677407","https://openalex.org/W4362468383","https://openalex.org/W4405350202","https://openalex.org/W4362692406","https://openalex.org/W7162104985","https://openalex.org/W4409227140","https://openalex.org/W4385327353","https://openalex.org/W7117366849","https://openalex.org/W7205296501"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-09T00:00:00"}