{"id":"https://openalex.org/W4383313330","doi":"https://doi.org/10.3389/fendo.2023.1149328","title":"GLP-1RAs caused gastrointestinal adverse reactions of drug withdrawal: a system review and network meta-analysis","display_name":"GLP-1RAs caused gastrointestinal adverse reactions of drug withdrawal: a system review and network meta-analysis","publication_year":2023,"publication_date":"2023-07-06","ids":{"openalex":"https://openalex.org/W4383313330","doi":"https://doi.org/10.3389/fendo.2023.1149328","pmid":"https://pubmed.ncbi.nlm.nih.gov/37484944","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10359616"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2023.1149328","doi":"https://doi.org/10.3389/fendo.2023.1149328","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1149328","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1149328/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1149328/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100404392","display_name":"Ziqi Zhang","orcid":"https://orcid.org/0000-0002-8587-8618","observed_orcids":["https://orcid.org/0000-0002-8587-8618","https://orcid.org/0009-0000-6694-3077"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqi Zhang","raw_affiliation_strings":["The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","The First Clinical Medical College of Nanjing University of Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064598275","display_name":"Qiling Zhang","orcid":"https://orcid.org/0000-0002-0241-4835","observed_orcids":["https://orcid.org/0000-0002-0241-4835"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiling Zhang","raw_affiliation_strings":["The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","The First Clinical Medical College of Nanjing University of Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023089209","display_name":"Ying Tan","orcid":"https://orcid.org/0000-0001-8243-4731","observed_orcids":["https://orcid.org/0000-0001-8243-4731","https://orcid.org/0000-0001-8495-0246"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Tan","raw_affiliation_strings":["The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","The First Clinical Medical College of Nanjing University of Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101459524","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0001-7498-8136","observed_orcids":["https://orcid.org/0000-0001-7498-8136"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","The First Clinical Medical College of Nanjing University of Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First Clinical Medical College of Nanjing University of Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009653075","display_name":"Xiqiao Zhou","orcid":"https://orcid.org/0000-0003-3122-3904","observed_orcids":["https://orcid.org/0000-0003-3122-3904"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I4210162009","display_name":"Jiangsu Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/05sm6p196","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162009"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiqiao Zhou","raw_affiliation_strings":["Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China","Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210162009","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210162009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376819","display_name":"Su Liu","orcid":"https://orcid.org/0000-0001-5805-5643","observed_orcids":["https://orcid.org/0000-0001-5805-5643"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I4210162009","display_name":"Jiangsu Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/05sm6p196","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162009"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su Liu","raw_affiliation_strings":["Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China","Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210162009","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210162009"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101426425","display_name":"Jiangyi Yu","orcid":"https://orcid.org/0000-0001-7159-5396","observed_orcids":["https://orcid.org/0000-0001-7159-5396","https://orcid.org/0000-0003-0691-6979","https://orcid.org/0000-0002-2393-3351"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I4210162009","display_name":"Jiangsu Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/05sm6p196","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162009"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiangyi Yu","raw_affiliation_strings":["Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China","Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210162009","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Department of Endocrinology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, China","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210162009"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101426425"],"corresponding_institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210162009","https://openalex.org/I881766915"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.6512,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.86597938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"14","issue":null,"first_page":"1149328","last_page":"1149328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-intolerance","display_name":"drug intolerance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.7609999775886536},{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/semaglutide","display_name":"semaglutide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dulaglutide","display_name":"dulaglutide","score":1.0},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7559999823570251},{"id":"https://openalex.org/keywords/appetite-suppression","display_name":"appetite suppression","score":0.7950000166893005},{"id":"https://openalex.org/keywords/type-2-diabetes-treatment","display_name":"type 2 diabetes treatment","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2909862629","wikidata":"https://www.wikidata.org/wiki/Q27261089","display_name":"Semaglutide","level":5,"score":0.9547964334487915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7416917085647583},{"id":"https://openalex.org/C2781308992","wikidata":"https://www.wikidata.org/wiki/Q2526479","display_name":"Liraglutide","level":4,"score":0.6792769432067871},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6000897288322449},{"id":"https://openalex.org/C2779829264","wikidata":"https://www.wikidata.org/wiki/Q21011228","display_name":"Dulaglutide","level":5,"score":0.5955269932746887},{"id":"https://openalex.org/C3020479747","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Gastric emptying","level":3,"score":0.5537751317024231},{"id":"https://openalex.org/C2776442814","wikidata":"https://www.wikidata.org/wiki/Q6659956","display_name":"Lixisenatide","level":5,"score":0.5411360263824463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5320530533790588},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5287349224090576},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4785257577896118},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.46414533257484436},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37382763624191284},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34275004267692566},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2960204780101776},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2380886673927307},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1393704116344452},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1114284098148346},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2023.1149328","doi":"https://doi.org/10.3389/fendo.2023.1149328","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1149328","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1149328/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10359616","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10359616","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10359616/pdf/fendo-14-1149328.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:37484944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37484944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Research Support, Non-U.S. Gov't"},{"id":"pmh:oai:doaj.org/article:de72112a0ed64712b4cfcf8a673ed9bd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/de72112a0ed64712b4cfcf8a673ed9bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2023.1149328","doi":"https://doi.org/10.3389/fendo.2023.1149328","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1149328","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1149328/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G1970234751","display_name":null,"funder_award_id":"8774117","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7914217194","display_name":null,"funder_award_id":"81774117","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383313330.pdf","grobid_xml":"https://content.openalex.org/works/W4383313330.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W807162506","https://openalex.org/W917052595","https://openalex.org/W1562038277","https://openalex.org/W1584571461","https://openalex.org/W1906367066","https://openalex.org/W1909310469","https://openalex.org/W1972204120","https://openalex.org/W1985743763","https://openalex.org/W1989713397","https://openalex.org/W1992055007","https://openalex.org/W1997595732","https://openalex.org/W1998717083","https://openalex.org/W2000465889","https://openalex.org/W2002057113","https://openalex.org/W2030546890","https://openalex.org/W2032322539","https://openalex.org/W2033128915","https://openalex.org/W2036806748","https://openalex.org/W2039246109","https://openalex.org/W2043092889","https://openalex.org/W2048929025","https://openalex.org/W2050826565","https://openalex.org/W2061883499","https://openalex.org/W2066046508","https://openalex.org/W2069665789","https://openalex.org/W2072691447","https://openalex.org/W2076140273","https://openalex.org/W2077751509","https://openalex.org/W2078090288","https://openalex.org/W2078839892","https://openalex.org/W2091808438","https://openalex.org/W2094250264","https://openalex.org/W2104675861","https://openalex.org/W2106036385","https://openalex.org/W2106709036","https://openalex.org/W2107080737","https://openalex.org/W2107949845","https://openalex.org/W2124984368","https://openalex.org/W2125043520","https://openalex.org/W2130583827","https://openalex.org/W2135064706","https://openalex.org/W2136546775","https://openalex.org/W2138077952","https://openalex.org/W2149042564","https://openalex.org/W2152835319","https://openalex.org/W2152984355","https://openalex.org/W2165556241","https://openalex.org/W2176915168","https://openalex.org/W2192722195","https://openalex.org/W2196942236","https://openalex.org/W2208772326","https://openalex.org/W2282578582","https://openalex.org/W2337735601","https://openalex.org/W2341277771","https://openalex.org/W2405832966","https://openalex.org/W2410056512","https://openalex.org/W2519510391","https://openalex.org/W2563047690","https://openalex.org/W2572398654","https://openalex.org/W2586052899","https://openalex.org/W2586129535","https://openalex.org/W2588681363","https://openalex.org/W2592954074","https://openalex.org/W2593452599","https://openalex.org/W2602373503","https://openalex.org/W2602700371","https://openalex.org/W2604469807","https://openalex.org/W2616718645","https://openalex.org/W2695892839","https://openalex.org/W2738799702","https://openalex.org/W2743088090","https://openalex.org/W2747812115","https://openalex.org/W2766765254","https://openalex.org/W2770940237","https://openalex.org/W2774301756","https://openalex.org/W2781586249","https://openalex.org/W2797402052","https://openalex.org/W2885653810","https://openalex.org/W2916841405","https://openalex.org/W2924479779","https://openalex.org/W2939443580","https://openalex.org/W2943546226","https://openalex.org/W2963323248","https://openalex.org/W2963614034","https://openalex.org/W2964087648","https://openalex.org/W2974621372","https://openalex.org/W2979558564","https://openalex.org/W2996231878","https://openalex.org/W2998516536","https://openalex.org/W3093042356","https://openalex.org/W3094403106","https://openalex.org/W3127371223","https://openalex.org/W3159005948","https://openalex.org/W3166343083","https://openalex.org/W3176497010","https://openalex.org/W3177393241","https://openalex.org/W3209468918","https://openalex.org/W3216209106","https://openalex.org/W4206445899","https://openalex.org/W4211259843","https://openalex.org/W4281778950","https://openalex.org/W4307904223","https://openalex.org/W4311708850"],"related_works":["https://openalex.org/W7118192943","https://openalex.org/W4311708850","https://openalex.org/W7162659880","https://openalex.org/W4205591291","https://openalex.org/W4391485990","https://openalex.org/W1971474519","https://openalex.org/W4405445936","https://openalex.org/W4413117488","https://openalex.org/W7214718128","https://openalex.org/W4401205486"],"abstract_inverted_index":{"Background:":[0],"Glucagon-like":[1],"peptide-1":[2],"receptor":[3],"agonists":[4],"(GLP-1RAs)":[5],"significantly":[6,147],"reduce":[7],"postprandial":[8],"blood":[9],"glucose,":[10],"inhibit":[11],"appetite,":[12],"and":[13,34,115,154,177],"delay":[14],"gastrointestinal":[15,51,110],"emptying.":[16],"However,":[17],"it":[18,191],"is":[19,192,204],"controversial":[20],"that":[21,120],"some":[22],"patients":[23],"are":[24],"intolerant":[25],"to":[26,50,59,136,149,158,193],"GLP-1RAs.":[27],"Methods:":[28],"PubMed,":[29],"Embase,":[30],"Web":[31],"of":[32,92,98,108,113,121,128,161,163,200,206,210],"Science,":[33],"Cochrane":[35],"Library":[36],"were":[37,84,145,179],"searched":[38],"for":[39],"randomized":[40],"controlled":[41],"trials":[42],"(RCTs)":[43],"using":[44],"GLP-1RAs":[45,100],"with":[46],"documented":[47],"withdrawal":[48],"due":[49],"adverse":[52,111,139],"reactions":[53,112],"(GI":[54],"AEs)":[55],"from":[56],"their":[57],"inception":[58],"September":[60],"28,":[61],"2022.":[62],"After":[63],"extracting":[64],"the":[65,69,93,99,124,126,129,133,159,164,170,180,184,186,188,198,207,211],"information":[66],"incorporated":[67],"into":[68],"studies,":[70],"a":[71,78],"random-effects":[72],"network":[73],"meta-analysis":[74],"was":[75,103,117],"performed":[76],"within":[77],"frequentist":[79],"framework.":[80],"Results:":[81],"64":[82],"RCTs":[83],"finally":[85],"enrolled,":[86],"which":[87],"included":[88],"six":[89],"major":[90],"categories":[91],"GLP-1RA.":[94],"The":[95,106],"sample":[96],"size":[97],"treatment":[101],"group":[102],"16,783":[104],"cases.":[105],"risk":[107,199],"intolerable":[109,142,172],"Liraglutide":[114,176],"Semaglutide":[116,178],"higher":[118,125,185],"than":[119],"Dulaglutide.":[122],"Meanwhile,":[123,197],"dose":[127],"same":[130],"GLP-1RA":[131],"preparation,":[132],"more":[134,189],"likely":[135,190],"cause":[137],"these":[138,201,214],"reactions.":[140],"These":[141],"GI":[143,173,195,202],"AEs":[144,203],"not":[146],"related":[148,157],"drug":[150],"homology":[151],"or":[152],"formulations":[153,209],"may":[155],"be":[156],"degree":[160],"suppression":[162],"appetite":[165],"center.":[166],"Conclusion:":[167],"Dulaglutide":[168],"caused":[169],"lowest":[171],"AEs,":[174],"while":[175],"highest.":[181],"For":[182],"Semaglutide,":[183],"dose,":[187],"drive":[194],"AEs.":[196],"independent":[205],"different":[208],"drug.":[212],"All":[213],"findings":[215],"can":[216],"effectively":[217],"guide":[218],"individualized":[219],"treatment.":[220],"Systematic":[221],"review":[222],"registration:":[223],"https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022359346,":[224],"identifier":[225],"CRD42022359346.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-07T00:00:00"}
