{"id":"https://openalex.org/W4382064923","doi":"https://doi.org/10.3390/antiox12071331","title":"Novel Acylselenourea Derivatives: Dual Molecules with Anticancer and Radical Scavenging Activity","display_name":"Novel Acylselenourea Derivatives: Dual Molecules with Anticancer and Radical Scavenging Activity","publication_year":2023,"publication_date":"2023-06-23","ids":{"openalex":"https://openalex.org/W4382064923","doi":"https://doi.org/10.3390/antiox12071331","pmid":"https://pubmed.ncbi.nlm.nih.gov/37507871","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10376326"},"language":"en","primary_location":{"id":"doi:10.3390/antiox12071331","doi":"https://doi.org/10.3390/antiox12071331","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox12071331","pdf_url":"https://www.mdpi.com/2076-3921/12/7/1331/pdf?version=1687526258","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3921/12/7/1331/pdf?version=1687526258","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065610222","display_name":"Nora Astrain-Red\u00edn","orcid":"https://orcid.org/0000-0001-8593-8994","observed_orcids":["https://orcid.org/0000-0001-8593-8994"]},"institutions":[{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Nora Astrain-Redin","raw_affiliation_strings":["Departamento de Tecnolog\u00eda y Qu\u00edmica Farmac\u00e9uticas, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain","Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0001-8593-8994","affiliations":[{"raw_affiliation_string":"Departamento de Tecnolog\u00eda y Qu\u00edmica Farmac\u00e9uticas, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I4405268258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036658711","display_name":"Asif Raza","orcid":"https://orcid.org/0000-0002-5716-7202","observed_orcids":["https://orcid.org/0000-0002-5716-7202"]},"institutions":[{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asif Raza","raw_affiliation_strings":["Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0002-5716-7202","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I4405268258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076267766","display_name":"Ignacio Enc\u00edo","orcid":"https://orcid.org/0000-0003-1732-1989","observed_orcids":["https://orcid.org/0000-0003-1732-1989"]},"institutions":[{"id":"https://openalex.org/I175051016","display_name":"Universidad P\u00fablica de Navarra (UPNA)","ror":"https://ror.org/02z0cah89","country_code":"ES","type":"education","lineage":["https://openalex.org/I175051016"]},{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignacio Enc\u00edo","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad P\u00fablica de Navarra, Avda. Bara\u00f1ain s/n, 31008 Pamplona, Spain","Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1732-1989","affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad P\u00fablica de Navarra, Avda. Bara\u00f1ain s/n, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I175051016"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001311093","display_name":"Arun Kumar Sharma","orcid":"https://orcid.org/0000-0002-7679-7779","observed_orcids":["https://orcid.org/0000-0002-7679-7779","https://orcid.org/0000-0002-5191-7738","https://orcid.org/0000-0001-9427-6208"]},"institutions":[{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun K. Sharma","raw_affiliation_strings":["Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0002-7679-7779","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I4405268258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063979460","display_name":"Daniel Plano","orcid":"https://orcid.org/0000-0002-8266-0445","observed_orcids":["https://orcid.org/0000-0002-8266-0445"]},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Daniel Plano","raw_affiliation_strings":["Departamento de Tecnolog\u00eda y Qu\u00edmica Farmac\u00e9uticas, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain","Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8266-0445","affiliations":[{"raw_affiliation_string":"Departamento de Tecnolog\u00eda y Qu\u00edmica Farmac\u00e9uticas, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011301639","display_name":"Carmen Sanmart\u00edn","orcid":"https://orcid.org/0000-0003-3431-7826","observed_orcids":["https://orcid.org/0000-0003-3431-7826","https://orcid.org/0009-0005-0924-2959"]},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Carmen Sanmart\u00edn","raw_affiliation_strings":["Departamento de Tecnolog\u00eda y Qu\u00edmica Farmac\u00e9uticas, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain","Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3431-7826","affiliations":[{"raw_affiliation_string":"Departamento de Tecnolog\u00eda y Qu\u00edmica Farmac\u00e9uticas, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Irunlarrea, 3, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011301639","https://openalex.org/A5063979460"],"corresponding_institution_ids":["https://openalex.org/I4210112085","https://openalex.org/I88155538"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2669},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2669},"fwci":1.0704,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69592409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"7","first_page":"1331","last_page":"1331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenoesters","display_name":"selenoesters","score":0.9039999842643738},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.890999972820282},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7960000038146973},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.460999995470047},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.753000020980835},{"id":"https://openalex.org/keywords/natural-product-inspired-synthesis","display_name":"natural product-inspired synthesis","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2776231299","wikidata":"https://www.wikidata.org/wiki/Q245489","display_name":"Trolox","level":4,"score":0.8112035393714905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7378113269805908},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.676809549331665},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.6740689277648926},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5980508923530579},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5753011703491211},{"id":"https://openalex.org/C2992339995","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Free radical scavenger","level":3,"score":0.5590998530387878},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5192853808403015},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5005128383636475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48817020654678345},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44791045784950256},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4179612994194031},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41068702936172485},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37353813648223877},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21800339221954346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14671137928962708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10365164279937744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.046987056732177734},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/antiox12071331","doi":"https://doi.org/10.3390/antiox12071331","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox12071331","pdf_url":"https://www.mdpi.com/2076-3921/12/7/1331/pdf?version=1687526258","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10376326","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10376326","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10376326/pdf/antioxidants-12-01331.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmid:37507871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37507871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:academica-e.unavarra.es:2454/46532","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2454/46532","pdf_url":null,"source":{"id":"https://openalex.org/S4306402560","display_name":"Academica-e (Universidad P\u00fablica de Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175051016","host_organization_name":"Universidad P\u00fablica de Navarra (UPNA)","host_organization_lineage":["https://openalex.org/I175051016"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:968e2e986614404f94f6f29ad21a0354","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/968e2e986614404f94f6f29ad21a0354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 12, Iss 7, p 1331 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antiox12071331","doi":"https://doi.org/10.3390/antiox12071331","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox12071331","pdf_url":"https://www.mdpi.com/2076-3921/12/7/1331/pdf?version=1687526258","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F7296444849","display_name":"Ministerio de Universidades","ror":"https://ror.org/03zcny908"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382064923.pdf","grobid_xml":"https://content.openalex.org/works/W4382064923.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W280009823","https://openalex.org/W1709997767","https://openalex.org/W1970101659","https://openalex.org/W1982210031","https://openalex.org/W1983560261","https://openalex.org/W2004055991","https://openalex.org/W2042199749","https://openalex.org/W2054110159","https://openalex.org/W2058891784","https://openalex.org/W2059205366","https://openalex.org/W2062158723","https://openalex.org/W2093925805","https://openalex.org/W2114918609","https://openalex.org/W2131350133","https://openalex.org/W2161500896","https://openalex.org/W2179739405","https://openalex.org/W2313688287","https://openalex.org/W2325461409","https://openalex.org/W2398678691","https://openalex.org/W2551365388","https://openalex.org/W2613578478","https://openalex.org/W2747558158","https://openalex.org/W2756856565","https://openalex.org/W2765761484","https://openalex.org/W2776113064","https://openalex.org/W2790769350","https://openalex.org/W2790926980","https://openalex.org/W2802809487","https://openalex.org/W2808314500","https://openalex.org/W2888723951","https://openalex.org/W2897823225","https://openalex.org/W2943452309","https://openalex.org/W2954854063","https://openalex.org/W2956329047","https://openalex.org/W2966157203","https://openalex.org/W2974950430","https://openalex.org/W2999585407","https://openalex.org/W3008096634","https://openalex.org/W3102237550","https://openalex.org/W3149099100","https://openalex.org/W3152676716","https://openalex.org/W3153831334","https://openalex.org/W4212777588","https://openalex.org/W4313824798","https://openalex.org/W4322753529"],"related_works":["https://openalex.org/W2999585407","https://openalex.org/W4212777588","https://openalex.org/W4391809470","https://openalex.org/W2884313159","https://openalex.org/W4313824798","https://openalex.org/W4391843647","https://openalex.org/W2283752873","https://openalex.org/W2886153043","https://openalex.org/W2061875236","https://openalex.org/W4283383104"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1],"surrounding":[2],"cancer":[3,112,132],"cells":[4],"provides":[5,181],"them":[6],"with":[7,116,136],"certain":[8],"growth":[9],"and":[10,29,89,110,124,140,149,161,187],"survival":[11],"advantages":[12],"necessary":[13],"for":[14],"disease":[15],"progression.":[16],"In":[17,32],"this":[18],"context,":[19],"Se-containing":[20],"molecules":[21,180],"have":[22,72,166],"gained":[23],"attention":[24],"due":[25],"to":[26,119,158,193],"their":[27,79,117],"anticancer":[28,55],"antioxidant":[30],"activity.":[31,64],"our":[33],"previous":[34],"work,":[35],"we":[36,165],"synthesized":[37,74],"a":[38],"library":[39],"of":[40,142,171,176,196],"39":[41],"selenoesters":[42],"containing":[43],"functional":[44],"groups":[45],"commonly":[46],"present":[47],"in":[48,78,90,106,173,185],"natural":[49],"products":[50],"(NP),":[51],"which":[52,190],"showed":[53,126],"potent":[54,127,148],"activity,":[56,189],"but":[57],"did":[58],"not":[59],"demonstrate":[60],"high":[61,137],"radical":[62,151,183],"scavenger":[63,82],"Thus,":[65],"20":[66],"novel":[67],"Se":[68,172],"derivatives":[69],"resembling":[70],"NP":[71],"been":[73],"presenting":[75],"acylselenourea":[76,177],"functionality":[77],"structures.":[80],"Radical":[81],"activity":[83,103,153],"was":[84,104],"tested":[85,131],"using":[86],"DPPH":[87,155],"assay":[88],"vitro":[91,186],"protective":[92],"effects":[93],"against":[94,129],"ROS-induced":[95],"cell":[96,113,133],"death":[97],"caused":[98],"by":[99],"H2O2.":[100],"Additionally,":[101],"antiproliferative":[102,188],"evaluated":[105],"prostate,":[107],"colon,":[108],"lung,":[109],"breast":[111],"lines,":[114,134],"along":[115,135],"ability":[118],"induce":[120],"apoptosis.":[121,144],"Compounds":[122],"1.I":[123],"5.I":[125],"cytotoxicity":[128],"the":[130,169,174,194],"selectivity":[138],"indexes":[139],"induction":[141],"caspase-mediated":[143],"These":[145],"compounds":[146],"exhibited":[147],"concentration-dependent":[150],"scavenging":[152],"achieving":[154],"inhibition":[156],"similar":[157],"ascorbic":[159],"acid":[160],"trolox.":[162],"To":[163],"conclude,":[164],"demonstrated":[167],"that":[168],"introduction":[170],"form":[175],"into":[178],"small":[179],"strong":[182],"scavengers":[184],"may":[191],"lead":[192],"development":[195],"promising":[197],"dual":[198],"compounds.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-06-27T00:00:00"}