{"id":"https://openalex.org/W4382631728","doi":"https://doi.org/10.1038/s41598-023-37271-1","title":"Refining the serum miR-371a-3p test for viable germ cell tumor detection","display_name":"Refining the serum miR-371a-3p test for viable germ cell tumor detection","publication_year":2023,"publication_date":"2023-06-29","ids":{"openalex":"https://openalex.org/W4382631728","doi":"https://doi.org/10.1038/s41598-023-37271-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/36993198","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10055551"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-37271-1","doi":"https://doi.org/10.1038/s41598-023-37271-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-37271-1","pdf_url":"https://www.nature.com/articles/s41598-023-37271-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-37271-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038130865","display_name":"John T. Lafin","orcid":"https://orcid.org/0000-0003-2335-8999","observed_orcids":["https://orcid.org/0000-0003-2335-8999"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Lafin","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065916505","display_name":"Cinzia G. Scarpini","orcid":"https://orcid.org/0000-0003-4730-5197","observed_orcids":["https://orcid.org/0000-0003-4730-5197"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cinzia G. Scarpini","raw_affiliation_strings":["Department of Pathology, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051632149","display_name":"Armon Amini","orcid":"https://orcid.org/0000-0002-8991-3708","observed_orcids":["https://orcid.org/0000-0002-8991-3708"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armon Amini","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022857840","display_name":"Bendu Konneh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bendu Konneh","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026208837","display_name":"Jeffrey M. Howard","orcid":"https://orcid.org/0000-0002-0196-3875","observed_orcids":["https://orcid.org/0000-0002-0196-3875"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Howard","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011903621","display_name":"Thomas Gerald","orcid":"https://orcid.org/0000-0002-8877-6799","observed_orcids":["https://orcid.org/0000-0002-8877-6799"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Gerald","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063133870","display_name":"Michelle M. Nu\u00f1o","orcid":"https://orcid.org/0000-0003-2031-929X","observed_orcids":["https://orcid.org/0000-0003-2031-929X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Nuno","raw_affiliation_strings":["Department of Population and Public Health Sciences, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Public Health Sciences, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019581189","display_name":"Jin Piao","orcid":"https://orcid.org/0000-0003-0516-6280","observed_orcids":["https://orcid.org/0000-0003-0516-6280"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Piao","raw_affiliation_strings":["Department of Population and Public Health Sciences, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Public Health Sciences, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103024812","display_name":"Anna Savelyeva","orcid":"https://orcid.org/0000-0002-9572-8904","observed_orcids":["https://orcid.org/0000-0002-9572-8904"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Savelyeva","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358033","display_name":"Zhaohui Wang","orcid":"https://orcid.org/0000-0001-7994-7464","observed_orcids":["https://orcid.org/0000-0001-7994-7464"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaohui Wang","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067028002","display_name":"Jeffrey Gagan","orcid":"https://orcid.org/0000-0003-4676-9969","observed_orcids":["https://orcid.org/0000-0003-4676-9969"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Gagan","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108050312","display_name":"Liwei Jia","orcid":"https://orcid.org/0000-0002-2118-6428","observed_orcids":["https://orcid.org/0000-0002-2118-6428"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liwei Jia","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030598774","display_name":"Cheryl M. Lewis","orcid":"https://orcid.org/0000-0003-2685-6475","observed_orcids":["https://orcid.org/0000-0003-2685-6475"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl M. Lewis","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sarah Murray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Murray","raw_affiliation_strings":["Department of Pathology, University of California San Diego, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California San Diego, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050362408","display_name":"Yun Cheng Sawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun C. Sawa","raw_affiliation_strings":["Department of Urology, University of California San Diego, Suite 1-200, 9400 Campus Point Drive, La Jolla, CA, 92037, USA","Department of Urology, University of California San Diego, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California San Diego, Suite 1-200, 9400 Campus Point Drive, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Urology, University of California San Diego, La Jolla, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091753897","display_name":"Vitaly Margulis","orcid":"https://orcid.org/0000-0002-5837-4561","observed_orcids":["https://orcid.org/0000-0002-5837-4561"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vitaly Margulis","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080037221","display_name":"Solomon L. Woldu","orcid":"https://orcid.org/0000-0003-3282-7670","observed_orcids":["https://orcid.org/0000-0003-3282-7670"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Solomon L. Woldu","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073118929","display_name":"Douglas W. Strand","orcid":"https://orcid.org/0000-0002-0746-927X","observed_orcids":["https://orcid.org/0000-0002-0746-927X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas W. Strand","raw_affiliation_strings":["Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051562152","display_name":"Nicholas Coleman","orcid":"https://orcid.org/0000-0002-5374-739X","observed_orcids":["https://orcid.org/0000-0002-5374-739X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Coleman","raw_affiliation_strings":["Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","Department of Pathology, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]},{"raw_affiliation_string":"Department of Pathology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086083448","display_name":"James F. Amatruda","orcid":"https://orcid.org/0000-0002-9901-2137","observed_orcids":["https://orcid.org/0000-0002-9901-2137"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Amatruda","raw_affiliation_strings":["Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, USA","Departments of Pediatrics and Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Departments of Pediatrics and Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078106172","display_name":"A. Lindsay Frazier","orcid":"https://orcid.org/0000-0003-4748-8552","observed_orcids":["https://orcid.org/0000-0003-4748-8552"]},"institutions":[{"id":"https://openalex.org/I4210166317","display_name":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center","ror":"https://ror.org/05k11pb55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113","https://openalex.org/I4210117453","https://openalex.org/I4210166317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Lindsay Frazier","raw_affiliation_strings":["Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, USA","institution_ids":["https://openalex.org/I4210166317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085468231","display_name":"Matthew Jonathan Murray","orcid":"https://orcid.org/0000-0002-4480-1147","observed_orcids":["https://orcid.org/0000-0002-4480-1147"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew J. Murray","raw_affiliation_strings":["Department of Pathology, University of Cambridge, Cambridge, UK","Department of Pediatric Hematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067264659","display_name":"Aditya Bagrodia","orcid":"https://orcid.org/0000-0002-3358-1193","observed_orcids":["https://orcid.org/0000-0002-3358-1193","https://orcid.org/0000-0001-9220-0349"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aditya Bagrodia","raw_affiliation_strings":["Department of Urology, University of California San Diego, Suite 1-200, 9400 Campus Point Drive, La Jolla, CA, 92037, USA. Bagrodia@health.ucsd.edu","Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA. Bagrodia@health.ucsd.edu","Department of Urology, University of California San Diego, La Jolla, USA","Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California San Diego, Suite 1-200, 9400 Campus Point Drive, La Jolla, CA, 92037, USA. Bagrodia@health.ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA. Bagrodia@health.ucsd.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Urology, University of California San Diego, La Jolla, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Urology, University of Texas Southwestern Medical Center, Dallas, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5067264659"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I867280407"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":8.0088,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.98453833,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"10558","last_page":"10558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-371a-3p","display_name":"miR-371a-3p","score":0.9919999837875366},{"id":"https://openalex.org/keywords/germ-cell-tumors","display_name":"germ cell tumors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/serum-mirna","display_name":"serum microRNA","score":0.6190000176429749},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.828000009059906},{"id":"https://openalex.org/keywords/inter-laboratory-concordance","display_name":"inter-laboratory concordance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/reference-genes","display_name":"reference genes","score":0.5709999799728394},{"id":"https://openalex.org/keywords/mir-30b-5p","display_name":"miR-30b-5p","score":0.9369999766349792},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.49000000953674316},{"id":"https://openalex.org/keywords/retroperitoneal-disease","display_name":"retroperitoneal disease","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.8106675148010254},{"id":"https://openalex.org/C94624232","wikidata":"https://www.wikidata.org/wiki/Q3150667","display_name":"Indeterminate","level":2,"score":0.710114598274231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.570872962474823},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4472469091415405},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40189114212989807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3780793845653534},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13423267006874084},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[],"locations_count":10,"locations":[{"id":"doi:10.1038/s41598-023-37271-1","doi":"https://doi.org/10.1038/s41598-023-37271-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-37271-1","pdf_url":"https://www.nature.com/articles/s41598-023-37271-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2644890/v1","doi":"https://doi.org/10.21203/rs.3.rs-2644890/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2644890/v1","pdf_url":"https://www.researchsquare.com/article/rs-2644890/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10310745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10310745","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10310745/pdf/41598_2023_Article_37271.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:36993198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36993198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Preprint"},{"id":"pmid:37386046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37386046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt15v5t0m6","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/15v5t0m6","pdf_url":"https://escholarship.org/content/qt15v5t0m6/qt15v5t0m6.pdf?t=sepign","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, vol 13, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10055551","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10055551","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10055551/pdf/nihpp-rs2644890v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/353903","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/353903","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/fef4a8da-933c-4953-9db7-f1fb8ae2ca45/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/354802","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/354802","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/ad197068-f4b4-4a57-a643-4a8680e46704/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:8f30f5097b144b91a537ae6cb38b1d83","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f30f5097b144b91a537ae6cb38b1d83","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-37271-1","doi":"https://doi.org/10.1038/s41598-023-37271-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-37271-1","pdf_url":"https://www.nature.com/articles/s41598-023-37271-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1424491230","display_name":null,"funder_award_id":"5 P30 CA142543 09","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1726070573","display_name":"Assay Validation of a Circulating miRNA Test for Diagnosis and Monitoring of Malignant Germ Cell Tumors","funder_award_id":"5uh2ca240688-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G428461830","display_name":null,"funder_award_id":"(CA142543)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4834239603","display_name":null,"funder_award_id":"RP170152","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8009936218","display_name":"Assay Validation of a Circulating miRNA Test for Diagnosis and Monitoring of Malignant Germ Cell Tumors","funder_award_id":"UH3CA240688","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G81203255","display_name":"Targeting the HNF4A and WNT/Beta-catenin pathways in childhood malignant yolk sac tumors.","funder_award_id":"RP170152","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G9000898154","display_name":"UT Southwestern Medical Center Simmons Comprehensive Cancer Center","funder_award_id":"P30CA142543","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382631728.pdf","grobid_xml":"https://content.openalex.org/works/W4382631728.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2006617902","https://openalex.org/W2055258512","https://openalex.org/W2098838369","https://openalex.org/W2106496119","https://openalex.org/W2152575748","https://openalex.org/W2186074472","https://openalex.org/W2581742479","https://openalex.org/W2582743722","https://openalex.org/W2972804703","https://openalex.org/W2974979812","https://openalex.org/W2990427812","https://openalex.org/W3082450800","https://openalex.org/W3095021426","https://openalex.org/W3129700545","https://openalex.org/W3152586373","https://openalex.org/W3191813620","https://openalex.org/W4289812930","https://openalex.org/W4311870759"],"related_works":["https://openalex.org/W4324136475","https://openalex.org/W4213035641","https://openalex.org/W7212086633","https://openalex.org/W3135468012","https://openalex.org/W4311870759","https://openalex.org/W3082450800","https://openalex.org/W7133201919","https://openalex.org/W4324136521","https://openalex.org/W4289812930","https://openalex.org/W4407700876"],"abstract_inverted_index":{"Circulating":[0],"miR-371a-3p":[1,29,113,159],"has":[2],"excellent":[3],"performance":[4,39,60],"in":[5,31,63,146],"the":[6,27,32,86],"detection":[7],"of":[8,40,66,70,112,125,129,149,152],"viable":[9],"(non-teratoma)":[10],"germ":[11],"cell":[12],"tumor":[13],"(GCT)":[14],"pre-orchiectomy;":[15],"however,":[16],"its":[17],"ability":[18],"to":[19,93,144,164,175,193],"detect":[20],"occult":[21,71,153],"disease":[22,35],"is":[23],"understudied.":[24],"To":[25],"refine":[26],"serum":[28,158],"assay":[30,59,140],"minimal":[33],"residual":[34],"setting":[36],"we":[37],"compared":[38],"raw":[41,105,170],"(Cq)":[42],"and":[43,51,120,181,191],"normalized":[44,108],"(\u2206Cq,":[45],"RQ)":[46],"values":[47],"from":[48,142],"prior":[49],"assays,":[50],"validated":[52],"interlaboratory":[53,96],"concordance":[54,111],"by":[55,78],"aliquot":[56],"swapping.":[57],"Revised":[58],"was":[61,76,99,114],"determined":[62,77],"a":[64,133,147],"cohort":[65],"32":[67],"patients":[68,150],"suspected":[69,151],"retroperitoneal":[72],"disease.":[73],"Assay":[74],"superiority":[75],"comparing":[79],"resulting":[80],"receiver-operator":[81],"characteristic":[82],"(ROC)":[83],"curves":[84],"using":[85,169],"Delong":[87],"method.":[88],"Pairwise":[89],"t-tests":[90],"were":[91,122],"used":[92],"test":[94,160],"for":[95,136,188],"concordance.":[97],"Performance":[98],"comparable":[100],"when":[101],"thresholding":[102],"based":[103],"on":[104],"Cq":[106,130,171],"vs.":[107],"values.":[109],"Interlaboratory":[110],"high,":[115],"but":[116],"reference":[117],"genes":[118],"miR-30b-5p":[119],"cel-miR-39-3p":[121],"discordant.":[123],"Introduction":[124],"an":[126,177,198],"indeterminate":[127,138,199],"range":[128],"28-35":[131],"with":[132,197],"repeat":[134],"run":[135],"any":[137,195],"improved":[139],"accuracy":[141],"0.84":[143],"0.92":[145],"group":[148],"GCT.":[154],"We":[155],"recommend":[156],"that":[157],"protocols":[161],"are":[162],"updated":[163],"(a)":[165],"utilize":[166],"threshold-based":[167],"approaches":[168],"values,":[172],"(b)":[173],"continue":[174],"include":[176],"endogenous":[178],"(e.g.,":[179,185],"miR-30b-5p)":[180],"exogenous":[182],"non-human":[183],"spike-in":[184],"cel-miR-39-3p)":[186],"microRNA":[187],"quality":[189],"control,":[190],"(c)":[192],"re-run":[194],"sample":[196],"result.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-07-01T00:00:00"}