{"id":"https://openalex.org/W4383557546","doi":"https://doi.org/10.3389/fimmu.2023.1209923","title":"Dimethyl fumarate-related immune and transcriptional signature is associated with clinical response in multiple sclerosis-treated patients","display_name":"Dimethyl fumarate-related immune and transcriptional signature is associated with clinical response in multiple sclerosis-treated patients","publication_year":2023,"publication_date":"2023-07-07","ids":{"openalex":"https://openalex.org/W4383557546","doi":"https://doi.org/10.3389/fimmu.2023.1209923","pmid":"https://pubmed.ncbi.nlm.nih.gov/37483622","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10360655"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2023.1209923","doi":"https://doi.org/10.3389/fimmu.2023.1209923","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1209923","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1209923/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1209923/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025854924","display_name":"Alicia S\u00e1nchez-Sanz","orcid":"https://orcid.org/0000-0003-1155-081X","observed_orcids":["https://orcid.org/0000-0003-1155-081X"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alicia S\u00e1nchez-Sanz","raw_affiliation_strings":["Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","PhD Program in Molecular Biosciences, Doctoral School, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"PhD Program in Molecular Biosciences, Doctoral School, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073610195","display_name":"Santiago Garc\u00eda\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0002-4540-9446","observed_orcids":["https://orcid.org/0000-0002-4540-9446"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Santiago Garc\u00eda-Mart\u00edn","raw_affiliation_strings":["Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001645714","display_name":"Julia Sab\u00edn Mu\u00f1oz","orcid":"https://orcid.org/0000-0001-5745-7544","observed_orcids":["https://orcid.org/0000-0001-5745-7544"]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julia Sab\u00edn-Mu\u00f1oz","raw_affiliation_strings":["Department of Neurology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020810700","display_name":"Irene Moreno\u2010Torres","orcid":"https://orcid.org/0000-0002-9951-9333","observed_orcids":["https://orcid.org/0000-0002-9951-9333"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Irene Moreno-Torres","raw_affiliation_strings":["Demyelinating Diseases Unit, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Demyelinating Diseases Unit, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085691944","display_name":"V\u0301\u0131ctor Elvira","orcid":"https://orcid.org/0000-0002-8967-4866","observed_orcids":["https://orcid.org/0000-0002-8967-4866"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"V\u00edctor Elvira","raw_affiliation_strings":["School of Mathematics, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027004121","display_name":"F\u00e1tima Al\u2010Shahrour","orcid":"https://orcid.org/0000-0003-2373-769X","observed_orcids":["https://orcid.org/0000-0003-2373-769X"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F\u00e1tima Al-Shahrour","raw_affiliation_strings":["Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048713337","display_name":"Ar\u00e1nzazu Garc\u00eda\u2010Grande","orcid":"https://orcid.org/0000-0001-5737-8918","observed_orcids":["https://orcid.org/0000-0001-5737-8918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aranzazu Garc\u00eda-Grande","raw_affiliation_strings":["Flow Cytometry Core Facility, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Core Facility, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000425996","display_name":"Elvira Ramil","orcid":"https://orcid.org/0000-0003-0785-3826","observed_orcids":["https://orcid.org/0000-0003-0785-3826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elvira Ramil","raw_affiliation_strings":["Sequencing Core Facility, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sequencing Core Facility, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080313546","display_name":"Ofir Rodr\u00edguez-De la Fuente","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ofir Rodr\u00edguez-De la Fuente","raw_affiliation_strings":["Department of Neurology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112955419","display_name":"Beatriz Brea-\u00c1lvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Brea-\u00c1lvarez","raw_affiliation_strings":["Radiodiagnostic Division, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiodiagnostic Division, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037293441","display_name":"Ruth Garc\u00eda-Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth Garc\u00eda-Hern\u00e1ndez","raw_affiliation_strings":["Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110613652","display_name":"Antonio Garc\u00eda\u2010Merino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092130","display_name":"Spanish Multiple Sclerosis Network","ror":"https://ror.org/00dgcm453","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210092130"]},{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Antonio Garc\u00eda-Merino","raw_affiliation_strings":["Department of Medicine, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","Department of Neurology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain","Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","Red Espa\u00f1ola de Esclerosis M\u00faltiple (REEM), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Department of Neurology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain","institution_ids":["https://openalex.org/I4210105637"]},{"raw_affiliation_string":"Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"Red Espa\u00f1ola de Esclerosis M\u00faltiple (REEM), Barcelona, Spain","institution_ids":["https://openalex.org/I4210092130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043033718","display_name":"Antonio S\u00e1nchez","orcid":"https://orcid.org/0000-0001-7168-6175","observed_orcids":["https://orcid.org/0000-0001-7168-6175"]},"institutions":[{"id":"https://openalex.org/I4210092130","display_name":"Spanish Multiple Sclerosis Network","ror":"https://ror.org/00dgcm453","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210092130"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Antonio Jos\u00e9 S\u00e1nchez-L\u00f3pez","raw_affiliation_strings":["Biobank, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","Red Espa\u00f1ola de Esclerosis M\u00faltiple (REEM), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biobank, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"Neuroimmunology Unit, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"Red Espa\u00f1ola de Esclerosis M\u00faltiple (REEM), Barcelona, Spain","institution_ids":["https://openalex.org/I4210092130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5043033718","https://openalex.org/A5110613652"],"corresponding_institution_ids":["https://openalex.org/I4210092130","https://openalex.org/I4210105637","https://openalex.org/I63634437"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.6164,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8206261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"14","issue":null,"first_page":"1209923","last_page":"1209923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimethyl-fumarate","display_name":"dimethyl fumarate","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.9660000205039978},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.6629999876022339},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.6740000247955322},{"id":"https://openalex.org/keywords/intermediate-monocytes","display_name":"intermediate monocytes","score":0.8899999856948853},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/transcriptomic-response","display_name":"transcriptomic response","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/clinical-response","display_name":"clinical response","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7764170169830322},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7301551103591919},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6561301946640015},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6407201290130615},{"id":"https://openalex.org/C2776819417","wikidata":"https://www.wikidata.org/wiki/Q418123","display_name":"Dimethyl fumarate","level":3,"score":0.6366366147994995},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6237388253211975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5767431259155273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.552316427230835},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5060715079307556},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4581325352191925},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4545433223247528},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.43350550532341003},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.289874792098999},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2436176836490631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22288790345191956},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15528351068496704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069462","descriptor_name":"Dimethyl Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2023.1209923","doi":"https://doi.org/10.3389/fimmu.2023.1209923","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1209923","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1209923/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10360655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10360655","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10360655/pdf/fimmu-14-1209923.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:37483622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37483622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1e48099cbabe47af932b66bcc498ce5e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1e48099cbabe47af932b66bcc498ce5e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2023.1209923","doi":"https://doi.org/10.3389/fimmu.2023.1209923","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1209923","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1209923/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1275134720","display_name":"Inmunofenotipo, transcriptoma y perfil cl\u00ednico de pacientes con esclerosis m\u00faltiple tratados con fingolimod y dimetilfumarato. Modelo para la predicci\u00f3n de respuesta en un estudio traslacional","funder_award_id":"PI18/01766","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G1433481478","display_name":"Inmunomodulaci\u00f3n y neuroprotecci\u00f3n en la terap\u00e9utica de la esclerosis m\u00faltiple: implicaci\u00f3n del sistema endocannabinoide y nuevos f\u00e1rmacos. Estudio longitudinal","funder_award_id":"PI15/02099","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4890342660","display_name":null,"funder_award_id":"FI19/00149","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6534704306","display_name":null,"funder_award_id":"PI15/02099, PI18/01766, FI19/00149","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383557546.pdf","grobid_xml":"https://content.openalex.org/works/W4383557546.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1828576284","https://openalex.org/W1967838438","https://openalex.org/W2046128399","https://openalex.org/W2068690343","https://openalex.org/W2093009907","https://openalex.org/W2101949814","https://openalex.org/W2113485611","https://openalex.org/W2179438025","https://openalex.org/W2205231349","https://openalex.org/W2288282768","https://openalex.org/W2336862132","https://openalex.org/W2343323874","https://openalex.org/W2555514711","https://openalex.org/W2577405982","https://openalex.org/W2592811885","https://openalex.org/W2594894796","https://openalex.org/W2605302503","https://openalex.org/W2606862055","https://openalex.org/W2612052367","https://openalex.org/W2734067368","https://openalex.org/W2735527928","https://openalex.org/W2756864941","https://openalex.org/W2777074421","https://openalex.org/W2805243014","https://openalex.org/W2808179851","https://openalex.org/W2884630794","https://openalex.org/W2896396308","https://openalex.org/W2920664301","https://openalex.org/W2944450968","https://openalex.org/W2960061163","https://openalex.org/W2981041443","https://openalex.org/W2996366052","https://openalex.org/W3007273059","https://openalex.org/W3013766799","https://openalex.org/W3025164808","https://openalex.org/W3045458080","https://openalex.org/W3046004853","https://openalex.org/W3193418223"],"related_works":["https://openalex.org/W2808179851","https://openalex.org/W4288036255","https://openalex.org/W2609394914","https://openalex.org/W2944450968","https://openalex.org/W2801318738","https://openalex.org/W2756864941","https://openalex.org/W2343323874","https://openalex.org/W2734067368","https://openalex.org/W7018636687","https://openalex.org/W2805243014"],"abstract_inverted_index":{"Background":[0],"and":[1,39,51,58,69,76,79,87,136,146,177,202,207,217,251,265,300,303],"objective:":[2],"Dimethyl":[3],"fumarate":[4],"(DMF)":[5],"is":[6,25],"an":[7,151,172],"immunomodulatory":[8],"drug":[9],"approved":[10],"for":[11,316],"the":[12,29,37,97,126,144,181,184,254,317],"therapy":[13],"of":[14,20,72,102,108,239,247,253,282,319,321],"multiple":[15],"sclerosis":[16],"(MS).":[17],"The":[18,241],"identification":[19],"response":[21,93,273,307,323],"biomarkers":[22,320],"to":[23,180,287,294,309,324],"DMF":[24,44,73,129,223,268,295],"a":[26,131,161,225,245,270,279,304],"necessity":[27],"in":[28,45,133,142,153,164,174,183,195,298],"clinical":[30,55],"practice.":[31],"With":[32],"this":[33],"aim,":[34],"we":[35],"studied":[36,315],"immunophenotypic":[38],"transcriptomic":[40,272,306],"changes":[41],"produced":[42,130],"by":[43,84,150,188],"peripheral":[46],"blood":[47],"mononuclear":[48],"cells":[49,141,176],"(PBMCs)":[50],"its":[52],"association":[53],"with":[54,229,276],"response.":[56],"Material":[57],"methods:":[59],"PBMCs":[60],"were":[61,82,178,261],"obtained":[62],"from":[63],"22":[64],"RRMS":[65],"patients":[66,116,159,170,191,293],"at":[67,112,205,220],"baseline":[68,206],"12":[70,221,237],"months":[71,238],"treatment.":[74,240],"Lymphocyte":[75],"monocyte":[77,299],"subsets,":[78],"gene":[80],"expression":[81],"assessed":[83],"flow":[85],"cytometry":[86],"next-generation":[88],"RNA":[89],"sequencing,":[90],"respectively.":[91,123],"Clinical":[92],"was":[94,244,274],"evaluated":[95],"using":[96],"composite":[98],"measure":[99],"\"no":[100],"evidence":[101],"disease":[103,109],"activity\"":[104,110],"NEDA-3":[105],"or":[106,120],"\"evidence":[107],"EDA-3":[111],"2":[113],"years,":[114],"classifying":[115],"into":[117],"responders":[118,264,277],"(n=15)":[119],"non-responders":[121,288,310],"(n=7),":[122],"Results:":[124],"In":[125,167],"whole":[127],"cohort,":[128],"decrease":[132,163,182],"effector":[134],"(TEM)":[135],"central":[137],"(TCM)":[138],"memory":[139],"T":[140,156,213],"both":[143],"CD4+":[145,154],"CD8+":[147],"compartments,":[148],"followed":[149],"increase":[152,173],"na\u00efve":[155],"cells.":[157],"Responder":[158,190,292],"presented":[160,193],"greater":[162],"TEM":[165],"lymphocytes.":[166],"addition,":[168],"responder":[169],"showed":[171],"NK":[175,200],"resistant":[179],"intermediate":[185],"monocytes":[186],"shown":[187],"non-responders.":[189,266],"also":[192],"differences":[194,297],"3":[196],"subpopulations":[197,209,302],"(NK":[198],"bright,":[199],"dim":[201],"CD8":[203],"TCM)":[204],"4":[208],"(intermediate":[210],"monocytes,":[211],"regulatory":[212],"cells,":[214],"CD4":[215,218],"TCM":[216],"TEMRA)":[219],"months.":[222],"induced":[224],"mild":[226],"transcriptional":[227],"effect,":[228],"only":[230],"328":[231],"differentially":[232],"expressed":[233],"genes":[234],"(DEGs)":[235],"after":[236],"overall":[242],"effect":[243],"downregulation":[246],"pro-inflammatory":[248],"genes,":[249],"chemokines,":[250],"activators":[252],"NF-kB":[255],"pathway.":[256],"At":[257],"baseline,":[258],"no":[259],"DEGs":[260,283],"found":[262],"between":[263],"During":[267],"treatment":[269,322],"differential":[271],"observed,":[275],"presenting":[278],"higher":[280],"number":[281],"(902":[284],"genes)":[285],"compared":[286,308],"(189":[289],"genes).":[290],"Conclusions:":[291],"exhibit":[296],"lymphocyte":[301],"distinguishable":[305],"that":[311],"should":[312],"be":[313],"further":[314],"validation":[318],"DMF.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-08T00:00:00"}