{"id":"https://openalex.org/W4382934825","doi":"https://doi.org/10.1016/j.mtbio.2023.100722","title":"Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer","display_name":"Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer","publication_year":2023,"publication_date":"2023-07-03","ids":{"openalex":"https://openalex.org/W4382934825","doi":"https://doi.org/10.1016/j.mtbio.2023.100722","pmid":"https://pubmed.ncbi.nlm.nih.gov/37545562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10401344"},"language":"en","primary_location":{"id":"doi:10.1016/j.mtbio.2023.100722","doi":"https://doi.org/10.1016/j.mtbio.2023.100722","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2023.100722","pdf_url":null,"source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.mtbio.2023.100722","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101649537","display_name":"Peilian Liu","orcid":"https://orcid.org/0000-0002-9167-278X","observed_orcids":["https://orcid.org/0000-0002-9167-278X"]},"institutions":[{"id":"https://openalex.org/I154833797","display_name":"Lingnan Normal University","ror":"https://ror.org/01h6ecw13","country_code":"CN","type":"education","lineage":["https://openalex.org/I154833797"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peilian Liu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China","School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China","institution_ids":["https://openalex.org/I154833797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013307481","display_name":"Yong Xiang Huang","orcid":"https://orcid.org/0000-0003-4270-9555","observed_orcids":["https://orcid.org/0000-0003-4270-9555"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Huang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102530697","display_name":"Chenyue Zhan","orcid":"https://orcid.org/0009-0006-1180-7821","observed_orcids":["https://orcid.org/0009-0006-1180-7821"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenyue Zhan","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460007","display_name":"Fu Zhang","orcid":"https://orcid.org/0000-0002-3546-5508","observed_orcids":["https://orcid.org/0000-0002-3546-5508","https://orcid.org/0000-0001-6419-0606"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fu Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111002641","display_name":"Chuansen Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154833797","display_name":"Lingnan Normal University","ror":"https://ror.org/01h6ecw13","country_code":"CN","type":"education","lineage":["https://openalex.org/I154833797"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuansen Deng","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China","institution_ids":["https://openalex.org/I154833797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102430046","display_name":"Yongmei Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154833797","display_name":"Lingnan Normal University","ror":"https://ror.org/01h6ecw13","country_code":"CN","type":"education","lineage":["https://openalex.org/I154833797"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongmei Jia","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China","institution_ids":["https://openalex.org/I154833797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067959426","display_name":"Tao Yu Wan","orcid":"https://orcid.org/0000-0002-8299-8921","observed_orcids":["https://orcid.org/0000-0002-8299-8921"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Wan","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101644514","display_name":"Sheng Wang","orcid":"https://orcid.org/0000-0003-3834-0660","observed_orcids":["https://orcid.org/0000-0003-3834-0660"]},"institutions":[{"id":"https://openalex.org/I154833797","display_name":"Lingnan Normal University","ror":"https://ror.org/01h6ecw13","country_code":"CN","type":"education","lineage":["https://openalex.org/I154833797"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sheng Wang","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China","institution_ids":["https://openalex.org/I154833797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100387298","display_name":"Bowen Li","orcid":"https://orcid.org/0000-0003-1550-4087","observed_orcids":["https://orcid.org/0000-0003-1550-4087"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","SG"],"is_corresponding":true,"raw_author_name":"Bowen Li","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China","Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-1550-4087","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100387298","https://openalex.org/A5101644514","https://openalex.org/A5102530697"],"corresponding_institution_ids":["https://openalex.org/I154833797","https://openalex.org/I165932596","https://openalex.org/I4210166576","https://openalex.org/I76130692"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":{"value":3150,"currency":"USD","value_usd":3150},"fwci":2.0875,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86858895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":null,"first_page":"100722","last_page":"100722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.46140000224113464,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nano-prodrug","display_name":"nanoprodrug","score":0.9100000262260437},{"id":"https://openalex.org/keywords/amphiphilic-self-assembly","display_name":"amphiphile self-assembly","score":0.9319999814033508},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.8820000290870667},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/indocyanine-green","display_name":"indocyanine green","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase-1","display_name":"NAD(P)H:quinone oxidoreductase 1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.9730484485626221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5295820236206055},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.49345746636390686},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4517386555671692},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44072994589805603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2771366238594055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13932165503501892},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11470577120780945},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.mtbio.2023.100722","doi":"https://doi.org/10.1016/j.mtbio.2023.100722","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2023.100722","pdf_url":null,"source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10401344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10401344","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10401344/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mater Today Bio","raw_type":"Text"},{"id":"pmid:37545562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37545562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials today. Bio","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ac5d9a76aa8345b1b66518cdf6681eef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ac5d9a76aa8345b1b66518cdf6681eef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Materials Today Bio, Vol 21, Iss , Pp 100722- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.mtbio.2023.100722","doi":"https://doi.org/10.1016/j.mtbio.2023.100722","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2023.100722","pdf_url":null,"source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2135124070","display_name":null,"funder_award_id":"32101124","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G291120111","display_name":null,"funder_award_id":"2021A1515010203","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7500699727","display_name":null,"funder_award_id":"32101063","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G785577107","display_name":null,"funder_award_id":"21878136","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8101909728","display_name":null,"funder_award_id":"32000992","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8500066733","display_name":null,"funder_award_id":"2022A1515011311","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G8553747003","display_name":null,"funder_award_id":"2021M702832","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320328731","display_name":"Lingnan Normal University","ror":"https://ror.org/01h6ecw13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382934825.pdf","grobid_xml":"https://content.openalex.org/works/W4382934825.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W399773961","https://openalex.org/W1891726280","https://openalex.org/W1997346441","https://openalex.org/W2021358479","https://openalex.org/W2024382973","https://openalex.org/W2045898351","https://openalex.org/W2115063003","https://openalex.org/W2214762685","https://openalex.org/W2268162105","https://openalex.org/W2282989227","https://openalex.org/W2554773181","https://openalex.org/W2610726328","https://openalex.org/W2761614994","https://openalex.org/W2768787438","https://openalex.org/W2770356122","https://openalex.org/W2772715504","https://openalex.org/W2804627070","https://openalex.org/W2898566330","https://openalex.org/W2907901432","https://openalex.org/W2907905968","https://openalex.org/W2916429698","https://openalex.org/W2917169363","https://openalex.org/W2962737634","https://openalex.org/W2962843582","https://openalex.org/W2999260798","https://openalex.org/W3011223867","https://openalex.org/W3011483887","https://openalex.org/W3031534691","https://openalex.org/W3035863374","https://openalex.org/W3087167818","https://openalex.org/W3088547513","https://openalex.org/W3089929987","https://openalex.org/W3096705092","https://openalex.org/W3096886301","https://openalex.org/W3109877706","https://openalex.org/W3125711003","https://openalex.org/W3156362806","https://openalex.org/W3158001029","https://openalex.org/W3193729404","https://openalex.org/W3212753789","https://openalex.org/W4210291515","https://openalex.org/W4213125851","https://openalex.org/W4214510107","https://openalex.org/W4225090126","https://openalex.org/W4281293112","https://openalex.org/W4284708685","https://openalex.org/W4284970245","https://openalex.org/W4290644178","https://openalex.org/W4296025208","https://openalex.org/W4311118596","https://openalex.org/W4313530498","https://openalex.org/W4315864198","https://openalex.org/W4317492689","https://openalex.org/W6848610867"],"related_works":["https://openalex.org/W4200176616","https://openalex.org/W4395956964","https://openalex.org/W4296025208","https://openalex.org/W4321788862","https://openalex.org/W2023096851","https://openalex.org/W3019363957","https://openalex.org/W4406632767","https://openalex.org/W2879212700","https://openalex.org/W4364370082","https://openalex.org/W4380488607"],"abstract_inverted_index":{"Rational":[0],"design":[1,199],"of":[2,47,58,75,141,182,200],"self-assembly":[3,73,90],"drug":[4,16,20,63,146,152],"amphiphiles":[5,68],"can":[6,35,92],"provide":[7,193],"a":[8,29,71,82,99,119,162],"promising":[9],"strategy":[10],"for":[11,40,205],"constructing":[12],"nano-prodrug":[13,39,142,164,204],"with":[14,107],"high":[15,23,120,179],"loading,":[17],"smart":[18],"stimuli-responsive":[19],"release":[21],"and":[22,49,78,84,135,143,157,185],"tumor":[24,155,183],"selectivity.":[25],"Herein,":[26],"we":[27],"report":[28],"small":[30],"molecular":[31],"amphiphile":[32],"prodrug":[33,77,117],"that":[34,69],"self-assemble":[36],"into":[37,61,81,196],"multifunctional":[38,100],"enhanced":[41],"anticancer":[42],"effect":[43,106],"by":[44,169],"the":[45,55,76,104,110,116,123,139,151,159,174,197],"combination":[46],"chemotherapy":[48],"phototherapy":[50,94],"(PDT/PTT).":[51],"In":[52],"this":[53,88,136],"prodrug,":[54],"simple":[56],"insertion":[57],"quinone":[59,111],"propionate":[60],"hydrophilic":[62],"Irinotecan":[64],"(Ir)":[65],"generates":[66],"suitable":[67],"endow":[70],"good":[72],"behavior":[74,91],"transform":[79],"it":[80],"stable":[83],"uniform":[85],"nanoparticle.":[86],"Interestingly,":[87],"excellent":[89],"load":[93],"agent":[95],"ICG":[96],"to":[97,122],"form":[98],"nano-prodrug,":[101,176],"thereby":[102],"enhancing":[103],"chemotherapeutic":[105],"PDT/PTT.":[108],"Importantly,":[109],"propionic":[112],"acid":[113],"moiety":[114],"in":[115,128],"showed":[118],"sensitivity":[121,137],"overexpressed":[124],"NAD(P)H:quinone":[125],"oxidoreductase-1":[126],"(NQO1)":[127],"non-small":[129],"cell":[130],"lung":[131],"cancer":[132,206],"(NSCLC)":[133],"cells,":[134],"enables":[138],"disassembly":[140],"efficient":[144],"NQO1-responsive":[145],"release.":[147],"To":[148],"further":[149],"enhance":[150],"accumulation":[153],"on":[154,173,187],"tissue":[156],"migrate":[158],"blood":[160],"clearance,":[161],"biomimetic":[163],"has":[165],"been":[166],"successfully":[167],"explored":[168],"coating":[170],"hybrid":[171],"membrane":[172],"above":[175],"which":[177],"displays":[178],"selective":[180],"inhibition":[181],"growth":[184],"metastasis":[186],"NSCLC":[188],"mice":[189],"model.":[190],"Our":[191],"findings":[192],"new":[194],"insights":[195],"rational":[198],"tumor-overexpressed":[201],"enzyme":[202],"responsive":[203],"combinational":[207],"therapy.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-04T00:00:00"}