{"id":"https://openalex.org/W4382394022","doi":"https://doi.org/10.1016/s1452-3981(23)16588-6","title":"Electrical Impedance Determination of Cancer Cell Viability in a 3-Dimensional Cell Culture Microfluidic Chip","display_name":"Electrical Impedance Determination of Cancer Cell Viability in a 3-Dimensional Cell Culture Microfluidic Chip","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W4382394022","doi":"https://doi.org/10.1016/s1452-3981(23)16588-6"},"language":"en","primary_location":{"id":"doi:10.1016/s1452-3981(23)16588-6","doi":"https://doi.org/10.1016/s1452-3981(23)16588-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1452-3981(23)16588-6","pdf_url":null,"source":{"id":"https://openalex.org/S48583931","display_name":"International Journal of Electrochemical Science","issn_l":"1452-3981","issn":["1452-3981"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Electrochemical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/s1452-3981(23)16588-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030901999","display_name":"Kin Fong Lei","orcid":"https://orcid.org/0000-0002-5356-2221","observed_orcids":["https://orcid.org/0000-0002-5356-2221"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kin Fong Lei","raw_affiliation_strings":["Department of Mechanical Engineering,","Graduate Institute of Medical Mechatronics,","These authors contribute equaly to the work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering,","institution_ids":[]},{"raw_affiliation_string":"Graduate Institute of Medical Mechatronics,","institution_ids":[]},{"raw_affiliation_string":"These authors contribute equaly to the work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054920568","display_name":"Min\u2010Hsien Wu","orcid":"https://orcid.org/0000-0002-3507-3512","observed_orcids":["https://orcid.org/0000-0002-3507-3512"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Min-Hsien Wu","raw_affiliation_strings":["Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, R.O.C","These authors contribute equaly to the work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"These authors contribute equaly to the work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001244388","display_name":"Che\u2010Wei Hsu","orcid":"https://orcid.org/0000-0002-6742-9835","observed_orcids":["https://orcid.org/0000-0002-6742-9835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Che-Wei Hsu","raw_affiliation_strings":["Graduate Institute of Medical Mechatronics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medical Mechatronics,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039305072","display_name":"Yi-Dao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Dao Chen","raw_affiliation_strings":["Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I173093425"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030901999"],"corresponding_institution_ids":[],"apc_list":{"value":1670,"currency":"USD","value_usd":1670},"apc_paid":{"value":1670,"currency":"USD","value_usd":1670},"fwci":0.6471,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.68314463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"7","issue":"12","first_page":"12817","last_page":"12828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.09619999676942825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.07509999722242355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrical-impedance","display_name":"electrical impedance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8849999904632568},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.9259999990463257},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/agarose","display_name":"agarose","score":0.6349999904632568},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6790000200271606},{"id":"https://openalex.org/keywords/drug-concentration","display_name":"drug concentration","score":0.5809999704360962},{"id":"https://openalex.org/keywords/impedance-measurement","display_name":"impedance measurement","score":0.5270000100135803},{"id":"https://openalex.org/keywords/field-monitoring","display_name":"field monitoring","score":0.5580000281333923},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6941781640052795},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6557397842407227},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5894574522972107},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5662820339202881},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.49057191610336304},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4791538119316101},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4696257412433624},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.43566375970840454},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.43476617336273193},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.43392640352249146},{"id":"https://openalex.org/C146763376","wikidata":"https://www.wikidata.org/wiki/Q81714","display_name":"Petri dish","level":2,"score":0.42293959856033325},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3843744695186615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32754456996917725},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2976810336112976},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2671511769294739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2118454873561859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14413437247276306},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.11310756206512451},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08155679702758789},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/s1452-3981(23)16588-6","doi":"https://doi.org/10.1016/s1452-3981(23)16588-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1452-3981(23)16588-6","pdf_url":null,"source":{"id":"https://openalex.org/S48583931","display_name":"International Journal of Electrochemical Science","issn_l":"1452-3981","issn":["1452-3981"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Electrochemical Science","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.658.2862","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.658.2862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://electrochemsci.org/papers/vol7/71212817.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:35a5e8bbfb6d442d8697914f6dbc7579","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/35a5e8bbfb6d442d8697914f6dbc7579","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Electrochemical Science, Vol 7, Iss 12, Pp 12817-12828 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s1452-3981(23)16588-6","doi":"https://doi.org/10.1016/s1452-3981(23)16588-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1452-3981(23)16588-6","pdf_url":null,"source":{"id":"https://openalex.org/S48583931","display_name":"International Journal of Electrochemical Science","issn_l":"1452-3981","issn":["1452-3981"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Electrochemical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7949903625","display_name":"Development of a Microfluidic Perfusion 3D Cell Culture and Measurement Biochip for Continuous Monitoring 3D Cellular Dynamic Response under Varied Culture Conditions","funder_award_id":"NSC101-2221-E182-003-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1975833234","https://openalex.org/W1977248858","https://openalex.org/W1977486054","https://openalex.org/W1980914827","https://openalex.org/W1982998929","https://openalex.org/W1986482303","https://openalex.org/W1988593504","https://openalex.org/W1995891480","https://openalex.org/W1999737291","https://openalex.org/W2004883732","https://openalex.org/W2009140949","https://openalex.org/W2009915078","https://openalex.org/W2017314138","https://openalex.org/W2019866887","https://openalex.org/W2021550972","https://openalex.org/W2026632078","https://openalex.org/W2029221716","https://openalex.org/W2037865481","https://openalex.org/W2039469634","https://openalex.org/W2040848333","https://openalex.org/W2045615212","https://openalex.org/W2066720294","https://openalex.org/W2074870369","https://openalex.org/W2095116679","https://openalex.org/W2102184700","https://openalex.org/W2125173052","https://openalex.org/W2138758415","https://openalex.org/W2138807887","https://openalex.org/W2141318698","https://openalex.org/W2269315037","https://openalex.org/W4382140350"],"related_works":["https://openalex.org/W1980915837","https://openalex.org/W1995746991","https://openalex.org/W4382140350","https://openalex.org/W2017071863","https://openalex.org/W2004883732","https://openalex.org/W3039544100","https://openalex.org/W3010019934","https://openalex.org/W4400018887","https://openalex.org/W2909072437","https://openalex.org/W1758456870"],"abstract_inverted_index":{"A":[0],"technique":[1,177],"of":[2,5,37,48,73,90,98,161],"quantitative":[3],"determination":[4],"cell":[6,11,29,54,76,127,153,173],"viability":[7,77],"in":[8,22,39,43,52,78,94,133],"three-dimensional":[9],"(3D)":[10],"culture":[12,30,55,92,123,128,163],"construct":[13,56,80,164],"is":[14,57,71],"proposed":[15,176],"based":[16],"on":[17],"on-site":[18,74],"electrical":[19],"impedance":[20,159],"measurement":[21,188],"a":[23,65,91,96,110,179,184],"microfluidic":[24,66],"chip.":[25],"In":[26,62],"vitro":[27],"3D":[28,53,79,126],"has":[31,178],"been":[32],"interpreted":[33],"for":[34,107,113,125,143],"faithfully":[35],"representation":[36],"the":[38,49,83,122,157,162,172,191],"vivo":[40],"cellular":[41,50,84,193],"responses":[42,51],"living":[44],"tissues.":[45],"However,":[46],"monitoring":[47],"normally":[58],"time-consuming":[59],"and":[60,70,109,139,186],"labor-intensive.":[61],"this":[63],"work,":[64],"chip":[67,87],"was":[68,105,119,165],"developed":[69],"capable":[72],"determining":[75],"without":[81],"affecting":[82],"behaviors.":[85],"The":[86,175],"mainly":[88],"consisted":[89],"chamber,":[93],"which":[95],"pair":[97],"vertical":[99],"electrodes":[100],"at":[101],"its":[102],"opposite":[103],"sidewalls":[104],"embedded":[106],"measurement,":[108],"fluidic":[111],"channel":[112],"perfusion":[114],"purpose.":[115],"Cancer":[116],"cells/agarose":[117],"suspension":[118],"loaded":[120],"into":[121],"chamber":[124],"with":[129,190],"perfusing":[130],"anti-cancer":[131],"drug":[132,148],"different":[134],"concentrations":[135],"(6,":[136],"12,":[137],"18,":[138],"24":[140],"\u03bcg":[141],"ml-1)":[142],"2":[144],"days.":[145],"Since":[146],"higher":[147],"concentration":[149],"led":[150],"to":[151,167,171,182],"more":[152],"damage":[154],"or":[155],"death,":[156],"total":[158],"magnitude":[160],"shown":[166],"be":[168],"reasonably":[169],"proportional":[170],"viability.":[174],"high":[180],"potential":[181],"develop":[183],"fast":[185],"easy":[187],"compared":[189],"conventional":[192],"analysis":[194],"techniques.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2023-06-29T00:00:00"}