{"id":"https://openalex.org/W4383302736","doi":"https://doi.org/10.1530/ec-23-0059","title":"Assessing treatment adherence is crucial to determine adequacy of mineralocorticoid therapy","display_name":"Assessing treatment adherence is crucial to determine adequacy of mineralocorticoid therapy","publication_year":2023,"publication_date":"2023-06-15","ids":{"openalex":"https://openalex.org/W4383302736","doi":"https://doi.org/10.1530/ec-23-0059","pmid":"https://pubmed.ncbi.nlm.nih.gov/37410094","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10448575"},"language":"en","primary_location":{"id":"doi:10.1530/ec-23-0059","doi":"https://doi.org/10.1530/ec-23-0059","is_oa":true,"landing_page_url":"https://doi.org/10.1530/ec-23-0059","pdf_url":"https://ec.bioscientifica.com/downloadpdf/journals/ec/aop/ec-23-0059/ec-23-0059.pdf","source":{"id":"https://openalex.org/S2764372638","display_name":"Endocrine Connections","issn_l":"2049-3614","issn":["2049-3614"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Connections","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ec.bioscientifica.com/downloadpdf/journals/ec/aop/ec-23-0059/ec-23-0059.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041071709","display_name":"Riccardo Pofi","orcid":"https://orcid.org/0000-0001-7808-5735","observed_orcids":["https://orcid.org/0000-0001-7808-5735"]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Riccardo Pofi","raw_affiliation_strings":["Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK","R Pofi, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital Oxford, UK OX3 7LJ, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland"],"raw_orcid":"https://orcid.org/0000-0001-7808-5735","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210129944"]},{"raw_affiliation_string":"R Pofi, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital Oxford, UK OX3 7LJ, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210129944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020440606","display_name":"Ilaria Bonaventura","orcid":"https://orcid.org/0000-0002-9333-5189","observed_orcids":["https://orcid.org/0000-0002-9333-5189"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Bonaventura","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joanne Duffy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104666","display_name":"Heartlands Hospital","ror":"https://ror.org/01bd5gh54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210104666"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanne Duffy","raw_affiliation_strings":["Department of Clinical Chemistry and Immunology, Heartlands Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Immunology, Heartlands Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I4210104666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043880043","display_name":"Zo\u00eb Maunsell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zoe Maunsell","raw_affiliation_strings":["Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK","Z Maunsell, Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Z Maunsell, Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom of Great Britain and Northern Ireland","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210147381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040351145","display_name":"Brian S. F. Shine","orcid":"https://orcid.org/0000-0002-1016-8638","observed_orcids":["https://orcid.org/0000-0002-1016-8638"]},"institutions":[{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian Shine","raw_affiliation_strings":["Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK","institution_ids":["https://openalex.org/I4210147381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107443371","display_name":"Andrea Maria Isidori","orcid":"https://orcid.org/0000-0002-9037-5417","observed_orcids":["https://orcid.org/0000-0002-9037-5417"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea M Isidori","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9037-5417","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083236737","display_name":"Jeremy Tomlinson","orcid":"https://orcid.org/0000-0002-3170-8533","observed_orcids":["https://orcid.org/0000-0002-3170-8533"]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210129944","display_name":"Oxford Centre for Diabetes, Endocrinology and Metabolism","ror":"https://ror.org/03myafa32","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210129944","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jeremy W Tomlinson","raw_affiliation_strings":["Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-3170-8533","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210129944"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5083236737"],"corresponding_institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149","https://openalex.org/I4210088942","https://openalex.org/I4210129944"],"apc_list":{"value":1750,"currency":"GBP","value_usd":2146},"apc_paid":{"value":1750,"currency":"GBP","value_usd":2146},"fwci":2.0339,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.87857439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/addison-s-disease","display_name":"Addison's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mineralocorticoid-replacement-therapy","display_name":"mineralocorticoid replacement therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7770000100135803},{"id":"https://openalex.org/keywords/fludrocortisone","display_name":"fludrocortisone","score":0.9750000238418579},{"id":"https://openalex.org/keywords/plasma-renin-concentration","display_name":"plasma renin concentration","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.8799999952316284},{"id":"https://openalex.org/keywords/potassium-levels","display_name":"potassium concentration","score":0.6150000095367432},{"id":"https://openalex.org/keywords/sodium-concentration","display_name":"sodium concentration","score":0.6240000128746033},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.75},{"id":"https://openalex.org/keywords/glucocorticoid-dose","display_name":"glucocorticoid dose","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.6119999885559082},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2776899810","wikidata":"https://www.wikidata.org/wiki/Q2697578","display_name":"Fludrocortisone","level":3,"score":0.8551088571548462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8368646502494812},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.6706645488739014},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.5042716264724731},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4883250892162323},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.4679412245750427},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4570382833480835},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.45337316393852234},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.4211265444755554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37734392285346985},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.336206316947937},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.16991344094276428},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.15028086304664612},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09444049000740051},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1530/ec-23-0059","doi":"https://doi.org/10.1530/ec-23-0059","is_oa":true,"landing_page_url":"https://doi.org/10.1530/ec-23-0059","pdf_url":"https://ec.bioscientifica.com/downloadpdf/journals/ec/aop/ec-23-0059/ec-23-0059.pdf","source":{"id":"https://openalex.org/S2764372638","display_name":"Endocrine Connections","issn_l":"2049-3614","issn":["2049-3614"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Connections","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10448575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10448575","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10448575/pdf/EC-23-0059.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocr Connect","raw_type":"Text"},{"id":"pmid:37410094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37410094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine connections","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f65dee6b9efb4273973b6cb866b42771","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f65dee6b9efb4273973b6cb866b42771","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrine Connections, Vol 12, Iss 9, Pp 1-10 (2023)","raw_type":"article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1706842","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1706842","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1530/ec-23-0059","doi":"https://doi.org/10.1530/ec-23-0059","is_oa":true,"landing_page_url":"https://doi.org/10.1530/ec-23-0059","pdf_url":"https://ec.bioscientifica.com/downloadpdf/journals/ec/aop/ec-23-0059/ec-23-0059.pdf","source":{"id":"https://openalex.org/S2764372638","display_name":"Endocrine Connections","issn_l":"2049-3614","issn":["2049-3614"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Connections","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6990652283","display_name":"Dissecting the steroid metabolome in the pathogenesis and treatment of metabolic liver disease","funder_award_id":"MR/P011462/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383302736.pdf","grobid_xml":"https://content.openalex.org/works/W4383302736.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W91700561","https://openalex.org/W1974733185","https://openalex.org/W1975828369","https://openalex.org/W1976145935","https://openalex.org/W2005988538","https://openalex.org/W2011054358","https://openalex.org/W2011162564","https://openalex.org/W2024918306","https://openalex.org/W2026741948","https://openalex.org/W2036474164","https://openalex.org/W2048548313","https://openalex.org/W2057624928","https://openalex.org/W2061756355","https://openalex.org/W2070417847","https://openalex.org/W2076157661","https://openalex.org/W2090175399","https://openalex.org/W2095586831","https://openalex.org/W2101737556","https://openalex.org/W2103673171","https://openalex.org/W2126102668","https://openalex.org/W2134766532","https://openalex.org/W2135257181","https://openalex.org/W2137991831","https://openalex.org/W2140341066","https://openalex.org/W2143649849","https://openalex.org/W2145909170","https://openalex.org/W2148614804","https://openalex.org/W2155441883","https://openalex.org/W2156174993","https://openalex.org/W2156903075","https://openalex.org/W2159870619","https://openalex.org/W2163559038","https://openalex.org/W2167733014","https://openalex.org/W2234917292","https://openalex.org/W2325416948","https://openalex.org/W2413174905","https://openalex.org/W2418539374","https://openalex.org/W2477360231","https://openalex.org/W2575365934","https://openalex.org/W2594005192","https://openalex.org/W2618539381","https://openalex.org/W2746562707","https://openalex.org/W2768960747","https://openalex.org/W2784849606","https://openalex.org/W2803519668","https://openalex.org/W2905424513","https://openalex.org/W2972054070","https://openalex.org/W2980565423","https://openalex.org/W2999688780","https://openalex.org/W3023960002","https://openalex.org/W3040395780","https://openalex.org/W3115251111","https://openalex.org/W3144695097","https://openalex.org/W4205488404","https://openalex.org/W4210400066","https://openalex.org/W4210984474","https://openalex.org/W4213059245","https://openalex.org/W4220938909","https://openalex.org/W4232933964","https://openalex.org/W4235279871","https://openalex.org/W4238693605","https://openalex.org/W4240657965","https://openalex.org/W4241229962","https://openalex.org/W4241998019","https://openalex.org/W4242189224","https://openalex.org/W4244006029","https://openalex.org/W4250971483","https://openalex.org/W4253743304","https://openalex.org/W4254423029","https://openalex.org/W4255804638","https://openalex.org/W4297830879","https://openalex.org/W4298282109"],"related_works":["https://openalex.org/W6986488669","https://openalex.org/W4297830879","https://openalex.org/W2768960747","https://openalex.org/W4307880062","https://openalex.org/W4367842367","https://openalex.org/W4403318864","https://openalex.org/W7001316120","https://openalex.org/W4240871187","https://openalex.org/W4414032681","https://openalex.org/W4403151662"],"abstract_inverted_index":{"Background:":[0],"There":[1],"is":[2],"no":[3],"consensus":[4],"strategy":[5],"for":[6,207],"mineralocorticoid":[7],"(MC)":[8],"therapy":[9],"titration":[10],"in":[11,263,287],"patients":[12,54,288],"with":[13,55,237,289],"primary":[14],"adrenal":[15],"insufficiency":[16],"(PAI).":[17],"We":[18,102],"aim":[19],"to":[20,31,41,139,176,194,227,274],"measure":[21],"serum":[22],"fludrocortisone":[23,27,126],"(sFC)":[24],"and":[25,30,38,62,87,91,109,117,120,165,184,213,257,278],"urine":[26],"(uFC)":[28],"levels":[29,64,259],"determine":[32],"their":[33],"utility,":[34],"alongside":[35],"clinical/biochemical":[36],"variables":[37,272],"treatment":[39,94],"adherence":[40,95,241,268],"guide":[42,228],"MC":[43,58,88,195,276],"replacement":[44,59,238,277],"dose":[45,127,136,141],"titration.":[46,230,266],"Methods:":[47],"Multi-centre,":[48],"observational,":[49],"cross-sectional":[50],"study":[51],"on":[52,57,270],"41":[53],"PAI":[56],"therapy.":[60,239],"sFC":[61,108,119,158,197,256],"uFC":[63,110,166,209,258],"(measured":[65],"by":[66],"liquid":[67],"chromatography-tandem":[68],"mass":[69],"spectrometry),":[70],"plasma":[71],"renin":[72],"concentration":[73],"(PRC),":[74],"electrolytes":[75],"(Na+,":[76],"K+),":[77],"mean":[78],"arterial":[79],"blood":[80],"pressure":[81],"(MAP),":[82],"total":[83],"daily":[84],"glucocorticoid":[85],"(dGC)":[86],"(dMC)":[89],"dose,":[90,196],"assessment":[92],"of":[93,284],"were":[96,235],"incorporated":[97],"into":[98,244],"statistical":[99],"models.":[100],"Results:":[101],"observed":[103],"a":[104,205],"close":[105],"relationship":[106],"between":[107,118],"(r":[111,128,142,149,159,167,178,186],"=":[112,115,129,132,143,150,153,160,163,168,179,187,190,217,220],"0.434,":[113],"P":[114,131,145,152,162,170,181,189,219],"0.005)":[116,221],"the":[121,124,223,232,245,250],"time":[122],"from":[123],"last":[125],"-0.355,":[130],"0.023).":[133],"Total":[134],"dMC":[135,229,265],"was":[137,174,242,249],"related":[138,175],"dGC":[140],"0.556,":[144],"<":[146,171,182],"0.001),":[147],"K+":[148,215],"-0.388,":[151],"0.013)":[154],"as":[155,157,222,282],"well":[156],"0.356,":[161],"0.022)":[164],"0.531,":[169],"0.001).":[172],"PRC":[173,211],"Na+":[177],"0.517,":[180],"0.001)":[183],"MAP":[185],"-0.427,":[188],"0.006),":[191],"but":[192],"not":[193,203,261],"or":[198,210],"uFC.":[199],"Regression":[200],"analyses":[201],"did":[202],"support":[204],"role":[206],"sFC,":[208],"measurements":[212],"confirmed":[214],"(B":[216],"-44.593,":[218],"most":[224],"important":[225],"variable":[226],"Of":[231],"patients,":[233],"32%":[234],"non-adherent":[236],"When":[240],"inserted":[243],"regression":[246],"model,":[247],"it":[248],"only":[251],"factor":[252],"affecting":[253],"dMC.":[254],"Conclusions:":[255],"are":[260],"helpful":[262],"guiding":[264],"Treatment":[267],"impacts":[269],"clinical":[271],"used":[273],"assess":[275],"should":[279],"be":[280],"included":[281],"part":[283],"routine":[285],"care":[286],"PAI.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-07-07T00:00:00"}