{"id":"https://openalex.org/W4383373908","doi":"https://doi.org/10.3389/fnins.2023.1223777","title":"CRISPR/Cas9: implication for modeling and therapy of amyotrophic lateral sclerosis","display_name":"CRISPR/Cas9: implication for modeling and therapy of amyotrophic lateral sclerosis","publication_year":2023,"publication_date":"2023-07-06","ids":{"openalex":"https://openalex.org/W4383373908","doi":"https://doi.org/10.3389/fnins.2023.1223777","pmid":"https://pubmed.ncbi.nlm.nih.gov/37483353","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10359984"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2023.1223777","doi":"https://doi.org/10.3389/fnins.2023.1223777","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1223777","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1223777/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1223777/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087137381","display_name":"Yajun Shi","orcid":"https://orcid.org/0000-0003-1178-5504","observed_orcids":["https://orcid.org/0000-0003-1178-5504"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]},{"id":"https://openalex.org/I4210156555","display_name":"Shandong Maternal and Child Health Hospital","ror":"https://ror.org/04ger2z06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajun Shi","raw_affiliation_strings":["Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210153519"]},{"raw_affiliation_string":"Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210156555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063739048","display_name":"Yan Zhao","orcid":"https://orcid.org/0000-0002-5866-5932","observed_orcids":["https://orcid.org/0000-0002-5866-5932"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040876484","display_name":"Likui Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Likui Lu","raw_affiliation_strings":["Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007224731","display_name":"Qinqin Gao","orcid":"https://orcid.org/0000-0002-1820-7611","observed_orcids":["https://orcid.org/0000-0002-1820-7611"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]},{"id":"https://openalex.org/I4210156555","display_name":"Shandong Maternal and Child Health Hospital","ror":"https://ror.org/04ger2z06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinqin Gao","raw_affiliation_strings":["Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210153519"]},{"raw_affiliation_string":"Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210156555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104140024","display_name":"Dongyi Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210156555","display_name":"Shandong Maternal and Child Health Hospital","ror":"https://ror.org/04ger2z06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156555"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongyi Yu","raw_affiliation_strings":["Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210156555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102761182","display_name":"Miao Sun","orcid":"https://orcid.org/0000-0002-8816-0599","observed_orcids":["https://orcid.org/0000-0002-8816-0599"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]},{"id":"https://openalex.org/I4210156555","display_name":"Shandong Maternal and Child Health Hospital","ror":"https://ror.org/04ger2z06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156555"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Miao Sun","raw_affiliation_strings":["Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210153519"]},{"raw_affiliation_string":"Key Laboratory of Birth Defect Prevention and Genetic Medicine of Shandong Health Commission, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210156555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102761182","https://openalex.org/A5104140024"],"corresponding_institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210153519","https://openalex.org/I4210156555"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.7028,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.60667964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":null,"first_page":"1223777","last_page":"1223777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.9850000143051147},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.9710000157356262},{"id":"https://openalex.org/keywords/animal-models-of-als","display_name":"animal models of ALS","score":0.8130000233650208},{"id":"https://openalex.org/keywords/als-therapeutics","display_name":"ALS therapeutics","score":0.6190000176429749},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.874239981174469},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.8487584590911865},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.623883843421936},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6189500093460083},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5142585635185242},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.5100803971290588},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4248006343841553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41350793838500977},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.412601113319397},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3756501078605652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36998483538627625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30654412508010864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20281332731246948},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16656574606895447}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2023.1223777","doi":"https://doi.org/10.3389/fnins.2023.1223777","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1223777","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1223777/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10359984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10359984","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10359984/pdf/fnins-17-1223777.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:37483353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37483353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ee3146b1da0c4a72a9d158b12cd8f863","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ee3146b1da0c4a72a9d158b12cd8f863","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2023.1223777","doi":"https://doi.org/10.3389/fnins.2023.1223777","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1223777","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1223777/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1248876586","display_name":null,"funder_award_id":"81,570,960","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2839965716","display_name":null,"funder_award_id":"81,974,244","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8643175780","display_name":null,"funder_award_id":"2019YFA0802600","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383373908.pdf","grobid_xml":"https://content.openalex.org/works/W4383373908.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W949737134","https://openalex.org/W1866665915","https://openalex.org/W1963646113","https://openalex.org/W1969418855","https://openalex.org/W2000046950","https://openalex.org/W2009697993","https://openalex.org/W2037991731","https://openalex.org/W2076363659","https://openalex.org/W2098978914","https://openalex.org/W2108191354","https://openalex.org/W2114142555","https://openalex.org/W2119947322","https://openalex.org/W2123746851","https://openalex.org/W2131174366","https://openalex.org/W2139264742","https://openalex.org/W2154945114","https://openalex.org/W2158168411","https://openalex.org/W2199695484","https://openalex.org/W2346821877","https://openalex.org/W2406553940","https://openalex.org/W2528746299","https://openalex.org/W2556818673","https://openalex.org/W2597637870","https://openalex.org/W2607299435","https://openalex.org/W2619342418","https://openalex.org/W2622060281","https://openalex.org/W2626238587","https://openalex.org/W2751464430","https://openalex.org/W2763212735","https://openalex.org/W2777540887","https://openalex.org/W2785267239","https://openalex.org/W2793309516","https://openalex.org/W2806828400","https://openalex.org/W2807481171","https://openalex.org/W2810654871","https://openalex.org/W2889934668","https://openalex.org/W2892231379","https://openalex.org/W2893679917","https://openalex.org/W2898018533","https://openalex.org/W2901845799","https://openalex.org/W2903516930","https://openalex.org/W2913447577","https://openalex.org/W2914942296","https://openalex.org/W2927314704","https://openalex.org/W2940971975","https://openalex.org/W2949846456","https://openalex.org/W2949903896","https://openalex.org/W2957790560","https://openalex.org/W2963515463","https://openalex.org/W2965024172","https://openalex.org/W2965612870","https://openalex.org/W2972754673","https://openalex.org/W2993401350","https://openalex.org/W2998881619","https://openalex.org/W3000070051","https://openalex.org/W3013381491","https://openalex.org/W3014186646","https://openalex.org/W3033498243","https://openalex.org/W3035764705","https://openalex.org/W3086480968","https://openalex.org/W3094421202","https://openalex.org/W3097971187","https://openalex.org/W3105388069","https://openalex.org/W3115743447","https://openalex.org/W3119800019","https://openalex.org/W3119933590","https://openalex.org/W3122079296","https://openalex.org/W3126915665","https://openalex.org/W3127855517","https://openalex.org/W3131949370","https://openalex.org/W3132485019","https://openalex.org/W3132845986","https://openalex.org/W3139194033","https://openalex.org/W3165625230","https://openalex.org/W3170811308","https://openalex.org/W3174830099","https://openalex.org/W3177131040","https://openalex.org/W3181507805","https://openalex.org/W3212007346","https://openalex.org/W4200255906","https://openalex.org/W4200518016","https://openalex.org/W4200595594","https://openalex.org/W4210339230","https://openalex.org/W4213078022","https://openalex.org/W4213435307","https://openalex.org/W4214584128","https://openalex.org/W4214881544","https://openalex.org/W4220740390","https://openalex.org/W4221132273","https://openalex.org/W4225758524","https://openalex.org/W4229367887","https://openalex.org/W4247178668","https://openalex.org/W4283021690","https://openalex.org/W4283118863","https://openalex.org/W4283725767","https://openalex.org/W4283726599","https://openalex.org/W4283732121","https://openalex.org/W4283749991","https://openalex.org/W4293724630","https://openalex.org/W4294839703","https://openalex.org/W4295338306","https://openalex.org/W4295896242","https://openalex.org/W4296324533","https://openalex.org/W4297539984","https://openalex.org/W4303699485","https://openalex.org/W4307028250","https://openalex.org/W4310588932","https://openalex.org/W4310951084","https://openalex.org/W4313256950","https://openalex.org/W4315928462","https://openalex.org/W4320493001","https://openalex.org/W4362737444","https://openalex.org/W4368367211"],"related_works":["https://openalex.org/W2794040144","https://openalex.org/W4413183201","https://openalex.org/W4386468678","https://openalex.org/W2797519282","https://openalex.org/W7201885166","https://openalex.org/W4389445785","https://openalex.org/W2286934294","https://openalex.org/W2777540887","https://openalex.org/W4221134961","https://openalex.org/W7046371426"],"abstract_inverted_index":{"Amyotrophic":[0],"lateral":[1],"sclerosis":[2],"(ALS)":[3],"is":[4,21],"a":[5,10,70],"deadly":[6],"neurological":[7],"disease":[8,67,93],"with":[9],"complicated":[11],"and":[12,51,95],"variable":[13],"pathophysiology":[14],"yet":[15],"to":[16,27,42,56],"be":[17],"fully":[18],"understood.":[19],"There":[20],"currently":[22],"no":[23],"effective":[24],"treatment":[25],"available":[26],"either":[28],"slow":[29],"or":[30],"terminate":[31],"it.":[32],"However,":[33],"recent":[34,91],"advances":[35],"in":[36],"ALS":[37,66,92,101],"genomics":[38],"have":[39,69],"linked":[40],"genes":[41],"phenotypes,":[43],"encouraging":[44],"the":[45,80,83,89,96],"creation":[46],"of":[47,82,85,98],"novel":[48],"therapeutic":[49],"approaches":[50],"giving":[52],"researchers":[53],"more":[54],"tools":[55],"create":[57],"efficient":[58],"animal":[59],"models.":[60],"Genetically":[61],"engineered":[62],"rodent":[63],"models":[64],"replicating":[65],"pathology":[68],"high":[71],"predictive":[72],"value":[73],"for":[74],"translational":[75],"research.":[76],"This":[77],"review":[78],"addresses":[79],"history":[81],"evolution":[84],"gene":[86],"editing":[87],"tools,":[88],"most":[90],"models,":[94],"application":[97],"CRISPR/Cas9":[99],"against":[100],"disease.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-07-07T00:00:00"}