{"id":"https://openalex.org/W4382679406","doi":"https://doi.org/10.1158/1078-0432.23608958","title":"Supplementary Figure S5 from Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin\u2013Drug Conjugate Response","display_name":"Supplementary Figure S5 from Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin\u2013Drug Conjugate Response","publication_year":2023,"publication_date":"2023-06-30","ids":{"openalex":"https://openalex.org/W4382679406","doi":"https://doi.org/10.1158/1078-0432.23608958"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.23608958","doi":"https://doi.org/10.1158/1078-0432.23608958","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.23608958","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.23608958","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081775094","display_name":"Huiyu Hu","orcid":"https://orcid.org/0000-0003-2866-9358","observed_orcids":["https://orcid.org/0000-0003-2866-9358","https://orcid.org/0009-0005-3467-8893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huiyu Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2866-9358","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027157934","display_name":"Thomas S.C. Ng","orcid":"https://orcid.org/0000-0002-3676-1800","observed_orcids":["https://orcid.org/0000-0002-3676-1800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas S.C. Ng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3676-1800","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044550389","display_name":"Mikyung Kang","orcid":"https://orcid.org/0000-0002-0592-1648","observed_orcids":["https://orcid.org/0000-0002-0592-1648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikyung Kang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0592-1648","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012809425","display_name":"Ella Scott","orcid":"https://orcid.org/0000-0002-5765-1299","observed_orcids":["https://orcid.org/0000-0002-5765-1299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ella Scott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5765-1299","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428087","display_name":"Ran Li","orcid":"https://orcid.org/0000-0002-8537-8824","observed_orcids":["https://orcid.org/0000-0002-8537-8824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ran Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8537-8824","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013844388","display_name":"Jeremy M. Quintana","orcid":"https://orcid.org/0000-0001-9820-1297","observed_orcids":["https://orcid.org/0000-0001-9820-1297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy M. Quintana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9820-1297","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064952203","display_name":"Dylan Matvey","orcid":"https://orcid.org/0000-0003-3825-2345","observed_orcids":["https://orcid.org/0000-0003-3825-2345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dylan Matvey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3825-2345","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037614536","display_name":"Venkata Rao Vantaku","orcid":"https://orcid.org/0000-0003-2846-8716","observed_orcids":["https://orcid.org/0000-0003-2846-8716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venkata R. Vantaku","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2846-8716","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067255019","display_name":"Ralph Weissleder","orcid":"https://orcid.org/0000-0003-0828-4143","observed_orcids":["https://orcid.org/0000-0003-0828-4143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph Weissleder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0828-4143","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008350987","display_name":"Sareh Parangi","orcid":"https://orcid.org/0000-0003-1280-2812","observed_orcids":["https://orcid.org/0000-0003-1280-2812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sareh Parangi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1280-2812","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047564466","display_name":"Miles Aaron Miller","orcid":"https://orcid.org/0000-0001-7638-8898","observed_orcids":["https://orcid.org/0000-0001-7638-8898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miles A. Miller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7638-8898","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0681999996304512,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9449999928474426},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7490000128746033},{"id":"https://openalex.org/keywords/albumin-drug-conjugates","display_name":"albumin-drug conjugates","score":0.9760000109672546},{"id":"https://openalex.org/keywords/igf1r-inhibition","display_name":"IGF1R inhibition","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C40017333","wikidata":"https://www.wikidata.org/wiki/Q321362","display_name":"Pinocytosis","level":4,"score":0.8071327805519104},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5756819248199463},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4736191928386688},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.47354215383529663},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46214282512664795},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.4438092112541199},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44202274084091187},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.41940176486968994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4003509283065796},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37405937910079956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3372306227684021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32794779539108276},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31388169527053833},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.27164965867996216},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13251399993896484},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10503694415092468},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.07997691631317139},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.06355994939804077},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.23608958","doi":"https://doi.org/10.1158/1078-0432.23608958","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.23608958","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.23608958","doi":"https://doi.org/10.1158/1078-0432.23608958","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.23608958","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402798098","https://openalex.org/W4379769083","https://openalex.org/W4382679249","https://openalex.org/W2924171542","https://openalex.org/W4362623775","https://openalex.org/W7148892422","https://openalex.org/W2800697168","https://openalex.org/W4392723966","https://openalex.org/W7130379144","https://openalex.org/W2887102916"],"abstract_inverted_index":{"IGF1R":[0],"inhibition":[1],"augments":[2],"macropinocytosis":[3],"and":[4],"is":[5],"blocked":[6],"by":[7],"IGF1":[8]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-07-01T00:00:00"}