{"id":"https://openalex.org/W4382679137","doi":"https://doi.org/10.1158/1078-0432.c.6721658","title":"Data from Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin\u2013Drug Conjugate Response","display_name":"Data from Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin\u2013Drug Conjugate Response","publication_year":2023,"publication_date":"2023-06-30","ids":{"openalex":"https://openalex.org/W4382679137","doi":"https://doi.org/10.1158/1078-0432.c.6721658"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6721658","doi":"https://doi.org/10.1158/1078-0432.c.6721658","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6721658","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6721658","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081775094","display_name":"Huiyu Hu","orcid":"https://orcid.org/0000-0003-2866-9358","observed_orcids":["https://orcid.org/0000-0003-2866-9358","https://orcid.org/0009-0005-3467-8893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huiyu Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2866-9358","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027157934","display_name":"Thomas S.C. Ng","orcid":"https://orcid.org/0000-0002-3676-1800","observed_orcids":["https://orcid.org/0000-0002-3676-1800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas S.C. Ng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3676-1800","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044550389","display_name":"Mikyung Kang","orcid":"https://orcid.org/0000-0002-0592-1648","observed_orcids":["https://orcid.org/0000-0002-0592-1648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikyung Kang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0592-1648","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012809425","display_name":"Ella Scott","orcid":"https://orcid.org/0000-0002-5765-1299","observed_orcids":["https://orcid.org/0000-0002-5765-1299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ella Scott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5765-1299","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428087","display_name":"Ran Li","orcid":"https://orcid.org/0000-0002-8537-8824","observed_orcids":["https://orcid.org/0000-0002-8537-8824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ran Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8537-8824","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013844388","display_name":"Jeremy M. Quintana","orcid":"https://orcid.org/0000-0001-9820-1297","observed_orcids":["https://orcid.org/0000-0001-9820-1297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy M. Quintana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9820-1297","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064952203","display_name":"Dylan Matvey","orcid":"https://orcid.org/0000-0003-3825-2345","observed_orcids":["https://orcid.org/0000-0003-3825-2345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dylan Matvey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3825-2345","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037614536","display_name":"Venkata Rao Vantaku","orcid":"https://orcid.org/0000-0003-2846-8716","observed_orcids":["https://orcid.org/0000-0003-2846-8716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venkata R. Vantaku","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2846-8716","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067255019","display_name":"Ralph Weissleder","orcid":"https://orcid.org/0000-0003-0828-4143","observed_orcids":["https://orcid.org/0000-0003-0828-4143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph Weissleder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0828-4143","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008350987","display_name":"Sareh Parangi","orcid":"https://orcid.org/0000-0003-1280-2812","observed_orcids":["https://orcid.org/0000-0003-1280-2812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sareh Parangi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1280-2812","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047564466","display_name":"Miles Aaron Miller","orcid":"https://orcid.org/0000-0001-7638-8898","observed_orcids":["https://orcid.org/0000-0001-7638-8898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miles A. Miller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7638-8898","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.7419999837875366},{"id":"https://openalex.org/keywords/albumin-drug-conjugates","display_name":"albumin-drug conjugates","score":0.8960000276565552},{"id":"https://openalex.org/keywords/monomethyl-auristatin-e","display_name":"monomethyl auristatin E","score":0.8700000047683716},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.7580000162124634},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.7279999852180481},{"id":"https://openalex.org/keywords/phenformin","display_name":"phenformin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7310000061988831},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nutrient-scavenging","display_name":"nutrient scavenging","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ret-inhibition","display_name":"RET inhibition","score":0.6290000081062317},{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.7749999761581421},{"id":"https://openalex.org/keywords/braf-inhibition","display_name":"BRAF inhibition","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2780256643","wikidata":"https://www.wikidata.org/wiki/Q3658382","display_name":"Anaplastic thyroid cancer","level":4,"score":0.6670724749565125},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5948992371559143},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5538944005966187},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.5188911557197571},{"id":"https://openalex.org/C2779341817","wikidata":"https://www.wikidata.org/wiki/Q5464665","display_name":"Follicular thyroid cancer","level":5,"score":0.4923347234725952},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4774616062641144},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4770756959915161},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45699283480644226},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.44007372856140137},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.42945998907089233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35819190740585327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32446151971817017},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32357504963874817},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.31831979751586914},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.26505738496780396},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.21403229236602783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1433401107788086},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.11830607056617737}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6721658","doi":"https://doi.org/10.1158/1078-0432.c.6721658","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6721658","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6721658.v1","doi":"https://doi.org/10.1158/1078-0432.c.6721658.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6721658.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6721658","doi":"https://doi.org/10.1158/1078-0432.c.6721658","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6721658","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402798098","https://openalex.org/W4379769083","https://openalex.org/W4362541476","https://openalex.org/W7148892422","https://openalex.org/W2080717317"],"abstract_inverted_index":{"AbstractPurpose:":[0],"Oncogene-driven":[1],"macropinocytosis":[2,36,134,165,215],"fuels":[3],"nutrient":[4,171],"scavenging":[5],"in":[6,14,100,186,190,216],"some":[7],"cancer":[8,33,53,57,66],"types,":[9],"yet":[10],"whether":[11],"this":[12],"occurs":[13],"thyroid":[15,32,52,56,65,217],"cancers":[16,218],"with":[17,179],"prominent":[18],"MAPK\u2013ERK":[19],"and":[20,35,62,72,80,86,91,129,137,170,173,196,219],"PI3K":[21],"pathway":[22],"mutations":[23],"remains":[24],"unclear.":[25],"We":[26],"hypothesized":[27],"that":[28],"understanding":[29],"links":[30],"between":[31],"signaling":[34],"might":[37],"uncover":[38],"new":[39],"therapeutic":[40],"strategies.":[41],"Experimental":[42],"Design:":[43],"Macropinocytosis":[44],"was":[45],"assessed":[46],"across":[47],"cells":[48,131],"derived":[49],"from":[50],"papillary":[51],"(PTC),":[54],"follicular":[55,60],"(FTC),":[58],"non-malignant":[59,136],"thyroid,":[61],"aggressive":[63],"anaplastic":[64],"(ATC),":[67],"by":[68,159,175],"imaging":[69],"fluorescent":[70],"dextran":[71],"serum":[73,120],"albumin.":[74],"The":[75],"impacts":[76],"of":[77,108,184,223],"ectopic":[78],"BRAFV600E":[79],"mutant":[81],"RAS,":[82],"genetic":[83],"PTEN":[84],"silencing,":[85],"inhibitors":[87],"targeting":[88],"RET,":[89],"BRAF,":[90],"MEK":[92],"kinases":[93],"were":[94,103],"quantified.":[95],"BrafV600E":[96],"p53\u2212/\u2212":[97],"ATC":[98,130,140,164,205],"tumors":[99,141],"immunocompetent":[101],"mice":[102],"used":[104],"to":[105,119,177,207,227],"measure":[106],"efficacy":[107],"an":[109],"albumin\u2013drug":[110],"conjugate":[111],"comprising":[112],"microtubule-destabilizing":[113],"monomethyl":[114],"auristatin":[115],"E":[116],"(MMAE)":[117],"linked":[118],"albumin":[121,143,195],"via":[122],"a":[123],"cathepsin-cleavable":[124],"peptide":[125],"(Alb-vc-MMAE).":[126],"Results:":[127],"FTC":[128],"showed":[132],"greater":[133],"than":[135],"PTC":[138],"cells.":[139],"accumulated":[142,194],"at":[144],"8.8%":[145],"injected":[146],"dose":[147],"per":[148],"gram":[149],"tissue.":[150],"Alb-vc-MMAE,":[151],"but":[152,188],"not":[153,189],"MMAE":[154],"alone,":[155],"reduced":[156,204],"tumor":[157],"size":[158],">90%":[160],"(P":[161],"<":[162],"0.01).":[163],"depended":[166],"on":[167],"MAPK/ERK":[168],"activity":[169],"signaling,":[172],"increased":[174],"up":[176],"230%":[178],"metformin,":[180],"phenformin,":[181],"or":[182],"inhibition":[183],"IGF1Ri":[185],"monoculture":[187],"vivo.":[191],"Macrophages":[192],"also":[193],"express":[197],"the":[198,221],"cognate":[199],"IGF1R":[200],"ligand,":[201],"IGF1,":[202],"which":[203],"responsiveness":[206],"IGF1Ri.":[208],"Conclusions:":[209],"These":[210],"findings":[211],"identify":[212],"regulated":[213],"oncogene-driven":[214],"demonstrate":[220],"potential":[222],"designing":[224],"albumin-bound":[225],"drugs":[226],"efficiently":[228],"treat":[229],"them.":[230]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-07-01T00:00:00"}
