{"id":"https://openalex.org/W4382700971","doi":"https://doi.org/10.1016/j.jphotobiol.2023.112753","title":"Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway","display_name":"Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway","publication_year":2023,"publication_date":"2023-06-30","ids":{"openalex":"https://openalex.org/W4382700971","doi":"https://doi.org/10.1016/j.jphotobiol.2023.112753","pmid":"https://pubmed.ncbi.nlm.nih.gov/37437439"},"language":"en","primary_location":{"id":"doi:10.1016/j.jphotobiol.2023.112753","doi":"https://doi.org/10.1016/j.jphotobiol.2023.112753","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jphotobiol.2023.112753","pdf_url":null,"source":{"id":"https://openalex.org/S148303206","display_name":"Journal of Photochemistry and Photobiology B Biology","issn_l":"1011-1344","issn":["1011-1344","1873-2682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Photochemistry and Photobiology B: Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.4411877","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028908529","display_name":"Feiying Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feiying Wu","raw_affiliation_strings":["Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113003084","display_name":"Xinyu Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Xia","raw_affiliation_strings":["Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780904","display_name":"Ting Lei","orcid":"https://orcid.org/0000-0001-7819-8780","observed_orcids":["https://orcid.org/0000-0001-7819-8780"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Lei","raw_affiliation_strings":["Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619883","display_name":"Huiying Du","orcid":"https://orcid.org/0009-0000-0628-2967","observed_orcids":["https://orcid.org/0009-0000-0628-2967"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiying Du","raw_affiliation_strings":["Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101406882","display_name":"Hui Hua","orcid":"https://orcid.org/0000-0003-4101-7143","observed_orcids":["https://orcid.org/0000-0003-4101-7143"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210108664","display_name":"International Peace Maternity & Child Health Hospital","ror":"https://ror.org/01byttc20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108664"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Hua","raw_affiliation_strings":["The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Shanghai Key Laboratory of Embryo Original Disease, Shanghai 200030, China","Shanghai Key Laboratory of Embryo Original Disease, Shanghai 200030, China","The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Shanghai Key Laboratory of Embryo Original Disease, Shanghai 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210108664"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Embryo Original Disease, Shanghai 200030, China","institution_ids":[]},{"raw_affiliation_string":"The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210108664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431996","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0003-4199-5406","observed_orcids":["https://orcid.org/0000-0003-4199-5406"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103175739","display_name":"Bin Xu","orcid":"https://orcid.org/0000-0001-8024-2066","observed_orcids":["https://orcid.org/0000-0001-8024-2066"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Xu","raw_affiliation_strings":["Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056417543","display_name":"Tianyao Yang","orcid":"https://orcid.org/0000-0003-0613-1338","observed_orcids":["https://orcid.org/0000-0003-0613-1338","https://orcid.org/0000-0002-8922-3627"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianyao Yang","raw_affiliation_strings":["Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China. Electronic address: tyyang@cmu.edu.cn","Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China; Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China. Electronic address: tyyang@cmu.edu.cn","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning 110122, China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056417543"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":1.4976,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.81016892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"245","issue":null,"first_page":"112753","last_page":"112753"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.23559999465942383,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.6959999799728394},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/uv-b-radiation","display_name":"UV-B radiation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9120000004768372},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/protein-deacetylation","display_name":"protein deacetylation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.728272020816803},{"id":"https://openalex.org/C2776529522","wikidata":"https://www.wikidata.org/wiki/Q18034700","display_name":"KEAP1","level":4,"score":0.6270098090171814},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6233600974082947},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5910676121711731},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46231991052627563},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44525203108787537},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4348151683807373},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41907066106796265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26839035749435425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26264694333076477},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.08852210640907288},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07319551706314087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jphotobiol.2023.112753","doi":"https://doi.org/10.1016/j.jphotobiol.2023.112753","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jphotobiol.2023.112753","pdf_url":null,"source":{"id":"https://openalex.org/S148303206","display_name":"Journal of Photochemistry and Photobiology B Biology","issn_l":"1011-1344","issn":["1011-1344","1873-2682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Photochemistry and Photobiology B: Biology","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4411877","doi":"https://doi.org/10.2139/ssrn.4411877","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4411877","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:37437439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37437439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of photochemistry and photobiology. B, Biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4411877","doi":"https://doi.org/10.2139/ssrn.4411877","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4411877","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W320197456","https://openalex.org/W2011261510","https://openalex.org/W2221645771","https://openalex.org/W2553698216","https://openalex.org/W2556227869","https://openalex.org/W2559770730","https://openalex.org/W2574794987","https://openalex.org/W2737474548","https://openalex.org/W2744021359","https://openalex.org/W2751842977","https://openalex.org/W2761586844","https://openalex.org/W2762844085","https://openalex.org/W2766958672","https://openalex.org/W2784211834","https://openalex.org/W2787909527","https://openalex.org/W2791397620","https://openalex.org/W2795248290","https://openalex.org/W2800344070","https://openalex.org/W2805897240","https://openalex.org/W2883032164","https://openalex.org/W2906700432","https://openalex.org/W2909398811","https://openalex.org/W2914049281","https://openalex.org/W2914453573","https://openalex.org/W2937852666","https://openalex.org/W2947506452","https://openalex.org/W2950510535","https://openalex.org/W2951801120","https://openalex.org/W2963873210","https://openalex.org/W2964549592","https://openalex.org/W2970943912","https://openalex.org/W2972195573","https://openalex.org/W2991156441","https://openalex.org/W2991601493","https://openalex.org/W2993445713","https://openalex.org/W2998625568","https://openalex.org/W3001577548","https://openalex.org/W3006353456","https://openalex.org/W3009004435","https://openalex.org/W3011384968","https://openalex.org/W3047032306","https://openalex.org/W3080345808","https://openalex.org/W3092012361","https://openalex.org/W3101367638","https://openalex.org/W3112417491","https://openalex.org/W3118885290","https://openalex.org/W3128719166","https://openalex.org/W3133567931","https://openalex.org/W3165716239","https://openalex.org/W3191688134","https://openalex.org/W3195718052","https://openalex.org/W3195940645","https://openalex.org/W3209255096","https://openalex.org/W3209469770","https://openalex.org/W4220897956","https://openalex.org/W4224441892","https://openalex.org/W4226165145","https://openalex.org/W4280633842","https://openalex.org/W4285011041","https://openalex.org/W6748328948","https://openalex.org/W6758615315","https://openalex.org/W6839547984"],"related_works":["https://openalex.org/W4378611061","https://openalex.org/W4401372111","https://openalex.org/W2963873210","https://openalex.org/W3003833322","https://openalex.org/W2003448438","https://openalex.org/W4400951228","https://openalex.org/W2158158765","https://openalex.org/W1981768098","https://openalex.org/W4403872253","https://openalex.org/W2551352130"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-07-01T00:00:00"}