{"id":"https://openalex.org/W4382044856","doi":"https://doi.org/10.1016/j.dnarep.2023.103529","title":"Spatial mapping of the DNA adducts in cancer","display_name":"Spatial mapping of the DNA adducts in cancer","publication_year":2023,"publication_date":"2023-06-26","ids":{"openalex":"https://openalex.org/W4382044856","doi":"https://doi.org/10.1016/j.dnarep.2023.103529","pmid":"https://pubmed.ncbi.nlm.nih.gov/37390674","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10330576"},"language":"en","primary_location":{"id":"doi:10.1016/j.dnarep.2023.103529","doi":"https://doi.org/10.1016/j.dnarep.2023.103529","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2023.103529","pdf_url":null,"source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.dnarep.2023.103529","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017085253","display_name":"Kimiko L. Krieger","orcid":"https://orcid.org/0000-0002-7432-2729","observed_orcids":["https://orcid.org/0000-0002-7432-2729"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimiko L. Krieger","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA","Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA","Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051042536","display_name":"Elise K. Mann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089171","display_name":"USA Mitchell Cancer Institute","ror":"https://ror.org/009wx7055","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210089171"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise K. Mann","raw_affiliation_strings":["Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA; Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA","Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA","Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA; Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA","institution_ids":["https://openalex.org/I4210089171","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA","institution_ids":["https://openalex.org/I4210089171","https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049009941","display_name":"Kevin J. Lee","orcid":"https://orcid.org/0000-0003-3233-5537","observed_orcids":["https://orcid.org/0000-0003-3233-5537"]},"institutions":[{"id":"https://openalex.org/I4210089171","display_name":"USA Mitchell Cancer Institute","ror":"https://ror.org/009wx7055","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210089171"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Lee","raw_affiliation_strings":["Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA; Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA","Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA","Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA; Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA","institution_ids":["https://openalex.org/I4210089171","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA","institution_ids":["https://openalex.org/I4210089171","https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034052114","display_name":"Elyse A. Bolterstein","orcid":"https://orcid.org/0000-0002-1145-9138","observed_orcids":["https://orcid.org/0000-0002-1145-9138"]},"institutions":[{"id":"https://openalex.org/I27639287","display_name":"Northeastern Illinois University","ror":"https://ror.org/04edns687","country_code":"US","type":"education","lineage":["https://openalex.org/I27639287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elyse Bolterstein","raw_affiliation_strings":["Department of Biology, Northeastern Illinois University, Chicago, IL 60625, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Northeastern Illinois University, Chicago, IL 60625, USA","institution_ids":["https://openalex.org/I27639287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031944201","display_name":"Deborah Jebakumar","orcid":"https://orcid.org/0000-0002-4272-132X","observed_orcids":["https://orcid.org/0000-0002-4272-132X"]},"institutions":[{"id":"https://openalex.org/I4210102330","display_name":"Baylor Scott & White Medical Center - Temple","ror":"https://ror.org/017cm6884","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102330","https://openalex.org/I4210160418"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Jebakumar","raw_affiliation_strings":["Department of Anatomic Pathology, Baylor Scott & White Medical Center, Temple, TX 76508, USA; Texas A&M College of Medicine, Temple, TX 76508, USA","Department of Anatomic Pathology, Baylor Scott & White Medical Center, Temple, Texas 76508, USA","Texas A&M College of Medicine, Temple, Texas 76508, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, Baylor Scott & White Medical Center, Temple, TX 76508, USA; Texas A&M College of Medicine, Temple, TX 76508, USA","institution_ids":["https://openalex.org/I4210102330","https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Anatomic Pathology, Baylor Scott & White Medical Center, Temple, Texas 76508, USA","institution_ids":["https://openalex.org/I4210102330"]},{"raw_affiliation_string":"Texas A&M College of Medicine, Temple, Texas 76508, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066263660","display_name":"Michael Ittmann","orcid":"https://orcid.org/0000-0003-4802-0978","observed_orcids":["https://orcid.org/0000-0003-4802-0978"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Ittmann","raw_affiliation_strings":["Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Human Tissue Acquisition & Pathology Shared Resource, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA","Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA","Human Tissue Acquisition & Pathology Shared Resource, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Human Tissue Acquisition & Pathology Shared Resource, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]},{"raw_affiliation_string":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Human Tissue Acquisition & Pathology Shared Resource, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035871433","display_name":"Valeria L. Dal Zotto","orcid":"https://orcid.org/0000-0002-6690-4788","observed_orcids":["https://orcid.org/0000-0002-6690-4788"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria L. Dal Zotto","raw_affiliation_strings":["Department of Pathology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085512777","display_name":"Mohamed Shaban","orcid":"https://orcid.org/0000-0003-4900-1859","observed_orcids":["https://orcid.org/0000-0003-4900-1859"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Shaban","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of South Alabama, Mobile, AL 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of South Alabama, Mobile, AL 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028395389","display_name":"Arun Sreekumar","orcid":"https://orcid.org/0000-0001-8956-3675","observed_orcids":["https://orcid.org/0000-0001-8956-3675","https://orcid.org/0000-0003-1582-3774"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun Sreekumar","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA","Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA","Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA","Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA","Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]},{"raw_affiliation_string":"Center for Translational Metabolism and Health Disparities (C-TMH), Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079768641","display_name":"Natalie R. Gassman","orcid":"https://orcid.org/0000-0002-8488-2332","observed_orcids":["https://orcid.org/0000-0002-8488-2332"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natalie R. Gassman","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: nrg2@uab.edu","Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: nrg2@uab.edu","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5079768641"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":3770,"currency":"USD","value_usd":3770},"apc_paid":{"value":3770,"currency":"USD","value_usd":3770},"fwci":0.7982,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66277655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"128","issue":null,"first_page":"103529","last_page":"103529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mutation-burden","display_name":"mutational burden","score":0.7860000133514404},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/exposome","display_name":"exposome","score":0.8930000066757202},{"id":"https://openalex.org/keywords/comet-assay","display_name":"comet assay","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.853082537651062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.70514315366745},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6971204280853271},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6499748826026917},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6329408884048462},{"id":"https://openalex.org/C119709500","wikidata":"https://www.wikidata.org/wiki/Q2142347","display_name":"Exposome","level":2,"score":0.5884612202644348},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5810108184814453},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4460389316082001},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.430902361869812},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41318392753601074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38057324290275574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32959693670272827},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2195395827293396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10528787970542908},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.dnarep.2023.103529","doi":"https://doi.org/10.1016/j.dnarep.2023.103529","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2023.103529","pdf_url":null,"source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},{"id":"pmid:37390674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37390674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA repair","raw_type":"Review"},{"id":"pmh:oai:pubmedcentral.nih.gov:10330576","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10330576","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10330576/pdf/nihms-1914363.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"DNA Repair (Amst)","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:baylor_docs-3039","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/baylor_docs/2069","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty and Staff Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/j.dnarep.2023.103529","doi":"https://doi.org/10.1016/j.dnarep.2023.103529","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dnarep.2023.103529","pdf_url":null,"source":{"id":"https://openalex.org/S3892243","display_name":"DNA repair","issn_l":"1568-7856","issn":["1568-7856","1568-7864"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Repair","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G140466841","display_name":null,"funder_award_id":"W81XWH-21-1-0154","funder_id":"https://openalex.org/F4320338485","funder_display_name":"DOD Prostate Cancer Research Program"},{"id":"https://openalex.org/G2534064166","display_name":null,"funder_award_id":"U54CA118948","funder_id":"https://openalex.org/F4320310431","funder_display_name":"University of Alabama at Birmingham"},{"id":"https://openalex.org/G3824129646","display_name":"ELEVATED URACIL GLYCOSYLASE COUPLED TO REDUCED BASE EXCISION REPAIR PROMOTES AA PCA PROGRESSION","funder_award_id":"W81XWH2210135","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5590945411","display_name":"DNA DAMAGE AS A PREDICTIVE BIOMARKER FOR IMMUNOTHERAPY RESPONSE IN OVARIAN CANCER","funder_award_id":"W81XWH2110596","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7256235758","display_name":null,"funder_award_id":"U54CA118948","funder_id":"https://openalex.org/F4320312852","funder_display_name":"University of Alabama"},{"id":"https://openalex.org/G7294853618","display_name":null,"funder_award_id":"W81XWH2210135","funder_id":"https://openalex.org/F4320338485","funder_display_name":"DOD Prostate Cancer Research Program"},{"id":"https://openalex.org/G9000884756","display_name":"3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership","funder_award_id":"U54CA118948","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310431","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205"},{"id":"https://openalex.org/F4320312852","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67"},{"id":"https://openalex.org/F4320317695","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W137364020","https://openalex.org/W151025649","https://openalex.org/W172976089","https://openalex.org/W241258565","https://openalex.org/W1487813067","https://openalex.org/W1815380513","https://openalex.org/W1961217184","https://openalex.org/W1969175894","https://openalex.org/W1975891294","https://openalex.org/W1982602899","https://openalex.org/W1987669043","https://openalex.org/W1996870276","https://openalex.org/W1996901117","https://openalex.org/W1997203477","https://openalex.org/W2001502878","https://openalex.org/W2004326614","https://openalex.org/W2008629383","https://openalex.org/W2025768430","https://openalex.org/W2027630134","https://openalex.org/W2044323589","https://openalex.org/W2052679982","https://openalex.org/W2065599963","https://openalex.org/W2070582215","https://openalex.org/W2071444261","https://openalex.org/W2080982746","https://openalex.org/W2092470694","https://openalex.org/W2093178531","https://openalex.org/W2099218265","https://openalex.org/W2104336168","https://openalex.org/W2116094026","https://openalex.org/W2120782836","https://openalex.org/W2134259738","https://openalex.org/W2136213337","https://openalex.org/W2145200068","https://openalex.org/W2157767005","https://openalex.org/W2161578347","https://openalex.org/W2173698021","https://openalex.org/W2185362250","https://openalex.org/W2211893000","https://openalex.org/W2215765065","https://openalex.org/W2225391592","https://openalex.org/W2264017649","https://openalex.org/W2292853421","https://openalex.org/W2295107390","https://openalex.org/W2307809763","https://openalex.org/W2313953393","https://openalex.org/W2315146644","https://openalex.org/W2317146774","https://openalex.org/W2336509392","https://openalex.org/W2347171811","https://openalex.org/W2418480763","https://openalex.org/W2471536144","https://openalex.org/W2519354012","https://openalex.org/W2590232874","https://openalex.org/W2592929672","https://openalex.org/W2604970350","https://openalex.org/W2607313532","https://openalex.org/W2614424865","https://openalex.org/W2735897797","https://openalex.org/W2747348737","https://openalex.org/W2750837125","https://openalex.org/W2760946358","https://openalex.org/W2779945812","https://openalex.org/W2800975962","https://openalex.org/W2802159733","https://openalex.org/W2803478805","https://openalex.org/W2807900228","https://openalex.org/W2889664156","https://openalex.org/W2896934366","https://openalex.org/W2900089068","https://openalex.org/W2902535017","https://openalex.org/W2906147404","https://openalex.org/W2906577547","https://openalex.org/W2911954305","https://openalex.org/W2913423296","https://openalex.org/W2945008795","https://openalex.org/W2948321041","https://openalex.org/W2957149875","https://openalex.org/W2957446832","https://openalex.org/W2962858109","https://openalex.org/W2963148916","https://openalex.org/W2968432620","https://openalex.org/W2969880113","https://openalex.org/W2970809556","https://openalex.org/W2977129830","https://openalex.org/W2984640760","https://openalex.org/W2988010028","https://openalex.org/W2996140569","https://openalex.org/W3004543888","https://openalex.org/W3013186141","https://openalex.org/W3041631341","https://openalex.org/W3083938406","https://openalex.org/W3092074970","https://openalex.org/W3098491829","https://openalex.org/W3107455121","https://openalex.org/W3113056502","https://openalex.org/W3159561463","https://openalex.org/W3173027590","https://openalex.org/W3173334270","https://openalex.org/W3190942156","https://openalex.org/W3196885070","https://openalex.org/W3198101038","https://openalex.org/W3215635740","https://openalex.org/W4205961803","https://openalex.org/W4206301031","https://openalex.org/W4206347388","https://openalex.org/W4210611519","https://openalex.org/W4210903467","https://openalex.org/W4212855699","https://openalex.org/W4223639185","https://openalex.org/W4245040372","https://openalex.org/W4285822031","https://openalex.org/W4287823947","https://openalex.org/W4293576553","https://openalex.org/W4294042823","https://openalex.org/W4294052977","https://openalex.org/W4295923807","https://openalex.org/W4296935236","https://openalex.org/W4298325886","https://openalex.org/W4302304914","https://openalex.org/W4307286999","https://openalex.org/W4307873083","https://openalex.org/W4308891334","https://openalex.org/W4317727238","https://openalex.org/W4318318928","https://openalex.org/W4318617280","https://openalex.org/W4319441954","https://openalex.org/W4323350443","https://openalex.org/W4377108212","https://openalex.org/W4379967769","https://openalex.org/W6600045627","https://openalex.org/W6600336938","https://openalex.org/W6683268651","https://openalex.org/W6702586867","https://openalex.org/W6794971368","https://openalex.org/W6804244097"],"related_works":["https://openalex.org/W2988010028","https://openalex.org/W2800975962","https://openalex.org/W3196885070","https://openalex.org/W4386948775","https://openalex.org/W4221095337","https://openalex.org/W1994669907","https://openalex.org/W3127517964","https://openalex.org/W3198101038","https://openalex.org/W3089297457","https://openalex.org/W2865062052"],"abstract_inverted_index":{"DNA":[0,15,32,43,51,69,83,96,101,113,125,135,167,181,199,211,224,243,258],"adducts":[1,84,114,138,225],"and":[2,10,26,36,56,76,85,104,117,136,149,161,186,215,247,269],"strand":[3,86],"breaks":[4],"are":[5],"induced":[6],"by":[7],"various":[8],"exogenous":[9,35],"endogenous":[11,37],"agents.":[12],"Accumulation":[13],"of":[14,31,50,68,94,133,142,165,194,197,223,242],"damage":[16,33,52,70,182,200,212,244],"is":[17,108],"implicated":[18],"in":[19,42,100,171,201,209,226,245,256],"many":[20],"disease":[21],"processes,":[22],"including":[23],"cancer,":[24],"aging,":[25],"neurodegeneration.":[27],"The":[28,169],"continuous":[29],"acquisition":[30],"from":[34,139],"stressors":[38],"coupled":[39],"with":[40,119,184,261,266],"defects":[41],"repair":[44],"pathways":[45],"contribute":[46],"to":[47,111,179,219,264,272],"the":[48,54,66,92,95,134,140,143,158,166,206,237,262,270],"accumulation":[49],"within":[53],"genome":[55],"genomic":[57],"instability.":[58],"While":[59],"mutational":[60],"burden":[61,89],"offers":[62,175],"some":[63],"insight":[64],"into":[65],"level":[67],"a":[71,120,176,192,234],"cell":[72],"may":[73],"have":[74],"experienced":[75],"subsequently":[77],"repaired,":[78],"it":[79],"does":[80],"not":[81],"quantify":[82,153],"breaks.":[87],"Mutational":[88],"also":[90,232],"infers":[91],"identity":[93],"damage.":[97,168],"With":[98],"advances":[99],"adduct":[102,126,259],"detection":[103,127,183,213],"quantification":[105],"methods,":[106],"there":[107],"an":[109,255],"opportunity":[110,178],"identify":[112],"driving":[115],"mutagenesis":[116],"correlate":[118],"known":[121],"exposome.":[122],"However,":[123,189],"most":[124],"methods":[128,214],"require":[129],"isolation":[130],"or":[131,228],"separation":[132],"its":[137],"context":[141,160,164],"nuclei.":[144],"Mass":[145],"spectrometry,":[146],"comet":[147],"assays,":[148],"other":[150,229],"techniques":[151,195],"precisely":[152],"lesion":[154],"types":[155],"but":[156],"lose":[157],"nuclear":[159,185],"even":[162],"tissue":[163,187],"growth":[170],"spatial":[172,221,240,267],"analysis":[173,222,241,268],"technologies":[174],"novel":[177],"leverage":[180],"context.":[188],"we":[190,204],"lack":[191],"wealth":[193],"capable":[196],"detecting":[198],"situ.":[202],"Here,":[203],"review":[205],"limited":[207],"existing":[208],"situ":[210,246,257],"examine":[216],"their":[217],"potential":[218,263],"offer":[220,233],"tumors":[227],"tissues.":[230],"We":[231],"perspective":[235],"on":[236],"need":[238],"for":[239],"highlight":[248],"Repair":[249],"Assisted":[250],"Damage":[251],"Detection":[252],"(RADD)":[253],"as":[254],"technique":[260],"integrate":[265],"challenges":[271],"be":[273],"addressed.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-27T00:00:00"}
