{"id":"https://openalex.org/W4382931433","doi":"https://doi.org/10.1101/2023.07.01.23292108","title":"Polymerized type I collagen down-regulates STAT-1 phosphorylation through engagement to LAIR-1 in M1-macrophages avoiding long COVID","display_name":"Polymerized type I collagen down-regulates STAT-1 phosphorylation through engagement to LAIR-1 in M1-macrophages avoiding long COVID","publication_year":2023,"publication_date":"2023-07-01","ids":{"openalex":"https://openalex.org/W4382931433","doi":"https://doi.org/10.1101/2023.07.01.23292108"},"language":"en","primary_location":{"id":"doi:10.1101/2023.07.01.23292108","doi":"https://doi.org/10.1101/2023.07.01.23292108","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.01.23292108","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/01/2023.07.01.23292108.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/01/2023.07.01.23292108.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031924696","display_name":"Elizabeth Olivares\u2010Mart\u00ednez","orcid":"https://orcid.org/0000-0002-9122-2607","observed_orcids":["https://orcid.org/0000-0002-9122-2607"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Elizabeth Olivares-Mart\u00ednez","raw_affiliation_strings":["Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-9122-2607","affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074655708","display_name":"Diego F. Hern\u00e1ndez\u2010Ram\u00edrez","orcid":"https://orcid.org/0000-0001-7293-2278","observed_orcids":["https://orcid.org/0000-0001-7293-2278"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Diego Francisco Hern\u00e1ndez-Ram\u00edrez","raw_affiliation_strings":["Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-7293-2278","affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026216929","display_name":"Carlos A. N\u00fa\u00f1ez\u2010\u00c1lvarez","orcid":"https://orcid.org/0000-0002-5051-0389","observed_orcids":["https://orcid.org/0000-0002-5051-0389"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Carlos Alberto N\u00fa\u00f1ez-\u00c1lvarez","raw_affiliation_strings":["Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-5051-0389","affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002951593","display_name":"M\u00f3nica Chapa Ibarg\u00fcengoitia","orcid":"https://orcid.org/0000-0001-7178-0073","observed_orcids":["https://orcid.org/0000-0001-7178-0073"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Chapa-Ibarguengoitia","raw_affiliation_strings":["Department of Radiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Radiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-7178-0073","affiliations":[{"raw_affiliation_string":"Department of Radiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Radiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042759475","display_name":"Silvia M\u00e9ndez\u2010Flores","orcid":"https://orcid.org/0000-0003-3312-5953","observed_orcids":["https://orcid.org/0000-0003-3312-5953"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Silvia M\u00e9ndez-Flores","raw_affiliation_strings":["Department of Dermatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Dermatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-3312-5953","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Dermatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073886542","display_name":"\u00c1ngel Alexis Priego-Ranero","orcid":"https://orcid.org/0000-0002-7801-6438","observed_orcids":["https://orcid.org/0000-0002-7801-6438"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"\u00c1ngel Priego- Ranero","raw_affiliation_strings":["Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-7801-6438","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077145580","display_name":"Daniel Azamar\u2010Llamas","orcid":"https://orcid.org/0000-0002-7833-2625","observed_orcids":["https://orcid.org/0000-0002-7833-2625"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Daniel Azamar-Llamas","raw_affiliation_strings":["Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-7833-2625","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054782373","display_name":"H\u00e9ctor Olvera\u2010Prado","orcid":"https://orcid.org/0000-0002-1230-0911","observed_orcids":["https://orcid.org/0000-0002-1230-0911"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"H\u00e9ctor Olvera-Prado","raw_affiliation_strings":["Department of Anesthesiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Anesthesiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-1230-0911","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Anesthesiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071986380","display_name":"Kenia Ilian Rivas\u2010Redonda","orcid":"https://orcid.org/0000-0003-3600-8971","observed_orcids":["https://orcid.org/0000-0003-3600-8971"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Kenia Ilian Rivas-Redonda","raw_affiliation_strings":["Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-3600-8971","affiliations":[{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027287190","display_name":"Eric Ochoa\u2010Hein","orcid":"https://orcid.org/0000-0002-9904-0998","observed_orcids":["https://orcid.org/0000-0002-9904-0998"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Eric Ochoa-Hein","raw_affiliation_strings":["Department of Hospital Epidemiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Hospital Epidemiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-9904-0998","affiliations":[{"raw_affiliation_string":"Department of Hospital Epidemiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Hospital Epidemiology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007307277","display_name":"Luis Gerardo L\u00f3pez-Mosqueda","orcid":"https://orcid.org/0000-0001-9971-5409","observed_orcids":["https://orcid.org/0000-0001-9971-5409"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Luis Gerardo L\u00f3pez-Mosqueda","raw_affiliation_strings":["Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-9971-5409","affiliations":[{"raw_affiliation_string":"Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002495910","display_name":"Estefano Rojas\u2010Casta\u00f1eda","orcid":"https://orcid.org/0000-0003-3236-8697","observed_orcids":["https://orcid.org/0000-0003-3236-8697"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Estefano Rojas-Casta\u00f1eda","raw_affiliation_strings":["Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-3236-8697","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Internal Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064936730","display_name":"Said Urbina\u2010Ter\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Said Urbina-Ter\u00e1n","raw_affiliation_strings":["Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005822997","display_name":"Luis Septi\u00e9n\u2010Stute","orcid":"https://orcid.org/0000-0003-0079-4210","observed_orcids":["https://orcid.org/0000-0003-0079-4210"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Luis Septi\u00e9n-Stute","raw_affiliation_strings":["Department of Pneumology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Pneumology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-0079-4210","affiliations":[{"raw_affiliation_string":"Department of Pneumology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Pneumology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089666473","display_name":"Thierry Hern\u00e1ndez\u2010Gilsoul","orcid":"https://orcid.org/0000-0002-9389-9945","observed_orcids":["https://orcid.org/0000-0002-9389-9945"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Thierry Hern\u00e1ndez-Gilsoul","raw_affiliation_strings":["Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-9389-9945","affiliations":[{"raw_affiliation_string":"Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Emergency Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003153202","display_name":"Diana Aguilar\u2010Le\u00f3n","orcid":"https://orcid.org/0000-0001-9667-0022","observed_orcids":["https://orcid.org/0000-0001-9667-0022"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Diana Aguilar-Le\u00f3n","raw_affiliation_strings":["Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","Mexico"],"raw_orcid":"https://orcid.org/0000-0001-9667-0022","affiliations":[{"raw_affiliation_string":"Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Department of Pathology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038748543","display_name":"Gonzalo Torres\u2010Villalobos","orcid":"https://orcid.org/0000-0002-0466-5857","observed_orcids":["https://orcid.org/0000-0002-0466-5857"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Gonzalo Torres-Villalobos","raw_affiliation_strings":["Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-0466-5857","affiliations":[{"raw_affiliation_string":"Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087039983","display_name":"Janette Furuzawa\u2010Carballeda","orcid":"https://orcid.org/0000-0001-5804-7221","observed_orcids":["https://orcid.org/0000-0001-5804-7221"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Janette Furuzawa-Carballeda","raw_affiliation_strings":["Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-5804-7221","affiliations":[{"raw_affiliation_string":"Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Departments of Experimental Surgery and Surgery, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038748543","https://openalex.org/A5087039983"],"corresponding_institution_ids":["https://openalex.org/I4210097900"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.36719998717308044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.36719998717308044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.1598999947309494,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lair-1","display_name":"LAIR-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9739999771118164},{"id":"https://openalex.org/keywords/long-covid","display_name":"long COVID","score":0.7289999723434448},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9599999785423279},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/collagen-receptor","display_name":"collagen receptor","score":0.4000000059604645},{"id":"https://openalex.org/keywords/interferon-gamma-signaling","display_name":"interferon-gamma signaling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8420000076293945},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7070000171661377},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.777999997138977},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.42800000309944153},{"id":"https://openalex.org/keywords/chronic-fatigue-syndrome","display_name":"chronic fatigue syndrome","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5604093670845032},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5413387417793274},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.5275765657424927},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5231669545173645},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5052626729011536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4846368432044983},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4528913199901581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44396013021469116},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42982080578804016},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3455106019973755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32869693636894226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3090406060218811},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.259522944688797},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09777802228927612},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.07522565126419067},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2023.07.01.23292108","doi":"https://doi.org/10.1101/2023.07.01.23292108","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.01.23292108","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/01/2023.07.01.23292108.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2023.07.01.23292108","doi":"https://doi.org/10.1101/2023.07.01.23292108","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.01.23292108","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/07/01/2023.07.01.23292108.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382931433.pdf","grobid_xml":"https://content.openalex.org/works/W4382931433.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W103484934","https://openalex.org/W1918028620","https://openalex.org/W1967201035","https://openalex.org/W1988985090","https://openalex.org/W2000433942","https://openalex.org/W2005690981","https://openalex.org/W2033323458","https://openalex.org/W2037299986","https://openalex.org/W2086440772","https://openalex.org/W2091095196","https://openalex.org/W2099944930","https://openalex.org/W2119492372","https://openalex.org/W2120379362","https://openalex.org/W2129122223","https://openalex.org/W2131381643","https://openalex.org/W2140380746","https://openalex.org/W2155043397","https://openalex.org/W2396288232","https://openalex.org/W2596139865","https://openalex.org/W2755846940","https://openalex.org/W2763970677","https://openalex.org/W2806617632","https://openalex.org/W2808825101","https://openalex.org/W2889245666","https://openalex.org/W3021841162","https://openalex.org/W3034095150","https://openalex.org/W3039752067","https://openalex.org/W3043373728","https://openalex.org/W3046473329","https://openalex.org/W3096383810","https://openalex.org/W3119664729","https://openalex.org/W3156022093","https://openalex.org/W3160535978","https://openalex.org/W3182866175","https://openalex.org/W3211831359","https://openalex.org/W4205879827","https://openalex.org/W4220985845","https://openalex.org/W4226367971","https://openalex.org/W4281385856","https://openalex.org/W4292528167","https://openalex.org/W4293694038","https://openalex.org/W4322584267","https://openalex.org/W4366291416"],"related_works":["https://openalex.org/W4406847868","https://openalex.org/W4412650545","https://openalex.org/W4386208915","https://openalex.org/W4387385345","https://openalex.org/W4281294320","https://openalex.org/W3092207907","https://openalex.org/W4328049415","https://openalex.org/W3011646840","https://openalex.org/W2924780342","https://openalex.org/W2939466116"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,223],"polymerized":[3],"type":[4,15,77],"I":[5,16,78],"collagen":[6,17,79],"(PTIC)":[7],"is":[8,256],"a":[9,48,161],"\u03b3-irradiated":[10],"mixture":[11],"of":[12,71,145,154,187,198,225,248,259],"pepsinized":[13],"porcine":[14],"and":[18,28,53,107,127,132,139,173,201,208,216,220,234,240,250,261,276],"polyvinylpyrrolidone":[19],"(PVP).":[20],"It":[21],"has":[22,38],"immunomodulatory":[23],"properties.":[24],"However,":[25],"the":[26,54,120,196,245,251],"receptor":[27,50],"signaling":[29,55,171],"pathway":[30,56],"through":[31],"which":[32],"it":[33],"exerts":[34],"its":[35],"therapeutic":[36],"effects":[37],"not":[39],"yet":[40],"been":[41],"identified.":[42],"Aim":[43],"To":[44],"evaluate":[45],"LAIR-1":[46,62,74,159,260],"as":[47],"potential":[49],"for":[51,93,119,269],"PTIC":[52,92,111,157,185,255,265],"evoked":[57],"by":[58,67,116,137,179],"ligand-receptor":[59],"binding.":[60],"Methods":[61],"binding":[63,168],"assay":[64],"was":[65,228],"performed":[66],"incubating":[68],"various":[69],"concentrations":[70],"recombinant":[72],"human":[73],"with":[75,90,151,160,212],"native":[76,165],"or":[80,109],"PTIC.":[81,155],"Macrophages":[82],"M1-":[83],"derived":[84],"from":[85,98,142],"THP-1":[86],"cells":[87,102],"were":[88,114,135],"cultured":[89],"2-10%":[91],"24":[94],"h.":[95],"Cell":[96],"lysates":[97],"THP-":[99],"1,":[100],"monocytes-like":[101],"(MLCs),":[103],"M1,":[104],"M1+IFN-\u03b3,":[105],"M1+LPS,":[106],"2":[108],"10%":[110],"treated":[112],"M1":[113,177,199],"analyzed":[115,136],"western":[117],"blot":[118],"transcription":[121,214],"factors":[122],"NF-\u03baB":[123],"(p65),":[124],"p38,":[125],"STAT-1,":[126],"pSTAT-1.":[128],"Cytokines,":[129],"Th1":[130,221],"cells,":[131],"M1/M2":[133],"macrophages":[134,178,200,219],"luminometry":[138],"flow":[140],"cytometry":[141],"blood":[143],"samples":[144],"symptomatic":[146,188],"COVID-19":[147,189,275],"outpatients":[148,190],"on":[149],"treatment":[150,186],"intramuscular":[152,184],"administration":[153],"Results":[156],"binds":[158],"similar":[162],"affinity":[163],"to":[164,230],"collagen.":[166],"This":[167],"decreases":[169],"STAT-1":[170,181,213,263],"IFN-\u03b3-induced":[172],"IL-1\u03b2":[174],"expression":[175],"in":[176,244],"down-regulating":[180],"phosphorylation.":[182,264],"Moreover,":[183],"decreased":[191,235],"at":[192],"statistically":[193],"significant":[194],"levels":[195],"percentage":[197],"cytokines":[202],"(IP-10,":[203],"MIF,":[204],"eotaxin,":[205],"IL-8,":[206],"IL-1RA,":[207],"M-":[209],"CSF)":[210],"associated":[211],"factor":[215],"increased":[217],"M2":[218],"cells.":[222],"downregulation":[224],"inflammatory":[226,272],"mediators":[227],"related":[229],"better":[231],"oxygen":[232],"saturation":[233],"dyspnea,":[236],"chest":[237],"pain,":[238],"cough,":[239],"chronic":[241],"fatigue":[242],"syndrome":[243],"acute":[246],"phase":[247],"infection":[249],"long":[252,277],"term.":[253],"Conclusion":[254],"an":[257],"agonist":[258],"down-regulates":[262],"could":[266],"be":[267],"relevant":[268],"treating":[270],"STAT-1-mediated":[271],"diseases,":[273],"including":[274],"COVID":[278]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-07-04T00:00:00"}