{"id":"https://openalex.org/W4382940591","doi":"https://doi.org/10.1016/j.ejcskn.2023.100003","title":"Neoadjuvant ipilimumab plus nivolumab in locally advanced melanoma: A real-world single-centre retrospective study","display_name":"Neoadjuvant ipilimumab plus nivolumab in locally advanced melanoma: A real-world single-centre retrospective study","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4382940591","doi":"https://doi.org/10.1016/j.ejcskn.2023.100003"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejcskn.2023.100003","doi":"https://doi.org/10.1016/j.ejcskn.2023.100003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcskn.2023.100003","pdf_url":"http://www.ejcskn.com/article/S2772611823000034/pdf","source":{"id":"https://openalex.org/S4387288999","display_name":"EJC Skin Cancer","issn_l":"2772-6118","issn":["2772-6118"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJC Skin Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ejcskn.com/article/S2772611823000034/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079528427","display_name":"Patrick Schummer","orcid":"https://orcid.org/0000-0001-9836-0933","observed_orcids":["https://orcid.org/0000-0001-9836-0933"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Patrick Schummer","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9836-0933","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078932407","display_name":"Valerie Glutsch","orcid":"https://orcid.org/0000-0001-9291-1327","observed_orcids":["https://orcid.org/0000-0001-9291-1327"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Valerie Glutsch","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023563304","display_name":"Lukas Haug","orcid":"https://orcid.org/0009-0008-8714-327X","observed_orcids":["https://orcid.org/0009-0008-8714-327X"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lukas Haug","raw_affiliation_strings":["Institute of Pathology, Julius-Maximilians-University, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Julius-Maximilians-University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082290482","display_name":"Mathias Tillmann Rosenfeldt","orcid":"https://orcid.org/0000-0001-7650-8458","observed_orcids":["https://orcid.org/0000-0001-7650-8458"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mathias Rosenfeldt","raw_affiliation_strings":["Institute of Pathology, Julius-Maximilians-University, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7650-8458","affiliations":[{"raw_affiliation_string":"Institute of Pathology, Julius-Maximilians-University, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019352973","display_name":"Johan Friso Lock","orcid":"https://orcid.org/0000-0002-9007-3937","observed_orcids":["https://orcid.org/0000-0002-9007-3937"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johann Lock","raw_affiliation_strings":["Department of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081475725","display_name":"Michael Meir","orcid":"https://orcid.org/0000-0002-4172-1176","observed_orcids":["https://orcid.org/0000-0002-4172-1176"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Meir","raw_affiliation_strings":["Department of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4172-1176","affiliations":[{"raw_affiliation_string":"Department of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083574042","display_name":"Agmal Scherzad","orcid":"https://orcid.org/0000-0003-3396-5995","observed_orcids":["https://orcid.org/0000-0003-3396-5995"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Agmal Scherzad","raw_affiliation_strings":["Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083890104","display_name":"Detlef Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Detlef Klein","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076078511","display_name":"Matthias Goebeler","orcid":"https://orcid.org/0000-0001-7095-9848","observed_orcids":["https://orcid.org/0000-0001-7095-9848"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Goebeler","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7095-9848","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019977537","display_name":"Hermann Kneitz","orcid":"https://orcid.org/0000-0002-9138-4550","observed_orcids":["https://orcid.org/0000-0002-9138-4550"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hermann Kneitz","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008750058","display_name":"Bastian Schilling","orcid":"https://orcid.org/0000-0001-8859-4103","observed_orcids":["https://orcid.org/0000-0001-8859-4103"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bastian Schilling","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8859-4103","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017486762","display_name":"Anja Gesierich","orcid":"https://orcid.org/0009-0003-7129-3699","observed_orcids":["https://orcid.org/0009-0003-7129-3699"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anja Gesierich","raw_affiliation_strings":["Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008750058","https://openalex.org/A5017486762","https://openalex.org/A5019352973","https://openalex.org/A5019977537","https://openalex.org/A5023563304","https://openalex.org/A5076078511","https://openalex.org/A5078932407","https://openalex.org/A5079528427","https://openalex.org/A5081475725","https://openalex.org/A5082290482","https://openalex.org/A5083574042","https://openalex.org/A5083890104"],"corresponding_institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":1.519,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83818412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"1","issue":null,"first_page":"100003","last_page":"100003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.4821999967098236,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/locally-advanced-melanoma","display_name":"locally advanced melanoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/stage-iii-melanoma","display_name":"stage III melanoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/nodal-metastases","display_name":"nodal metastases","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pathological-response","display_name":"pathological response","score":0.7300000190734863},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.9390000104904175},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9599999785423279},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.4560000002384186},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.9638940095901489},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.9336901903152466},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8920024633407593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6659969687461853},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.643865704536438},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.596723735332489},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5003988742828369},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.44032564759254456},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41854792833328247},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.41599202156066895},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3349398970603943},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2345103621482849},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16173702478408813},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.05895543098449707}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejcskn.2023.100003","doi":"https://doi.org/10.1016/j.ejcskn.2023.100003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcskn.2023.100003","pdf_url":"http://www.ejcskn.com/article/S2772611823000034/pdf","source":{"id":"https://openalex.org/S4387288999","display_name":"EJC Skin Cancer","issn_l":"2772-6118","issn":["2772-6118"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJC Skin Cancer","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2437080e875a497a91a012672d5efdd1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2437080e875a497a91a012672d5efdd1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EJC Skin Cancer, Vol 1, Iss , Pp 100003- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ejcskn.2023.100003","doi":"https://doi.org/10.1016/j.ejcskn.2023.100003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcskn.2023.100003","pdf_url":"http://www.ejcskn.com/article/S2772611823000034/pdf","source":{"id":"https://openalex.org/S4387288999","display_name":"EJC Skin Cancer","issn_l":"2772-6118","issn":["2772-6118"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJC Skin Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382940591.pdf","grobid_xml":"https://content.openalex.org/works/W4382940591.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2019607817","https://openalex.org/W2346188454","https://openalex.org/W2762347490","https://openalex.org/W2783914781","https://openalex.org/W2810879984","https://openalex.org/W2947338182","https://openalex.org/W2947765148","https://openalex.org/W2974506773","https://openalex.org/W2991047437","https://openalex.org/W3082456432","https://openalex.org/W3087697977","https://openalex.org/W3126577181","https://openalex.org/W3127822472","https://openalex.org/W3138702983","https://openalex.org/W3153228158","https://openalex.org/W4205327275","https://openalex.org/W4281783912","https://openalex.org/W4295836994","https://openalex.org/W4317378119","https://openalex.org/W4322718735"],"related_works":["https://openalex.org/W7170175571","https://openalex.org/W4408499561","https://openalex.org/W4412399286","https://openalex.org/W7163691813","https://openalex.org/W2891804073","https://openalex.org/W2894796660","https://openalex.org/W7166060326","https://openalex.org/W3088064920","https://openalex.org/W4237115020","https://openalex.org/W4410494026"],"abstract_inverted_index":{"Background":[0],"Neoadjuvant":[1],"immune-checkpoint":[2],"inhibition":[3],"(neoICI)":[4],"with":[5,44,48,57,117,201,231],"ipilimumab":[6,58,202],"and":[7,29,60,64,88,97,136,150,166,204],"nivolumab":[8,61,205],"has":[9],"shown":[10],"high":[11,208],"pathologic":[12,107],"response":[13,66,108,209],"rates":[14,152,210],"as":[15,17,67,69,186,211,213],"well":[16,68,212,224],"a":[18,103,121,126,143,219,241],"long-lasting":[19],"relapse-free":[20,70,216],"survival":[21,71,74,77,80],"in":[22,111,192,226,240],"stage":[23],"III":[24],"melanoma":[25,42],"patients.":[26,196],"However,":[27],"safety":[28],"efficacy":[30],"data":[31],"from":[32],"real-world":[33,228],"patients":[34,43,101],"is":[35],"very":[36],"limited.":[37],"Methods":[38],"Stage":[39],"IIIB-IV":[40],"(M1a)":[41],"macroscopic":[45],"nodal":[46],"metastases":[47],"or":[49],"without":[50],"synchronous":[51],"non-nodal":[52],"lesions":[53],"received":[54,102],"combined":[55,104,199],"neoICI":[56,87,200,222,239],"1mg/kg":[59,203],"3mg/kg.":[62],"Radiological":[63],"pathological":[65,122],"(RFS),":[72],"event-free":[73],"(EFS),":[75],"overall":[76],"(OS),":[78],"melanoma-specific":[79],"(MSS),":[81],"adverse":[82],"events":[83],"(AE)":[84],"related":[85],"to":[86],"subsequent":[89],"therapies":[90],"were":[91,153,184],"analysed.":[92],"Results":[93],"Between":[94],"November":[95],"2018":[96],"October":[98],"2021,":[99],"23":[100],"neoICI.":[105],"A":[106],"was":[109,223],"achieved":[110],"65%":[112],"(15/23)":[113],"of":[114,129,180,195,238],"the":[115,146],"patients,":[116],"43%":[118],"(10/23)":[119],"achieving":[120],"complete":[123],"response.":[124],"At":[125,142],"median":[127,132],"follow-up":[128],"22.8":[130],"months,":[131],"RFS,":[133,147],"EFS,":[134,148],"OS":[135,149],"MSS":[137,151],"have":[138],"not":[139],"been":[140],"reached.":[141],"3-year":[144],"landmark,":[145],"77.6%":[154],"(95%":[155,159,163,168],"CI":[156,160,164,169],"60.1-100),":[157],"61.8%":[158],"43.8-87.1),":[161],"62.0%":[162],"42.2-91.0)":[165],"76.7%":[167],"55.7-100),":[170],"respectively.":[171],"Regarding":[172],"AE,":[173],"70%":[174],"(16/23)":[175],"had":[176],"immune-related":[177],"AE":[178],"(irAEs)":[179],"any":[181],"grade":[182,189],"which":[183],"classified":[185],"severe":[187],"(\u2265":[188],"3)":[190],"irAEs":[191,235],"13%":[193],"(3/23)":[194],"Conclusion":[197],"The":[198],"3mg/kg":[206],"showed":[207],"long":[214],"lasting":[215],"survival.":[217],"Besides":[218],"promising":[220],"efficacy,":[221],"tolerated":[225],"our":[227],"patient":[229],"cohort":[230],"only":[232],"few":[233],"high-grade":[234],"indicating":[236],"feasibility":[237],"non-trial":[242],"setting.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-07-04T00:00:00"}