{"id":"https://openalex.org/W4382807709","doi":"https://doi.org/10.26502/jsr.10020304","title":"Real-Life Efficacy of Liraglutide Therapy on Weight-Loss in Patients with Overweight and Obesity","display_name":"Real-Life Efficacy of Liraglutide Therapy on Weight-Loss in Patients with Overweight and Obesity","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4382807709","doi":"https://doi.org/10.26502/jsr.10020304"},"language":"en","primary_location":{"id":"doi:10.26502/jsr.10020304","doi":"https://doi.org/10.26502/jsr.10020304","is_oa":true,"landing_page_url":"https://doi.org/10.26502/jsr.10020304","pdf_url":null,"source":{"id":"https://openalex.org/S4210216346","display_name":"Journal of Surgery and Research","issn_l":"2640-1002","issn":["2640-1002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.26502/jsr.10020304","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michela Del Prete","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michela Del Prete","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089512678","display_name":"Federico Vignati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federico Vignati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110764425","display_name":"Gianleone Di Sacco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianleone Di Sacco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061525369","display_name":"Lidia Gavazzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lidia Gavazzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002829781","display_name":"Daniela Dellepiane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Dellepiane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062324538","display_name":"Fabrizio Muratori","orcid":"https://orcid.org/0000-0002-5153-8033","observed_orcids":["https://orcid.org/0000-0002-5153-8033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabrizio Muratori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1345,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36490416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"06","issue":"02","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":0.890999972820282},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7789999842643738},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.5789999961853027},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8989999890327454},{"id":"https://openalex.org/keywords/long-term-efficacy","display_name":"long-term efficacy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/body-mass-index-reduction","display_name":"body mass index reduction","score":0.8259999752044678},{"id":"https://openalex.org/keywords/real-world-treatment-outcomes","display_name":"real-world treatment outcomes","score":0.4909999966621399},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7519999742507935},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.45399999618530273},{"id":"https://openalex.org/keywords/weight-regain","display_name":"weight regain","score":0.3149999976158142},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.5289999842643738},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5450000166893005},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.3610000014305115},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2781308992","wikidata":"https://www.wikidata.org/wiki/Q2526479","display_name":"Liraglutide","level":4,"score":0.9624056220054626},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.8532558083534241},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7943323254585266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7823536396026611},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6806375980377197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3902057707309723},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.377037912607193},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.24525323510169983},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2357332408428192},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16283726692199707}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26502/jsr.10020304","doi":"https://doi.org/10.26502/jsr.10020304","is_oa":true,"landing_page_url":"https://doi.org/10.26502/jsr.10020304","pdf_url":null,"source":{"id":"https://openalex.org/S4210216346","display_name":"Journal of Surgery and Research","issn_l":"2640-1002","issn":["2640-1002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.26502/jsr.10020304","doi":"https://doi.org/10.26502/jsr.10020304","is_oa":true,"landing_page_url":"https://doi.org/10.26502/jsr.10020304","pdf_url":null,"source":{"id":"https://openalex.org/S4210216346","display_name":"Journal of Surgery and Research","issn_l":"2640-1002","issn":["2640-1002"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7204441560","https://openalex.org/W3037683713","https://openalex.org/W7058563428","https://openalex.org/W4400685016","https://openalex.org/W3216600551","https://openalex.org/W4386117032","https://openalex.org/W807162506","https://openalex.org/W3121446156","https://openalex.org/W2913427490","https://openalex.org/W4403605864"],"abstract_inverted_index":{"Introduction:":[0],"Liraglutide":[1,108],"is":[2],"approved":[3],"for":[4],"long-term":[5,26,166,316],"weight-loss":[6],"in":[7,31,38,43,126,147,282,305],"patients":[8,39,52,95,150,174,208,216,283],"with":[9,33,40,53,74,104,120,162,188,213,231,280,284,289],"overweight":[10],"and":[11,35,57,85,101,119,143,151,182,193,200,224,236,243,250,262,267,286,303],"obesity":[12,41,54,285],"as":[13],"an":[14],"adjunct":[15],"to":[16,62,68,71,98,139],"lifestyle":[17],"modification.":[18],"Here,":[19],"we":[20],"reported":[21],"our":[22,44,63,148],"real-life":[23,149,278],"experience":[24],"on":[25,211],"efficacy":[27,142,276],"of":[28,116,123,135,145,160,179,185,198,221,227,241,277,310],"liraglutide":[29,146,163,255,281,311],"therapy":[30,103,161,256,279,312],"association":[32],"dietary":[34,100],"behavioral":[36,102],"advice,":[37],"followed":[42],"outpatient":[45],"clinic.":[46],"Methods:":[47],"We":[48],"retrospectively":[49],"assessed":[50],"109":[51],"(92":[55],"females":[56],"17":[58],"males)":[59],"consecutively":[60],"admitted":[61],"observation":[64],"from":[65,129,292],"September":[66],"2018":[67],"October":[69],"2019":[70],"lose":[72],"weight":[73,81,155,167,178,192,220,235,248,260,301,317],"liraglutide.":[75,214],"At":[76],"the":[77,121,130,141,153,259,275,293],"first":[78],"visit,":[79],"mean":[80,86,177,183,190,194,219,225,233,237],"was":[82,91,109,138],"93.2\u00b117.9":[83],"kg":[84,181,223],"body":[87],"mass":[88],"index":[89],"(BMI)":[90],"34.0\u00b15.5":[92],"kg/m2.":[93,202,245],"All":[94],"were":[96,209],"required":[97],"follow":[99,172,205],"concomitant":[105],"drug":[106],"treatment.":[107],"administered":[110],"once-daily":[111],"subcutaneously":[112],"at":[113,265],"starting":[114,131],"dose":[115],"0.6":[117],"mg":[118,125],"achievement":[122],"3.0":[124],"two":[127],"months":[128,159,309],"therapy.":[132],"The":[133,246],"aim":[134],"this":[136],"study":[137],"evaluate":[140],"safety":[144],"how":[152,299],"early":[154,247,300],"loss":[156,249,261,302],"after":[157,253,307],"4":[158,308],"can":[164,313],"predict":[165,258,315],"loss.":[168,318],"Results:":[169],"After":[170,203],"4-month":[171,254],"up,":[173,206],"had":[175,217],"a":[176,189,218,232],"83.3\u00b116.3":[180],"BMI":[184,195,226,238,251,263,306],"30.4\u00b15.0":[186],"kg/m2,":[187],"percentage":[191,234],"reduction":[196,239,304],"respectively":[197,240],"-10.5\u00b13.8%":[199],"-3.6\u00b11.4":[201],"12-month":[204,268],"34":[207],"still":[210],"treatment":[212],"These":[215],"78.9\u00b113.5":[222],"28.5\u00b14.6":[228],"kg/":[229],"m2,":[230],"-22.0\u00b15.0%":[242],"-8.1\u00b12.4":[244],"changes":[252,264],"significantly":[257,314],"6-":[266],"follow-up":[269],"(p<0.0001).":[270],"Conclusions:":[271],"Our":[272,296],"results":[273],"confirm":[274],"are":[287],"consistent":[288],"data":[290,297],"obtained":[291],"clinical":[294],"trials.":[295],"show":[298]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-02T00:00:00"}