{"id":"https://openalex.org/W4383552185","doi":"https://doi.org/10.3390/antib12030046","title":"Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in Immunotherapy","display_name":"Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in Immunotherapy","publication_year":2023,"publication_date":"2023-07-06","ids":{"openalex":"https://openalex.org/W4383552185","doi":"https://doi.org/10.3390/antib12030046","pmid":"https://pubmed.ncbi.nlm.nih.gov/37489368","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10366852"},"language":"en","primary_location":{"id":"doi:10.3390/antib12030046","doi":"https://doi.org/10.3390/antib12030046","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antib12030046","pdf_url":"https://www.mdpi.com/2073-4468/12/3/46/pdf?version=1688636862","source":{"id":"https://openalex.org/S2739070576","display_name":"Antibodies","issn_l":"2073-4468","issn":["2073-4468"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4468/12/3/46/pdf?version=1688636862","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035130685","display_name":"Christopher W. Chung","orcid":"https://orcid.org/0000-0002-2166-0177","observed_orcids":["https://orcid.org/0000-0002-2166-0177"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Chung","raw_affiliation_strings":["GeneOne Life Science, Inc., Seoul 04500, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneOne Life Science, Inc., Seoul 04500, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083086057","display_name":"Sagar B. Kudchodkar","orcid":"https://orcid.org/0000-0003-1754-6803","observed_orcids":["https://orcid.org/0000-0003-1754-6803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sagar B. Kudchodkar","raw_affiliation_strings":["GeneOne Life Science, Inc., Seoul 04500, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneOne Life Science, Inc., Seoul 04500, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109621247","display_name":"Curtis N. Chung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Curtis N. Chung","raw_affiliation_strings":["GeneOne Life Science, Inc., Seoul 04500, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneOne Life Science, Inc., Seoul 04500, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026393206","display_name":"Young K. Park","orcid":"https://orcid.org/0000-0002-1048-2117","observed_orcids":["https://orcid.org/0000-0002-1048-2117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young K. Park","raw_affiliation_strings":["GeneOne Life Science, Inc., Seoul 04500, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneOne Life Science, Inc., Seoul 04500, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007426408","display_name":"Ziyang Xu","orcid":"https://orcid.org/0000-0001-7690-7029","observed_orcids":["https://orcid.org/0000-0001-7690-7029"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziyang Xu","raw_affiliation_strings":["Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067992777","display_name":"Norbert Pardi","orcid":"https://orcid.org/0000-0003-1008-6242","observed_orcids":["https://orcid.org/0000-0003-1008-6242"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norbert Pardi","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0003-1008-6242","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075831694","display_name":"Mohamed Abdel\u2010Mohsen","orcid":"https://orcid.org/0000-0002-9945-4314","observed_orcids":["https://orcid.org/0000-0002-9945-4314"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Abdel-Mohsen","raw_affiliation_strings":["The Wistar Institute, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0002-9945-4314","affiliations":[{"raw_affiliation_string":"The Wistar Institute, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038753752","display_name":"Kar Muthumani","orcid":"https://orcid.org/0000-0002-6807-2065","observed_orcids":["https://orcid.org/0000-0002-6807-2065"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kar Muthumani","raw_affiliation_strings":["GeneOne Life Science, Inc., Seoul 04500, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-6807-2065","affiliations":[{"raw_affiliation_string":"GeneOne Life Science, Inc., Seoul 04500, Republic of Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038753752"],"corresponding_institution_ids":[],"apc_list":{"value":1600,"currency":"CHF","value_usd":1779},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1779},"fwci":1.3354,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.79928571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"3","first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.328900009393692,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9929999709129333},{"id":"https://openalex.org/keywords/synthetic-nucleic-acids","display_name":"synthetic nucleic acids","score":0.9079999923706055},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.4779999852180481},{"id":"https://openalex.org/keywords/accessibility-of-treatment","display_name":"accessibility of treatment","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.892351508140564},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6960771679878235},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5842630863189697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5647584795951843},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5428507328033447},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.499072790145874},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4768206477165222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4260566532611847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4259953498840332},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3910641074180603},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3727676272392273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07099542021751404}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/antib12030046","doi":"https://doi.org/10.3390/antib12030046","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antib12030046","pdf_url":"https://www.mdpi.com/2073-4468/12/3/46/pdf?version=1688636862","source":{"id":"https://openalex.org/S2739070576","display_name":"Antibodies","issn_l":"2073-4468","issn":["2073-4468"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10366852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10366852","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10366852/pdf/antibodies-12-00046.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies (Basel)","raw_type":"Text"},{"id":"pmid:37489368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37489368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:34b15e90a84d436290d76e1435b6127e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/34b15e90a84d436290d76e1435b6127e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antibodies, Vol 12, Iss 3, p 46 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antib12030046","doi":"https://doi.org/10.3390/antib12030046","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antib12030046","pdf_url":"https://www.mdpi.com/2073-4468/12/3/46/pdf?version=1688636862","source":{"id":"https://openalex.org/S2739070576","display_name":"Antibodies","issn_l":"2073-4468","issn":["2073-4468"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383552185.pdf","grobid_xml":"https://content.openalex.org/works/W4383552185.grobid-xml"},"referenced_works_count":159,"referenced_works":["https://openalex.org/W64973136","https://openalex.org/W81209440","https://openalex.org/W868412864","https://openalex.org/W1062587256","https://openalex.org/W1158385620","https://openalex.org/W1420726270","https://openalex.org/W1578375703","https://openalex.org/W1821381892","https://openalex.org/W1963637896","https://openalex.org/W1965696997","https://openalex.org/W1967999719","https://openalex.org/W1971998789","https://openalex.org/W1973323884","https://openalex.org/W1991064719","https://openalex.org/W1992274022","https://openalex.org/W1994495694","https://openalex.org/W2005920135","https://openalex.org/W2007098121","https://openalex.org/W2009551908","https://openalex.org/W2010967515","https://openalex.org/W2014495927","https://openalex.org/W2016110802","https://openalex.org/W2016364569","https://openalex.org/W2021376182","https://openalex.org/W2025980739","https://openalex.org/W2028453932","https://openalex.org/W2029131536","https://openalex.org/W2030522563","https://openalex.org/W2031152984","https://openalex.org/W2031808723","https://openalex.org/W2035925557","https://openalex.org/W2043950000","https://openalex.org/W2053801470","https://openalex.org/W2058438178","https://openalex.org/W2058647478","https://openalex.org/W2063927796","https://openalex.org/W2065633718","https://openalex.org/W2070426326","https://openalex.org/W2072832670","https://openalex.org/W2073739917","https://openalex.org/W2075020461","https://openalex.org/W2075227451","https://openalex.org/W2080951809","https://openalex.org/W2082820578","https://openalex.org/W2087017620","https://openalex.org/W2087439897","https://openalex.org/W2095553811","https://openalex.org/W2100018747","https://openalex.org/W2103648543","https://openalex.org/W2111389460","https://openalex.org/W2114581604","https://openalex.org/W2114741749","https://openalex.org/W2115048752","https://openalex.org/W2120423141","https://openalex.org/W2137574173","https://openalex.org/W2141028568","https://openalex.org/W2143036112","https://openalex.org/W2143743183","https://openalex.org/W2143941734","https://openalex.org/W2148043455","https://openalex.org/W2151181830","https://openalex.org/W2154714325","https://openalex.org/W2156788486","https://openalex.org/W2157341237","https://openalex.org/W2158153222","https://openalex.org/W2162970812","https://openalex.org/W2164148151","https://openalex.org/W2165181966","https://openalex.org/W2249755146","https://openalex.org/W2264232485","https://openalex.org/W2307564614","https://openalex.org/W2339658610","https://openalex.org/W2417233462","https://openalex.org/W2486840518","https://openalex.org/W2519469630","https://openalex.org/W2593990758","https://openalex.org/W2626337750","https://openalex.org/W2634629274","https://openalex.org/W2742522266","https://openalex.org/W2747674589","https://openalex.org/W2754401101","https://openalex.org/W2755042688","https://openalex.org/W2756467165","https://openalex.org/W2761417170","https://openalex.org/W2775750859","https://openalex.org/W2789458710","https://openalex.org/W2791854174","https://openalex.org/W2792638493","https://openalex.org/W2810653215","https://openalex.org/W2810793599","https://openalex.org/W2811471765","https://openalex.org/W2811482166","https://openalex.org/W2884096061","https://openalex.org/W2895762589","https://openalex.org/W2900706296","https://openalex.org/W2901732892","https://openalex.org/W2902838323","https://openalex.org/W2904862952","https://openalex.org/W2907569389","https://openalex.org/W2915308412","https://openalex.org/W2915388137","https://openalex.org/W2920220762","https://openalex.org/W2920817121","https://openalex.org/W2933886569","https://openalex.org/W2937887082","https://openalex.org/W2944452880","https://openalex.org/W2945697388","https://openalex.org/W2946690483","https://openalex.org/W2947249571","https://openalex.org/W2948534853","https://openalex.org/W2965776922","https://openalex.org/W2982997046","https://openalex.org/W2991149352","https://openalex.org/W2992606840","https://openalex.org/W2999216889","https://openalex.org/W3005597080","https://openalex.org/W3007447370","https://openalex.org/W3011360311","https://openalex.org/W3023221378","https://openalex.org/W3031193422","https://openalex.org/W3036298160","https://openalex.org/W3037578051","https://openalex.org/W3045596302","https://openalex.org/W3046042268","https://openalex.org/W3102945151","https://openalex.org/W3107896279","https://openalex.org/W3112388253","https://openalex.org/W3122317529","https://openalex.org/W3128957495","https://openalex.org/W3129297995","https://openalex.org/W3136166831","https://openalex.org/W3137081615","https://openalex.org/W3162445048","https://openalex.org/W3177445689","https://openalex.org/W3188940990","https://openalex.org/W3195594615","https://openalex.org/W3198250402","https://openalex.org/W3198359021","https://openalex.org/W3208782404","https://openalex.org/W3209735640","https://openalex.org/W3211380677","https://openalex.org/W3217355073","https://openalex.org/W4200200443","https://openalex.org/W4205377647","https://openalex.org/W4210527405","https://openalex.org/W4223516255","https://openalex.org/W4226027283","https://openalex.org/W4229453549","https://openalex.org/W4233249586","https://openalex.org/W4281254240","https://openalex.org/W4292647883","https://openalex.org/W4293685785","https://openalex.org/W4294251783","https://openalex.org/W4297235449","https://openalex.org/W4300963224","https://openalex.org/W4302293779","https://openalex.org/W4307842911","https://openalex.org/W4308510590","https://openalex.org/W4321213515"],"related_works":["https://openalex.org/W4388140599","https://openalex.org/W2032487246","https://openalex.org/W7125980753","https://openalex.org/W4406989030","https://openalex.org/W6930531171","https://openalex.org/W3011544836","https://openalex.org/W7107953676","https://openalex.org/W4393029124","https://openalex.org/W4414617558","https://openalex.org/W7216879163"],"abstract_inverted_index":{"Harnessing":[0],"the":[1,84,173],"immune":[2,71],"system":[3],"to":[4,65,105,123,132,171],"combat":[5],"disease":[6],"has":[7],"revolutionized":[8],"medical":[9],"treatment.":[10],"Monoclonal":[11],"antibodies":[12,49],"(mAbs),":[13],"in":[14,25,112,140],"particular,":[15],"have":[16],"emerged":[17],"as":[18],"important":[19],"immunotherapeutic":[20],"agents":[21],"with":[22],"clinical":[23],"relevance":[24],"treating":[26],"a":[27],"wide":[28],"range":[29],"of":[30,54,88,143,177],"diseases,":[31,35],"including":[32,127,164],"allergies,":[33],"autoimmune":[34],"neurodegenerative":[36],"disorders,":[37],"cancer,":[38],"and":[39,50,86,95,102,115,151,168,175],"infectious":[40],"diseases.":[41,182],"These":[42,136],"mAbs":[43],"are":[44,92,119],"developed":[45],"from":[46],"naturally":[47],"occurring":[48],"target":[51,66],"specific":[52],"epitopes":[53],"single":[55],"molecules,":[56],"minimizing":[57],"off-target":[58],"effects.":[59],"Antibodies":[60],"can":[61],"also":[62],"be":[63],"designed":[64],"particular":[67],"pathogens":[68],"or":[69,75],"modulate":[70],"function":[72],"by":[73],"activating":[74],"suppressing":[76],"certain":[77],"pathways.":[78],"Despite":[79],"their":[80,110,169],"benefit":[81],"for":[82,139,160,180],"patients,":[83],"production":[85,142],"administration":[87,153],"monoclonal":[89,125,144,161],"antibody":[90,162],"therapeutics":[91],"laborious,":[93],"costly,":[94],"time-consuming.":[96],"Administration":[97],"often":[98],"requires":[99],"inpatient":[100],"stays":[101],"repeated":[103],"dosing":[104],"maintain":[106],"therapeutic":[107],"levels,":[108],"limiting":[109],"use":[111],"underserved":[113],"populations":[114],"developing":[116,120],"countries.":[117],"Researchers":[118],"alternate":[121],"methods":[122,137,159],"deliver":[124],"antibodies,":[126,145],"synthetic":[128,165],"nucleic":[129,166],"acid-based":[130],"delivery,":[131,163],"overcome":[133],"these":[134],"limitations.":[135],"allow":[138],"vivo":[141],"which":[146],"would":[147],"significantly":[148],"reduce":[149],"costs":[150],"simplify":[152],"logistics.":[154],"This":[155],"review":[156],"explores":[157],"new":[158],"acids,":[167],"potential":[170],"increase":[172],"accessibility":[174],"utility":[176],"life-saving":[178],"treatments":[179],"several":[181]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-08T00:00:00"}
