{"id":"https://openalex.org/W4383501103","doi":"https://doi.org/10.1016/j.gore.2023.101237","title":"Durable remission in a patient with ERBB2-amplified recurrent mucinous ovarian carcinoma treated with Trastuzumab-Carboplatin-Paclitaxel","display_name":"Durable remission in a patient with ERBB2-amplified recurrent mucinous ovarian carcinoma treated with Trastuzumab-Carboplatin-Paclitaxel","publication_year":2023,"publication_date":"2023-07-07","ids":{"openalex":"https://openalex.org/W4383501103","doi":"https://doi.org/10.1016/j.gore.2023.101237","pmid":"https://pubmed.ncbi.nlm.nih.gov/37449085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10336730"},"language":"en","primary_location":{"id":"doi:10.1016/j.gore.2023.101237","doi":"https://doi.org/10.1016/j.gore.2023.101237","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gore.2023.101237","pdf_url":null,"source":{"id":"https://openalex.org/S2764639750","display_name":"Gynecologic Oncology Reports","issn_l":"2352-5789","issn":["2352-5789"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.gore.2023.101237","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040073496","display_name":"Alexander J. Neil","orcid":"https://orcid.org/0000-0002-3351-787X","observed_orcids":["https://orcid.org/0000-0002-3351-787X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander J. Neil","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014639724","display_name":"Michael George Muto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Muto","raw_affiliation_strings":["Division of Gynecologic Oncology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018953179","display_name":"David L. Kolin","orcid":"https://orcid.org/0000-0002-7631-6525","observed_orcids":["https://orcid.org/0000-0002-7631-6525"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Kolin","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076246054","display_name":"Panagiotis A. Konstantinopoulos","orcid":"https://orcid.org/0000-0002-1032-1479","observed_orcids":["https://orcid.org/0000-0002-1032-1479"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Panagiotis A. Konstantinopoulos","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018953179","https://openalex.org/A5076246054"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453"],"apc_list":{"value":750,"currency":"USD","value_usd":750},"apc_paid":{"value":750,"currency":"USD","value_usd":750},"fwci":0.4798,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65554621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"48","issue":null,"first_page":"101237","last_page":"101237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mucinous-ovarian-carcinoma","display_name":"mucinous ovarian carcinoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.8679999709129333},{"id":"https://openalex.org/keywords/erbb2-amplification","display_name":"ERBB2 amplification","score":0.9470000267028809},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7910000085830688},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":1.0},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/secondary-cytoreductive-surgery","display_name":"secondary cytoreductive surgery","score":0.9020000100135803},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.546999990940094},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/long-term-remission","display_name":"long-term remission","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9182292819023132},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9034289121627808},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.7759757041931152},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6493098139762878},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.6463038921356201},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.5690057277679443},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5548798441886902},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5481134653091431},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.5420023798942566},{"id":"https://openalex.org/C2777874381","wikidata":"https://www.wikidata.org/wiki/Q6931137","display_name":"Mucinous carcinoma","level":4,"score":0.5378111600875854},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.5143641233444214},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.448237806558609},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.43745312094688416},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2958613634109497},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2619711458683014},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.26166611909866333},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.17889776825904846},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.09083747863769531}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.gore.2023.101237","doi":"https://doi.org/10.1016/j.gore.2023.101237","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gore.2023.101237","pdf_url":null,"source":{"id":"https://openalex.org/S2764639750","display_name":"Gynecologic Oncology Reports","issn_l":"2352-5789","issn":["2352-5789"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10336730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10336730","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10336730/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecol Oncol Rep","raw_type":"Text"},{"id":"pmid:37449085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37449085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic oncology reports","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:14440632f14748219cf1e8d145c428d8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/14440632f14748219cf1e8d145c428d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gynecologic Oncology Reports, Vol 48, Iss , Pp 101237- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.gore.2023.101237","doi":"https://doi.org/10.1016/j.gore.2023.101237","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gore.2023.101237","pdf_url":null,"source":{"id":"https://openalex.org/S2764639750","display_name":"Gynecologic Oncology Reports","issn_l":"2352-5789","issn":["2352-5789"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1860655878","https://openalex.org/W2006621710","https://openalex.org/W2046793599","https://openalex.org/W2048623699","https://openalex.org/W2118228232","https://openalex.org/W2125991972","https://openalex.org/W2128904109","https://openalex.org/W2338039884","https://openalex.org/W2401769767","https://openalex.org/W2416660942","https://openalex.org/W2594059953","https://openalex.org/W2792445620","https://openalex.org/W2924865772","https://openalex.org/W2936836467","https://openalex.org/W2970379806","https://openalex.org/W2996972368","https://openalex.org/W3045983904","https://openalex.org/W4379662279"],"related_works":["https://openalex.org/W2048623699","https://openalex.org/W4312186674","https://openalex.org/W7212241606","https://openalex.org/W4388673920","https://openalex.org/W3160664198","https://openalex.org/W2011408267","https://openalex.org/W7096339587","https://openalex.org/W2338039884","https://openalex.org/W4390788606","https://openalex.org/W2128904109"],"abstract_inverted_index":{"Patients":[0],"with":[1,26,42,88,102,106,125,141],"advanced":[2,89],"stage":[3],"or":[4,65,90],"recurrent":[5,27,91],"mucinous":[6,29,92,122],"ovarian":[7,30,93,123],"carcinoma":[8,31,94],"exhibit":[9],"poor":[10,19],"response":[11],"to":[12],"standard":[13,107],"platinum-":[14],"and":[15,18,39,56,95,109,128,146],"taxane-based":[16],"chemotherapy":[17],"prognosis.":[20],"We":[21],"report":[22],"a":[23,142],"29-year-old":[24],"patient":[25,61,136],"ERBB2-amplified":[28],"(with":[32],"expansile":[33,121],"growth":[34],"pattern":[35,133],"at":[36],"initial":[37],"diagnosis":[38],"previously":[40],"treated":[41],"adjuvant":[43],"capecitabine/oxaliplatin)":[44],"who":[45],"underwent":[46],"optimal":[47],"secondary":[48,76],"cytoreduction":[49],"followed":[50],"by":[51],"6":[52],"cycles":[53],"of":[54,68,83,99,149],"carboplatin/paclitaxel/trastuzumab":[55],"1-year":[57],"maintenance":[58],"trastuzumab.":[59],"This":[60,78,114],"remains":[62],"without":[63],"radiologic":[64],"biochemical":[66],"evidence":[67],"disease":[69],"for":[70],"more":[71,143],"than":[72],"3":[73],"years":[74],"after":[75],"cytoreduction.":[77],"case":[79,115],"supports":[80],"routine":[81],"assessment":[82],"HER2":[84],"status":[85],"in":[86,104,111],"patients":[87],"highlights":[96],"the":[97,118],"potential":[98],"HER2-targeted":[100],"therapy":[101],"trastuzumab":[103],"combination":[105],"carboplatin":[108],"paclitaxel":[110],"this":[112,135],"disease.":[113],"also":[116],"raises":[117],"possibility":[119],"that":[120],"carcinomas":[124],"ERBB2":[126],"amplification":[127],"p53":[129],"mutant":[130],"immunohistochemical":[131],"staining":[132],"(as":[134],"had)":[137],"may":[138],"be":[139],"associated":[140],"aggressive":[144],"behavior":[145],"higher":[147],"risk":[148],"relapse.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-07-08T00:00:00"}
