{"id":"https://openalex.org/W4382631677","doi":"https://doi.org/10.1038/s41467-023-39549-4","title":"Single cell Hi-C identifies plastic chromosome conformations underlying the gastrulation enhancer landscape","display_name":"Single cell Hi-C identifies plastic chromosome conformations underlying the gastrulation enhancer landscape","publication_year":2023,"publication_date":"2023-06-29","ids":{"openalex":"https://openalex.org/W4382631677","doi":"https://doi.org/10.1038/s41467-023-39549-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/37386027","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10310791"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-39549-4","doi":"https://doi.org/10.1038/s41467-023-39549-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-39549-4","pdf_url":"https://www.nature.com/articles/s41467-023-39549-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-39549-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004716132","display_name":"Nimrod Rappoport","orcid":"https://orcid.org/0000-0002-0951-6244","observed_orcids":["https://orcid.org/0000-0002-0951-6244"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nimrod Rappoport","raw_affiliation_strings":["Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062681384","display_name":"Elad Chomsky","orcid":"https://orcid.org/0000-0003-3028-5425","observed_orcids":["https://orcid.org/0000-0003-3028-5425"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Elad Chomsky","raw_affiliation_strings":["Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058410050","display_name":"Takashi Nagano","orcid":"https://orcid.org/0000-0003-1536-8927","observed_orcids":["https://orcid.org/0000-0003-1536-8927"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["GB","JP"],"is_corresponding":false,"raw_author_name":"Takashi Nagano","raw_affiliation_strings":["Laboratory for Nuclear Dynamics, Institute for Protein Research, Osaka University, Osaka, Japan","Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Nuclear Dynamics, Institute for Protein Research, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047232674","display_name":"Charlie Seibert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlie Seibert","raw_affiliation_strings":["Department of Biological Science, Florida State University, Tallahassee, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034863002","display_name":"Yaniv Lubling","orcid":"https://orcid.org/0000-0003-3461-9621","observed_orcids":["https://orcid.org/0000-0003-3461-9621"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yaniv Lubling","raw_affiliation_strings":["Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":"https://orcid.org/0000-0003-3461-9621","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004215664","display_name":"Yael Baran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yael Baran","raw_affiliation_strings":["Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004510264","display_name":"Aviezer Lifshitz","orcid":"https://orcid.org/0000-0002-8458-9507","observed_orcids":["https://orcid.org/0000-0002-8458-9507"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aviezer Lifshitz","raw_affiliation_strings":["Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":"https://orcid.org/0000-0002-8458-9507","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091579227","display_name":"Wing\u2010Kit Leung","orcid":"https://orcid.org/0000-0003-3039-4904","observed_orcids":["https://orcid.org/0000-0003-3039-4904"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I4405286456","display_name":"Institute for Protein Research, The University of Osaka","ror":"https://ror.org/0268snt13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["GB","JP"],"is_corresponding":false,"raw_author_name":"Wing Leung","raw_affiliation_strings":["Laboratory for Nuclear Dynamics, Institute for Protein Research, Osaka University, Osaka, Japan","Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Nuclear Dynamics, Institute for Protein Research, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I4405286456","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067018310","display_name":"Zohar Mukamel","orcid":"https://orcid.org/0000-0002-1623-9564","observed_orcids":["https://orcid.org/0000-0002-1623-9564"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Zohar Mukamel","raw_affiliation_strings":["Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":"https://orcid.org/0000-0002-1623-9564","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038806020","display_name":"Ron Shamir A","orcid":"https://orcid.org/0000-0003-1889-9870","observed_orcids":["https://orcid.org/0000-0003-1889-9870"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ron Shamir","raw_affiliation_strings":["The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049273208","display_name":"Peter Fraser","orcid":"https://orcid.org/0000-0002-0041-1227","observed_orcids":["https://orcid.org/0000-0002-0041-1227"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Peter Fraser","raw_affiliation_strings":["Department of Biological Science, Florida State University, Tallahassee, FL, USA. pfraser@bio.fsu.edu","Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK. pfraser@bio.fsu.edu","Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-0041-1227","affiliations":[{"raw_affiliation_string":"Department of Biological Science, Florida State University, Tallahassee, FL, USA. pfraser@bio.fsu.edu","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK. pfraser@bio.fsu.edu","institution_ids":["https://openalex.org/I1302113299"]},{"raw_affiliation_string":"Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083312685","display_name":"Amos Tanay","orcid":"https://orcid.org/0000-0001-9419-3824","observed_orcids":["https://orcid.org/0000-0001-9419-3824"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Amos Tanay","raw_affiliation_strings":["Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. amos.tanay@weizmann.ac.il","Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":"https://orcid.org/0000-0001-9419-3824","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. amos.tanay@weizmann.ac.il","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Computer Science and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5049273208","https://openalex.org/A5083312685"],"corresponding_institution_ids":["https://openalex.org/I103163165","https://openalex.org/I1302113299","https://openalex.org/I53964585"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":2.2171,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.89290775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"3844","last_page":"3844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-cell-hi-c","display_name":"single-cell Hi-C","score":0.7580000162124634},{"id":"https://openalex.org/keywords/chromatin-conformation","display_name":"chromatin conformation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/enhancer-landscape","display_name":"enhancer landscape","score":0.6909999847412109},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.5659999847412109},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6549999713897705},{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.796999990940094},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cell-fate-differentiation","display_name":"cell fate differentiation","score":0.38499999046325684},{"id":"https://openalex.org/keywords/ectoderm","display_name":"ectoderm","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mesoderm","display_name":"mesoderm","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.7732648253440857},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.7531027793884277},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.737917423248291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7263179421424866},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.6767365336418152},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6166556477546692},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5198167562484741},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.49207133054733276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48759403824806213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19909486174583435},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.17338410019874573},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054262","descriptor_name":"Gastrulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-023-39549-4","doi":"https://doi.org/10.1038/s41467-023-39549-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-39549-4","pdf_url":"https://www.nature.com/articles/s41467-023-39549-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10310791","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10310791","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10310791/pdf/41467_2023_Article_39549.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37386027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37386027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/356810","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/356810","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/201cd93c-f0c2-483c-998c-dd227d20989b/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39549-4","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-39549-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9405487864e141ed95c600dc5cb8ef6e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9405487864e141ed95c600dc5cb8ef6e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-39549-4","doi":"https://doi.org/10.1038/s41467-023-39549-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-39549-4","pdf_url":"https://www.nature.com/articles/s41467-023-39549-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3711085794","display_name":null,"funder_award_id":"1339/18","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G5935785691","display_name":null,"funder_award_id":"3165 / 19","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G7103229710","display_name":"a novel strategy toward chromatin dynamics based on precise single-cell information","funder_award_id":"18H02374","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320312914","display_name":"Blavatnik Family Foundation","ror":"https://ror.org/049hmt962"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335375","display_name":"Planning and Budgeting Committee of the Council for Higher Education of Israel","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382631677.pdf","grobid_xml":"https://content.openalex.org/works/W4382631677.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W2056482755","https://openalex.org/W2064537118","https://openalex.org/W2070021921","https://openalex.org/W2073504534","https://openalex.org/W2080477348","https://openalex.org/W2100884254","https://openalex.org/W2161212572","https://openalex.org/W2243544746","https://openalex.org/W2337802231","https://openalex.org/W2530292798","https://openalex.org/W2551543748","https://openalex.org/W2553838260","https://openalex.org/W2557097554","https://openalex.org/W2558827688","https://openalex.org/W2582946425","https://openalex.org/W2594764564","https://openalex.org/W2731989040","https://openalex.org/W2755403661","https://openalex.org/W2756584474","https://openalex.org/W2765567136","https://openalex.org/W2805879691","https://openalex.org/W2812344549","https://openalex.org/W2898514070","https://openalex.org/W2908798728","https://openalex.org/W2912272542","https://openalex.org/W2917835243","https://openalex.org/W2929173597","https://openalex.org/W2945489451","https://openalex.org/W2949773289","https://openalex.org/W2953105755","https://openalex.org/W2965729444","https://openalex.org/W2971932838","https://openalex.org/W2972909971","https://openalex.org/W2979981308","https://openalex.org/W2990380375","https://openalex.org/W2994681856","https://openalex.org/W2994813193","https://openalex.org/W2996410805","https://openalex.org/W2999585791","https://openalex.org/W3045946041","https://openalex.org/W3087339707","https://openalex.org/W4224290465","https://openalex.org/W4282925821","https://openalex.org/W4298055410"],"related_works":["https://openalex.org/W2731989040","https://openalex.org/W2989756098","https://openalex.org/W3118481910","https://openalex.org/W4412038677","https://openalex.org/W2726235340","https://openalex.org/W7095514383","https://openalex.org/W2808264195","https://openalex.org/W2967878730","https://openalex.org/W4415488917","https://openalex.org/W2002831389"],"abstract_inverted_index":{"Embryonic":[0],"development":[1],"involves":[2],"massive":[3],"proliferation":[4,22],"and":[5,17,23,51,55,85,110,122,131,143,172],"differentiation":[6,128],"of":[7,99,129,141],"cell":[8,24,40,71],"lineages.":[9],"This":[10],"must":[11],"be":[12,91],"supported":[13],"by":[14,170],"chromosome":[15,78],"replication":[16,76],"epigenetic":[18,95],"reprogramming,":[19],"but":[20,134],"how":[21],"fate":[25],"acquisition":[26],"are":[27,88,102,117,165],"balanced":[28],"in":[29,46,139],"this":[30],"process":[31],"is":[32],"not":[33],"well":[34],"understood.":[35],"Here":[36],"we":[37],"use":[38],"single":[39],"Hi-C":[41],"to":[42,90],"map":[43],"chromosomal":[44,160],"conformations":[45],"post-gastrulation":[47],"mouse":[48],"embryo":[49],"cells":[50,116,164],"study":[52],"their":[53],"distributions":[54],"correlations":[56],"with":[57,120],"matching":[58],"embryonic":[59,65,154,163],"transcriptional":[60],"atlases.":[61],"We":[62],"find":[63],"that":[64,150],"chromosomes":[66],"show":[67],"a":[68],"remarkably":[69],"strong":[70],"cycle":[72],"signature.":[73],"Despite":[74],"that,":[75],"timing,":[77],"compartment":[79,112,132],"structure,":[80],"topological":[81],"associated":[82,119],"domains":[83],"(TADs)":[84],"promoter-enhancer":[86,145],"contacts":[87,138],"shown":[89],"variable":[92],"between":[93],"distinct":[94],"states.":[96],"About":[97],"10%":[98],"the":[100],"nuclei":[101],"identified":[103],"as":[104],"primitive":[105],"erythrocytes,":[106],"showing":[107,125,166],"exceptionally":[108],"compact":[109],"organized":[111],"structure.":[113],"The":[114,147],"remaining":[115],"broadly":[118],"ectoderm":[121,142],"mesoderm":[123,144],"identities,":[124],"only":[126],"mild":[127],"TADs":[130],"structures,":[133],"more":[135],"specific":[136,159],"localized":[137],"hundreds":[140],"pairs.":[146],"data":[148],"suggest":[149],"while":[151],"fully":[152],"committed":[153],"lineages":[155],"can":[156],"rapidly":[157],"acquire":[158],"conformations,":[161],"most":[162],"plastic":[167],"signatures":[168],"driven":[169],"complex":[171],"intermixed":[173],"enhancer":[174],"landscapes.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-01T00:00:00"}
