{"id":"https://openalex.org/W4383187486","doi":"https://doi.org/10.1096/fj.202300611r","title":"Bioflavonoid luteolin prevents sFlt \u20101 release via HIF \u20101\u03b1 inhibition in cultured human placenta","display_name":"Bioflavonoid luteolin prevents sFlt \u20101 release via HIF \u20101\u03b1 inhibition in cultured human placenta","publication_year":2023,"publication_date":"2023-07-05","ids":{"openalex":"https://openalex.org/W4383187486","doi":"https://doi.org/10.1096/fj.202300611r","pmid":"https://pubmed.ncbi.nlm.nih.gov/37405762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10348062"},"language":"en","primary_location":{"id":"doi:10.1096/fj.202300611r","doi":"https://doi.org/10.1096/fj.202300611r","is_oa":true,"landing_page_url":"https://doi.org/10.1096/fj.202300611r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202300611R","source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202300611R","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057019686","display_name":"Adrian C. Eddy","orcid":"https://orcid.org/0000-0002-9945-2810","observed_orcids":["https://orcid.org/0000-0002-9945-2810"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian C. Eddy","raw_affiliation_strings":["Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0002-9945-2810","affiliations":[{"raw_affiliation_string":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038906178","display_name":"Chun-yi Chiang","orcid":"https://orcid.org/0009-0008-6983-0252","observed_orcids":["https://orcid.org/0009-0008-6983-0252"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun Yi Chiang","raw_affiliation_strings":["Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0009-0008-6983-0252","affiliations":[{"raw_affiliation_string":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039275625","display_name":"Augustine Rajakumar","orcid":"https://orcid.org/0000-0002-4975-6082","observed_orcids":["https://orcid.org/0000-0002-4975-6082"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Augustine Rajakumar","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Emory University, Atlanta, Georgia, USA"],"raw_orcid":"https://orcid.org/0000-0002-4975-6082","affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082451578","display_name":"Frank Travis Spradley","orcid":"https://orcid.org/0000-0003-3293-2753","observed_orcids":["https://orcid.org/0000-0003-3293-2753"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank T. Spradley","raw_affiliation_strings":["Department of Pharmacology & Toxicology University of Mississippi Medical Center  Jackson Mississippi USA","Department of Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA","Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA"],"raw_orcid":"https://orcid.org/0000-0003-3293-2753","affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology University of Mississippi Medical Center  Jackson Mississippi USA","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Department of Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059089028","display_name":"Patricia Dauer","orcid":"https://orcid.org/0000-0002-8374-5512","observed_orcids":["https://orcid.org/0000-0002-8374-5512"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Dauer","raw_affiliation_strings":["Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0002-8374-5512","affiliations":[{"raw_affiliation_string":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033919728","display_name":"Joey P. Granger","orcid":"https://orcid.org/0000-0002-4078-5629","observed_orcids":["https://orcid.org/0000-0002-4078-5629"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joey P. Granger","raw_affiliation_strings":["Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi, USA"],"raw_orcid":"https://orcid.org/0000-0002-4078-5629","affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030601893","display_name":"Sarosh Rana","orcid":"https://orcid.org/0000-0002-5828-7433","observed_orcids":["https://orcid.org/0000-0002-5828-7433"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarosh Rana","raw_affiliation_strings":["Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0002-5828-7433","affiliations":[{"raw_affiliation_string":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030601893"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":6.5114,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.97736941,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"8","first_page":"e23078","last_page":"e23078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/soluble-fms-like-tyrosine-kinase-1","display_name":"soluble fms-like tyrosine kinase-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cytotrophoblast","display_name":"cytotrophoblast","score":0.8460000157356262},{"id":"https://openalex.org/keywords/antiangiogenic-factors","display_name":"anti-angiogenic factors","score":0.6930000185966492},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.652999997138977},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7760000228881836},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.6269999742507935},{"id":"https://openalex.org/keywords/placental-hypoxia","display_name":"placental hypoxia","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.6544344425201416},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6370199918746948},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6309319138526917},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5471715331077576},{"id":"https://openalex.org/C2779184299","wikidata":"https://www.wikidata.org/wiki/Q7558944","display_name":"Soluble fms-like tyrosine kinase-1","level":5,"score":0.541507363319397},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.5161643624305725},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.515924334526062},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.45599430799484253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4481198787689209},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38589930534362793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31883156299591064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3022341728210449},{"id":"https://openalex.org/C2776871010","wikidata":"https://www.wikidata.org/wiki/Q18030500","display_name":"Placental growth factor","level":4,"score":0.28321921825408936},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2580839693546295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.157221257686615},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.10453370213508606},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.09482133388519287},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047311","descriptor_name":"Luteolin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047311","descriptor_name":"Luteolin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1096/fj.202300611r","doi":"https://doi.org/10.1096/fj.202300611r","is_oa":true,"landing_page_url":"https://doi.org/10.1096/fj.202300611r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202300611R","source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:37405762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37405762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10348062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10348062","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10348062/pdf/nihms-1915420.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FASEB J","raw_type":"Text"},{"id":"pmh:oai:uchicago.tind.io:6647","doi":null,"is_oa":true,"landing_page_url":"http://knowledge.uchicago.edu/record/6647","pdf_url":null,"source":{"id":"https://openalex.org/S4306402460","display_name":"Knowledge@UChicago (University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40347166","host_organization_name":"University of Chicago","host_organization_lineage":["https://openalex.org/I40347166"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knowledge.uchicago.edu/record/6647","raw_type":"Text"},{"id":"doi:10.6082/w9kxj-zeg04","doi":"https://doi.org/10.6082/w9kxj-zeg04","is_oa":true,"landing_page_url":"https://doi.org/10.6082/w9kxj-zeg04","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6082/z957z-j0e14","doi":"https://doi.org/10.6082/z957z-j0e14","is_oa":true,"landing_page_url":"https://doi.org/10.6082/z957z-j0e14","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1096/fj.202300611r","doi":"https://doi.org/10.1096/fj.202300611r","is_oa":true,"landing_page_url":"https://doi.org/10.1096/fj.202300611r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202300611R","source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1259918194","display_name":"Luteolin as a therapeutic for hypertension in pregnancy","funder_award_id":"1r56hl157579-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1948743433","display_name":null,"funder_award_id":"1R56HL157579-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2281790343","display_name":null,"funder_award_id":"GM104357","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3517524281","display_name":null,"funder_award_id":"R00130577","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3928495550","display_name":null,"funder_award_id":"/ NHLBI R00130577","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4748495603","display_name":null,"funder_award_id":"R56 HL157579","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5474420044","display_name":null,"funder_award_id":"NIGMS P20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6522513317","display_name":null,"funder_award_id":"GM121334","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7656362809","display_name":"Cardiorenal and Metabolic Diseases Research Center","funder_award_id":"P20GM104357","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8050617282","display_name":null,"funder_award_id":"GM104357","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8071485332","display_name":null,"funder_award_id":"AWD-001111","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000055609","display_name":null,"funder_award_id":"GM104357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000115208","display_name":null,"funder_award_id":"GM121334","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000863976","display_name":"Mississippi Center of Excellence in Perinatal Research, Phase 2","funder_award_id":"P20GM121334","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000892833","display_name":"Cardiorenal and Metabolic Diseases Research Center","funder_award_id":"P30GM149404","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000894110","display_name":"Mississippi Center for Clinical and Translational Research","funder_award_id":"U54GM115428","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000896017","display_name":"Hypertension and Cardiorenal Research Training Program","funder_award_id":"T32HL105324","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000902280","display_name":"Aspirin to prevent cardiac dysfunction in preeclampsia","funder_award_id":"R01HL148191","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383187486.pdf","grobid_xml":"https://content.openalex.org/works/W4383187486.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1797820897","https://openalex.org/W1849560193","https://openalex.org/W1873908353","https://openalex.org/W1973816411","https://openalex.org/W1984970610","https://openalex.org/W1997559135","https://openalex.org/W2002123180","https://openalex.org/W2002763203","https://openalex.org/W2005519305","https://openalex.org/W2014193833","https://openalex.org/W2015382047","https://openalex.org/W2018891761","https://openalex.org/W2018967387","https://openalex.org/W2036469757","https://openalex.org/W2041237929","https://openalex.org/W2072756039","https://openalex.org/W2079113836","https://openalex.org/W2081255404","https://openalex.org/W2086073438","https://openalex.org/W2100369246","https://openalex.org/W2108889231","https://openalex.org/W2109069677","https://openalex.org/W2113726274","https://openalex.org/W2121228569","https://openalex.org/W2123266930","https://openalex.org/W2127491141","https://openalex.org/W2128439704","https://openalex.org/W2129194432","https://openalex.org/W2129206669","https://openalex.org/W2133614334","https://openalex.org/W2134502189","https://openalex.org/W2143180984","https://openalex.org/W2150823776","https://openalex.org/W2152343080","https://openalex.org/W2167503858","https://openalex.org/W2185931826","https://openalex.org/W2340668831","https://openalex.org/W2400126132","https://openalex.org/W2570520425","https://openalex.org/W2600849944","https://openalex.org/W2603446044","https://openalex.org/W2755022538","https://openalex.org/W2761347059","https://openalex.org/W2804487010","https://openalex.org/W2804636211","https://openalex.org/W2809067420","https://openalex.org/W2892268363","https://openalex.org/W2901511860","https://openalex.org/W2902105889","https://openalex.org/W2922230818","https://openalex.org/W2935104625","https://openalex.org/W3011312429","https://openalex.org/W3017118294","https://openalex.org/W3022171609","https://openalex.org/W3047961043","https://openalex.org/W3094219366","https://openalex.org/W3158004988","https://openalex.org/W3185442036","https://openalex.org/W3200096697","https://openalex.org/W3210815723","https://openalex.org/W4294084375"],"related_works":["https://openalex.org/W4378649577","https://openalex.org/W4378648598","https://openalex.org/W2152343080","https://openalex.org/W2076868127","https://openalex.org/W2102916843","https://openalex.org/W2733093534","https://openalex.org/W150822171","https://openalex.org/W144710689","https://openalex.org/W6902118155","https://openalex.org/W2093772580"],"abstract_inverted_index":{"Preeclampsia":[0],"(PE)":[1,114],"is":[2,10],"a":[3,11,84,173,190,235],"serious":[4],"hypertensive":[5],"complication":[6],"of":[7,14,27,33,40,88,121,127,152,197,231,241],"pregnancy":[8],"and":[9,17,22,72,112,124,129,138,175,213],"leading":[12],"cause":[13],"maternal":[15,21],"death":[16],"major":[18],"contributor":[19],"to":[20,64,68,91,95,159,170,199,211],"perinatal":[23],"morbidity,":[24],"including":[25],"establishment":[26],"long-term":[28],"complications.":[29],"The":[30,195],"continued":[31],"prevalence":[32],"PE":[34],"stresses":[35],"the":[36,50,142,148,206,239],"need":[37],"for":[38,192,238],"identification":[39],"novel":[41,66,236],"treatments":[42],"which":[43],"can":[44],"target":[45],"prohypertensive":[46],"factors":[47],"implicated":[48],"in":[49,165,172,181,186,221],"disease":[51],"pathophysiology,":[52],"such":[53],"as":[54,209],"soluble":[55],"fms-like":[56],"tyrosine":[57],"kinase":[58,218],"1":[59],"(sFlt-1).":[60],"We":[61,82],"set":[62],"out":[63],"identify":[65],"compounds":[67,90,144],"reduce":[69,96],"placental":[70,102,107,167],"sFlt-1":[71,97,128,153,164,193,228],"determine":[73],"whether":[74],"this":[75],"occurs":[76],"via":[77],"hypoxia-inducible":[78],"factor":[79],"(HIF)-1\u03b1":[80],"inhibition.":[81],"utilized":[83],"commercially":[85],"available":[86],"library":[87],"natural":[89,143],"assess":[92],"their":[93],"ability":[94,196],"release":[98],"from":[99,109],"primary":[100],"human":[101],"cytotrophoblast":[103],"cells":[104],"(CTBs).":[105],"Human":[106],"explants":[108,168],"normotensive":[110],"(NT)":[111],"preeclamptic":[113],"pregnancies":[115],"were":[116,132,184],"treated":[117],"with":[118,155],"varying":[119],"concentrations":[120],"luteolin.":[122],"Protein":[123],"mRNA":[125],"expression":[126,183],"upstream":[130,215],"mediators":[131],"evaluated":[133],"using":[134],"ELISA,":[135],"western":[136],"blot,":[137],"real-time":[139],"PCR.":[140],"Of":[141],"examined,":[145],"luteolin":[146,198],"showed":[147],"most":[149],"potent":[150],"inhibition":[151,230],"release,":[154],">95%":[156],"reduction":[157],"compared":[158,169],"vehicle-treated.":[160],"Luteolin":[161,225],"significantly":[162],"inhibited":[163],"cultured":[166],"vehicle-treated":[171],"dose-":[174],"time-dependent":[176],"manner.":[177],"Additionally,":[178],"significant":[179,222],"decreases":[180],"HIF-1\u03b1":[182,201,223],"observed":[185],"luteolin-treated":[187],"explants,":[188],"suggesting":[189],"mechanism":[191],"downregulation.":[194],"inhibit":[200],"may":[202],"be":[203],"mediated":[204],"through":[205,229],"Akt":[207,212],"pathway,":[208],"inhibitors":[210],"its":[214],"regulator":[216],"phosphatidylinositol-3":[217],"(PI3K)":[219],"resulted":[220],"reduction.":[224],"reduces":[226],"anti-angiogenic":[227],"HIF-1\u03b1,":[232],"making":[233],"it":[234],"candidate":[237],"treatment":[240],"PE.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-06T00:00:00"}