{"id":"https://openalex.org/W4383499315","doi":"https://doi.org/10.1097/qad.0000000000003644","title":"Breakthrough HIV-1 infection in setting of cabotegravir for HIV pre-exposure prophylaxis","display_name":"Breakthrough HIV-1 infection in setting of cabotegravir for HIV pre-exposure prophylaxis","publication_year":2023,"publication_date":"2023-07-03","ids":{"openalex":"https://openalex.org/W4383499315","doi":"https://doi.org/10.1097/qad.0000000000003644","pmid":"https://pubmed.ncbi.nlm.nih.gov/37418423"},"language":"en","primary_location":{"id":"doi:10.1097/qad.0000000000003644","doi":"https://doi.org/10.1097/qad.0000000000003644","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0000000000003644","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077906636","display_name":"Aniruddha Hazra","orcid":"https://orcid.org/0000-0001-8557-4465","observed_orcids":["https://orcid.org/0000-0001-8557-4465"]},"institutions":[{"id":"https://openalex.org/I1296644651","display_name":"Howard Brown Health Center","ror":"https://ror.org/01sw9e110","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1296644651"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aniruddha Hazra","raw_affiliation_strings":["Howard Brown Health","Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, IL","Howard Brown Health, Chicago, IL, USA","Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Brown Health","institution_ids":["https://openalex.org/I1296644651"]},{"raw_affiliation_string":"Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, IL","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]},{"raw_affiliation_string":"Howard Brown Health, Chicago, IL, USA","institution_ids":["https://openalex.org/I1296644651"]},{"raw_affiliation_string":"Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045910681","display_name":"Raphael J. Landovitz","orcid":"https://orcid.org/0000-0002-1442-714X","observed_orcids":["https://orcid.org/0000-0002-1442-714X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raphael J. Landovitz","raw_affiliation_strings":["Center for Clinical AIDS Research and Education, David Geffen School of Medicine, University of California, Los Angeles, CA","Center for Clinical AIDS Research and Education, David Geffen School of Medicine, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical AIDS Research and Education, David Geffen School of Medicine, University of California, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Center for Clinical AIDS Research and Education, David Geffen School of Medicine, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082007029","display_name":"Mark A. Marzinke","orcid":"https://orcid.org/0000-0003-1670-8786","observed_orcids":["https://orcid.org/0000-0003-1670-8786"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Marzinke","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092420315","display_name":"Connor Quinby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1296644651","display_name":"Howard Brown Health Center","ror":"https://ror.org/01sw9e110","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1296644651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor Quinby","raw_affiliation_strings":["Howard Brown Health","Howard Brown Health, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Brown Health","institution_ids":["https://openalex.org/I1296644651"]},{"raw_affiliation_string":"Howard Brown Health, Chicago, IL, USA","institution_ids":["https://openalex.org/I1296644651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036969908","display_name":"Catherine M. Creticos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1296644651","display_name":"Howard Brown Health Center","ror":"https://ror.org/01sw9e110","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1296644651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Creticos","raw_affiliation_strings":["Howard Brown Health","Howard Brown Health, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Brown Health","institution_ids":["https://openalex.org/I1296644651"]},{"raw_affiliation_string":"Howard Brown Health, Chicago, IL, USA","institution_ids":["https://openalex.org/I1296644651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5077906636"],"corresponding_institution_ids":["https://openalex.org/I1296644651","https://openalex.org/I40347166","https://openalex.org/I4210087865"],"apc_list":null,"apc_paid":null,"fwci":2.2194,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.87414188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"37","issue":"11","first_page":"1711","last_page":"1714"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cabotegravir","display_name":"cabotegravir","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hiv-1-viral-load","display_name":"HIV-1 viral load","score":0.593999981880188},{"id":"https://openalex.org/keywords/hiv-seroconversion","display_name":"HIV seroconversion","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7760863304138184},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.730742871761322},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.7025169134140015},{"id":"https://openalex.org/C2779496540","wikidata":"https://www.wikidata.org/wiki/Q7239230","display_name":"Pre-exposure prophylaxis","level":5,"score":0.4928715229034424},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.4843240976333618},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.476764976978302},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.4271591603755951},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4122685492038727},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35990291833877563},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.3476870059967041},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3471706509590149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3321187496185303},{"id":"https://openalex.org/C2776939746","wikidata":"https://www.wikidata.org/wiki/Q853451","display_name":"Men who have sex with men","level":4,"score":0.1777939796447754},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D054659","descriptor_name":"Diketopiperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065129","descriptor_name":"Pre-Exposure Prophylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/qad.0000000000003644","doi":"https://doi.org/10.1097/qad.0000000000003644","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0000000000003644","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:37418423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37418423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2269355620","https://openalex.org/W2602409846","https://openalex.org/W2899917447","https://openalex.org/W2903077777","https://openalex.org/W3046201616","https://openalex.org/W3137354410","https://openalex.org/W3190424399","https://openalex.org/W4221037082","https://openalex.org/W4226116413","https://openalex.org/W4306249062"],"related_works":["https://openalex.org/W4410298521","https://openalex.org/W4401894229","https://openalex.org/W4310701600","https://openalex.org/W4409146142","https://openalex.org/W4400958721","https://openalex.org/W4411219584","https://openalex.org/W4406955244","https://openalex.org/W4283781862","https://openalex.org/W7204112203","https://openalex.org/W4407354770"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1,62],"describe":[2],"the":[3,10,24,110,119],"first":[4,111],"case":[5,112],"of":[6,12,113,121],"HIV-1":[7,51,74],"infection":[8,75,98],"in":[9,23],"setting":[11,120],"long-acting":[13],"injectable":[14],"cabotegravir":[15],"(CAB-LA)":[16],"for":[17],"HIV":[18,97],"pre-exposure":[19,115],"prophylaxis":[20,116],"to":[21,36,83],"occur":[22,133],"real":[25],"world.":[26],"DESIGN:":[27],"Case":[28],"report.":[29],"METHODS:":[30],"Electronic":[31],"medical":[32],"records":[33],"were":[34,55],"reviewed":[35],"assess":[37],"patient":[38],"history":[39,95],"and":[40,50,88,101,125,128],"CAB-LA":[41,84,103,114],"administration":[42],"details.":[43],"Plasma":[44],"fourth-generation":[45],"HIV-1/2":[46],"Ag/Ab":[47],"combination":[48],"immunoassay":[49],"RNA":[52],"quantitative":[53],"PCR":[54],"performed":[56],"at":[57,70],"each":[58],"injection":[59],"visit.":[60],"RESULTS:":[61],"report":[63],"a":[64,122],"28-year-old":[65],"sex-diverse":[66],"person":[67],"assigned":[68],"male":[69],"birth":[71],"who":[72],"acquired":[73],"91":[76],"days":[77],"after":[78],"transitioning":[79],"from":[80],"tenofovir":[81],"alafenamideemtricitabine":[82],"despite":[85,99],"on-time":[86,100],"dosing":[87],"appropriate":[89,102],"laboratory":[90],"monitoring.":[91],"CONCLUSION:":[92],"This":[93],"patient's":[94],"suggests":[96],"injections.":[104],"To":[105],"our":[106],"knowledge,":[107],"this":[108],"is":[109],"failure":[117],"outside":[118],"clinical":[123],"trial":[124],"highlights":[126],"diagnostic":[127],"management":[129],"challenges":[130],"that":[131],"may":[132],"with":[134],"such":[135],"breakthrough":[136],"infections.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-08T00:00:00"}
