{"id":"https://openalex.org/W4383065765","doi":"https://doi.org/10.1016/j.celrep.2023.112724","title":"The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2","display_name":"The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2","publication_year":2023,"publication_date":"2023-07-01","ids":{"openalex":"https://openalex.org/W4383065765","doi":"https://doi.org/10.1016/j.celrep.2023.112724","pmid":"https://pubmed.ncbi.nlm.nih.gov/37410595"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2023.112724","doi":"https://doi.org/10.1016/j.celrep.2023.112724","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.112724","pdf_url":"http://www.cell.com/article/S2211124723007350/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124723007350/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048275641","display_name":"Julia Katharina Charlotte Kre\u00df","orcid":"https://orcid.org/0000-0002-7391-0406","observed_orcids":["https://orcid.org/0000-0002-7391-0406"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Katharina Charlotte Kre\u00df","raw_affiliation_strings":["Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040212203","display_name":"Christina Jessen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Jessen","raw_affiliation_strings":["Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019109227","display_name":"Anita Hufnagel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anita Hufnagel","raw_affiliation_strings":["Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069836877","display_name":"Werner Schmitz","orcid":"https://orcid.org/0000-0003-0485-7303","observed_orcids":["https://orcid.org/0000-0003-0485-7303"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Schmitz","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of W\u00fcrzburg, 97074 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of W\u00fcrzburg, 97074 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075844908","display_name":"Thamara Nishida Xavier da Silva","orcid":"https://orcid.org/0000-0001-5236-8470","observed_orcids":["https://orcid.org/0000-0001-5236-8470"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thamara Nishida Xavier da Silva","raw_affiliation_strings":["Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062018633","display_name":"Anc\u00e9ly Ferreira dos Santos","orcid":"https://orcid.org/0000-0003-4985-6187","observed_orcids":["https://orcid.org/0000-0003-4985-6187"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anc\u00e9ly Ferreira dos Santos","raw_affiliation_strings":["Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023274542","display_name":"Laura Mosteo","orcid":"https://orcid.org/0000-0002-4410-2370","observed_orcids":["https://orcid.org/0000-0002-4410-2370"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106789","display_name":"Ludwig Cancer Research","ror":"https://ror.org/01e473h50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210106789","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Laura Mosteo","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK; Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal","Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal","Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK; Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I40120149","https://openalex.org/I4210106789","https://openalex.org/I4210158732"]},{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210106789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002433296","display_name":"Colin R. Goding","orcid":"https://orcid.org/0000-0002-1614-3909","observed_orcids":["https://orcid.org/0000-0002-1614-3909"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106789","display_name":"Ludwig Cancer Research","ror":"https://ror.org/01e473h50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210106789","https://openalex.org/I4210150094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin R. Goding","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210106789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065710911","display_name":"Jos\u00e9 Pedro Friedmann Angeli","orcid":"https://orcid.org/0000-0001-7706-1379","observed_orcids":["https://orcid.org/0000-0001-7706-1379"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Pedro Friedmann Angeli","raw_affiliation_strings":["Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056044576","display_name":"Svenja Meierjohann","orcid":"https://orcid.org/0000-0002-9058-7196","observed_orcids":["https://orcid.org/0000-0002-9058-7196"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210100919","display_name":"Comprehensive Cancer Center Mainfranken","ror":"https://ror.org/013tmk464","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I25974101","https://openalex.org/I4210100919","https://openalex.org/I4210126310"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Svenja Meierjohann","raw_affiliation_strings":["Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany; Comprehensive Cancer Center Mainfranken, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany. Electronic address: svenja.meierjohann@uni-wuerzburg.de","Comprehensive Cancer Center Mainfranken, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9058-7196","affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany; Comprehensive Cancer Center Mainfranken, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany. Electronic address: svenja.meierjohann@uni-wuerzburg.de","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210100919","https://openalex.org/I4210126310"]},{"raw_affiliation_string":"Comprehensive Cancer Center Mainfranken, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210100919","https://openalex.org/I4210126310"]},{"raw_affiliation_string":"Institute of Pathology, University of W\u00fcrzburg, 97080 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5056044576"],"corresponding_institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210100919","https://openalex.org/I4210126310"],"apc_list":{"value":5460,"currency":"USD","value_usd":5460},"apc_paid":{"value":5355,"currency":"EUR","value_usd":5775},"fwci":12.4512,"has_fulltext":true,"cited_by_count":144,"citation_normalized_percentile":{"value":0.99512958,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"42","issue":"7","first_page":"112724","last_page":"112724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.9769999980926514},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.972000002861023},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chac1","display_name":"CHAC1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glutathione-degradation","display_name":"glutathione degradation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cystine-uptake","display_name":"cystine uptake","score":0.8679999709129333},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":0.921999990940094},{"id":"https://openalex.org/keywords/thioredoxin","display_name":"thioredoxin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6729999780654907},{"id":"https://openalex.org/keywords/electrophilic-stress","display_name":"electrophilic stress","score":0.8209999799728394},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cellular-resilience","display_name":"cellular resilience","score":0.5230000019073486},{"id":"https://openalex.org/keywords/tumor-plasticity","display_name":"tumor plasticity","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8427554965019226},{"id":"https://openalex.org/C2780900454","wikidata":"https://www.wikidata.org/wiki/Q21102119","display_name":"ATF4","level":4,"score":0.7099056839942932},{"id":"https://openalex.org/C2779638656","wikidata":"https://www.wikidata.org/wiki/Q6043166","display_name":"Integrated stress response","level":5,"score":0.6227976679801941},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.6196998953819275},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5546817779541016},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.4160001277923584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3940686583518982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3725881576538086},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.34237825870513916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21110329031944275},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12760141491889954},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.06065356731414795},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003553","descriptor_name":"Cystine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.celrep.2023.112724","doi":"https://doi.org/10.1016/j.celrep.2023.112724","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.112724","pdf_url":"http://www.cell.com/article/S2211124723007350/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:37410595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37410595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:35031","doi":null,"is_oa":true,"landing_page_url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/35031","pdf_url":"https://opus.bibliothek.uni-wuerzburg.de/files/35031/1-s2.0-S2211124723007350-main.pdf","source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e9c771ed6d1c4e52a0f3a51015e08aa6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e9c771ed6d1c4e52a0f3a51015e08aa6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 42, Iss 7, Pp 112724- (2023)","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:ce9a123e-fa2d-43a8-bf40-7780c4bc311c","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:ce9a123e-fa2d-43a8-bf40-7780c4bc311c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2023.112724","doi":"https://doi.org/10.1016/j.celrep.2023.112724","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.112724","pdf_url":"http://www.cell.com/article/S2211124723007350/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G155481424","display_name":null,"funder_award_id":"ME1899/6-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320325356","display_name":"Julius-Maximilians-Universit\u00e4t W\u00fcrzburg","ror":"https://ror.org/00fbnyb24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383065765.pdf","grobid_xml":"https://content.openalex.org/works/W4383065765.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1968439134","https://openalex.org/W1980195461","https://openalex.org/W1981280480","https://openalex.org/W1991039871","https://openalex.org/W1995185113","https://openalex.org/W1996311090","https://openalex.org/W2007064404","https://openalex.org/W2008322756","https://openalex.org/W2048098925","https://openalex.org/W2072299899","https://openalex.org/W2082927951","https://openalex.org/W2083278580","https://openalex.org/W2085201901","https://openalex.org/W2096492418","https://openalex.org/W2098131661","https://openalex.org/W2115338196","https://openalex.org/W2117692326","https://openalex.org/W2119080788","https://openalex.org/W2126635195","https://openalex.org/W2128845732","https://openalex.org/W2129042241","https://openalex.org/W2130029858","https://openalex.org/W2134703818","https://openalex.org/W2140331807","https://openalex.org/W2152175948","https://openalex.org/W2155324869","https://openalex.org/W2161446823","https://openalex.org/W2171089964","https://openalex.org/W2173466127","https://openalex.org/W2186855780","https://openalex.org/W2337964991","https://openalex.org/W2518959324","https://openalex.org/W2577256604","https://openalex.org/W2617266043","https://openalex.org/W2640064441","https://openalex.org/W2783383798","https://openalex.org/W2791462773","https://openalex.org/W2884607428","https://openalex.org/W2900705752","https://openalex.org/W2944727022","https://openalex.org/W2979432897","https://openalex.org/W2984723145","https://openalex.org/W2988716798","https://openalex.org/W3006997302","https://openalex.org/W3009495596","https://openalex.org/W3014107922","https://openalex.org/W3035475906","https://openalex.org/W3072295979","https://openalex.org/W3083505424","https://openalex.org/W3088913508","https://openalex.org/W3135675512","https://openalex.org/W3137653259","https://openalex.org/W3142445179","https://openalex.org/W3158536242","https://openalex.org/W3161536731","https://openalex.org/W4200497629","https://openalex.org/W4210282047","https://openalex.org/W4248692504","https://openalex.org/W4253612184","https://openalex.org/W4283720033","https://openalex.org/W6769944288"],"related_works":["https://openalex.org/W3038503389","https://openalex.org/W2754122880","https://openalex.org/W7155519179","https://openalex.org/W1421415727","https://openalex.org/W3009495596","https://openalex.org/W2463176095","https://openalex.org/W3008733464","https://openalex.org/W2035676834","https://openalex.org/W2015360869","https://openalex.org/W4412441314"],"abstract_inverted_index":{"The":[0,47],"redox":[1,18],"regulator":[2],"NRF2":[3,40,70,88,94,109,128],"becomes":[4],"activated":[5,51],"upon":[6],"oxidative":[7],"and":[8,11,24,39,57,65,72,115,149],"electrophilic":[9],"stress":[10,36,56],"orchestrates":[12],"a":[13,59],"response":[14,37,129],"program":[15],"associated":[16],"with":[17],"regulation,":[19],"metabolism,":[20],"tumor":[21],"therapy":[22],"resistance,":[23],"immune":[25],"suppression.":[26],"Here,":[27],"we":[28,79,124],"describe":[29],"an":[30,137],"unrecognized":[31],"link":[32],"between":[33],"the":[34,43,74,103,119,127,135,142],"integrated":[35],"(ISR)":[38],"mediated":[41],"by":[42,98],"ISR":[44,48],"effector":[45],"ATF4.":[46],"is":[49],"commonly":[50],"after":[52],"starvation":[53],"or":[54],"ER":[55],"plays":[58],"central":[60],"role":[61],"in":[62,147],"tissue":[63],"homeostasis":[64],"cancer":[66],"plasticity.":[67],"ATF4":[68],"increases":[69],"transcription":[71],"induces":[73],"glutathione-degrading":[75],"enzyme":[76],"CHAC1,":[77],"which":[78],"now":[80],"show":[81],"to":[82],"be":[83],"critically":[84],"important":[85],"for":[86,141],"maintaining":[87],"activation.":[89],"In-depth":[90],"analyses":[91],"reveal":[92],"that":[93,126],"supports":[95],"ATF4-induced":[96],"cells":[97],"increasing":[99],"cystine":[100],"uptake":[101],"via":[102],"glutamate-cystine":[104],"antiporter":[105],"xCT.":[106],"In":[107,122],"addition,":[108],"upregulates":[110],"genes":[111],"mediating":[112],"thioredoxin":[113],"usage":[114],"regeneration,":[116],"thus":[117],"balancing":[118],"glutathione":[120],"decrease.":[121],"conclusion,":[123],"demonstrate":[125],"serves":[130],"as":[131],"second":[132],"layer":[133],"of":[134,144],"ISR,":[136],"observation":[138],"highly":[139],"relevant":[140],"understanding":[143],"cellular":[145],"resilience":[146],"health":[148],"disease.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":60},{"year":2025,"cited_by_count":45},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-05T00:00:00"}
