{"id":"https://openalex.org/W4382011140","doi":"https://doi.org/10.1111/trf.17461","title":"How do we\u2026consistently provide high\u2010dose granulocyte products for transfusions in neutropenic patients?","display_name":"How do we\u2026consistently provide high\u2010dose granulocyte products for transfusions in neutropenic patients?","publication_year":2023,"publication_date":"2023-06-26","ids":{"openalex":"https://openalex.org/W4382011140","doi":"https://doi.org/10.1111/trf.17461","pmid":"https://pubmed.ncbi.nlm.nih.gov/37358345"},"language":"en","primary_location":{"id":"doi:10.1111/trf.17461","doi":"https://doi.org/10.1111/trf.17461","is_oa":true,"landing_page_url":"https://doi.org/10.1111/trf.17461","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.17461","source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.17461","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092262118","display_name":"Robert Bubar","orcid":"https://orcid.org/0000-0003-0121-4636","observed_orcids":["https://orcid.org/0000-0003-0121-4636"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Bubar","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-0121-4636","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047472906","display_name":"Joseph E. Kiss","orcid":"https://orcid.org/0000-0001-6767-1528","observed_orcids":["https://orcid.org/0000-0001-6767-1528"]},"institutions":[{"id":"https://openalex.org/I4210126756","display_name":"Vitalant","ror":"https://ror.org/02x9rq768","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126756","https://openalex.org/I4210157777"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Kiss","raw_affiliation_strings":["Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210126756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008827736","display_name":"Darrell J. Triulzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126756","display_name":"Vitalant","ror":"https://ror.org/02x9rq768","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126756","https://openalex.org/I4210157777"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrell J. Triulzi","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210126756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048242523","display_name":"Pam D'Andrea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126756","display_name":"Vitalant","ror":"https://ror.org/02x9rq768","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126756","https://openalex.org/I4210157777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pam D'Andrea","raw_affiliation_strings":["Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210126756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092262119","display_name":"Ashley Zilich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126756","display_name":"Vitalant","ror":"https://ror.org/02x9rq768","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126756","https://openalex.org/I4210157777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Zilich","raw_affiliation_strings":["Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210126756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052847380","display_name":"Alesia Kaplan","orcid":"https://orcid.org/0000-0002-8746-0549","observed_orcids":["https://orcid.org/0000-0002-8746-0549"]},"institutions":[{"id":"https://openalex.org/I4210126756","display_name":"Vitalant","ror":"https://ror.org/02x9rq768","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126756","https://openalex.org/I4210157777"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alesia Kaplan","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Vitalant, Northeast Division, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210126756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5092262118"],"corresponding_institution_ids":["https://openalex.org/I4210134769"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.9868,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75787863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"63","issue":"7","first_page":"1267","last_page":"1276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.12759999930858612,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.11659999936819077,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-transfusion","display_name":"granulocyte transfusion","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neutropenic-patients","display_name":"neutropenic patients","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.8444654941558838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8242676258087158},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.7275998592376709},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5006635189056396},{"id":"https://openalex.org/C2775933685","wikidata":"https://www.wikidata.org/wiki/Q1124860","display_name":"Donation","level":2,"score":0.46928107738494873},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46890437602996826},{"id":"https://openalex.org/C2777371436","wikidata":"https://www.wikidata.org/wiki/Q3237071","display_name":"Leukapheresis","level":4,"score":0.4685947000980377},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.46512341499328613},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38234591484069824},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3292185962200165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29757916927337646},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09713232517242432},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/trf.17461","doi":"https://doi.org/10.1111/trf.17461","is_oa":true,"landing_page_url":"https://doi.org/10.1111/trf.17461","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.17461","source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:37358345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37358345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1111/trf.17461","doi":"https://doi.org/10.1111/trf.17461","is_oa":true,"landing_page_url":"https://doi.org/10.1111/trf.17461","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.17461","source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382011140.pdf","grobid_xml":"https://content.openalex.org/works/W4382011140.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1752262398","https://openalex.org/W1881939314","https://openalex.org/W1985582375","https://openalex.org/W1988755521","https://openalex.org/W1992265081","https://openalex.org/W2016997982","https://openalex.org/W2032573070","https://openalex.org/W2055689496","https://openalex.org/W2056656542","https://openalex.org/W2072885795","https://openalex.org/W2072924069","https://openalex.org/W2075745070","https://openalex.org/W2092454540","https://openalex.org/W2134969379","https://openalex.org/W2169928650","https://openalex.org/W2276688320","https://openalex.org/W2400950886","https://openalex.org/W2413407752","https://openalex.org/W2754259390","https://openalex.org/W3170272680","https://openalex.org/W3213008142","https://openalex.org/W4214933640","https://openalex.org/W4224257837","https://openalex.org/W4236594756"],"related_works":["https://openalex.org/W4400342572","https://openalex.org/W2015816925","https://openalex.org/W3196222036","https://openalex.org/W2412041862","https://openalex.org/W2106803404","https://openalex.org/W2349444282","https://openalex.org/W4389166519","https://openalex.org/W2601565514","https://openalex.org/W1983037083","https://openalex.org/W2325369164"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,133,145],"therapeutic":[3],"use":[4],"of":[5,11,39,90,123,147,155,171,189,215,237,244],"granulocyte":[6,54,81,125,148,190,207,224],"transfusions":[7,191],"for":[8,79,241],"the":[9,50,187,200,213],"treatment":[10],"infections":[12],"in":[13,166,173,192],"immunocompromised":[14],"patients":[15,176],"has":[16],"been":[17],"a":[18,31,37,58,62,66,153,232],"controversial":[19],"practice.":[20],"Randomized":[21],"controlled":[22],"trials":[23],"suggest":[24],"that":[25,199,212],"benefit":[26],"may":[27],"be":[28],"provided":[29],"when":[30],"high\u2010dose":[32,233,238],"product,":[33],"defined":[34],"as":[35],"providing":[36],"dose":[38],"at":[40,61,97],"least":[41],"0.6":[42],"\u00d7":[43,143,157],"109/kg,":[44],"is":[45,195,226],"offered.":[46],"Here":[47],"we":[48],"describe":[49],"collection":[51],"process":[52],"and":[53,86,93,116,217,228],"product":[55,111],"yield":[56,136,154,231],"over":[57],"four\u2010year":[59],"period":[60],"donation":[63],"center":[64],"supplying":[65],"large,":[67],"tertiary":[68],"academic":[69],"medical":[70],"center.":[71],"Methods":[72],"A":[73,121],"retrospective":[74],"chart":[75],"review":[76],"was":[77,141,161],"performed":[78],"apheresis":[80,223],"donations":[82],"collected":[83,101,128],"between":[84],"2018":[85],"2021":[87],"following":[88,138],"implementation":[89,140],"combined":[91],"G\u2010CSF":[92,105,139,216],"dexamethasone":[94,218],"donor":[95,103,113,219],"stimulation":[96],"our":[98],"institution.":[99],"Data":[100],"includes":[102],"demographics,":[104],"administration":[106],"timeline,":[107],"pre\u2010collection":[108],"cell":[109],"counts,":[110],"yields,":[112],"adverse":[114],"events,":[115],"post\u2010transfusion":[117],"ANC":[118,169],"increments.":[119],"Results":[120],"total":[122],"269":[124],"units":[126,239],"were":[127],"from":[129],"184":[130],"unique":[131],"donors.":[132],"median":[134,168],"neutrophil":[135],"(ANC)":[137],"7.5":[142],"1010/unit.":[144],"proportion":[146],"products":[149,164,201],"meeting":[150],"or":[151],"exceeding":[152],"4.0":[156],"1010":[158],"per":[159],"unit":[160],"96.5%.":[162],"These":[163],"resulted":[165],"measurable":[167],"increment":[170],"550/\u03bcL":[172],"transfused":[174,203],"adult":[175],"(n":[177],"=":[178],"166":[179],"transfusions).":[180],"Discussion":[181],"In":[182],"order":[183],"to":[184,197],"properly":[185],"assess":[186],"effectiveness":[188],"patients,":[193],"it":[194],"necessary":[196],"ensure":[198],"being":[202],"contain":[204],"an":[205],"adequate":[206],"dose.":[208],"This":[209],"study":[210],"demonstrates":[211],"combination":[214],"stimulation,":[220],"followed":[221],"by":[222,247],"collection,":[225],"safe":[227],"can":[229],"reliably":[230],"product.":[234],"Consistent":[235],"production":[236],"allows":[240],"better":[242],"assessment":[243],"patient":[245],"outcomes":[246],"reducing":[248],"dosage":[249],"variability.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-27T00:00:00"}