{"id":"https://openalex.org/W4382469271","doi":"https://doi.org/10.30699/ijbd.16.1.97","title":"OCT4B1 Dysregulation Is a Key Factor in Different Sensitivity of Normal Cells and Breast Cancer Cells to the Curcumin","display_name":"OCT4B1 Dysregulation Is a Key Factor in Different Sensitivity of Normal Cells and Breast Cancer Cells to the Curcumin","publication_year":2023,"publication_date":"2023-03-01","ids":{"openalex":"https://openalex.org/W4382469271","doi":"https://doi.org/10.30699/ijbd.16.1.97"},"language":"en","primary_location":{"id":"doi:10.30699/ijbd.16.1.97","doi":"https://doi.org/10.30699/ijbd.16.1.97","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30699/ijbd.16.1.97","pdf_url":"http://ijbd.ir/files/site1/user_files_395953/mohamadaminjavidi-A-10-892-1-6fcf51e.pdf","source":{"id":"https://openalex.org/S4210216757","display_name":"Iranian Journal of Breast Disease","issn_l":"1735-9406","issn":["1735-9406","2645-7482"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Breast Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://ijbd.ir/files/site1/user_files_395953/mohamadaminjavidi-A-10-892-1-6fcf51e.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015911474","display_name":"Maryam Tahmasebi Birgani","orcid":"https://orcid.org/0000-0002-9624-1903","observed_orcids":["https://orcid.org/0000-0002-9624-1903"]},"institutions":[{"id":"https://openalex.org/I119939603","display_name":"Ahvaz Jundishapur University of Medical Sciences","ror":"https://ror.org/01rws6r75","country_code":"IR","type":"education","lineage":["https://openalex.org/I119939603"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Tahmasebi-Birgani","raw_affiliation_strings":[". Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057991471","display_name":"Mohammad Amin Javidi","orcid":"https://orcid.org/0000-0003-2812-0111","observed_orcids":["https://orcid.org/0000-0003-2812-0111"]},"institutions":[{"id":"https://openalex.org/I2802694670","display_name":"Academic Center for Education, Culture and Research","ror":"https://ror.org/0126z4b94","country_code":"IR","type":"nonprofit","lineage":["https://openalex.org/I2802694670"]},{"id":"https://openalex.org/I4210128983","display_name":"Motamed Cancer Institute","ror":"https://ror.org/02f71a260","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210128983"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Amin Javidi","raw_affiliation_strings":["Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran","institution_ids":["https://openalex.org/I2802694670","https://openalex.org/I4210128983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040915789","display_name":"Majid Sadeghizadeh","orcid":"https://orcid.org/0000-0002-2497-3152","observed_orcids":["https://orcid.org/0000-0002-2497-3152","https://orcid.org/0000-0002-7380-4099"]},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Majid Sadeghizadeh","raw_affiliation_strings":["Dpartment of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dpartment of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity, Tehran, Iran","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013295187","display_name":"Seyed Javad Mowla","orcid":"https://orcid.org/0000-0002-3300-6332","observed_orcids":["https://orcid.org/0000-0002-3300-6332"]},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Javad Mowla","raw_affiliation_strings":["Dpartment of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dpartment of Genetics, Faculty of biological sciences, Tarbiat Modares Univesity, Tehran, Iran","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015800764","display_name":"Farhood Najafi","orcid":"https://orcid.org/0000-0003-3094-1322","observed_orcids":["https://orcid.org/0000-0003-3094-1322"]},"institutions":[{"id":"https://openalex.org/I4210145678","display_name":"Institute for Color Science and Technology","ror":"https://ror.org/047yd9004","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210145678"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farhood Najafi","raw_affiliation_strings":["Department of Resin and Additives, Institute for Color Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Resin and Additives, Institute for Color Science and Technology","institution_ids":["https://openalex.org/I4210145678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035229807","display_name":"Saeedeh Ghiasvand","orcid":"https://orcid.org/0000-0002-5589-4545","observed_orcids":["https://orcid.org/0000-0002-5589-4545"]},"institutions":[{"id":"https://openalex.org/I4210146087","display_name":"Malayer University","ror":"https://ror.org/03rk9sq81","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210146087"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saeedeh Ghiasvand","raw_affiliation_strings":["Departments of Biology, Faculty of Science, Malayer University, Malayer, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biology, Faculty of Science, Malayer University, Malayer, Iran","institution_ids":["https://openalex.org/I4210146087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057078246","display_name":"Hamid Zaferani Arani","orcid":"https://orcid.org/0000-0001-6790-5910","observed_orcids":["https://orcid.org/0000-0001-6790-5910"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamid Zaferani Arani","raw_affiliation_strings":["Young Researchers and Elite Club , Tehran University of Medical Sciences , Islamic Azad University , Tehran , Iran","Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Young Researchers and Elite Club , Tehran University of Medical Sciences , Islamic Azad University , Tehran , Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I70640408"]},{"raw_affiliation_string":"Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran","institution_ids":["https://openalex.org/I110525433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1047,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29721362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"16","issue":"1","first_page":"97","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.13920000195503235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.7229999899864197},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.7870000004768372},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.675000011920929},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/normal-fibroblasts","display_name":"normal fibroblasts","score":0.6370000243186951},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8091418743133545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6971189975738525},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.566868245601654},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5404454469680786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4232720136642456},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.41258078813552856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36269891262054443},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32744041085243225},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10788106918334961},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.30699/ijbd.16.1.97","doi":"https://doi.org/10.30699/ijbd.16.1.97","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30699/ijbd.16.1.97","pdf_url":"http://ijbd.ir/files/site1/user_files_395953/mohamadaminjavidi-A-10-892-1-6fcf51e.pdf","source":{"id":"https://openalex.org/S4210216757","display_name":"Iranian Journal of Breast Disease","issn_l":"1735-9406","issn":["1735-9406","2645-7482"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Breast Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.30699/ijbd.16.1.97","doi":"https://doi.org/10.30699/ijbd.16.1.97","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30699/ijbd.16.1.97","pdf_url":"http://ijbd.ir/files/site1/user_files_395953/mohamadaminjavidi-A-10-892-1-6fcf51e.pdf","source":{"id":"https://openalex.org/S4210216757","display_name":"Iranian Journal of Breast Disease","issn_l":"1735-9406","issn":["1735-9406","2645-7482"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Breast Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382469271.pdf","grobid_xml":"https://content.openalex.org/works/W4382469271.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W180998158","https://openalex.org/W1142652223","https://openalex.org/W1972179974","https://openalex.org/W1973354465","https://openalex.org/W1984956585","https://openalex.org/W1992199366","https://openalex.org/W2000098894","https://openalex.org/W2004878973","https://openalex.org/W2025069710","https://openalex.org/W2045879015","https://openalex.org/W2048496968","https://openalex.org/W2050433177","https://openalex.org/W2057070812","https://openalex.org/W2065305397","https://openalex.org/W2085360669","https://openalex.org/W2086734345","https://openalex.org/W2126663390","https://openalex.org/W2132870913","https://openalex.org/W2137377470","https://openalex.org/W2137631271","https://openalex.org/W2144491599","https://openalex.org/W2152262425","https://openalex.org/W2154354520","https://openalex.org/W2158547522","https://openalex.org/W2217238545","https://openalex.org/W2233241575","https://openalex.org/W2263207463","https://openalex.org/W2604567159","https://openalex.org/W2751037842","https://openalex.org/W2789317493","https://openalex.org/W2890841793","https://openalex.org/W2903846222","https://openalex.org/W2979839640","https://openalex.org/W6648264977"],"related_works":["https://openalex.org/W2036905565","https://openalex.org/W2759051904","https://openalex.org/W2090647015","https://openalex.org/W2810971566","https://openalex.org/W2472836858","https://openalex.org/W3029842759","https://openalex.org/W1855644362","https://openalex.org/W2187456576","https://openalex.org/W2901410810","https://openalex.org/W3171650408"],"abstract_inverted_index":{"Introduction:The":[0],"crucial":[1],"and":[2,31,34,38,95,101,104,121,144,154,159,249],"vital":[3,256],"player":[4],"in":[5,42,84,141,152,164,180,190,206,238,258],"tumor":[6],"recurrence":[7],"is":[8,13,227],"the":[9,46,64,68,74,77,110,116,129,132,136,175,193,207,219,233],"tumorinitiating":[10],"cells":[11,51,93,98,183,214,240,261],"(TICs).OCT4":[12],"a":[14,165,255],"widely":[15],"appreciated":[16],"non-cell":[17],"surface":[18],"for":[19,168],"TICs,":[20],"dedicating":[21],"detrimental":[22],"properties":[23],"to":[24,55,72,108,127,187,218,223,232,253,263],"these":[25,62,239,259],"cells,":[26,192],"including":[27,247],"self-renewal,":[28],"epithelial-mesenchymal":[29],"capacity,":[30],"drug":[32],"resistance.OCT4":[33],"its":[35],"partners":[36],"Sox2":[37],"Nanog":[39,194,250],"are":[40,52,215,251],"up-regulated":[41],"stem":[43,50,92],"cells;":[44],"on":[45,61],"other":[47],"hand,":[48],"normal":[49,182],"more":[53,216],"resistant":[54,217,262],"various":[56],"herbal":[57],"remedies":[58],"like":[59],"curcumin.Based":[60],"facts,":[63],"main":[65],"objective":[66],"of":[67,76,113,119,131,135,178,202],"present":[69],"study":[70],"was":[71,125],"investigate":[73],"alteration":[75,130],"mentioned":[78,137],"genes":[79,138,204],"expression":[80,117,134,177,196,201,235],"after":[81,139,157,162,198,209,241],"curcumin":[82,220],"treatment":[83,140,163,172,210,221,242],"breast":[85],"cancer":[86,169,224],"cell,":[87],"human":[88],"bone":[89],"marrow":[90],"mesenchymal":[91],"(hBM-MSCs),":[94],"non-tumor":[96,260],"fibroblast":[97],"(HSFPI3).":[99],"Materials":[100],"Methods:MTT":[102],"assay":[103],"AnnexinV/PI":[105],"were":[106],"performed":[107,126],"calculate":[109],"effective":[111],"concentration":[112,167],"curcumin.To":[114],"assess":[115],"level":[118],"OCT4":[120],"Nanog,":[122],"real-time":[123],"PCR":[124],"quantify":[128],"mRNA":[133,176,195],"MDA-MB231,":[142],"hBM-MSCs,":[143],"HSFPI3.Results:":[145],"Curcumin":[146],"could":[147],"not":[148],"induce":[149],"significant":[150],"apoptosis":[151],"hBM-MSCs":[153],"HSFPI3":[155,191],"even":[156],"24":[158],"36":[160],"hours":[161],"toxic":[166],"cells.After":[170],"36-hour":[171],"with":[173,211,243],"DNC,":[174],"Oct4-B1":[179,248],"both":[181,203],"enhanced":[184],"significantly":[185],"compared":[186,222],"untreated":[188],"samples.Furthermore,":[189],"increased":[197],"this":[199,244],"treatment.The":[200],"decreased":[205],"MDA-MB231":[208],"DNC.Conclusion:":[212],"Non-tumor":[213],"cells.The":[225],"reason":[226],"at":[228],"least":[229],"partially":[230],"due":[231],"different":[234],"pattern":[236],"results":[237],"reagent.Pluripotent":[245],"markers,":[246],"proposed":[252],"play":[254],"role":[257],"curcumin.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-06-29T00:00:00"}
