{"id":"https://openalex.org/W4382989005","doi":"https://doi.org/10.1021/acs.biochem.3c00161","title":"Redefining the Structure of Tip Links in Hair Cells","display_name":"Redefining the Structure of Tip Links in Hair Cells","publication_year":2023,"publication_date":"2023-07-03","ids":{"openalex":"https://openalex.org/W4382989005","doi":"https://doi.org/10.1021/acs.biochem.3c00161","pmid":"https://pubmed.ncbi.nlm.nih.gov/37399091"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.3c00161","doi":"https://doi.org/10.1021/acs.biochem.3c00161","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.3c00161","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/20/2022.08.19.504503.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112751439","display_name":"Veerpal Kaur","orcid":"https://orcid.org/0000-0002-7082-1870","observed_orcids":["https://orcid.org/0000-0002-7082-1870"]},"institutions":[{"id":"https://openalex.org/I165916956","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79","country_code":"IN","type":"education","lineage":["https://openalex.org/I165916956"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Veerpal Kaur","raw_affiliation_strings":["Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India","institution_ids":["https://openalex.org/I165916956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059557721","display_name":"Sanat K. Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165916956","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79","country_code":"IN","type":"education","lineage":["https://openalex.org/I165916956"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanat K. Ghosh","raw_affiliation_strings":["Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India","institution_ids":["https://openalex.org/I165916956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045589478","display_name":"Tripta Bhatia","orcid":"https://orcid.org/0000-0002-3858-9290","observed_orcids":["https://orcid.org/0000-0002-3858-9290"]},"institutions":[{"id":"https://openalex.org/I165916956","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79","country_code":"IN","type":"education","lineage":["https://openalex.org/I165916956"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tripta Bhatia","raw_affiliation_strings":["Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India","institution_ids":["https://openalex.org/I165916956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012560225","display_name":"Sabyasachi Rakshit","orcid":"https://orcid.org/0000-0002-8083-6857","observed_orcids":["https://orcid.org/0000-0002-8083-6857"]},"institutions":[{"id":"https://openalex.org/I165916956","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79","country_code":"IN","type":"education","lineage":["https://openalex.org/I165916956"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sabyasachi Rakshit","raw_affiliation_strings":["Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India"],"raw_orcid":"https://orcid.org/0000-0002-8083-6857","affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India","institution_ids":["https://openalex.org/I165916956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012560225"],"corresponding_institution_ids":["https://openalex.org/I165916956"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.487,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.50782828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"62","issue":"15","first_page":"2244","last_page":"2251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tip-links","display_name":"tip links","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cdh23","display_name":"CDH23","score":0.921999990940094},{"id":"https://openalex.org/keywords/pcdh15","display_name":"PCDH15","score":1.0},{"id":"https://openalex.org/keywords/hair-cells","display_name":"hair cells","score":0.6159999966621399},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.968999981880188},{"id":"https://openalex.org/keywords/lipid-vesicles","display_name":"lipid vesicles","score":0.753000020980835},{"id":"https://openalex.org/keywords/protein-aggregation-kinetics","display_name":"protein aggregation kinetics","score":0.6389999985694885},{"id":"https://openalex.org/keywords/hearing","display_name":"hearing","score":0.31700000166893005},{"id":"https://openalex.org/keywords/balance","display_name":"balance","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.839458703994751},{"id":"https://openalex.org/C163911330","wikidata":"https://www.wikidata.org/wiki/Q7251899","display_name":"Protocadherin","level":4,"score":0.8269855380058289},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.6704496145248413},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.5779469609260559},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5665197968482971},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48542627692222595},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.44780197739601135},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.4443408250808716},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.40777990221977234},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3238431215286255},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2047404944896698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18869364261627197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18586090207099915},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.12257009744644165},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000091363","descriptor_name":"Protocadherins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.biochem.3c00161","doi":"https://doi.org/10.1021/acs.biochem.3c00161","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.3c00161","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"doi:10.1101/2022.08.19.504503","doi":"https://doi.org/10.1101/2022.08.19.504503","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.19.504503","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/20/2022.08.19.504503.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37399091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37399091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2022.08.19.504503","doi":"https://doi.org/10.1101/2022.08.19.504503","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.08.19.504503","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/08/20/2022.08.19.504503.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6390250565","display_name":null,"funder_award_id":"CRG/2020/003431","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G8045444169","display_name":"Deciphering The Mechano-Responsive Behavior Of Cadherins In Hearing","funder_award_id":"IA/I/15/1/501817","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"},{"id":"https://openalex.org/G8773295541","display_name":null,"funder_award_id":"IA/I/15/1/501817","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"},{"id":"https://openalex.org/F4320327182","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"},{"id":"https://openalex.org/F4320335065","display_name":"National Centre for Biological Sciences","ror":"https://ror.org/03gf8rp76"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382989005.pdf","grobid_xml":"https://content.openalex.org/works/W4382989005.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1514414732","https://openalex.org/W1580313606","https://openalex.org/W1967448179","https://openalex.org/W2021285999","https://openalex.org/W2038000805","https://openalex.org/W2042004725","https://openalex.org/W2047841553","https://openalex.org/W2070310244","https://openalex.org/W2084921526","https://openalex.org/W2092597147","https://openalex.org/W2099014270","https://openalex.org/W2122077421","https://openalex.org/W2128055507","https://openalex.org/W2143842176","https://openalex.org/W2163356019","https://openalex.org/W2288271511","https://openalex.org/W2468475393","https://openalex.org/W2622876719","https://openalex.org/W2628954376","https://openalex.org/W2747618704","https://openalex.org/W2803345086","https://openalex.org/W2883277820","https://openalex.org/W2884346337","https://openalex.org/W2885305701","https://openalex.org/W2899484091","https://openalex.org/W2912492964","https://openalex.org/W2921772310","https://openalex.org/W2986034268","https://openalex.org/W3048271700","https://openalex.org/W3088401141","https://openalex.org/W3111700642","https://openalex.org/W3125247928","https://openalex.org/W4200265960","https://openalex.org/W4291287707","https://openalex.org/W4327814616"],"related_works":["https://openalex.org/W1975397823","https://openalex.org/W2048635513","https://openalex.org/W2061227806","https://openalex.org/W4389023704","https://openalex.org/W2747618704","https://openalex.org/W4254551096","https://openalex.org/W2346954084","https://openalex.org/W7099591419","https://openalex.org/W2787792243","https://openalex.org/W7119362122"],"abstract_inverted_index":{"Tip":[0],"links":[1,23,82,129,151],"are":[2,83,130],"seen":[3],"under":[4],"microscopes":[5],"as":[6],"double-helical":[7,37],"tetrameric":[8],"complexes":[9],"of":[10,35,47,55,63,76,102,127,149],"long":[11],"nonclassical":[12],"cadherins,":[13],"cadherin-23":[14,48,56,77,140,159],"and":[15,29,68,72,87,123,139],"protocadherin-15.":[16],"The":[17],"twisted":[18],"filamentous":[19],"structure":[20],"enables":[21],"tip":[22,81,103,128,150,163],"to":[24],"regulate":[25],"mechanotransduction":[26],"in":[27,66,89],"hearing":[28],"balance.":[30],"While":[31],"the":[32,36,112,146],"molecular":[33],"details":[34],"protocadherin-15":[38,136,155],"cis":[39,57,78,100,117,137,156],"dimers":[40,101,118,138],"have":[41],"been":[42],"deciphered,":[43],"a":[44,53],"similar":[45],"conformation":[46],"is":[49,152],"still":[50],"elusive.":[51],"In":[52],"search":[54],"dimers,":[58,157],"we":[59,94,143],"performed":[60],"photoinduced":[61],"cross-linking":[62],"unmodified":[64],"proteins":[65],"solution":[67],"on":[69],"lipid":[70,92],"membranes":[71],"observed":[73],"no":[74],"trace":[75],"dimers.":[79],"Reportedly,":[80],"dynamic":[84],"connections,":[85],"assembling":[86],"disassembling":[88],"seconds.":[90],"Using":[91],"vesicles,":[93],"measured":[95],"significantly":[96],"slower":[97],"aggregations":[98],"between":[99,115,135],"link":[104],"cadherins":[105],"than":[106],"via":[107],"dimer\u2013monomer":[108],"interactions,":[109],"indicating":[110],"that":[111,145],"trans":[113],"interactions":[114],"two":[116],"may":[119],"possess":[120],"steric":[121],"restraints":[122],"defer":[124],"reassociations.":[125],"Reconnections":[126],"thus":[131],"kinetically":[132],"most":[133],"desired":[134],"monomers.":[141],"Here":[142],"propose":[144],"helical":[147],"geometry":[148],"induced":[153],"by":[154],"while":[158],"remains":[160],"single":[161],"before":[162],"linking.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-07-04T00:00:00"}