{"id":"https://openalex.org/W4383215399","doi":"https://doi.org/10.1016/j.bbadis.2023.166801","title":"Melanoma cells with acquired resistance to vemurafenib have decreased autophagic flux and display enhanced ability to transfer resistance","display_name":"Melanoma cells with acquired resistance to vemurafenib have decreased autophagic flux and display enhanced ability to transfer resistance","publication_year":2023,"publication_date":"2023-07-06","ids":{"openalex":"https://openalex.org/W4383215399","doi":"https://doi.org/10.1016/j.bbadis.2023.166801","pmid":"https://pubmed.ncbi.nlm.nih.gov/37419396"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbadis.2023.166801","doi":"https://doi.org/10.1016/j.bbadis.2023.166801","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2023.166801","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bbadis.2023.166801","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088069554","display_name":"Celia N. P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Celia N. P\u00e9rez","raw_affiliation_strings":["Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I73822459"]},{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]},{"raw_affiliation_string":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018156118","display_name":"Cristian Roberto Falc\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Cristian R. Falc\u00f3n","raw_affiliation_strings":["Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I73822459"]},{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]},{"raw_affiliation_string":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092403288","display_name":"Johinna Delgado Mons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Johinna Delgado Mons","raw_affiliation_strings":["Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I73822459"]},{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]},{"raw_affiliation_string":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104139399","display_name":"Federico Cuello Orlandi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Federico Cuello Orlandi","raw_affiliation_strings":["Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I73822459"]},{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]},{"raw_affiliation_string":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092403289","display_name":"Mercedes Sangiacomo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mercedes Sangiacomo","raw_affiliation_strings":["Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I73822459"]},{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]},{"raw_affiliation_string":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042829507","display_name":"Juan Manuel Fernandez-Mu\u00f1oz","orcid":"https://orcid.org/0000-0003-1827-4926","observed_orcids":["https://orcid.org/0000-0003-1827-4926"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210157473","display_name":"Instituto de Medicina y Biolog\u00eda Experimental de Cuyo","ror":"https://ror.org/05q52xn14","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210152303","https://openalex.org/I4210157473","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Juan M. Fernandez-Mu\u00f1oz","raw_affiliation_strings":["Instituto de Biolog\u00eda y Medicina Experimental de Cuyo (IMBECU), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda y Medicina Experimental de Cuyo (IMBECU), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060424979","display_name":"Martin E. Guerrero-Gimenez","orcid":"https://orcid.org/0000-0002-5306-5065","observed_orcids":["https://orcid.org/0000-0002-5306-5065"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210157473","display_name":"Instituto de Medicina y Biolog\u00eda Experimental de Cuyo","ror":"https://ror.org/05q52xn14","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210152303","https://openalex.org/I4210157473","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mart\u00edn Guerrero","raw_affiliation_strings":["Instituto de Biolog\u00eda y Medicina Experimental de Cuyo (IMBECU), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda y Medicina Experimental de Cuyo (IMBECU), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108848562","display_name":"Paula G. Benito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I15881080","display_name":"Universidad Nacional de Cuyo","ror":"https://ror.org/05sn8wf81","country_code":"AR","type":"education","lineage":["https://openalex.org/I15881080"]},{"id":"https://openalex.org/I4210147606","display_name":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza","ror":"https://ror.org/04jpdpb33","country_code":"AR","type":"facility","lineage":["https://openalex.org/I15881080","https://openalex.org/I4210147606"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Paula G. Benito","raw_affiliation_strings":["Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM), Universidad Nacional de Cuyo-CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM), Universidad Nacional de Cuyo-CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I15881080","https://openalex.org/I4210147606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103029156","display_name":"Mar\u00eda Isabel Colombo","orcid":"https://orcid.org/0000-0002-5788-9256","observed_orcids":["https://orcid.org/0000-0002-5788-9256"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I15881080","display_name":"Universidad Nacional de Cuyo","ror":"https://ror.org/05sn8wf81","country_code":"AR","type":"education","lineage":["https://openalex.org/I15881080"]},{"id":"https://openalex.org/I4210147606","display_name":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza","ror":"https://ror.org/04jpdpb33","country_code":"AR","type":"facility","lineage":["https://openalex.org/I15881080","https://openalex.org/I4210147606"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda I. Colombo","raw_affiliation_strings":["Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM), Universidad Nacional de Cuyo-CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM), Universidad Nacional de Cuyo-CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I15881080","https://openalex.org/I4210147606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016615726","display_name":"Felipe Carlos Mart\u00edn Zoppino","orcid":"https://orcid.org/0000-0002-3348-8319","observed_orcids":["https://orcid.org/0000-0002-3348-8319"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210157473","display_name":"Instituto de Medicina y Biolog\u00eda Experimental de Cuyo","ror":"https://ror.org/05q52xn14","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210152303","https://openalex.org/I4210157473","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Felipe C.M.. Zoppino","raw_affiliation_strings":["Instituto de Biolog\u00eda y Medicina Experimental de Cuyo (IMBECU), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda y Medicina Experimental de Cuyo (IMBECU), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210157473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011568208","display_name":"Sergio E. Alvarez","orcid":"https://orcid.org/0000-0002-4609-7835","observed_orcids":["https://orcid.org/0000-0002-4609-7835"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210118440","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - San Luis","ror":"https://ror.org/02r8b4p12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210118440","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Sergio E. Alvarez","raw_affiliation_strings":["Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina. Electronic address: sealvar@email.unsl.edu.ar","Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina; Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina. Electronic address: sealvar@email.unsl.edu.ar","institution_ids":["https://openalex.org/I4210118440","https://openalex.org/I73822459"]},{"raw_affiliation_string":"Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis (UNSL), Ej\u00e9rcito de los Andes 950, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I73822459"]},{"raw_affiliation_string":"Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas (IMIBIO-SL), CONICET, Argentina","institution_ids":["https://openalex.org/I151201029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5011568208"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210118440","https://openalex.org/I73822459"],"apc_list":{"value":3660,"currency":"USD","value_usd":3660},"apc_paid":null,"fwci":0.7555,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.63045622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"1869","issue":"7","first_page":"166801","last_page":"166801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/vemurafenib-resistance","display_name":"vemurafenib resistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5720000267028809},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8610000014305115},{"id":"https://openalex.org/keywords/rab27a","display_name":"Rab27a","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rab27b","display_name":"Rab27b","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":0.9879999756813049},{"id":"https://openalex.org/keywords/drug-resistance-transfer","display_name":"drug resistance transfer","score":0.5709999799728394},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.5789999961853027},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4779999852180481},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.8780862092971802},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7691825032234192},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7643756866455078},{"id":"https://openalex.org/C2776470698","wikidata":"https://www.wikidata.org/wiki/Q21851559","display_name":"V600E","level":4,"score":0.600455641746521},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5747358202934265},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5014410018920898},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48990076780319214},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.47807836532592773},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46310609579086304},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.44208085536956787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.407914400100708},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.394814670085907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3656289875507355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3642604351043701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20420441031455994},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.1973220705986023},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15138211846351624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1161099374294281},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.07135069370269775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077484","descriptor_name":"Vemurafenib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbadis.2023.166801","doi":"https://doi.org/10.1016/j.bbadis.2023.166801","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2023.166801","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},{"id":"pmid:37419396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37419396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta. Molecular basis of disease","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbadis.2023.166801","doi":"https://doi.org/10.1016/j.bbadis.2023.166801","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2023.166801","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1945938728","https://openalex.org/W1982968264","https://openalex.org/W1985928174","https://openalex.org/W2005432843","https://openalex.org/W2030459426","https://openalex.org/W2032211985","https://openalex.org/W2038264590","https://openalex.org/W2047607345","https://openalex.org/W2051851026","https://openalex.org/W2052561616","https://openalex.org/W2053737173","https://openalex.org/W2092437923","https://openalex.org/W2096376467","https://openalex.org/W2100239923","https://openalex.org/W2107132781","https://openalex.org/W2108244474","https://openalex.org/W2108537717","https://openalex.org/W2108819945","https://openalex.org/W2114104545","https://openalex.org/W2119735934","https://openalex.org/W2131271579","https://openalex.org/W2136309995","https://openalex.org/W2139830524","https://openalex.org/W2141224543","https://openalex.org/W2146512944","https://openalex.org/W2175014893","https://openalex.org/W2197124664","https://openalex.org/W2299181842","https://openalex.org/W2314266733","https://openalex.org/W2323326409","https://openalex.org/W2469418432","https://openalex.org/W2531977544","https://openalex.org/W2736538915","https://openalex.org/W2740118758","https://openalex.org/W2740618823","https://openalex.org/W2756272041","https://openalex.org/W2760567897","https://openalex.org/W2800339942","https://openalex.org/W2802435800","https://openalex.org/W2803702078","https://openalex.org/W2897455122","https://openalex.org/W2903060444","https://openalex.org/W2905113713","https://openalex.org/W2922270413","https://openalex.org/W2923849202","https://openalex.org/W2937680741","https://openalex.org/W2953861209","https://openalex.org/W2954653485","https://openalex.org/W2959686060","https://openalex.org/W2979112298","https://openalex.org/W2996253303","https://openalex.org/W3016058897","https://openalex.org/W3017842849","https://openalex.org/W3032185138","https://openalex.org/W3044644125","https://openalex.org/W3081102636","https://openalex.org/W3088783523","https://openalex.org/W3091722685","https://openalex.org/W3091934903","https://openalex.org/W3097920809","https://openalex.org/W3099891956","https://openalex.org/W3167360675","https://openalex.org/W3181676626","https://openalex.org/W3182981660","https://openalex.org/W3183401273","https://openalex.org/W3202671220","https://openalex.org/W4205412196","https://openalex.org/W4206662285","https://openalex.org/W4210392902","https://openalex.org/W4224243709","https://openalex.org/W4294308001","https://openalex.org/W6751842113","https://openalex.org/W6801742204"],"related_works":["https://openalex.org/W2736538915","https://openalex.org/W4409117112","https://openalex.org/W7024278069","https://openalex.org/W2062466754","https://openalex.org/W1975019139","https://openalex.org/W2914546008","https://openalex.org/W7221537419","https://openalex.org/W3009767991","https://openalex.org/W4399122784","https://openalex.org/W2763418553"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-06T00:00:00"}
