{"id":"https://openalex.org/W4382933801","doi":"https://doi.org/10.1101/2023.06.28.23292008","title":"AI-based analysis of the shunt treatment in pre- and post-surgery computed tomography brain scans of iNPH patients","display_name":"AI-based analysis of the shunt treatment in pre- and post-surgery computed tomography brain scans of iNPH patients","publication_year":2023,"publication_date":"2023-07-03","ids":{"openalex":"https://openalex.org/W4382933801","doi":"https://doi.org/10.1101/2023.06.28.23292008"},"language":"en","primary_location":{"id":"doi:10.1101/2023.06.28.23292008","doi":"https://doi.org/10.1101/2023.06.28.23292008","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.06.28.23292008","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/03/2023.06.28.23292008.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/03/2023.06.28.23292008.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066296139","display_name":"S. Shailja","orcid":"https://orcid.org/0000-0002-5056-9989","observed_orcids":["https://orcid.org/0000-0002-5056-9989"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. Shailja","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, Santa Barbara"],"raw_orcid":"https://orcid.org/0000-0002-5056-9989","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, Santa Barbara","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030553555","display_name":"Christopher Nguyen","orcid":"https://orcid.org/0000-0003-3347-1530","observed_orcids":["https://orcid.org/0000-0003-3347-1530"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210096636","display_name":"University of California, Irvine Medical Center","ror":"https://ror.org/00cm8nm15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096636","https://openalex.org/I4210137750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Nguyen","raw_affiliation_strings":["Department of Neurosurgery, University of California, Irvine Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-3347-1530","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Irvine Medical Center","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210096636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092384532","display_name":"Krithika Thanigaivelan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krithika Thanigaivelan","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, Santa Barbara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, Santa Barbara","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092384533","display_name":"Vikram Bhagavatula","orcid":"https://orcid.org/0000-0001-6116-1105","observed_orcids":["https://orcid.org/0000-0001-6116-1105"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Bhagavatula","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, Santa Barbara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, Santa Barbara","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068183578","display_name":"Jefferson W. Chen","orcid":"https://orcid.org/0000-0003-0624-6864","observed_orcids":["https://orcid.org/0000-0003-0624-6864"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210096636","display_name":"University of California, Irvine Medical Center","ror":"https://ror.org/00cm8nm15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096636","https://openalex.org/I4210137750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jefferson W. Chen","raw_affiliation_strings":["Department of Neurosurgery, University of California, Irvine Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-0624-6864","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Irvine Medical Center","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210096636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071938464","display_name":"Bangalore S Manjunath","orcid":"https://orcid.org/0000-0003-2804-3611","observed_orcids":["https://orcid.org/0000-0003-2804-3611"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. S. Manjunath","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of California, Santa Barbara"],"raw_orcid":"https://orcid.org/0000-0003-2804-3611","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, Santa Barbara","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066296139"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-normal-pressure-hydrocephalus","display_name":"idiopathic normal pressure hydrocephalus","score":1.0},{"id":"https://openalex.org/keywords/ventriculoperitoneal-shunt","display_name":"ventriculoperitoneal shunt","score":0.9620000123977661},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.5019999742507935},{"id":"https://openalex.org/keywords/shunt-patency","display_name":"shunt patency","score":0.6790000200271606},{"id":"https://openalex.org/keywords/brain-compliance","display_name":"brain compliance","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2780968331","wikidata":"https://www.wikidata.org/wiki/Q1890115","display_name":"Shunt (medical)","level":2,"score":0.7599998116493225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7366877794265747},{"id":"https://openalex.org/C2778134817","wikidata":"https://www.wikidata.org/wiki/Q193003","display_name":"Hydrocephalus","level":2,"score":0.548083484172821},{"id":"https://openalex.org/C3020038371","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular volume","level":4,"score":0.4211149215698242},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4112928509712219},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3415863811969757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32156631350517273},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.0},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2023.06.28.23292008","doi":"https://doi.org/10.1101/2023.06.28.23292008","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.06.28.23292008","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/03/2023.06.28.23292008.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2023.06.28.23292008","doi":"https://doi.org/10.1101/2023.06.28.23292008","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.06.28.23292008","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/03/2023.06.28.23292008.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G821890410","display_name":"SI2-SSI: LIMPID: Large-Scale IMage Processing Infrastructure Development","funder_award_id":"1664172","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332500","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382933801.pdf","grobid_xml":"https://content.openalex.org/works/W4382933801.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2003873323","https://openalex.org/W2131803961","https://openalex.org/W2136773811","https://openalex.org/W2305470624","https://openalex.org/W2786790223","https://openalex.org/W2967445385","https://openalex.org/W2993767100","https://openalex.org/W3000903946","https://openalex.org/W3034873006","https://openalex.org/W3091587967","https://openalex.org/W3109556460","https://openalex.org/W3122065698","https://openalex.org/W3199514989","https://openalex.org/W4205249103","https://openalex.org/W4206212079","https://openalex.org/W4220809821","https://openalex.org/W4225159036","https://openalex.org/W4372347022"],"related_works":["https://openalex.org/W4399391004","https://openalex.org/W7155198573","https://openalex.org/W7166765350","https://openalex.org/W7164850129","https://openalex.org/W7128483010","https://openalex.org/W4400291532","https://openalex.org/W4413523702","https://openalex.org/W2786790223","https://openalex.org/W2990211823","https://openalex.org/W2000010852"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"This":[2,174,322],"study":[3,283,287,301],"examines":[4],"whether":[5],"quantifiable":[6],"changes":[7,180,220],"can":[8],"be":[9,355],"detected":[10],"in":[11,14,35,160,181,201,210,221,242],"ventricular":[12,36,74,182,202,222,279],"volume":[13,37,75,183,203,223],"Idiopathic":[15],"Normal":[16],"Pressure":[17],"Hydrocephalus":[18],"(iNPH)":[19],"patients":[20,40],"that":[21,31],"undergo":[22],"ventriculo-peritoneal":[23],"shunt":[24,42,115,128,187,227,241,329],"procedures.":[25],"There":[26],"is":[27,91,248],"no":[28],"known":[29,250],"metric":[30,76,90,150,175,217,313],"characterizes":[32],"the":[33,69,94,125,144,168,171,193,292,297,326,332,344,358],"change":[34],"for":[38,81,189,229,238],"iNPH":[39,59,165,197,212,230,258,315,363],"after":[41,114,186,226],"placement.":[43],"Methods":[44],"Two":[45],"de-identified":[46],"and":[47,60,113,136,157,164,185,205,225,262,274,294,331,364],"independent":[48],"datasets":[49],"are":[50,65,121,139],"studied:":[51],"45":[52],"brain":[53,335],"CT":[54,109,272],"scans":[55,110,273],"(24":[56],"diagnosed":[57],"with":[58,103,141,196,245],"21":[61],"normal":[62,163],"elderly":[63],"individuals)":[64],"used":[66],"to":[67,93,123,143,178,342,357],"evaluate":[68],"effectiveness":[70],"of":[71,85,106,127,132,170,257,271,296,328,362],"our":[72,86],"proposed":[73,145,149],"as":[77,233],"a":[78,104,199,206,239,243,339],"diagnostic":[79],"tool":[80],"iNPH.":[82,246],"The":[83,255,309],"performance":[84,169,348],"deep":[87,311],"learning":[88],"model-based":[89],"compared":[92],"traditional":[95],"Evan\u2019s":[96,172],"Index":[97],"using":[98],"ROC":[99],"analysis.":[100],"16":[101,190],"subjects":[102,195],"total":[105],"50":[107],"longitudinal":[108],"taken":[111],"before":[112,184,224],"surgery":[116,188,228,330],"across":[117,349],"different":[118],"imaging":[119],"centers":[120],"studied":[122,140],"quantify":[124],"impact":[126],"treatment.":[129],"Clinical":[130],"symptoms":[131],"gait,":[133],"balance,":[134],"cognition,":[135],"bladder":[137],"continence":[138],"respect":[142],"metric.":[146],"Results":[147],"Our":[148,215,286],"achieves":[151],"high":[152],"accuracy":[153,317],"(0.95),":[154],"precision":[155],"(0.96),":[156],"recall":[158],"(0.96)":[159],"distinguishing":[161],"between":[162],"subjects,":[166],"surpassing":[167],"Index.":[173],"allows":[176],"us":[177],"track":[179],"subjects.":[191],"Notably,":[192],"15":[194],"demonstrate":[198],"decrease":[200],"post-surgery":[204],"concurrent":[207],"clinical":[208,261,360],"improvement":[209],"their":[211],"symptomatology.":[213],"Conclusion":[214],"novel":[216],"accurately":[218],"quantifies":[219],"patients,":[231],"serving":[232],"an":[234],"effective":[235],"radiographic":[236,263,320],"marker":[237],"functioning":[240],"patient":[244],"What":[247,281],"already":[249],"on":[251,268,334],"this":[252,282,300],"topic":[253],"\u2013":[254,285,308],"diagnosis":[256,316],"involves":[259],"both":[260],"stigmata.":[264],"Radiologists":[265],"rely":[266],"largely":[267],"visual":[269],"examination":[270],"provide":[275,338],"qualitative":[276],"evaluations":[277],"about":[278,291],"volume.":[280],"adds":[284],"provides":[288],"quantitative":[289],"information":[290],"patency":[293],"function":[295],"shunt.":[298],"How":[299],"might":[302],"affect":[303],"research,":[304],"practice,":[305],"or":[306],"policy":[307],"validated":[310],"learning-based":[312],"enhances":[314],"by":[318],"tracking":[319],"biomarkers.":[321],"facilitates":[323],"decision-making":[324],"regarding":[325],"efficacy":[327],"effect":[333],"compliance.":[336],"We":[337],"web":[340],"interface":[341],"apply":[343],"metric,":[345],"its":[346],"reliable":[347],"multiple":[350],"institutional":[351],"scanner":[352],"types":[353],"could":[354],"adapted":[356],"real-time":[359],"evaluation":[361],"improve":[365],"treatment":[366],"workflows.":[367]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-07-04T00:00:00"}