{"id":"https://openalex.org/W4383554873","doi":"https://doi.org/10.1186/s40249-023-01116-w","title":"Cost of treatment support for multidrug-resistant tuberculosis using patient-centred approaches in Ethiopia: a model-based method","display_name":"Cost of treatment support for multidrug-resistant tuberculosis using patient-centred approaches in Ethiopia: a model-based method","publication_year":2023,"publication_date":"2023-07-07","ids":{"openalex":"https://openalex.org/W4383554873","doi":"https://doi.org/10.1186/s40249-023-01116-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/37420269","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10327382"},"language":"en","primary_location":{"id":"doi:10.1186/s40249-023-01116-w","doi":"https://doi.org/10.1186/s40249-023-01116-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40249-023-01116-w","pdf_url":"https://idpjournal.biomedcentral.com/counter/pdf/10.1186/s40249-023-01116-w","source":{"id":"https://openalex.org/S2737837740","display_name":"Infectious Diseases of Poverty","issn_l":"2049-9957","issn":["2049-9957","2095-5162"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Diseases of Poverty","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://idpjournal.biomedcentral.com/counter/pdf/10.1186/s40249-023-01116-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053826380","display_name":"Laura Ro\u0219u","orcid":"https://orcid.org/0000-0003-1172-0962","observed_orcids":["https://orcid.org/0000-0003-1172-0962"]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Laura Rosu","raw_affiliation_strings":["Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK. laura.rosu@lstmed.ac.uk","Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK"],"raw_orcid":"https://orcid.org/0000-0003-1172-0962","affiliations":[{"raw_affiliation_string":"Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK. laura.rosu@lstmed.ac.uk","institution_ids":["https://openalex.org/I194839184"]},{"raw_affiliation_string":"Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK","institution_ids":["https://openalex.org/I194839184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032059436","display_name":"Lucy E. Morgan","orcid":"https://orcid.org/0000-0003-0987-2350","observed_orcids":["https://orcid.org/0000-0003-0987-2350"]},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucy Morgan","raw_affiliation_strings":["Management Science, Lancaster University, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Management Science, Lancaster University, Lancaster, UK","institution_ids":["https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003048299","display_name":"Ewan Tomeny","orcid":"https://orcid.org/0000-0003-4547-2389","observed_orcids":["https://orcid.org/0000-0003-4547-2389"]},"institutions":[{"id":"https://openalex.org/I194839184","display_name":"Liverpool School of Tropical Medicine","ror":"https://ror.org/03svjbs84","country_code":"GB","type":"funder","lineage":["https://openalex.org/I194839184"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ewan M. Tomeny","raw_affiliation_strings":["Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L35QA, UK","institution_ids":["https://openalex.org/I194839184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016098496","display_name":"Claire Worthington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Worthington","raw_affiliation_strings":["Management Science, Lancaster University, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Management Science, Lancaster University, Lancaster, UK","institution_ids":["https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mengdi Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mengdi Jin","raw_affiliation_strings":["Management Science, Lancaster University, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Management Science, Lancaster University, Lancaster, UK","institution_ids":["https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032479975","display_name":"Jasper Nidoi","orcid":"https://orcid.org/0000-0002-1189-5861","observed_orcids":["https://orcid.org/0000-0002-1189-5861"]},"institutions":[{"id":"https://openalex.org/I72227227","display_name":"Makerere University","ror":"https://ror.org/03dmz0111","country_code":"UG","type":"education","lineage":["https://openalex.org/I72227227"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Jasper Nidoi","raw_affiliation_strings":["Makerere University Lung Institute, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Makerere University Lung Institute, Kampala, Uganda","institution_ids":["https://openalex.org/I72227227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029701178","display_name":"David Worthington","orcid":"https://orcid.org/0000-0003-1400-0194","observed_orcids":["https://orcid.org/0000-0003-1400-0194"]},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Worthington","raw_affiliation_strings":["Management Science, Lancaster University, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Management Science, Lancaster University, Lancaster, UK","institution_ids":["https://openalex.org/I67415387"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053826380"],"corresponding_institution_ids":["https://openalex.org/I194839184"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.9704,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.72531536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"65","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11531","display_name":"Healthcare Systems and Reforms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/patient-centered-care","display_name":"patient-centered care","score":0.8679999709129333},{"id":"https://openalex.org/keywords/health-system-costs","display_name":"health system costs","score":0.7139999866485596},{"id":"https://openalex.org/keywords/patient-costs","display_name":"patient costs","score":0.8550000190734863},{"id":"https://openalex.org/keywords/treatment-completion","display_name":"treatment completion","score":0.45399999618530273},{"id":"https://openalex.org/keywords/stream-trial","display_name":"STREAM trial","score":0.6110000014305115},{"id":"https://openalex.org/keywords/discrete-event-simulation","display_name":"discrete event simulation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ethiopia","display_name":"Ethiopia","score":0.5379999876022339},{"id":"https://openalex.org/keywords/health-care-reform","display_name":"health care reform","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7054446935653687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5992504358291626},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.5012238025665283},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4988212585449219},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3478771448135376},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19860157370567322},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.16484299302101135},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1415463387966156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11908367276191711}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003365","descriptor_name":"Costs and Cost Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005002","descriptor_name":"Ethiopia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s40249-023-01116-w","doi":"https://doi.org/10.1186/s40249-023-01116-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40249-023-01116-w","pdf_url":"https://idpjournal.biomedcentral.com/counter/pdf/10.1186/s40249-023-01116-w","source":{"id":"https://openalex.org/S2737837740","display_name":"Infectious Diseases of Poverty","issn_l":"2049-9957","issn":["2049-9957","2095-5162"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Diseases of Poverty","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10327382","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10327382","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10327382/pdf/40249_2023_Article_1116.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Dis Poverty","raw_type":"Text"},{"id":"pmid:37420269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37420269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious diseases of poverty","raw_type":"Journal Article"},{"id":"pmh:oai:archive.lstmed.ac.uk:22777","doi":null,"is_oa":false,"landing_page_url":"https://archive.lstmed.ac.uk/22777/1/40249_2023_Article_1116.pdf","pdf_url":"https://archive.lstmed.ac.uk/22777/1/40249_2023_Article_1116.pdf","source":{"id":"https://openalex.org/S4306400185","display_name":"LSTM Online Archive (Liverpool School of Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I194839184","host_organization_name":"Liverpool School of Tropical Medicine","host_organization_lineage":["https://openalex.org/I194839184"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Infectious Diseases of Poverty, Vol 12, Issue 1, e65.","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:86a576240a71470a880308461031703e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/86a576240a71470a880308461031703e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infectious Diseases of Poverty, Vol 12, Iss 1, Pp 1-9 (2023)","raw_type":"article"},{"id":"pmh:oai:eprints.lancs.ac.uk:198428","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lancs.ac.uk/id/eprint/198428/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s40249-023-01116-w","doi":"https://doi.org/10.1186/s40249-023-01116-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40249-023-01116-w","pdf_url":"https://idpjournal.biomedcentral.com/counter/pdf/10.1186/s40249-023-01116-w","source":{"id":"https://openalex.org/S2737837740","display_name":"Infectious Diseases of Poverty","issn_l":"2049-9957","issn":["2049-9957","2095-5162"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Diseases of Poverty","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383554873.pdf","grobid_xml":"https://content.openalex.org/works/W4383554873.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1975654711","https://openalex.org/W2052166920","https://openalex.org/W2084864721","https://openalex.org/W2126187822","https://openalex.org/W2129072523","https://openalex.org/W2166704963","https://openalex.org/W2592131336","https://openalex.org/W2741120696","https://openalex.org/W2801570560","https://openalex.org/W2806395561","https://openalex.org/W2905202568","https://openalex.org/W2908949990","https://openalex.org/W2921026546","https://openalex.org/W3015360863","https://openalex.org/W3033609190","https://openalex.org/W3046060887","https://openalex.org/W3116585449","https://openalex.org/W3139354411","https://openalex.org/W3198937258","https://openalex.org/W3215005393"],"related_works":["https://openalex.org/W2757276398","https://openalex.org/W3046060887","https://openalex.org/W2801570560","https://openalex.org/W2907633773","https://openalex.org/W4393407742","https://openalex.org/W3036809344","https://openalex.org/W2465290192","https://openalex.org/W2535045428","https://openalex.org/W3015360863","https://openalex.org/W4388794473"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patient":[1],"and":[2,29,47,50,75,171,183,202,209,224,263,274,304],"health":[3,35,195],"system":[4,196],"costs":[5,46,62,241],"for":[6,103,163,200,205,222,227,250,266,282],"treating":[7,164],"multidrug-resistant":[8],"tuberculosis":[9],"(MDR-TB)":[10],"remain":[11],"high":[12],"even":[13],"after":[14],"treatment":[15,135,170,269],"duration":[16,249],"was":[17,119],"shortened.":[18],"Many":[19],"patients":[20,143,165,213],"do":[21,214],"not":[22,215,253],"finish":[23],"treatment,":[24],"contributing":[25],"to":[26,44,59,79,91,109,121,285],"increased":[27],"transmission":[28],"antimicrobial":[30],"resistance.":[31],"A":[32],"restructure":[33],"of":[34,55,68,95,100,126,132,141,308],"services,":[36],"that":[37,261,278],"is":[38,58,280,302],"more":[39],"patient-centred":[40,74,182,201,223,262],"has":[41],"the":[42,56,66,80,96,123,133,139,146,157,190,206,228,306],"potential":[43],"reduce":[45],"increase":[48],"trust":[49],"patient":[51,152,210],"satisfaction.":[52],"The":[53,117,181],"aim":[54],"study":[57],"investigate":[60],"how":[61,300],"would":[63],"change":[64,254],"in":[65,71,174,232,244,288],"delivery":[67,136],"MDR-TB":[69,106,169,268,301],"care":[70],"Ethiopia":[72],"under":[73],"hybrid":[76,184,207,229,264],"approaches":[77],"compared":[78],"current":[81],"standard-of-care.":[82],"METHODS:":[83],"We":[84],"used":[85,295],"published":[86],"data,":[87],"collected":[88],"from":[89,156,192],"2017":[90],"2020":[92],"as":[93],"part":[94],"Standard":[97],"Treatment":[98],"Regimen":[99],"Anti-Tuberculosis":[101],"Drugs":[102],"Patients":[104],"with":[105],"(STREAM)":[107],"trial,":[108],"populate":[110],"a":[111,167,194,217],"discrete":[112],"event":[113],"simulation":[114],"(DES)":[115],"model.":[116],"model":[118,148],"developed":[120],"represent":[122],"key":[124],"characteristics":[125],"patients'":[127],"clinical":[128],"pathways":[129,140],"following":[130],"each":[131],"three":[134],"strategies.":[137],"To":[138],"1000":[142],"generated":[144],"by":[145],"DES":[147],"we":[149],"applied":[150],"relevant":[151],"cost":[153,270],"data":[154],"derived":[155],"STREAM":[158],"trial.":[159],"Costs":[160],"are":[161,172,186],"calculated":[162],"using":[166],"9-month":[168],"presented":[173],"2021":[175],"United":[176],"States":[177],"dollars":[178],"(USD).":[179],"RESULTS:":[180],"strategies":[185,265,284],"less":[187,271],"costly":[188],"than":[189,272],"standard-of-care,":[191],"both":[193],"(by":[197,219],"USD":[198,203,220,225],"219":[199],"276":[204],"strategy)":[208],"perspective":[211],"when":[212],"have":[216],"guardian":[218],"389":[221],"152":[226],"strategy).":[230],"Changes":[231],"indirect":[233],"costs,":[234,236,238],"staff":[235],"transport":[237],"inpatient":[239],"stay":[240],"or":[242,247],"changes":[243],"directly-observed-treatment":[245],"frequency":[246],"hospitalisation":[248],"standard-of-care":[251,273],"did":[252],"our":[255],"results.":[256],"CONCLUSION:":[257],"Our":[258],"findings":[259],"show":[260],"delivering":[267],"provide":[275],"critical":[276],"evidence":[277],"there":[279],"scope":[281],"such":[283],"be":[286,294],"implemented":[287],"routine":[289],"care.":[290],"These":[291],"results":[292],"should":[293],"inform":[296],"country-level":[297],"decisions":[298],"on":[299],"delivered":[303],"also":[305],"design":[307],"future":[309],"implementation":[310],"trials.":[311]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-07-08T00:00:00"}