{"id":"https://openalex.org/W4382600824","doi":"https://doi.org/10.21037/jgo-23-308","title":"Prognostic evaluation of pancreatic cancer based on the model of chemo-radiotherapy resistance-related genes","display_name":"Prognostic evaluation of pancreatic cancer based on the model of chemo-radiotherapy resistance-related genes","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4382600824","doi":"https://doi.org/10.21037/jgo-23-308","pmid":"https://pubmed.ncbi.nlm.nih.gov/37435207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10331760"},"language":"en","primary_location":{"id":"doi:10.21037/jgo-23-308","doi":"https://doi.org/10.21037/jgo-23-308","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-23-308","pdf_url":"https://jgo.amegroups.com/article/viewFile/76107/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jgo.amegroups.com/article/viewFile/76107/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017352295","display_name":"Hui\u2010Chuan Sun","orcid":"https://orcid.org/0000-0003-3761-7058","observed_orcids":["https://orcid.org/0000-0003-3761-7058"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Sun","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101498565","display_name":"Weigang Zhang","orcid":"https://orcid.org/0000-0002-2488-159X","observed_orcids":["https://orcid.org/0000-0002-2488-159X"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weigang Zhang","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080298080","display_name":"Yunqian Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunqian Chu","raw_affiliation_strings":["Department of Oncology, The Affiliated Hospital of Nanjing Medical University, Changzhou No. 2 People's Hospital, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Nanjing Medical University, Changzhou No. 2 People's Hospital, Changzhou, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lei Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feiran Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feiran Gong","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102029891","display_name":"Kai Chen","orcid":"https://orcid.org/0009-0001-4594-1053","observed_orcids":["https://orcid.org/0009-0001-4594-1053"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Chen","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100318325","https://openalex.org/A5102029891"],"corresponding_institution_ids":["https://openalex.org/I4210153519"],"apc_list":null,"apc_paid":null,"fwci":0.5203,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62817829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"3","first_page":"1525","last_page":"1545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.7419999837875366},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6200000047683716},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.781000018119812},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/jag1","display_name":"JAG1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.7990000247955322},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.609000027179718},{"id":"https://openalex.org/keywords/risk-model","display_name":"risk model","score":0.3869999945163727},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8221821784973145},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7656046748161316},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6224539279937744},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.620171070098877},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.587264358997345},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5849332809448242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5048871636390686},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4508483409881592},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4438381791114807},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.424514502286911}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/jgo-23-308","doi":"https://doi.org/10.21037/jgo-23-308","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-23-308","pdf_url":"https://jgo.amegroups.com/article/viewFile/76107/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10331760","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10331760","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10331760/pdf/jgo-14-03-1525.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastrointest Oncol","raw_type":"Text"},{"id":"pmid:37435207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37435207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/jgo-23-308","doi":"https://doi.org/10.21037/jgo-23-308","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-23-308","pdf_url":"https://jgo.amegroups.com/article/viewFile/76107/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3709360814","display_name":null,"funder_award_id":"81873587","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382600824.pdf","grobid_xml":"https://content.openalex.org/works/W4382600824.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W119540838","https://openalex.org/W1578012610","https://openalex.org/W1901801026","https://openalex.org/W1914685501","https://openalex.org/W1931508686","https://openalex.org/W1942368628","https://openalex.org/W1983418140","https://openalex.org/W1984413324","https://openalex.org/W1985268469","https://openalex.org/W1988220127","https://openalex.org/W2001029542","https://openalex.org/W2001555806","https://openalex.org/W2019096247","https://openalex.org/W2024440110","https://openalex.org/W2025247022","https://openalex.org/W2027368033","https://openalex.org/W2034272820","https://openalex.org/W2040827891","https://openalex.org/W2048911358","https://openalex.org/W2060551076","https://openalex.org/W2065357818","https://openalex.org/W2065445233","https://openalex.org/W2078288469","https://openalex.org/W2089609493","https://openalex.org/W2099320651","https://openalex.org/W2111437716","https://openalex.org/W2115658806","https://openalex.org/W2125106680","https://openalex.org/W2131594442","https://openalex.org/W2143953275","https://openalex.org/W2145232127","https://openalex.org/W2149199519","https://openalex.org/W2150424120","https://openalex.org/W2151155898","https://openalex.org/W2153022581","https://openalex.org/W2156908220","https://openalex.org/W2160232534","https://openalex.org/W2161109457","https://openalex.org/W2175221016","https://openalex.org/W2297899744","https://openalex.org/W2412717755","https://openalex.org/W2580610149","https://openalex.org/W2588330188","https://openalex.org/W2593880624","https://openalex.org/W2595310490","https://openalex.org/W2601577871","https://openalex.org/W2607129810","https://openalex.org/W2619317414","https://openalex.org/W2626917996","https://openalex.org/W2683486796","https://openalex.org/W2789272070","https://openalex.org/W2883223808","https://openalex.org/W2891589486","https://openalex.org/W2911188335","https://openalex.org/W2914275547","https://openalex.org/W2915514153","https://openalex.org/W2917919815","https://openalex.org/W2942792191","https://openalex.org/W2945579431","https://openalex.org/W2950019572","https://openalex.org/W2953057790","https://openalex.org/W2972602909","https://openalex.org/W2976240910","https://openalex.org/W3012244554","https://openalex.org/W3022442866","https://openalex.org/W3023361537","https://openalex.org/W3033368801","https://openalex.org/W3081692890","https://openalex.org/W3118936295","https://openalex.org/W3123318267","https://openalex.org/W3132812950","https://openalex.org/W3175752499","https://openalex.org/W3178064698","https://openalex.org/W3200288467","https://openalex.org/W4211253487","https://openalex.org/W4225088434","https://openalex.org/W4244911976","https://openalex.org/W4283519192","https://openalex.org/W4284988216","https://openalex.org/W4297905036"],"related_works":["https://openalex.org/W4309662462","https://openalex.org/W4408095577","https://openalex.org/W2976240910","https://openalex.org/W4405080569","https://openalex.org/W4391687055","https://openalex.org/W3087370685","https://openalex.org/W2601267111","https://openalex.org/W2242051475","https://openalex.org/W4387959453","https://openalex.org/W4392454085"],"abstract_inverted_index":{"Background:":[0],"The":[1,21,31,118,298],"incidence":[2],"and":[3,12,57,66,80,97,101,127,156,169,177,186,205,268,276,287,301,312,334],"mortality":[4,23],"of":[5,24,40,111,139,194,219,227,265,279,292,315,329,342],"pancreatic":[6,25,41,59,82,113,179,243,280,293,316,332,343],"cancer":[7,26,42,60,83,180,244,266,281,294,317,333],"are":[8],"almost":[9],"the":[10,13,55,87,112,130,137,166,213,217,220,228,237,262,274,310,327,340],"same,":[11],"5-year":[14],"survival":[15,218,240],"rate":[16],"is":[17,27],"less":[18],"than":[19,225],"10%.":[20],"high":[22],"related":[28],"to":[29,35,184,212,235,258],"chemo-radiotherapy.":[30],"present":[32],"study":[33,285],"aimed":[34],"establish":[36],"a":[37,67,108,146,152,157,190,250,289],"prognostic":[38,109,290,337],"signature":[39,291],"based":[43],"on":[44,94],"chemo-radiotherapy":[45,277],"resistant-related":[46],"genes":[47,142],"(CRRGs).":[48],"Methods:":[49],"In":[50],"this":[51],"study,":[52],"we":[53,75,173],"explored":[54],"radiation-resistant":[56],"chemotherapy-resistant":[58,178],"cell":[61,84,318],"lines":[62,85],"by":[63,145,207],"colony":[64,153],"formation":[65,154],"subcutaneous":[68,158],"tumor":[69,159],"model":[70,110,160,192],"in":[71,86,117,161,167,170,242,261,299,302,331],"nude":[72,162],"mice.":[73,163],"Next,":[74],"obtained":[76],"CRRGs":[77,196,330],"from":[78],"radiation-":[79],"gemcitabine-resistant":[81],"Gene":[88],"Expression":[89],"Omnibus":[90],"(GEO)":[91],"database.":[92],"Based":[93],"univariate":[95],"Cox":[96,105],"least":[98],"absolute":[99],"shrinkage":[100],"selection":[102],"operator":[103],"(LASSO)":[104],"regression":[106],"analyses,":[107],"adenocarcinoma":[114],"(PAAD)":[115],"cohort":[116,132],"Cancer":[119],"Genome":[120],"Atlas":[121],"(TCGA)":[122],"database":[123],"(N=177)":[124],"was":[125,223],"established":[126,286],"verified":[128,144],"using":[129,208,295],"GEO":[131],"data":[133],"set":[134],"(N=112).":[135],"Finally,":[136],"functions":[138],"candidate":[140,251],"target":[141,252],"were":[143,182],"methyl":[147],"thiazolyl":[148],"tetrazolium":[149],"(MTT)":[150],"assay,":[151,155],"Results:":[164],"Through":[165],"vitro":[168,300],"vivo":[171,303],"experiments,":[172],"found":[174,269],"that":[175,226,270,306],"radiotherapy-":[176],"cells":[181],"cross-resistant":[183],"chemotherapy":[185],"radiotherapy.":[187],"We":[188,231,246],"constructed":[189],"risk":[191],"consisting":[193],"nine":[195,296],"(SNAP25,":[197],"GPR87,":[198],"DLL1,":[199],"LAD1,":[200],"WASF3,":[201],"ARHGAP29,":[202],"ZBED2,":[203],"GAD1,":[204],"JAG1)":[206],"public":[209],"databases.":[210],"According":[211],"Kaplan-Meier":[214],"curve":[215],"analysis,":[216],"high-risk":[221],"group":[222],"worse":[224],"low-risk":[229],"group.":[230],"then":[232],"used":[233],"nomograms":[234],"predict":[236],"1/3/5-year":[238],"overall":[239],"(OS)":[241],"patients.":[245],"chose":[247],"JAG1":[248,271,307],"as":[249],"since":[253],"it":[254],"has":[255],"been":[256],"proven":[257],"be":[259],"involved":[260],"stemness":[263],"maintenance":[264],"cells,":[267],"silencing":[272],"inhibited":[273],"proliferation":[275,311],"tolerance":[278,314],"cells.":[282],"Conclusions:":[283],"This":[284],"validated":[288],"CRRGs.":[297],"experiments":[304],"showed":[305],"could":[308],"promote":[309],"chemoradiotherapy":[313],"lines.":[319],"These":[320],"findings":[321],"may":[322],"offer":[323],"new":[324],"insights":[325],"into":[326],"role":[328],"provide":[335],"novel":[336],"biomarkers":[338],"for":[339],"treatment":[341],"cancer.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-30T00:00:00"}