{"id":"https://openalex.org/W4382243853","doi":"https://doi.org/10.1158/1078-0432.c.6715507","title":"Data from Comparative Genomic Analysis of Pancreatic Acinar Cell Carcinoma (PACC) and Pancreatic Ductal Adenocarcinoma (PDAC) Unveils New Actionable Genomic Aberrations in PACC","display_name":"Data from Comparative Genomic Analysis of Pancreatic Acinar Cell Carcinoma (PACC) and Pancreatic Ductal Adenocarcinoma (PDAC) Unveils New Actionable Genomic Aberrations in PACC","publication_year":2023,"publication_date":"2023-06-27","ids":{"openalex":"https://openalex.org/W4382243853","doi":"https://doi.org/10.1158/1078-0432.c.6715507"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6715507","doi":"https://doi.org/10.1158/1078-0432.c.6715507","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6715507","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6715507","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043773782","display_name":"Vaia Florou","orcid":"https://orcid.org/0000-0001-5558-753X","observed_orcids":["https://orcid.org/0000-0001-5558-753X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vaia Florou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5558-753X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029537789","display_name":"Andrew Elliott","orcid":"https://orcid.org/0000-0001-8494-8031","observed_orcids":["https://orcid.org/0000-0001-8494-8031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Elliott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8494-8031","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051591843","display_name":"Matthew H. Bailey","orcid":"https://orcid.org/0000-0003-4526-9727","observed_orcids":["https://orcid.org/0000-0003-4526-9727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew H. Bailey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4526-9727","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Stone","orcid":"https://orcid.org/0009-0008-1368-3687","observed_orcids":["https://orcid.org/0009-0008-1368-3687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Stone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1368-3687","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001580260","display_name":"Kajsa E. Affolter","orcid":"https://orcid.org/0000-0002-1703-0535","observed_orcids":["https://orcid.org/0000-0002-1703-0535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kajsa Affolter","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1703-0535","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054848065","display_name":"Heloisa Prado Soares","orcid":"https://orcid.org/0000-0002-5185-2583","observed_orcids":["https://orcid.org/0000-0002-5185-2583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heloisa P. Soares","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5185-2583","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080264243","display_name":"Chris Nevala-Plagemann","orcid":"https://orcid.org/0000-0003-4048-2692","observed_orcids":["https://orcid.org/0000-0003-4048-2692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Nevala-Plagemann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4048-2692","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053671455","display_name":"Courtney L. Scaife","orcid":"https://orcid.org/0000-0003-2497-4961","observed_orcids":["https://orcid.org/0000-0003-2497-4961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney Scaife","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2497-4961","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061883893","display_name":"Phillip Walker","orcid":"https://orcid.org/0009-0009-5324-6219","observed_orcids":["https://orcid.org/0009-0009-5324-6219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip Walker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5324-6219","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040325455","display_name":"Wolfgang Michael Korn","orcid":"https://orcid.org/0000-0002-0124-6841","observed_orcids":["https://orcid.org/0000-0002-0124-6841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Michael Korn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0124-6841","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062667375","display_name":"Emil Lou","orcid":"https://orcid.org/0000-0002-1607-1386","observed_orcids":["https://orcid.org/0000-0002-1607-1386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emil Lou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1607-1386","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012936802","display_name":"Rachna T. Shroff","orcid":"https://orcid.org/0000-0003-0066-2672","observed_orcids":["https://orcid.org/0000-0003-0066-2672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachna T. Shroff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0066-2672","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065012486","display_name":"Peter J. Hosein","orcid":"https://orcid.org/0000-0001-8537-6397","observed_orcids":["https://orcid.org/0000-0001-8537-6397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Hosein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8537-6397","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029563022","display_name":"Ignacio Garrido\u2010Laguna","orcid":"https://orcid.org/0000-0003-2273-9028","observed_orcids":["https://orcid.org/0000-0003-2273-9028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ignacio Garrido-Laguna","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2273-9028","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-acinar-cell-carcinoma","display_name":"pancreatic acinar cell carcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7419999837875366},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7829999923706055},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":1.0},{"id":"https://openalex.org/keywords/palb2","display_name":"PALB2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/encorafenib","display_name":"encorafenib","score":0.9179999828338623},{"id":"https://openalex.org/keywords/binimetinib","display_name":"binimetinib","score":1.0},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8859999775886536},{"id":"https://openalex.org/keywords/actionable-genomic-alterations","display_name":"actionable genomic alterations","score":0.7129999995231628},{"id":"https://openalex.org/keywords/intertumoral-heterogeneity","display_name":"intertumoral heterogeneity","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6486776471138},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.524125874042511},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4708040952682495},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.4635097086429596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3808109164237976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3608008623123169},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35811561346054077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.333906352519989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1952148675918579},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14234000444412231},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11060816049575806}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.c.6715507","doi":"https://doi.org/10.1158/1078-0432.c.6715507","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6715507","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6715507.v1","doi":"https://doi.org/10.1158/1078-0432.c.6715507.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6715507.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6715507.v3","doi":"https://doi.org/10.1158/1078-0432.c.6715507.v3","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6715507.v3","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6715507","doi":"https://doi.org/10.1158/1078-0432.c.6715507","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6715507","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379095614","https://openalex.org/W7122380883","https://openalex.org/W7221715579","https://openalex.org/W7118293589","https://openalex.org/W7162695819","https://openalex.org/W2093232036","https://openalex.org/W4399564816","https://openalex.org/W2773109548","https://openalex.org/W7169733909","https://openalex.org/W4405746944"],"abstract_inverted_index":{"AbstractBackground:":[0],"Pure":[1,161],"pancreatic":[2,93],"acinar":[3],"cell":[4,156,236],"carcinomas":[5],"(PACC)":[6],"are":[7,219],"rare":[8],"malignancies":[9],"with":[10,20,109,126,159,169,200],"no":[11],"established":[12],"treatment.":[13,253],"PACC":[14,42,54,110,135,148,162,223,244],"demonstrates":[15],"significant":[16],"genetic":[17],"intertumoral":[18],"heterogeneity":[19],"multiple":[21],"pathways":[22],"involved,":[23],"suggesting":[24],"using":[25],"targeted":[26],"cancer":[27],"therapeutics":[28],"to":[29,43,166],"treat":[30],"this":[31,195],"disease.":[32],"We":[33,84,128],"aggregated":[34],"one":[35,183],"of":[36,40,62,88,92,107,142,212,228,242],"the":[37,45,139,177,229],"largest":[38],"datasets":[39],"pure":[41,134,143,243],"examine":[44],"genomic":[46,90,164,240],"variability":[47],"and":[48,73,136,153,174,208,224,233],"explore":[49],"patient-specific":[50],"therapeutic":[51],"targets.":[52],"Methods:":[53],"specimens":[55],"(n":[56,64,70],"=":[57,65,71,78,98],"51)":[58],"underwent":[59],"next-generation":[60],"sequencing":[61],"DNA":[63],"29)":[66,79],"or":[67],"whole":[68],"exome":[69],"22)":[72],"RNA":[74],"(whole":[75],"transcriptome,":[76],"n":[77,97],"at":[80,112,181],"a":[81,89,104,185,189],"commercial":[82],"laboratory.":[83],"performed":[85],"comparative":[86],"analyses":[87],"cohort":[91],"ductal":[94],"adenocarcinomas":[95],"(PDAC;":[96],"4,205).":[99],"In":[100,238],"parallel,":[101],"we":[102],"conducted":[103],"retrospective":[105],"review":[106],"patients":[108,125,179],"treated":[111,180,199],"Huntsman":[113],"Cancer":[114],"Institute":[115],"(HCI).":[116],"Results:":[117],"The":[118],"real-world":[119],"dataset":[120],"included":[121],"samples":[122],"from":[123],"51":[124],"PACC.":[127,144],"found":[129],"key":[130],"molecular":[131],"differences":[132,146,221],"between":[133,222],"PDAC,":[137,225],"highlighting":[138],"unique":[140],"characteristics":[141],"Major":[145],"in":[147,171],"include":[149],"lower":[150],"MAPK":[151,230],"signaling":[152,231],"less":[154,234],"stromal":[155,235],"abundance":[157],"compared":[158],"PDAC.":[160],"showed":[163],"loss-of-heterozygosity":[165],"largely":[167],"coincide":[168],"mutations":[170],"BRCA1,":[172],"BRCA2,":[173],"PALB2.":[175],"Of":[176],"7":[178],"HCI,":[182],"had":[184],"tumor":[186],"that":[187],"harbored":[188],"BRAF-V600E":[190],"mutation.":[191],"Leveraging":[192],"precision":[193],"oncology,":[194],"patient":[196,252],"is":[197],"being":[198],"encorafenib":[201],"plus":[202],"binimetinib,":[203],"achieving":[204],"an":[205],"exceptionally":[206],"durable":[207],"ongoing":[209],"complete":[210],"response":[211],"more":[213],"than":[214],"3":[215],"years.":[216],"Conclusions:":[217],"There":[218],"major":[220],"including":[226],"downregulation":[227],"pathway,":[232],"abundance.":[237],"addition,":[239],"characterization":[241],"revealed":[245],"frequent":[246],"targetable":[247],"alterations,":[248],"which":[249],"can":[250],"guide":[251]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-28T00:00:00"}
