{"id":"https://openalex.org/W4382776209","doi":"https://doi.org/10.3390/ijms241310849","title":"Relevance of KCNJ5 in Pathologies of Heart Disease","display_name":"Relevance of KCNJ5 in Pathologies of Heart Disease","publication_year":2023,"publication_date":"2023-06-29","ids":{"openalex":"https://openalex.org/W4382776209","doi":"https://doi.org/10.3390/ijms241310849","pmid":"https://pubmed.ncbi.nlm.nih.gov/37446026","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10341679"},"language":"en","primary_location":{"id":"doi:10.3390/ijms241310849","doi":"https://doi.org/10.3390/ijms241310849","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241310849","pdf_url":"https://www.mdpi.com/1422-0067/24/13/10849/pdf?version=1688027078","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/13/10849/pdf?version=1688027078","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135611846","display_name":"Karisa Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karisa M. Meyer","raw_affiliation_strings":["Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009065047","display_name":"Nipun Malhotra","orcid":"https://orcid.org/0000-0002-2748-6747","observed_orcids":["https://orcid.org/0000-0002-2748-6747"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nipun Malhotra","raw_affiliation_strings":["Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0002-2748-6747","affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112950286","display_name":"Jung seo Kwak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung seo Kwak","raw_affiliation_strings":["Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051430483","display_name":"Mona El Refaey","orcid":"https://orcid.org/0000-0003-3989-0920","observed_orcids":["https://orcid.org/0000-0003-3989-0920"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mona El Refaey","raw_affiliation_strings":["Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0003-3989-0920","affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051430483"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":0.5385,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.52486188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"13","first_page":"10849","last_page":"10849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.27250000834465027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kcnj5","display_name":"KCNJ5","score":1.0},{"id":"https://openalex.org/keywords/girk4","display_name":"GIRK4","score":0.9879999756813049},{"id":"https://openalex.org/keywords/girk-channels","display_name":"GIRK channels","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cardiac-potassium-channels","display_name":"cardiac potassium channels","score":0.5730000138282776},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"long QT syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/sinus-node-dysfunction","display_name":"sick sinus syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/g-protein-gated-inwardly-rectifying-potassium-channels","display_name":"G protein-coupled inwardly rectifying potassium channels","score":0.8080000281333923},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.5441310405731201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45595529675483704},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43578827381134033},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.37590110301971436},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3204646110534668},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.08421799540519714},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012804","descriptor_name":"Sick Sinus Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051676","descriptor_name":"G Protein-Coupled Inwardly-Rectifying Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms241310849","doi":"https://doi.org/10.3390/ijms241310849","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241310849","pdf_url":"https://www.mdpi.com/1422-0067/24/13/10849/pdf?version=1688027078","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10341679","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10341679","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10341679/pdf/ijms-24-10849.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37446026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37446026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms241310849","doi":"https://doi.org/10.3390/ijms241310849","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241310849","pdf_url":"https://www.mdpi.com/1422-0067/24/13/10849/pdf?version=1688027078","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3791825247","display_name":"Defining new pathways for cardiac automaticity","funder_award_id":"R00HL146969","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7609098992","display_name":"Defining new pathways for cardiac automaticity","funder_award_id":"K99HL146969","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382776209.pdf","grobid_xml":"https://content.openalex.org/works/W4382776209.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W187608677","https://openalex.org/W265000889","https://openalex.org/W1501723147","https://openalex.org/W1898633796","https://openalex.org/W1963583500","https://openalex.org/W1968925586","https://openalex.org/W1974423108","https://openalex.org/W1983128983","https://openalex.org/W1987014245","https://openalex.org/W1991449126","https://openalex.org/W2002662427","https://openalex.org/W2004202674","https://openalex.org/W2014303946","https://openalex.org/W2014580405","https://openalex.org/W2015841601","https://openalex.org/W2020311676","https://openalex.org/W2023205832","https://openalex.org/W2023453938","https://openalex.org/W2024139001","https://openalex.org/W2024626278","https://openalex.org/W2032977377","https://openalex.org/W2040487409","https://openalex.org/W2044851415","https://openalex.org/W2045824665","https://openalex.org/W2045925368","https://openalex.org/W2047478923","https://openalex.org/W2053874415","https://openalex.org/W2058606373","https://openalex.org/W2061858869","https://openalex.org/W2068524893","https://openalex.org/W2076777326","https://openalex.org/W2081355665","https://openalex.org/W2083780717","https://openalex.org/W2085347267","https://openalex.org/W2086425231","https://openalex.org/W2087348303","https://openalex.org/W2089400376","https://openalex.org/W2092153435","https://openalex.org/W2107213822","https://openalex.org/W2111995467","https://openalex.org/W2126616537","https://openalex.org/W2129513982","https://openalex.org/W2135491838","https://openalex.org/W2141917534","https://openalex.org/W2142701430","https://openalex.org/W2146136214","https://openalex.org/W2149278368","https://openalex.org/W2150193516","https://openalex.org/W2153316394","https://openalex.org/W2154788287","https://openalex.org/W2157796632","https://openalex.org/W2164282511","https://openalex.org/W2217368532","https://openalex.org/W2228545523","https://openalex.org/W2260208019","https://openalex.org/W2273010779","https://openalex.org/W2325842765","https://openalex.org/W2390663394","https://openalex.org/W2402564818","https://openalex.org/W2501661547","https://openalex.org/W2591171709","https://openalex.org/W2737204392","https://openalex.org/W2782877976","https://openalex.org/W2805212013","https://openalex.org/W2811424783","https://openalex.org/W2905372434","https://openalex.org/W2910786776","https://openalex.org/W2913772219","https://openalex.org/W2947341597","https://openalex.org/W3003054269","https://openalex.org/W3024327193","https://openalex.org/W3026753735","https://openalex.org/W3033164764","https://openalex.org/W3036082201","https://openalex.org/W3081241911","https://openalex.org/W3087335733","https://openalex.org/W3123022377","https://openalex.org/W3124299110","https://openalex.org/W3125406550","https://openalex.org/W3134750987","https://openalex.org/W3196300076","https://openalex.org/W3197054512","https://openalex.org/W3197179229","https://openalex.org/W3213329656","https://openalex.org/W4212973550","https://openalex.org/W4223534056","https://openalex.org/W4223625638","https://openalex.org/W4283736924","https://openalex.org/W4308774242","https://openalex.org/W4309506674"],"related_works":["https://openalex.org/W2496002952","https://openalex.org/W345674027","https://openalex.org/W2062229830","https://openalex.org/W3004796247","https://openalex.org/W4308774242","https://openalex.org/W2061774604","https://openalex.org/W7162558025","https://openalex.org/W2910786776","https://openalex.org/W4200525738","https://openalex.org/W2584389912"],"abstract_inverted_index":{"Abnormalities":[0],"in":[1,11,24,53,88,93,114,132,144],"G-protein-gated":[2],"inwardly":[3],"rectifying":[4],"potassium":[5],"(GIRK)":[6],"channels":[7],"have":[8,90,141],"been":[9,91,142],"implicated":[10],"diseased":[12],"states":[13],"of":[14,21,42,112,116,126,130,139],"the":[15,19,36,38,55,69,110,122,128],"cardiovascular":[16,84,133],"system;":[17],"however,":[18],"role":[20,52,129],"GIRK4":[22,47,65],"(Kir3.4)":[23],"cardiac":[25,61],"physiology":[26],"and":[27,45,103,124],"pathophysiology":[28],"has":[29],"yet":[30],"to":[31],"be":[32],"completely":[33],"understood.":[34],"Within":[35],"heart,":[37],"KACh":[39,71],"channel,":[40,72],"consisting":[41],"two":[43,46],"GIRK1":[44],"subunits,":[48],"plays":[49],"a":[50,80],"major":[51],"modulating":[54],"parasympathetic":[56],"nervous":[57],"system\u2019s":[58],"influence":[59],"on":[60],"physiology.":[62],"Being":[63],"that":[64],"is":[66],"necessary":[67],"for":[68,83],"functional":[70],"KCNJ5,":[73],"which":[74],"encodes":[75],"GIRK4,":[76],"it":[77],"presents":[78],"as":[79,135],"therapeutic":[81],"target":[82],"pathology.":[85],"Human":[86],"variants":[87,138],"KCNJ5":[89,113,131,140],"identified":[92,143],"familial":[94],"hyperaldosteronism":[95],"type":[96],"III,":[97],"long":[98],"QT":[99],"syndrome,":[100],"atrial":[101],"fibrillation,":[102],"sinus":[104],"node":[105],"dysfunction.":[106],"Here,":[107],"we":[108,120],"explore":[109],"relevance":[111],"each":[115],"these":[117],"diseases.":[118],"Further,":[119],"address":[121],"limitations":[123],"complexities":[125],"discerning":[127],"pathophysiology,":[134],"identical":[136],"human":[137],"several":[145],"diseases":[146],"with":[147],"overlapping":[148],"pathophysiology.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-07-02T00:00:00"}