{"id":"https://openalex.org/W4383552002","doi":"https://doi.org/10.2147/ijn.s413692","title":"Osteoclast-Derived Exosomal miR-5134-5p Interferes with Alveolar Bone Homeostasis by Targeting the JAK2/STAT3 Axis","display_name":"Osteoclast-Derived Exosomal miR-5134-5p Interferes with Alveolar Bone Homeostasis by Targeting the JAK2/STAT3 Axis","publication_year":2023,"publication_date":"2023-07-01","ids":{"openalex":"https://openalex.org/W4383552002","doi":"https://doi.org/10.2147/ijn.s413692","pmid":"https://pubmed.ncbi.nlm.nih.gov/37441084"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s413692","doi":"https://doi.org/10.2147/ijn.s413692","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s413692","pdf_url":"https://www.dovepress.com/getfile.php?fileID=91019","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=91019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043283748","display_name":"Lai Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lai Pan","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027035725","display_name":"Chenyi Zhang","orcid":"https://orcid.org/0000-0001-7837-8562","observed_orcids":["https://orcid.org/0000-0001-7837-8562"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyi Zhang","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-7837-8562","affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102603141","display_name":"Haizheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haizheng Zhang","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111792662","display_name":"Ting Ke","orcid":"https://orcid.org/0009-0003-3290-7408","observed_orcids":["https://orcid.org/0009-0003-3290-7408"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Ke","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026216731","display_name":"Mengyao Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Bian","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111219838","display_name":"Yuxuan Yang","orcid":"https://orcid.org/0009-0000-5292-713X","observed_orcids":["https://orcid.org/0009-0000-5292-713X"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxuan Yang","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101225573","display_name":"Lili Chen","orcid":"https://orcid.org/0009-0003-4304-5946","observed_orcids":["https://orcid.org/0009-0003-4304-5946"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Chen","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114514330","display_name":"Jingyi Tan","orcid":"https://orcid.org/0009-0001-8597-6998","observed_orcids":["https://orcid.org/0009-0001-8597-6998"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Tan","raw_affiliation_strings":["Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.0183,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.8796966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"Volume 18","issue":null,"first_page":"3727","last_page":"3744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.5884000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.30399999022483826,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0729999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-periodontitis","display_name":"chronic periodontitis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.890999972820282},{"id":"https://openalex.org/keywords/jak2-stat3-signaling-pathway","display_name":"JAK2/STAT3 signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/periodontal-inflammation","display_name":"periodontal inflammation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.6240000128746033},{"id":"https://openalex.org/keywords/periodontal-regeneration","display_name":"periodontal regeneration","score":0.6269999742507935},{"id":"https://openalex.org/keywords/bone-homeostasis","display_name":"bone homeostasis","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.7237051129341125},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5864444375038147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5494274497032166},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.53969806432724},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5128862857818604},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48552489280700684},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.48236578702926636},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.450114369392395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44098594784736633},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.439212441444397},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.4363234341144562},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.41950374841690063},{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.4180675745010376},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32805079221725464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23082002997398376},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.19851338863372803},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19633379578590393},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14101585745811462},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12406915426254272},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11751687526702881},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2147/ijn.s413692","doi":"https://doi.org/10.2147/ijn.s413692","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s413692","pdf_url":"https://www.dovepress.com/getfile.php?fileID=91019","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:37441084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37441084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10335290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10335290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:dovepress.com/84994","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/osteoclast-derived-exosomal-mir-5134-5p-interferes-with-alveolar-bone--peer-reviewed-fulltext-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s413692","doi":"https://doi.org/10.2147/ijn.s413692","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s413692","pdf_url":"https://www.dovepress.com/getfile.php?fileID=91019","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G181286086","display_name":null,"funder_award_id":"81800972","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G632347299","display_name":null,"funder_award_id":"82170954","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383552002.pdf","grobid_xml":"https://content.openalex.org/works/W4383552002.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W2005794914","https://openalex.org/W2037497588","https://openalex.org/W2299414460","https://openalex.org/W2513456796","https://openalex.org/W2741932595","https://openalex.org/W2765797682","https://openalex.org/W2771553433","https://openalex.org/W2786987313","https://openalex.org/W2802213056","https://openalex.org/W2807518326","https://openalex.org/W2883826970","https://openalex.org/W2908918388","https://openalex.org/W2921461531","https://openalex.org/W2994883897","https://openalex.org/W3005941992","https://openalex.org/W3011547660","https://openalex.org/W3016559380","https://openalex.org/W3043352885","https://openalex.org/W3047449667","https://openalex.org/W3093748423","https://openalex.org/W3110561625","https://openalex.org/W3112770854","https://openalex.org/W3128372814","https://openalex.org/W3128862004","https://openalex.org/W3166873110","https://openalex.org/W3171930456","https://openalex.org/W3203293249","https://openalex.org/W4200514974","https://openalex.org/W4212982535","https://openalex.org/W4220673149","https://openalex.org/W4220805479","https://openalex.org/W4223942579","https://openalex.org/W4224230014","https://openalex.org/W4224308209","https://openalex.org/W4224943369","https://openalex.org/W4282581781","https://openalex.org/W4285492081","https://openalex.org/W4287147347","https://openalex.org/W4290659426","https://openalex.org/W4306405326","https://openalex.org/W4313254452","https://openalex.org/W4313597583","https://openalex.org/W4317475550","https://openalex.org/W4322498174"],"related_works":["https://openalex.org/W2373306182","https://openalex.org/W2389326405","https://openalex.org/W2157573016","https://openalex.org/W2389191308","https://openalex.org/W2401376174","https://openalex.org/W2366074894","https://openalex.org/W2054672665","https://openalex.org/W2058177391","https://openalex.org/W2237057952","https://openalex.org/W1980360189"],"abstract_inverted_index":{"Background:":[0],"In":[1,235],"chronic":[2],"periodontitis,":[3],"exosomes":[4],"transport":[5],"various":[6],"informative":[7],"substances":[8],"between":[9],"osteoclasts":[10,30],"and":[11,34,36,43,54,90,106,113,157,192,215,218,225,261,268,280,291],"osteoblasts":[12,57,109,182,206],"in":[13,41,44,164,176,181,205,259,264,296],"alveolar":[14,147,269,293],"bone.":[15],"Herein,":[16],"we":[17,102],"aimed":[18],"to":[19],"investigate":[20],"the":[21,37,52,104,121,125,135,144,232,237,265,283],"effect":[22],"of":[23,39,49,56,83,108,137,146,220,243,251],"exosomal":[24,275],"micro-ribonucleic":[25],"acid":[26],"(miRNA/miR)-5134-5p":[27],"derived":[28],"from":[29],"on":[31,51],"osteoblastic":[32,278],"proliferation":[33,53,105,156,279],"differentiation":[35,55,107,158,281],"development":[38],"periodontitis":[40],"vivo":[42],"vitro.":[45,165],"Methods:":[46],"The":[47,81,186],"effects":[48],"OC-Exos":[50,117,163,286],"were":[58,86,118,140,159],"identified":[59],"by":[60,79,92,110,131,142,151,162],"Real-time":[61],"quantitative":[62],"reverse":[63],"polymerase":[64],"chain":[65],"reaction":[66],"(qRT-PCR),":[67],"Western":[68],"blot(WB),":[69],"alkaline":[70],"phosphatase(ALP)":[71],"staining,":[72,134],"etc.":[73,115],"Exosomal":[74],"miRNA":[75,84,166],"expression":[76,136,172,204,224],"was":[77,129,149,173],"analyzed":[78],"sequencing.":[80],"sites":[82],"action":[85],"predicted":[87],"through":[88],"TargetScan":[89],"tested":[91],"double":[93],"luciferase":[94],"assay.":[95],"After":[96],"transfecting":[97],"miR-5134-5p":[98,171,191,203,276],"mimic/inhibitor":[99],"into":[100,120],"osteoblasts,":[101],"measured":[103],"ALP":[111],"staining":[112],"WB,":[114],"Furthermore,":[116],"injected":[119],"gingival":[122],"sulcus":[123],"at":[124],"ligation":[126],"site.":[127],"Inflammation":[128],"observed":[130,150],"Hematoxylin-eosin":[132],"(H&E)":[133],"inflammatory":[138,247,252],"factors":[139,253],"detected":[141],"qRT-PCR,":[143],"resorption":[145,295],"bone":[148,270,294],"Micro":[152],"CT.":[153],"Results:":[154],"Osteoblastic":[155],"negatively":[160],"regulated":[161],"sequencing":[167],"analysis":[168],"revealed":[169,189],"that":[170,190],"significantly":[174],"elevated":[175],"OC-Exos,":[177],"which":[178],"also":[179],"increased":[180],"following":[183],"OC-Exo":[184,238],"intervention.":[185],"dual-luciferase":[187],"assay":[188],"Janus":[193],"kinase":[194],"2":[195],"(JAK2)":[196],"had":[197,231],"binding":[198],"sites.":[199],"miR-5134-5p-mimics":[200],"could":[201],"upregulate":[202],"while":[207],"downregulating":[208],"Runt-related":[209],"transcription":[210,221],"factor":[211],"2(Runx2),":[212],"phosphorylated-JAK2":[213],"(p-JAK2),":[214],"phosphorylated-signal":[216],"transducer":[217],"activator":[219],"3":[222],"(p-STAT3)":[223],"inhibited":[226],"osteogenic":[227],"differentiation.":[228],"However,":[229],"miR-5134-5p-inhibitor":[230],"opposite":[233],"effect.":[234],"vivo,":[236],"group":[239],"demonstrated":[240],"morphological":[241],"disruption":[242],"periodontal":[244,288],"tissue,":[245],"massive":[246],"cell":[248],"infiltration,":[249],"upregulation":[250],"mRNA":[254],"expression,":[255],"a":[256],"significant":[257],"decrease":[258],"BV/TV,":[260],"an":[262],"increase":[263],"cementoenamel":[266],"junction":[267],"crest":[271],"distance.":[272],"Conclusion:":[273],"Osteoclast-derived":[274],"inhibits":[277],"via":[282],"JAK2/STAT3":[284],"pathway.":[285],"exacerbate":[287],"tissue":[289],"inflammation":[290],"accelerate":[292],"mice":[297],"with":[298],"experimental":[299],"periodontitis.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
