{"id":"https://openalex.org/W4382987504","doi":"https://doi.org/10.1186/s12916-023-02903-w","title":"Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study","display_name":"Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study","publication_year":2023,"publication_date":"2023-07-03","ids":{"openalex":"https://openalex.org/W4382987504","doi":"https://doi.org/10.1186/s12916-023-02903-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/37400795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10318778"},"language":"en","primary_location":{"id":"doi:10.1186/s12916-023-02903-w","doi":"https://doi.org/10.1186/s12916-023-02903-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-023-02903-w","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-023-02903-w","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-023-02903-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069167620","display_name":"Guoyi Yang","orcid":"https://orcid.org/0000-0002-4387-386X","observed_orcids":["https://orcid.org/0000-0002-4387-386X"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Guoyi Yang","raw_affiliation_strings":["School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. yanggy@connect.hku.hk","School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-4387-386X","affiliations":[{"raw_affiliation_string":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. yanggy@connect.hku.hk","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020377532","display_name":"Catherine Mary Schooling","orcid":"https://orcid.org/0000-0001-9933-5887","observed_orcids":["https://orcid.org/0000-0001-9933-5887","https://orcid.org/0000-0001-5394-5399"]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","US"],"is_corresponding":false,"raw_author_name":"C. Mary Schooling","raw_affiliation_strings":["Graduate School of Public Health and Health Policy, City University of New York, New York, USA","School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Public Health and Health Policy, City University of New York, New York, USA","institution_ids":["https://openalex.org/I174216632"]},{"raw_affiliation_string":"School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069167620"],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":3.3491,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.93739286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"235","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.33399999141693115,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asgr1","display_name":"ASGR1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8059999942779541},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7490000128746033},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8880000114440918},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9559999704360962},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.699999988079071},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8679999709129333},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6000000238418579},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.8230000138282776},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.609000027179718},{"id":"https://openalex.org/keywords/drug-target-mendelian-randomization","display_name":"drug-target Mendelian randomization","score":0.6470000147819519},{"id":"https://openalex.org/keywords/phenome-wide-association-study","display_name":"phenome-wide association study","score":0.8420000076293945},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7984763383865356},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.7780002355575562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5471930503845215},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38472500443458557},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38294270634651184},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21269431710243225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18988963961601257},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1317000389099121},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002769","descriptor_name":"Cholelithiasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037263","descriptor_name":"Asialoglycoprotein Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12916-023-02903-w","doi":"https://doi.org/10.1186/s12916-023-02903-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-023-02903-w","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-023-02903-w","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10318778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10318778","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10318778/pdf/12916_2023_Article_2903.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med","raw_type":"Text"},{"id":"pmid:37400795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37400795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5f4f335ae50548e9985bde4d1e4655ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5f4f335ae50548e9985bde4d1e4655ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medicine, Vol 21, Iss 1, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12916-023-02903-w","doi":"https://doi.org/10.1186/s12916-023-02903-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-023-02903-w","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-023-02903-w","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382987504.pdf","grobid_xml":"https://content.openalex.org/works/W4382987504.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1596038729","https://openalex.org/W1905058580","https://openalex.org/W1965389059","https://openalex.org/W1972696558","https://openalex.org/W1983943582","https://openalex.org/W1995000907","https://openalex.org/W2065146037","https://openalex.org/W2073836327","https://openalex.org/W2089003251","https://openalex.org/W2094214280","https://openalex.org/W2097510503","https://openalex.org/W2108038333","https://openalex.org/W2110065044","https://openalex.org/W2175128997","https://openalex.org/W2238851414","https://openalex.org/W2310542696","https://openalex.org/W2404380044","https://openalex.org/W2481252033","https://openalex.org/W2508534964","https://openalex.org/W2517028648","https://openalex.org/W2550031966","https://openalex.org/W2565422852","https://openalex.org/W2589064416","https://openalex.org/W2614566443","https://openalex.org/W2750901335","https://openalex.org/W2763871199","https://openalex.org/W2786098141","https://openalex.org/W2808548053","https://openalex.org/W2895486342","https://openalex.org/W2910645688","https://openalex.org/W2921209497","https://openalex.org/W2946187515","https://openalex.org/W2969859411","https://openalex.org/W2996918050","https://openalex.org/W3012157230","https://openalex.org/W3012570809","https://openalex.org/W3012758303","https://openalex.org/W3016489931","https://openalex.org/W3035607564","https://openalex.org/W3038164454","https://openalex.org/W3080355783","https://openalex.org/W3082575318","https://openalex.org/W3121173001","https://openalex.org/W3122256196","https://openalex.org/W3160134203","https://openalex.org/W3164845562","https://openalex.org/W3176823452","https://openalex.org/W3198540846","https://openalex.org/W3202209876","https://openalex.org/W3205287818","https://openalex.org/W3205644245","https://openalex.org/W3213204823","https://openalex.org/W3214653312","https://openalex.org/W4224230462","https://openalex.org/W4224299153","https://openalex.org/W4282838906","https://openalex.org/W4282841534","https://openalex.org/W4283212560","https://openalex.org/W4289638327","https://openalex.org/W4289951974","https://openalex.org/W4296325222","https://openalex.org/W4308771635"],"related_works":["https://openalex.org/W6920545698","https://openalex.org/W7113181163","https://openalex.org/W4387965212","https://openalex.org/W4387138061","https://openalex.org/W4413102506","https://openalex.org/W4404861030","https://openalex.org/W4392504668","https://openalex.org/W2888235673","https://openalex.org/W4293585246","https://openalex.org/W4389621497"],"abstract_inverted_index":{"BACKGROUND:":[0],"Asialoglycoprotein":[1],"receptor":[2],"1":[3,172],"(ASGR1)":[4],"is":[5],"emerging":[6],"as":[7],"a":[8,41,59,83,122],"potential":[9],"drug":[10],"target":[11],"to":[12,46,63,91,137,222],"reduce":[13],"low-density":[14],"lipoprotein":[15],"(LDL)-cholesterol":[16],"and":[17,33,57,67,76,110,152,174,184,203,216,242,254,281,286],"coronary":[18],"artery":[19],"disease":[20],"(CAD)":[21],"risk.":[22,154],"Here,":[23],"we":[24],"investigated":[25],"genetically":[26,48,271],"mimicked":[27,49,116,140,156,187,263,272],"ASGR1":[28,52,117,141,157,188,208,223,264,273],"inhibitors":[29,53,118,142,158,189,209,265,274],"on":[30,54],"all-cause":[31,55,267],"mortality":[32,56],"any":[34,93],"possible":[35,68],"adverse":[36,69],"effects.":[37,95],"METHODS:":[38],"We":[39,80],"conducted":[40],"drug-target":[42],"Mendelian":[43],"randomization":[44],"study":[45,86],"assess":[47],"effects":[50,219],"of":[51,87,234],"25":[58],"priori":[60],"outcomes":[61],"relevant":[62],"lipid":[64,105,214],"traits,":[65,168,279],"CAD,":[66],"effects,":[70],"i.e.":[71],"liver":[72,276],"function,":[73],"cholelithiasis,":[74,194],"adiposity":[75,195],"type":[77,197],"2":[78,198],"diabetes.":[79,199],"also":[81],"performed":[82],"phenome-wide":[84],"association":[85],"1951":[88],"health-related":[89],"phenotypes":[90],"identify":[92],"novel":[94],"Associations":[96,200],"found":[97],"were":[98,119,143,159,179,190,205,220,229,238,248],"compared":[99,210],"with":[100,121,146,162,182,193,201,211],"those":[101],"for":[102,207,227,232,240,244],"currently":[103,212],"used":[104,213],"modifiers,":[106,215],"assessed":[107],"using":[108,250],"colocalization,":[109],"replicated":[111,249],"where":[112],"possible.":[113],"RESULTS:":[114],"Genetically":[115,139,155,186,262],"associated":[120,145,161,181,192],"longer":[123],"lifespan":[124,241],"(3.31":[125],"years":[126],"per":[127],"standard":[128],"deviation":[129],"reduction":[130],"in":[131],"LDL-cholesterol,":[132],"95%":[133],"confidence":[134],"interval":[135],"1.01":[136],"5.62).":[138],"inversely":[144,180],"apolipoprotein":[147],"B":[148],"(apoB),":[149],"triglycerides":[150],"(TG)":[151],"CAD":[153],"positively":[160],"alkaline":[163],"phosphatase,":[164],"gamma":[165],"glutamyltransferase,":[166],"erythrocyte":[167,278],"insulin-like":[169],"growth":[170],"factor":[171],"(IGF-1)":[173],"C-reactive":[175],"protein":[176],"(CRP),":[177],"but":[178,237,283],"albumin":[183,285],"calcium.":[185,287],"not":[191],"or":[196],"apoB":[202],"TG":[204],"stronger":[206],"most":[217,233],"non-lipid":[218],"specific":[221],"inhibitors.":[224],"The":[225],"probabilities":[226],"colocalization":[228],">":[230],"0.80":[231],"these":[235],"associations,":[236],"0.42":[239],"0.30":[243],"CAD.":[245],"These":[246],"associations":[247],"alternative":[251],"genetic":[252,258],"instruments":[253],"other":[255],"publicly":[256],"available":[257],"summary":[259],"statistics.":[260],"CONCLUSIONS:":[261],"reduced":[266],"mortality.":[268],"Beyond":[269],"lipid-lowering,":[270],"increased":[275],"enzymes,":[277],"IGF-1":[280],"CRP,":[282],"decreased":[284]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-04T00:00:00"}