{"id":"https://openalex.org/W4383534085","doi":"https://doi.org/10.9734/jpri/2023/v35i177388","title":"Preformulation Studies of Varenicline for Formulation and Development of a Novel Orally Disintegrating Film","display_name":"Preformulation Studies of Varenicline for Formulation and Development of a Novel Orally Disintegrating Film","publication_year":2023,"publication_date":"2023-07-07","ids":{"openalex":"https://openalex.org/W4383534085","doi":"https://doi.org/10.9734/jpri/2023/v35i177388"},"language":"en","primary_location":{"id":"doi:10.9734/jpri/2023/v35i177388","doi":"https://doi.org/10.9734/jpri/2023/v35i177388","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jpri/2023/v35i177388","pdf_url":"https://journaljpri.com/index.php/JPRI/article/download/7388/14756","source":{"id":"https://openalex.org/S4210206555","display_name":"Journal of Pharmaceutical Research International","issn_l":"2231-2919","issn":["2231-2919","2456-9119"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Research International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journaljpri.com/index.php/JPRI/article/download/7388/14756","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027971611","display_name":"Prakruti Amin","orcid":"https://orcid.org/0009-0003-5256-4027","observed_orcids":["https://orcid.org/0009-0003-5256-4027"]},"institutions":[{"id":"https://openalex.org/I29563240","display_name":"Gujarat Technological University","ror":"https://ror.org/059x8vm09","country_code":"IN","type":"education","lineage":["https://openalex.org/I29563240"]},{"id":"https://openalex.org/I333550923","display_name":"Kadi Sarva Vishwavidyalaya","ror":"https://ror.org/05edrtk54","country_code":"IN","type":"education","lineage":["https://openalex.org/I333550923"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prakruti Amin","raw_affiliation_strings":["Gujarat Technological University, Ahmedabad, Gujarat, India and Department of Pharmaceutics, Kadi Sarva Vishwavidyalaya, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gujarat Technological University, Ahmedabad, Gujarat, India and Department of Pharmaceutics, Kadi Sarva Vishwavidyalaya, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India","institution_ids":["https://openalex.org/I29563240","https://openalex.org/I333550923"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047581936","display_name":"Manish P. Patel","orcid":"https://orcid.org/0000-0002-7705-9217","observed_orcids":["https://orcid.org/0000-0002-7705-9217"]},"institutions":[{"id":"https://openalex.org/I29563240","display_name":"Gujarat Technological University","ror":"https://ror.org/059x8vm09","country_code":"IN","type":"education","lineage":["https://openalex.org/I29563240"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Patel","raw_affiliation_strings":["Department of Pharmaceutics, L. M. College of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, L. M. College of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I29563240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1918,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.31153008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"35","issue":"17","first_page":"31","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.2777999937534332,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.121799997985363,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varenicline","display_name":"varenicline","score":1.0},{"id":"https://openalex.org/keywords/orally-disintegrating-films","display_name":"orally disintegrating films","score":0.9150000214576721},{"id":"https://openalex.org/keywords/preformulation","display_name":"preformulation","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.46299999952316284},{"id":"https://openalex.org/keywords/physicochemical-characterization","display_name":"physicochemical characterization","score":0.734000027179718},{"id":"https://openalex.org/keywords/uv-spectrophotometric-assay","display_name":"UV spectrophotometric assay","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nicotinic-agonists","display_name":"nicotinic agonists","score":0.7080000042915344},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.6029999852180481},{"id":"https://openalex.org/keywords/drug-quantification","display_name":"pharmaceutical analysis","score":0.33799999952316284},{"id":"https://openalex.org/keywords/excipient-compatibility","display_name":"excipient compatibility","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2777053506","wikidata":"https://www.wikidata.org/wiki/Q411330","display_name":"Varenicline","level":3,"score":0.951779842376709},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.7190257906913757},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.6153284907341003},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.5222664475440979},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5003855228424072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4924357831478119},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48209527134895325},{"id":"https://openalex.org/C2777301948","wikidata":"https://www.wikidata.org/wiki/Q417343","display_name":"Cytisine","level":4,"score":0.4730983078479767},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.44347402453422546},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.3524533808231354},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3486475348472595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19421181082725525},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11661222577095032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09809204936027527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08105134963989258},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.9734/jpri/2023/v35i177388","doi":"https://doi.org/10.9734/jpri/2023/v35i177388","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jpri/2023/v35i177388","pdf_url":"https://journaljpri.com/index.php/JPRI/article/download/7388/14756","source":{"id":"https://openalex.org/S4210206555","display_name":"Journal of Pharmaceutical Research International","issn_l":"2231-2919","issn":["2231-2919","2456-9119"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Research International","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-05159473v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05159473","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmaceutical Research International, 2023, 35 (17), pp.31-40","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.9734/jpri/2023/v35i177388","doi":"https://doi.org/10.9734/jpri/2023/v35i177388","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jpri/2023/v35i177388","pdf_url":"https://journaljpri.com/index.php/JPRI/article/download/7388/14756","source":{"id":"https://openalex.org/S4210206555","display_name":"Journal of Pharmaceutical Research International","issn_l":"2231-2919","issn":["2231-2919","2456-9119"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383534085.pdf","grobid_xml":"https://content.openalex.org/works/W4383534085.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W140541985","https://openalex.org/W830557743","https://openalex.org/W2026355813","https://openalex.org/W2029029691","https://openalex.org/W2042927990","https://openalex.org/W2049660697","https://openalex.org/W2056230174","https://openalex.org/W2121944011","https://openalex.org/W2136710096","https://openalex.org/W2184913504","https://openalex.org/W2596547636","https://openalex.org/W4402407178"],"related_works":["https://openalex.org/W7009788343","https://openalex.org/W4249018970","https://openalex.org/W2895610191","https://openalex.org/W4404160564","https://openalex.org/W7154470955","https://openalex.org/W4230210308","https://openalex.org/W10638854","https://openalex.org/W1993112595","https://openalex.org/W2101520329","https://openalex.org/W2356317465"],"abstract_inverted_index":{"Objective:":[0],"The":[1,134,163,203,217,228],"major":[2],"goal":[3],"of":[4,37,136,153,165,177,195,207,230,234,239],"pre-formulation":[5],"research":[6],"is":[7,15,91,128,225],"to":[8,73,130],"create":[9],"a":[10,78,92,185],"drug":[11,39,235],"delivery":[12],"system":[13],"that":[14],"stable,":[16],"elegant,":[17],"safe,":[18],"and":[19,33,90,102,142,157,171,209],"effective":[20],"by":[21,109,116,140,169],"determining":[22],"the":[23,27,34,51,54,59,100,111,123,175,192,198,213,223,231,253],"drug's":[24],"kinetic":[25],"profile,":[26],"formulation's":[28],"compatibility":[29],"with":[30,106],"various":[31],"excipients,":[32],"physico-chemical":[35,232],"characteristics":[36],"new":[38],"molecules.":[40],"This":[41],"could":[42],"offer":[43],"crucial":[44],"support":[45],"for":[46,53,67,151],"executing":[47],"formulation":[48,69],"design":[49],"or":[50],"need":[52],"molecular":[55],"change.":[56],"Therefore,":[57],"in":[58,155,179],"current":[60],"study,":[61],"studies":[62],"on":[63,115],"Varenicline":[64],"(VAR)'s":[65],"appropriateness":[66],"oral":[68,240],"were":[70],"conducted.":[71],"Similar":[72],"cytisine,":[74],"VAR":[75,98,137,154,166,178],"functions":[76],"as":[77,248,250],"partial":[79,93,96],"nicotine":[80,120,131],"receptor":[81,88],"agonist.":[82,94],"It":[83,118],"blocks":[84],"alpha-4-beta-2":[85],"nicotinic":[86],"acetylcholine":[87],"subtypes":[89],"Through":[95],"agonism,":[97],"reduces":[99],"urge":[101],"withdrawal":[103],"symptoms":[104],"associated":[105],"quitting":[107],"efforts":[108],"inhibiting":[110],"dopaminergic":[112],"activation":[113],"brought":[114],"smoking.":[117],"stops":[119],"from":[121],"stimulating":[122],"mesolimbic":[124],"dopamine":[125],"pathway,":[126],"which":[127],"linked":[129],"addiction.":[132],"Methods:":[133],"authenticity":[135,164],"was":[138,149,167,189,201],"established":[139,168],"DSC":[141,170],"FTIR":[143,172],"spectra.":[144,173],"A":[145],"UV":[146,186,199],"spectrophotometric":[147,187],"method":[148],"employed":[150],"determination":[152,176],"bulk":[156,180],"active":[158],"pharmaceutical":[159,183],"ingredient":[160],"(API).":[161],"Results:":[162],"For":[174],"API":[181],"(active":[182],"ingredient),":[184],"approach":[188],"used.":[190],"In":[191],"concentration":[193],"range":[194],"5\u201340":[196],"g/ml,":[197],"technique":[200],"linear.":[202],"lower%":[204],"CV":[205],"values":[206],"intraday":[208],"interday":[210],"variability":[211],"indicate":[212],"proposed":[214],"methodology's":[215],"robustness.":[216],"higher":[218],"regression":[219],"coefficient":[220],"value(0.999)":[221],"indicates":[222,237],"methodology":[224],"robust.":[226],"Conclusions:":[227],"outcome":[229],"experiments":[233],"molecule":[236],"suitability":[238],"route.":[241],"Additionally,":[242],"at":[243],"different":[244],"conditions":[245],"like":[246],"solid":[247],"well":[249],"liquid":[251],"state,":[252],"drugmoleculewasobservedstable.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2023-07-08T00:00:00"}
