{"id":"https://openalex.org/W4382011898","doi":"https://doi.org/10.1111/acel.13895","title":"Reduction of class I histone deacetylases ameliorates ER \u2010mitochondria cross\u2010talk in Alzheimer's disease","display_name":"Reduction of class I histone deacetylases ameliorates ER \u2010mitochondria cross\u2010talk in Alzheimer's disease","publication_year":2023,"publication_date":"2023-06-26","ids":{"openalex":"https://openalex.org/W4382011898","doi":"https://doi.org/10.1111/acel.13895","pmid":"https://pubmed.ncbi.nlm.nih.gov/37358017","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10410063"},"language":"en","primary_location":{"id":"doi:10.1111/acel.13895","doi":"https://doi.org/10.1111/acel.13895","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.13895","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.13895","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.13895","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044733126","display_name":"Daniela Marinho","orcid":"https://orcid.org/0000-0002-4124-6483","observed_orcids":["https://orcid.org/0000-0002-4124-6483"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Daniela Marinho","raw_affiliation_strings":["CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-4124-6483","affiliations":[{"raw_affiliation_string":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053721388","display_name":"Ildete L. Ferreira","orcid":"https://orcid.org/0000-0001-6552-4479","observed_orcids":["https://orcid.org/0000-0001-6552-4479"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Ildete Lu\u00edsa Ferreira","raw_affiliation_strings":["CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-6552-4479","affiliations":[{"raw_affiliation_string":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088500920","display_name":"Ricardo Lorenzoni","orcid":"https://orcid.org/0000-0002-1432-639X","observed_orcids":["https://orcid.org/0000-0002-1432-639X"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ricardo Lorenzoni","raw_affiliation_strings":["CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-1432-639X","affiliations":[{"raw_affiliation_string":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072179022","display_name":"Sandra M. Cardoso","orcid":"https://orcid.org/0000-0002-2199-0555","observed_orcids":["https://orcid.org/0000-0002-2199-0555"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sandra M. Cardoso","raw_affiliation_strings":["CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-2199-0555","affiliations":[{"raw_affiliation_string":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060131002","display_name":"Isabel J. Santana","orcid":"https://orcid.org/0000-0002-8114-9434","observed_orcids":["https://orcid.org/0000-0002-8114-9434"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Isabel Santana","raw_affiliation_strings":["CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal","Neurology Department CHUC\u2010Centro Hospitalar e Universit\u00e1rio de Coimbra  Coimbra Portugal"],"raw_orcid":"https://orcid.org/0000-0002-8114-9434","affiliations":[{"raw_affiliation_string":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Neurology Department CHUC\u2010Centro Hospitalar e Universit\u00e1rio de Coimbra  Coimbra Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043027619","display_name":"Ana Cristina Rego","orcid":"https://orcid.org/0000-0003-0700-3776","observed_orcids":["https://orcid.org/0000-0003-0700-3776"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"A. Cristina Rego","raw_affiliation_strings":["CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-0700-3776","affiliations":[{"raw_affiliation_string":"CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"raw_affiliation_string":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"FMUC-Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043027619","https://openalex.org/A5053721388"],"corresponding_institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I4405252802","https://openalex.org/I76903346"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":3.5116,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.94528506,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"22","issue":"8","first_page":"e13895","last_page":"e13895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/class-i-histone-deacetylases","display_name":"class I histone deacetylases","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hdac3","display_name":"HDAC3","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6620000004768372},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8560000061988831},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ht22-cells","display_name":"HT22 cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.7739999890327454},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7423473000526428},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6801444292068481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6413205862045288},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5354174971580505},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5228855013847351},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4768865406513214},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4656643867492676},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40713611245155334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20209527015686035},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17924892902374268},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07578560709953308}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/acel.13895","doi":"https://doi.org/10.1111/acel.13895","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.13895","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.13895","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10410063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10410063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"Text"},{"id":"pmid:37358017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37358017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"},{"id":"pmh:oai:estudogeral.uc.pt:10316/112082","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/112082","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1111/acel.13895","doi":"https://doi.org/10.1111/acel.13895","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.13895","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.13895","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1942867608","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","funder_award_id":"UIDP/04539/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G488238527","display_name":null,"funder_award_id":"POCI\u201001\u20100145\u2010FEDER\u2010032316","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5727291857","display_name":null,"funder_award_id":"PhD fellowship 2020.07951.BD","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G63235041","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","funder_award_id":"UIDB/04539/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7287271309","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia - Laborat\u00f3rio Associado","funder_award_id":"LA/P/0058/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G877093892","display_name":null,"funder_award_id":"CENTRO-01\u20130145-FEDER-000012-HealthyAging2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382011898.pdf"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1578038979","https://openalex.org/W1846838131","https://openalex.org/W1867176171","https://openalex.org/W1946089979","https://openalex.org/W1951572307","https://openalex.org/W1967016606","https://openalex.org/W1967464880","https://openalex.org/W1978582104","https://openalex.org/W1994743002","https://openalex.org/W1998865079","https://openalex.org/W2013037750","https://openalex.org/W2034859720","https://openalex.org/W2051690270","https://openalex.org/W2069381818","https://openalex.org/W2078562267","https://openalex.org/W2090054406","https://openalex.org/W2091387807","https://openalex.org/W2094185904","https://openalex.org/W2097226847","https://openalex.org/W2098491485","https://openalex.org/W2108078777","https://openalex.org/W2115017507","https://openalex.org/W2129943582","https://openalex.org/W2135085078","https://openalex.org/W2138315398","https://openalex.org/W2142186280","https://openalex.org/W2142388403","https://openalex.org/W2153879016","https://openalex.org/W2166131107","https://openalex.org/W2407095306","https://openalex.org/W2579986879","https://openalex.org/W2582524520","https://openalex.org/W2593784471","https://openalex.org/W2744186560","https://openalex.org/W2766127467","https://openalex.org/W2767266537","https://openalex.org/W2782691869","https://openalex.org/W2788754582","https://openalex.org/W2798054687","https://openalex.org/W2801978222","https://openalex.org/W2802371149","https://openalex.org/W2805782061","https://openalex.org/W2811022618","https://openalex.org/W2884569230","https://openalex.org/W2901707926","https://openalex.org/W2905941760","https://openalex.org/W2969731445","https://openalex.org/W2970114486","https://openalex.org/W2972721556","https://openalex.org/W2975505461","https://openalex.org/W2995724962","https://openalex.org/W2999283181","https://openalex.org/W3003139723","https://openalex.org/W3009967163","https://openalex.org/W3025772309","https://openalex.org/W3042456270","https://openalex.org/W3047605799","https://openalex.org/W3076991851","https://openalex.org/W3087671839","https://openalex.org/W3093279023","https://openalex.org/W3123956652","https://openalex.org/W3135675308","https://openalex.org/W3143784180","https://openalex.org/W3184640198","https://openalex.org/W3189276108","https://openalex.org/W3194347240","https://openalex.org/W3203275991","https://openalex.org/W4211036635","https://openalex.org/W4214626746","https://openalex.org/W4221036460","https://openalex.org/W4224620999","https://openalex.org/W4226066519","https://openalex.org/W4285797617"],"related_works":["https://openalex.org/W3036566658","https://openalex.org/W2155344992","https://openalex.org/W4293109687","https://openalex.org/W7154975165","https://openalex.org/W2142815459","https://openalex.org/W2017801195","https://openalex.org/W2495259257","https://openalex.org/W1978582104","https://openalex.org/W2266031261","https://openalex.org/W4363648005"],"abstract_inverted_index":{"Abstract":[0],"Several":[1],"molecular":[2],"mechanisms":[3],"have":[4],"been":[5],"described":[6],"in":[7,44,48,60,67,97,114,132,137,148,173,216,235,255],"Alzheimer's":[8],"disease":[9],"(AD),":[10],"including":[11],"repressed":[12],"gene":[13],"transcription":[14],"and":[15,17,57,64,82,101,108,119,160,192,207,238],"mitochondrial":[16,102,106,161],"endoplasmic":[18],"reticulum":[19],"(ER)":[20],"dysfunction.":[21],"In":[22],"this":[23],"study,":[24],"we":[25],"evaluate":[26],"the":[27,95,210,213,226],"potential":[28],"efficacy":[29],"of":[30,38,129,167,186,189,228,245],"transcriptional":[31,243],"modifications":[32],"exerted":[33],"by":[34],"inhibition":[35],"or":[36],"knockdown":[37,166],"class":[39,90],"I":[40,91],"histone":[41],"deacetylases":[42],"(HDACs)":[43],"ameliorating":[45],"ER\u2010mitochondria":[46,110,149,156,246],"cross\u2010talk":[47],"AD":[49,61,217,222,236],"models.":[50,240],"Data":[51,241],"show":[52],"increased":[53,65],"HDAC3":[54,168],"protein":[55,229],"levels":[56,128,188],"decreased":[58,169],"acetyl\u2010H3":[59],"human":[62,70],"cortex,":[63],"HDAC2\u20103":[66],"MCI":[68],"peripheral":[69],"cells,":[71],"HT22":[72,121],"mouse":[73,84,116],"hippocampal":[74,117,218],"cells":[75,138,237],"exposed":[76,139],"to":[77,140],"A\u03b2":[78,194],"1\u201342":[79],"oligomers":[80],"(A\u03b2O)":[81],"APP/PS1":[83,176],"hippocampus.":[85],"Tacedinaline":[86],"(Tac,":[87],"a":[88,249],"selective":[89],"HDAC":[92],"inhibitor)":[93],"counteracted":[94],"increase":[96],"ER\u2010Ca":[98,170],"2+":[99,104,158,163,171,203],"retention":[100],"Ca":[103,157,162,202],"accumulation,":[105],"depolarization":[107],"impaired":[109],"cross\u2010talk,":[111],"as":[112,233,248],"observed":[113,234],"3xTg\u2010AD":[115],"neurons":[118],"A\u03b2O\u2010exposed":[120],"cells.":[122,175,220],"We":[123],"further":[124],"demonstrated":[125],"diminished":[126],"mRNA":[127,187],"proteins":[130],"involved":[131],"mitochondrial\u2010associated":[133],"ER":[134],"membranes":[135],"(MAM)":[136],"A\u03b2O":[141],"upon":[142],"Tac":[143,180,200],"treatment,":[144],"along":[145],"with":[146,179],"reduction":[147],"contacts":[150],"(MERCS)":[151],"length.":[152],"HDAC2":[153],"silencing":[154],"reduced":[155,193],"transfer":[159],"retention,":[164],"while":[165],"accumulation":[172],"A\u03b2O\u2010treated":[174],"mice":[177],"treated":[178],"(30":[181],"mg/kg/day)":[182],"also":[183],"showed":[184],"regulation":[185,227,244],"MAM\u2010related":[190],"proteins,":[191],"levels.":[195],"These":[196],"data":[197],"demonstrate":[198],"that":[199],"normalizes":[201],"signaling":[204],"between":[205,212],"mitochondria":[206],"ER,":[208],"involving":[209],"tethering":[211],"two":[214],"organelles":[215],"neural":[219],"Tac\u2010mediated":[221],"amelioration":[223],"occurs":[224],"through":[225],"expression":[230],"at":[231],"MAM,":[232],"animal":[239],"support":[242],"communication":[247],"promising":[250],"target":[251],"for":[252],"innovative":[253],"therapeutics":[254],"AD.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-27T00:00:00"}