{"id":"https://openalex.org/W4383058729","doi":"https://doi.org/10.1002/bit.28485","title":"Optimization of physical microenvironment to maintain the quiescence of human induced pluripotent stem cell\u2010derived hepatic stellate cells","display_name":"Optimization of physical microenvironment to maintain the quiescence of human induced pluripotent stem cell\u2010derived hepatic stellate cells","publication_year":2023,"publication_date":"2023-07-04","ids":{"openalex":"https://openalex.org/W4383058729","doi":"https://doi.org/10.1002/bit.28485","pmid":"https://pubmed.ncbi.nlm.nih.gov/37401657"},"language":"en","primary_location":{"id":"doi:10.1002/bit.28485","doi":"https://doi.org/10.1002/bit.28485","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bit.28485","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.28485","source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.28485","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046883097","display_name":"Ya Gong","orcid":"https://orcid.org/0009-0000-0092-4973","observed_orcids":["https://orcid.org/0009-0000-0092-4973"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ya Gong","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0000-0092-4973","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006649407","display_name":"Mathieu Danoy","orcid":"https://orcid.org/0000-0003-3399-2301","observed_orcids":["https://orcid.org/0000-0003-3399-2301"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mathieu Danoy","raw_affiliation_strings":["Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3399-2301","affiliations":[{"raw_affiliation_string":"Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040231836","display_name":"Taketomo Kido","orcid":"https://orcid.org/0000-0001-9790-0862","observed_orcids":["https://orcid.org/0000-0001-9790-0862"]},"institutions":[{"id":"https://openalex.org/I4405286657","display_name":"Institute for Quantitative Biosciences, The University of Tokyo","ror":"https://ror.org/02qwvne14","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286657","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taketomo Kido","raw_affiliation_strings":["Institute of Quantitative Biosciences, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Quantitative Biosciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286657","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013309273","display_name":"Kento Mitsuhashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kento Mitsuhashi","raw_affiliation_strings":["Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002318246","display_name":"Hyun-Jin Choi","orcid":"https://orcid.org/0000-0001-8795-0970","observed_orcids":["https://orcid.org/0000-0001-8795-0970"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hyunjin Choi","raw_affiliation_strings":["Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008853059","display_name":"Tomoaki Matsugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152248","display_name":"Mitsui Chemicals (Japan)","ror":"https://ror.org/05wh5fw51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118089","https://openalex.org/I4210152248"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Matsugi","raw_affiliation_strings":["Mitsui Chemicals Inc., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsui Chemicals Inc., Tokyo, Japan","institution_ids":["https://openalex.org/I4210152248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100633811","display_name":"Jingjing Yang","orcid":"https://orcid.org/0000-0002-3106-3798","observed_orcids":["https://orcid.org/0000-0002-3106-3798"]},"institutions":[{"id":"https://openalex.org/I4210152248","display_name":"Mitsui Chemicals (Japan)","ror":"https://ror.org/05wh5fw51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118089","https://openalex.org/I4210152248"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jingjing Yang","raw_affiliation_strings":["Mitsui Chemicals Inc., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsui Chemicals Inc., Tokyo, Japan","institution_ids":["https://openalex.org/I4210152248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084965275","display_name":"Katsuhiro Esashika","orcid":"https://orcid.org/0009-0000-1433-0148","observed_orcids":["https://orcid.org/0009-0000-1433-0148"]},"institutions":[{"id":"https://openalex.org/I4210152248","display_name":"Mitsui Chemicals (Japan)","ror":"https://ror.org/05wh5fw51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118089","https://openalex.org/I4210152248"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiro Esashika","raw_affiliation_strings":["Mitsui Chemicals Inc., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsui Chemicals Inc., Tokyo, Japan","institution_ids":["https://openalex.org/I4210152248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008148847","display_name":"JUN C. TAKAHASHI","orcid":"https://orcid.org/0000-0002-0134-1179","observed_orcids":["https://orcid.org/0000-0002-0134-1179"]},"institutions":[{"id":"https://openalex.org/I4210152248","display_name":"Mitsui Chemicals (Japan)","ror":"https://ror.org/05wh5fw51","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118089","https://openalex.org/I4210152248"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Takahashi","raw_affiliation_strings":["Mitsui Chemicals Inc., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsui Chemicals Inc., Tokyo, Japan","institution_ids":["https://openalex.org/I4210152248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035753084","display_name":"Masaki Nishikawa","orcid":"https://orcid.org/0000-0003-4253-3211","observed_orcids":["https://orcid.org/0000-0003-4253-3211"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Nishikawa","raw_affiliation_strings":["Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009868639","display_name":"Taichi Ito","orcid":"https://orcid.org/0000-0002-1589-8242","observed_orcids":["https://orcid.org/0000-0002-1589-8242"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taichi Ito","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1589-8242","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069121285","display_name":"Atsushi Miyajima","orcid":"https://orcid.org/0000-0003-3176-5906","observed_orcids":["https://orcid.org/0000-0003-3176-5906"]},"institutions":[{"id":"https://openalex.org/I4405286657","display_name":"Institute for Quantitative Biosciences, The University of Tokyo","ror":"https://ror.org/02qwvne14","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286657","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Miyajima","raw_affiliation_strings":["Institute of Quantitative Biosciences, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Quantitative Biosciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286657","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009726796","display_name":"Yasuyuki Sakai","orcid":"https://orcid.org/0000-0002-2249-6516","observed_orcids":["https://orcid.org/0000-0002-2249-6516","https://orcid.org/0000-0001-7734-5398"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Sakai","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046883097"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":{"value":4840,"currency":"USD","value_usd":4840},"fwci":0.4836,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59145726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"120","issue":"8","first_page":"2345","last_page":"2356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hepatic-stellate-cell-activation","display_name":"hepatic stellate cell activation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8370000123977661},{"id":"https://openalex.org/keywords/in-vitro-liver-models","display_name":"in vitro liver models","score":0.7419999837875366},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.8923712968826294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7294230461120605},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6857833862304688},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.672629714012146},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6267751455307007},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.513316810131073},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47574540972709656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45978525280952454},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.44990500807762146},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4144458770751953},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.41262978315353394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35006392002105713},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3341602683067322},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31760504841804504},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17156332731246948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06227657198905945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bit.28485","doi":"https://doi.org/10.1002/bit.28485","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bit.28485","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.28485","source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},{"id":"pmid:37401657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37401657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and bioengineering","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/bit.28485","doi":"https://doi.org/10.1002/bit.28485","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bit.28485","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.28485","source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2079265164","display_name":"Mathematical Dynamic Modeling of Heterogeneous Liver Cells","funder_award_id":"22H00595","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3784835807","display_name":"Development of a novel liver disease model using genetically modified human induced pluripotent stem cells and analysis of fibrosis mechanisms","funder_award_id":"21H02710","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5266575847","display_name":null,"funder_award_id":"23H03834","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8349094663","display_name":null,"funder_award_id":"23H03836","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4383058729.pdf","grobid_xml":"https://content.openalex.org/works/W4383058729.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1598270217","https://openalex.org/W1808406820","https://openalex.org/W1846286601","https://openalex.org/W1965498876","https://openalex.org/W1965588383","https://openalex.org/W1970509035","https://openalex.org/W1971163936","https://openalex.org/W1975318062","https://openalex.org/W1980199136","https://openalex.org/W2002863207","https://openalex.org/W2007485712","https://openalex.org/W2010988303","https://openalex.org/W2023026872","https://openalex.org/W2023952437","https://openalex.org/W2027665912","https://openalex.org/W2045424388","https://openalex.org/W2046913258","https://openalex.org/W2055417401","https://openalex.org/W2062652813","https://openalex.org/W2067188612","https://openalex.org/W2070960038","https://openalex.org/W2077967017","https://openalex.org/W2086361957","https://openalex.org/W2090565792","https://openalex.org/W2102079607","https://openalex.org/W2111288662","https://openalex.org/W2121353065","https://openalex.org/W2122530058","https://openalex.org/W2149489859","https://openalex.org/W2154530183","https://openalex.org/W2163036793","https://openalex.org/W2165062244","https://openalex.org/W2241161952","https://openalex.org/W2254177481","https://openalex.org/W2280422486","https://openalex.org/W2346671729","https://openalex.org/W2406511418","https://openalex.org/W2582439362","https://openalex.org/W2613180696","https://openalex.org/W2885317802","https://openalex.org/W2887856756","https://openalex.org/W2935769860","https://openalex.org/W2953174209","https://openalex.org/W2998892996","https://openalex.org/W3033308994","https://openalex.org/W3094299399","https://openalex.org/W3185967030","https://openalex.org/W3200845079","https://openalex.org/W3216066330","https://openalex.org/W4243729710","https://openalex.org/W4306885030"],"related_works":["https://openalex.org/W7197025080","https://openalex.org/W7119082516","https://openalex.org/W3216066330","https://openalex.org/W4306885030","https://openalex.org/W637873502","https://openalex.org/W2810174843","https://openalex.org/W3156814156","https://openalex.org/W1986980150","https://openalex.org/W4316034793","https://openalex.org/W3118040750"],"abstract_inverted_index":{"Hepatic":[0],"stellate":[1],"cells":[2,70],"(HSCs)":[3],"play":[4],"a":[5,104,112,187],"crucial":[6],"role":[7],"in":[8,38,54,111,135,146,186,195],"liver":[9,197],"fibrosis":[10],"by":[11,121,163],"producing":[12],"excessive":[13],"extracellular":[14],"matrix":[15],"(ECM)":[16],"following":[17],"chronic":[18],"inflammation.":[19],"However,":[20,82],"studying":[21],"HSC":[22],"function":[23],"has":[24],"been":[25],"challenging":[26],"due":[27],"to":[28,75,107,118,152,154,178,184],"the":[29,41,61,73,167,191],"limited":[30],"availability":[31],"of":[32,63,80,133,158,193],"primary":[33,44],"human":[34,66],"quiescent":[35],"HSCs":[36,85,180],"(qHSCs)":[37],"vitro,":[39],"and":[40,102],"fact":[42],"that":[43,129],"qHSCs":[45,64],"quickly":[46],"activate":[47,88],"when":[48],"cultured":[49],"on":[50,90],"plastic":[51,92],"plates.":[52,93],"Advances":[53],"stem":[55,69],"cell":[56],"technology":[57],"have":[58],"allowed":[59],"for":[60,116,199],"generation":[62],"from":[65,100],"induced":[67],"pluripotent":[68],"(hiPSCs)":[71],"with":[72,166,181],"potential":[74],"provide":[76],"an":[77],"unlimited":[78],"source":[79],"cells.":[81],"differentiated":[83],"quiescent-like":[84],"(iqHSCs)":[86],"also":[87],"spontaneously":[89],"conventional":[91],"In":[94],"this":[95],"study,":[96],"we":[97],"generated":[98],"iqHSCs":[99,110,134],"hiPSCs":[101],"developed":[103],"culture":[105,125,132,173],"method":[106,174],"maintain":[108],"such":[109],"lowly":[113],"activated":[114,155],"state":[115],"up":[117],"5":[119],"days":[120],"optimizing":[122],"their":[123,143,150],"physical":[124],"microenvironment.":[126],"We":[127],"observed":[128],"three-dimensional":[130],"(3D)":[131],"soft":[136],"type":[137],"1":[138],"collagen":[139],"hydrogels":[140],"significantly":[141],"inhibited":[142],"spontaneous":[144],"activation":[145],"vitro":[147,196],"while":[148],"maintaining":[149],"ability":[151],"convert":[153],"state.":[156],"Activation":[157],"iqHSC":[159],"was":[160],"successfully":[161],"modeled":[162],"stimulating":[164],"them":[165],"fibrotic":[168],"cytokine":[169],"TGF\u03b21.":[170],"Hence,":[171],"our":[172],"can":[175],"be":[176],"used":[177],"generate":[179],"functions":[182],"comparable":[183],"those":[185],"healthy":[188],"liver,":[189],"facilitating":[190],"development":[192],"accurate":[194],"models":[198],"identifying":[200],"novel":[201],"therapeutic":[202],"agents.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-05T00:00:00"}
