{"id":"https://openalex.org/W4383301966","doi":"https://doi.org/10.1111/all.15809","title":"D\u20102\u2010hydroxyglutarate suppresses allergic sensitization in a murine model of experimental asthma","display_name":"D\u20102\u2010hydroxyglutarate suppresses allergic sensitization in a murine model of experimental asthma","publication_year":2023,"publication_date":"2023-07-05","ids":{"openalex":"https://openalex.org/W4383301966","doi":"https://doi.org/10.1111/all.15809","pmid":"https://pubmed.ncbi.nlm.nih.gov/37408337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10732592"},"language":"en","primary_location":{"id":"doi:10.1111/all.15809","doi":"https://doi.org/10.1111/all.15809","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.15809","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.15809","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.15809","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086869714","display_name":"Anuj Tharakan","orcid":"https://orcid.org/0000-0001-8795-1009","observed_orcids":["https://orcid.org/0000-0001-8795-1009"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuj Tharakan","raw_affiliation_strings":["Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734316","display_name":"Ankit Kumar","orcid":"https://orcid.org/0000-0002-8849-760X","observed_orcids":["https://orcid.org/0000-0002-8849-760X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankit Kumar","raw_affiliation_strings":["Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059559405","display_name":"Jeremy C. Allegood","orcid":"https://orcid.org/0009-0007-1741-9923","observed_orcids":["https://orcid.org/0009-0007-1741-9923"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Allegood","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038797261","display_name":"L. Ashley Cowart","orcid":"https://orcid.org/0000-0002-5312-5232","observed_orcids":["https://orcid.org/0000-0002-5312-5232"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Ashley Cowart","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA","Hunter Holmes McGuire Veteran's Affairs Medical Center, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Hunter Holmes McGuire Veteran's Affairs Medical Center, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049658773","display_name":"Daniel H. Conrad","orcid":"https://orcid.org/0000-0002-4791-2694","observed_orcids":["https://orcid.org/0000-0002-4791-2694"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel H. Conrad","raw_affiliation_strings":["Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":"https://orcid.org/0000-0002-4791-2694","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068767093","display_name":"Rebecca Martin","orcid":"https://orcid.org/0000-0001-9948-5463","observed_orcids":["https://orcid.org/0000-0001-9948-5463"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca K. Martin","raw_affiliation_strings":["Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":"https://orcid.org/0000-0001-9948-5463","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068767093"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":{"value":4900,"currency":"USD","value_usd":4900},"fwci":1.3838,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.81290938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"78","issue":"11","first_page":"3014","last_page":"3016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-2-hydroxyglutarate","display_name":"D-2-hydroxyglutarate","score":0.996999979019165},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/allergen-sensitization","display_name":"allergen sensitization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/type-2-cytokines","display_name":"type 2 cytokines","score":0.8299999833106995},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7649999856948853},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.953000009059906},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9150000214576721},{"id":"https://openalex.org/keywords/specific-ige","display_name":"specific IgE","score":0.8999999761581421},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8259999752044678},{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.7879999876022339},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.772253692150116},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7206298112869263},{"id":"https://openalex.org/C2778166374","wikidata":"https://www.wikidata.org/wiki/Q29938","display_name":"House dust mite","level":4,"score":0.5900776386260986},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5793241858482361},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5391199588775635},{"id":"https://openalex.org/C32046619","wikidata":"https://www.wikidata.org/wiki/Q14878303","display_name":"Interleukin 13","level":4,"score":0.5031346678733826},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.45973384380340576},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4511066675186157},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.43725132942199707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42330995202064514},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.4180009663105011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41391804814338684},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.33649224042892456},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.3201650381088257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2176797091960907},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21095547080039978},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.19746863842010498},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1677529513835907},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1425161361694336},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.08891099691390991},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.07384246587753296}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005977","descriptor_name":"Glutarates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/all.15809","doi":"https://doi.org/10.1111/all.15809","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.15809","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.15809","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:37408337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37408337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:10732592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10732592","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10732592/pdf/nihms-1945919.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Allergy","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/all.15809","doi":"https://doi.org/10.1111/all.15809","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.15809","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.15809","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1003362385","display_name":null,"funder_award_id":"UL1TR002649","funder_id":"https://openalex.org/F4320332941","funder_display_name":"Center for Clinical and Translational Research"},{"id":"https://openalex.org/G3015141988","display_name":null,"funder_award_id":"UL1TR002649","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G3692472045","display_name":null,"funder_award_id":"IK6 BX006315","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4092236035","display_name":null,"funder_award_id":"I01BX000200","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4830243258","display_name":"Novel sphingolipid metabolites in myocardial ischemia","funder_award_id":"R01HL151243","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5040968163","display_name":"Center for Clinical and Translational Research","funder_award_id":"UL1TR002649","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000860372","display_name":"VCU Medical Scientist Training Program","funder_award_id":"T32GM144294","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000888536","display_name":"Massey Cancer Center -\u00a0Cancer Center Support Grant","funder_award_id":"P30CA016059","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332941","display_name":"Center for Clinical and Translational Research","ror":"https://ror.org/01njes783"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383301966.pdf","grobid_xml":"https://content.openalex.org/works/W4383301966.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2508408314","https://openalex.org/W2803675314","https://openalex.org/W2892016825","https://openalex.org/W2965364009","https://openalex.org/W2972117287","https://openalex.org/W3143022601"],"related_works":["https://openalex.org/W4385685469","https://openalex.org/W4409296051","https://openalex.org/W7167489173","https://openalex.org/W6945673278","https://openalex.org/W4416448782","https://openalex.org/W1031372329","https://openalex.org/W2130414223","https://openalex.org/W2796684200","https://openalex.org/W4313423692","https://openalex.org/W3033123528"],"abstract_inverted_index":{"To":[0],"the":[1,9,123,136,152,165,171,175,181,186],"Editor,Asthma":[2],"is":[3,12,28,68,95],"a":[4,71,143],"chronic":[5],"inflammatory":[6],"disease":[7],"affecting":[8],"airways":[10],"which":[11,103,157],"characterized":[13],"by":[14,30,47,70,97,102],"reversible":[15],"airflow":[16],"obstruction,":[17],"bronchial":[18],"hyperresponsiveness,":[19],"and":[20,36,38,42,55,75,107,131],"airway":[21,26],"remodeling.In":[22],"allergic":[23,129,132],"asthma,":[24],"this":[25],"pathology":[27],"mediated":[29,96],"Type":[31,56],"2":[32,52,57],"cytokines":[33],"(IL-4,":[34],"IL-5,":[35,41],"IL-13)":[37],"allergen-specific":[39,63],"IgE.IL-4,":[40],"IL-13":[43,76],"are":[44,111,126],"predominantly":[45],"produced":[46],"lung":[48],"resident":[49],"T":[50,78,83],"helper":[51,80,85],"(Th2)":[53],"cells":[54,67,81,99],"innate":[58],"lymphoid":[59],"cells.The":[60],"production":[61],"of":[62,73,91,139,146,168,174],"IgE":[64],"from":[65],"B":[66],"driven":[69],"subset":[72],"IL-4":[74],"producing":[77],"follicular":[79,84],"termed":[82],"13":[86],"(Tfh13)":[87],"cells.1,2":[88],"The":[89,148],"initiation":[90],"these":[92,169],"T-cell":[93],"responses":[94],"dendritic":[98],"(DCs).The":[100],"mechanisms":[101],"DCs":[104],"regulate":[105],"Th2":[106],"Tfh13":[108],"polarization,":[109],"however,":[110],"unclear.Several":[112],"genome-wide":[113],"association":[114],"studies":[115],"have":[116],"identified":[117],"that":[118,185],"single-nucleotide":[119],"polymorphisms":[120],"(SNPs)":[121],"in":[122],"D2HGDH":[124,149,176],"locus":[125,177],"associated":[127,141],"with":[128,135,142],"asthma":[130],"rhinitis":[133],"risk,":[134],"G":[137],"allele":[138],"rs34290285":[140],"lower":[144],"risk":[145],"disease.3":[147],"gene":[150],"encodes":[151],"enzyme":[153],"D-2hydroxyglutarate":[154],"dehydrogenase":[155],"(D2HGDH),":[156],"converts":[158],"D-2-hydroxyglutarate":[159],"(D2HG)":[160],"to":[161],"\u03b1-ketoglutarate":[162],"(\u03b1-KG).To":[163],"elucidate":[164],"functional":[166],"consequences":[167],"SNPs,":[170],"regulatory":[172],"landscape":[173],"was":[178],"analyzed":[179],"using":[180],"ENCODE":[182],"database.We":[183],"found":[184],"sentinel":[187]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-07T00:00:00"}
