{"id":"https://openalex.org/W4383313666","doi":"https://doi.org/10.1126/science.adh3892","title":"Principles of human pre-60 S biogenesis","display_name":"Principles of human pre-60 S biogenesis","publication_year":2023,"publication_date":"2023-07-06","ids":{"openalex":"https://openalex.org/W4383313666","doi":"https://doi.org/10.1126/science.adh3892","pmid":"https://pubmed.ncbi.nlm.nih.gov/36993238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10054963"},"language":"en","primary_location":{"id":"doi:10.1126/science.adh3892","doi":"https://doi.org/10.1126/science.adh3892","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.adh3892","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2023.03.14.532478.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036579138","display_name":"Arnaud Vanden Broeck","orcid":"https://orcid.org/0000-0003-0930-4249","observed_orcids":["https://orcid.org/0000-0003-0930-4249"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arnaud Vanden Broeck","raw_affiliation_strings":["Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York 10065, USA","Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-0930-4249","affiliations":[{"raw_affiliation_string":"Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York 10065, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031074465","display_name":"Sebastian Klinge","orcid":"https://orcid.org/0000-0002-9373-4737","observed_orcids":["https://orcid.org/0000-0002-9373-4737"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sebastian Klinge","raw_affiliation_strings":["Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York 10065, USA","Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-9373-4737","affiliations":[{"raw_affiliation_string":"Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York 10065, USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031074465","https://openalex.org/A5036579138"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":5.7415,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.97897327,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"381","issue":"6653","first_page":"eadh3892","last_page":"eadh3892"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosome-assembly","display_name":"ribosome assembly","score":0.9049999713897705},{"id":"https://openalex.org/keywords/assembly-factors","display_name":"assembly factors","score":0.6919999718666077},{"id":"https://openalex.org/keywords/nucleolus","display_name":"nucleolus","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pre-rrna-processing","display_name":"pre-rRNA processing","score":0.9319999814033508},{"id":"https://openalex.org/keywords/rna-degradation","display_name":"RNA degradation","score":0.5659999847412109},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/atpase","display_name":"ATPase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/rna-conformational-change","display_name":"RNA conformational change","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6318010687828064},{"id":"https://openalex.org/C2779419633","wikidata":"https://www.wikidata.org/wiki/Q7322423","display_name":"Ribosome biogenesis","level":5,"score":0.6294376850128174},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6074284911155701},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.5832895636558533},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.5165411829948425},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.48390206694602966},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.47211897373199463},{"id":"https://openalex.org/C129194359","wikidata":"https://www.wikidata.org/wiki/Q2636953","display_name":"Eukaryotic Ribosome","level":5,"score":0.4550929069519043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44214293360710144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44043001532554626},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.4123755395412445},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39780932664871216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37863656878471375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3089662790298462},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1126/science.adh3892","doi":"https://doi.org/10.1126/science.adh3892","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.adh3892","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"doi:10.1101/2023.03.14.532478","doi":"https://doi.org/10.1101/2023.03.14.532478","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.03.14.532478","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2023.03.14.532478.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:36993238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36993238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37410842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37410842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10054963","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10054963","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/322965","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/322965","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science, 381 (6653), eadh3892 (2023-07-07)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1101/2023.03.14.532478","doi":"https://doi.org/10.1101/2023.03.14.532478","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.03.14.532478","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2023.03.14.532478.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000909391","display_name":"ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling","funder_award_id":"R01GM129325","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320312920","display_name":"G. Harold and Leila Y. Mathers Foundation","ror":"https://ror.org/02a7hjv13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383313666.pdf","grobid_xml":"https://content.openalex.org/works/W4383313666.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W1918704078","https://openalex.org/W1955957810","https://openalex.org/W1964480899","https://openalex.org/W1970546448","https://openalex.org/W1976337128","https://openalex.org/W2009110345","https://openalex.org/W2013779315","https://openalex.org/W2014874299","https://openalex.org/W2020068229","https://openalex.org/W2037055277","https://openalex.org/W2041157094","https://openalex.org/W2043274355","https://openalex.org/W2044386270","https://openalex.org/W2046797733","https://openalex.org/W2080190754","https://openalex.org/W2083968636","https://openalex.org/W2084596957","https://openalex.org/W2085098052","https://openalex.org/W2092594973","https://openalex.org/W2099385135","https://openalex.org/W2101610042","https://openalex.org/W2107025693","https://openalex.org/W2124693268","https://openalex.org/W2127322768","https://openalex.org/W2130966021","https://openalex.org/W2142161929","https://openalex.org/W2144081223","https://openalex.org/W2154241726","https://openalex.org/W2155858493","https://openalex.org/W2168029884","https://openalex.org/W2188223075","https://openalex.org/W2226203144","https://openalex.org/W2271648019","https://openalex.org/W2347171555","https://openalex.org/W2407366427","https://openalex.org/W2546735327","https://openalex.org/W2557904026","https://openalex.org/W2587625522","https://openalex.org/W2592503616","https://openalex.org/W2593511418","https://openalex.org/W2624125560","https://openalex.org/W2728385286","https://openalex.org/W2734736563","https://openalex.org/W2751387723","https://openalex.org/W2765112592","https://openalex.org/W2765837144","https://openalex.org/W2770436140","https://openalex.org/W2775096538","https://openalex.org/W2788198022","https://openalex.org/W2788833468","https://openalex.org/W2789427410","https://openalex.org/W2793021023","https://openalex.org/W2794358105","https://openalex.org/W2799964814","https://openalex.org/W2803479625","https://openalex.org/W2891167139","https://openalex.org/W2895261801","https://openalex.org/W2895950820","https://openalex.org/W2897056819","https://openalex.org/W2901258541","https://openalex.org/W2901941802","https://openalex.org/W2903232633","https://openalex.org/W2912949690","https://openalex.org/W2944819910","https://openalex.org/W2946528398","https://openalex.org/W2950967305","https://openalex.org/W2966070481","https://openalex.org/W2973457155","https://openalex.org/W2980434314","https://openalex.org/W2982544614","https://openalex.org/W2988833431","https://openalex.org/W3000744971","https://openalex.org/W3043079810","https://openalex.org/W3043270172","https://openalex.org/W3044914877","https://openalex.org/W3083406432","https://openalex.org/W3085713937","https://openalex.org/W3110425738","https://openalex.org/W3133656302","https://openalex.org/W3168514793","https://openalex.org/W3177828909","https://openalex.org/W3186624543","https://openalex.org/W3196605237","https://openalex.org/W3197208223","https://openalex.org/W3213779066","https://openalex.org/W4213206917","https://openalex.org/W4221097859","https://openalex.org/W4225166092","https://openalex.org/W4250894749","https://openalex.org/W4295427504","https://openalex.org/W4297264236","https://openalex.org/W4308616699","https://openalex.org/W4308653678","https://openalex.org/W4309720754","https://openalex.org/W4312018515","https://openalex.org/W4312018782","https://openalex.org/W4318293845","https://openalex.org/W4318617067","https://openalex.org/W4322615740","https://openalex.org/W6912303761"],"related_works":["https://openalex.org/W4385237550","https://openalex.org/W2407366427","https://openalex.org/W2775096538","https://openalex.org/W2788198022","https://openalex.org/W2593418709","https://openalex.org/W2536231941","https://openalex.org/W3043079810","https://openalex.org/W2794358105","https://openalex.org/W1980595317","https://openalex.org/W2949746407"],"abstract_inverted_index":{"Abstract":[0],"During":[1],"early":[2],"stages":[3,88],"of":[4,15,26,39,43,54,84,113,127,135,142],"human":[5,44,114,136],"large":[6],"ribosomal":[7],"subunit":[8],"(60":[9],"S":[10,28,49,116],")":[11],"biogenesis,":[12],"an":[13,31],"ensemble":[14,112],"assembly":[16,50,65],"factors":[17],"establishes":[18],"and":[19,46,71,74],"fine-tunes":[20],"the":[21,82,96,107,124],"essential":[22],"RNA":[23,93,100,108],"functional":[24,85],"centers":[25],"pre-60":[27,48,115],"particles":[29,70,117,138],"by":[30,106],"unknown":[32],"mechanism.":[33],"Here,":[34],"we":[35],"report":[36],"a":[37,91,119],"series":[38],"cryo-electron":[40],"microscopy":[41],"structures":[42,58,134],"nucleolar":[45,69],"nuclear":[47],"intermediates":[51],"at":[52],"resolutions":[53],"2.5-3.2":[55],"\u00c5.":[56],"These":[57],"show":[59],"how":[60,72,90],"protein":[61],"interaction":[62],"hubs":[63],"tether":[64],"factor":[66],"complexes":[67],"to":[68,81,103,122],"GTPases":[73],"ATPases":[75],"couple":[76],"irreversible":[77],"nucleotide":[78],"hydrolysis":[79],"steps":[80],"installation":[83],"centers.":[86],"Nuclear":[87],"highlight":[89],"conserved":[92],"processing":[94,105],"complex,":[95],"rixosome,":[97],"couples":[98],"large-scale":[99],"conformational":[101],"changes":[102],"pre-rRNA":[104],"degradation":[109],"machinery.":[110],"Our":[111],"provides":[118],"rich":[120],"foundation":[121],"elucidate":[123],"molecular":[125],"principles":[126,141],"ribosome":[128,144],"formation.":[129],"One-Sentence":[130],"Summary":[131],"High-resolution":[132],"cryo-EM":[133],"pre-60S":[137],"reveal":[139],"new":[140],"eukaryotic":[143],"assembly.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-07T00:00:00"}
