{"id":"https://openalex.org/W4382011091","doi":"https://doi.org/10.1002/j.2040-4603.2023.tb00269.x","title":"Insulin Regulation of Hepatic Lipid Homeostasis","display_name":"Insulin Regulation of Hepatic Lipid Homeostasis","publication_year":2023,"publication_date":"2023-06-26","ids":{"openalex":"https://openalex.org/W4382011091","doi":"https://doi.org/10.1002/j.2040-4603.2023.tb00269.x","pmid":"https://pubmed.ncbi.nlm.nih.gov/37358513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760932"},"language":"en","primary_location":{"id":"doi:10.1002/j.2040-4603.2023.tb00269.x","doi":"https://doi.org/10.1002/j.2040-4603.2023.tb00269.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.2040-4603.2023.tb00269.x","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"journal-article"},"volume":{"id":"https://openalex.org/W2787983500","display_name":"Comprehensive Physiology"},"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10760932/pdf/nihms-1952611.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047754816","display_name":"Kahealani Uehara","orcid":"https://orcid.org/0000-0003-1142-3466","observed_orcids":["https://orcid.org/0000-0003-1142-3466"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kahealani Uehara","raw_affiliation_strings":["Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031048434","display_name":"Dominic Santoleri","orcid":"https://orcid.org/0000-0002-4468-6564","observed_orcids":["https://orcid.org/0000-0002-4468-6564"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominic Santoleri","raw_affiliation_strings":["Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046816854","display_name":"Anna E. Garcia Whitlock","orcid":"https://orcid.org/0000-0003-2980-9885","observed_orcids":["https://orcid.org/0000-0003-2980-9885"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna E. Garcia Whitlock","raw_affiliation_strings":["Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043009124","display_name":"Paul M. Titchenell","orcid":"https://orcid.org/0000-0002-9941-5649","observed_orcids":["https://orcid.org/0000-0002-9941-5649"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul M. Titchenell","raw_affiliation_strings":["Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043009124"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":10.4286,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.99203103,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"13","issue":"3","first_page":"4785","last_page":"4809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.4749000072479248,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.4749000072479248,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.19619999825954437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.1331000030040741,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.7829999923706055},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8980000019073486},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hepatic-glucose-production","display_name":"hepatic glucose production","score":0.7480000257492065},{"id":"https://openalex.org/keywords/fatty-acid-degradation","display_name":"fatty acid degradation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/triacylglycerol-biosynthesis","display_name":"triglyceride synthesis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7710000276565552},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5270000100135803},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.829414963722229},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6439598798751831},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6420014500617981},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6108983159065247},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5936149954795837},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5292037725448608},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5053454041481018},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.4630254805088043},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4627494812011719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4561658501625061},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.4423261880874634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38779041171073914},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.19951856136322021},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.19735121726989746},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15187937021255493}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/j.2040-4603.2023.tb00269.x","doi":"https://doi.org/10.1002/j.2040-4603.2023.tb00269.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.2040-4603.2023.tb00269.x","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"journal-article"},{"id":"doi:10.1002/cphy.c220015","doi":"https://doi.org/10.1002/cphy.c220015","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cphy.c220015","pdf_url":null,"source":{"id":"https://openalex.org/S18747983","display_name":"Comprehensive physiology","issn_l":"2040-4603","issn":["2040-4603"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"other"},{"id":"pmid:37358513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37358513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comprehensive Physiology","raw_type":"Review"},{"id":"pmh:oai:pubmedcentral.nih.gov:10760932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760932","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10760932/pdf/nihms-1952611.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Compr Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10760932","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760932","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10760932/pdf/nihms-1952611.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Compr Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1394151085","display_name":null,"funder_award_id":"NRSA F31","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4700570560","display_name":"Regulation of Hepatic Phosphatidylcholine Synthesis by mTORC1","funder_award_id":"F31DK128876","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8904051755","display_name":"Hepatic mTORC1 Signaling and the Regulation of Lipid Homeostasis","funder_award_id":"R01DK125497","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000878197","display_name":"University of Pennsylvania Diabetes Research Center","funder_award_id":"P30DK019525","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382011091.pdf","grobid_xml":"https://content.openalex.org/works/W4382011091.grobid-xml"},"referenced_works_count":363,"referenced_works":["https://openalex.org/W15748964","https://openalex.org/W17816724","https://openalex.org/W140477238","https://openalex.org/W200185773","https://openalex.org/W240175869","https://openalex.org/W1014806999","https://openalex.org/W1459431390","https://openalex.org/W1485806819","https://openalex.org/W1495673540","https://openalex.org/W1498982174","https://openalex.org/W1499573413","https://openalex.org/W1518126931","https://openalex.org/W1523158326","https://openalex.org/W1523351848","https://openalex.org/W1530473730","https://openalex.org/W1533598873","https://openalex.org/W1542298899","https://openalex.org/W1542778840","https://openalex.org/W1544261684","https://openalex.org/W1551374056","https://openalex.org/W1554239817","https://openalex.org/W1554600107","https://openalex.org/W1556524613","https://openalex.org/W1562882576","https://openalex.org/W1563466338","https://openalex.org/W1575864823","https://openalex.org/W1580725718","https://openalex.org/W1583767403","https://openalex.org/W1588762192","https://openalex.org/W1595100801","https://openalex.org/W1595547726","https://openalex.org/W1596556260","https://openalex.org/W1598767975","https://openalex.org/W1602648506","https://openalex.org/W1603786143","https://openalex.org/W1665938856","https://openalex.org/W1697523131","https://openalex.org/W1726025741","https://openalex.org/W1748636648","https://openalex.org/W1759512595","https://openalex.org/W1790807154","https://openalex.org/W1861740442","https://openalex.org/W1875175786","https://openalex.org/W1918384196","https://openalex.org/W1925369262","https://openalex.org/W1927993810","https://openalex.org/W1963872182","https://openalex.org/W1964624702","https://openalex.org/W1966549856","https://openalex.org/W1966606518","https://openalex.org/W1966985989","https://openalex.org/W1967502002","https://openalex.org/W1969867925","https://openalex.org/W1972744939","https://openalex.org/W1974413554","https://openalex.org/W1975189993","https://openalex.org/W1976094170","https://openalex.org/W1976995910","https://openalex.org/W1977128714","https://openalex.org/W1977577301","https://openalex.org/W1979794194","https://openalex.org/W1981436281","https://openalex.org/W1982810858","https://openalex.org/W1983698019","https://openalex.org/W1984981644","https://openalex.org/W1985113364","https://openalex.org/W1985592156","https://openalex.org/W1985829345","https://openalex.org/W1986278333","https://openalex.org/W1986876315","https://openalex.org/W1987734980","https://openalex.org/W1988723645","https://openalex.org/W1989007214","https://openalex.org/W1990342059","https://openalex.org/W1990731286","https://openalex.org/W1990805315","https://openalex.org/W1991713765","https://openalex.org/W1991757604","https://openalex.org/W1991760464","https://openalex.org/W1991876528","https://openalex.org/W1992994456","https://openalex.org/W1994173047","https://openalex.org/W1994261934","https://openalex.org/W1994381425","https://openalex.org/W1998265194","https://openalex.org/W1998493448","https://openalex.org/W1998736193","https://openalex.org/W2000154217","https://openalex.org/W2000692520","https://openalex.org/W2000815833","https://openalex.org/W2000962819","https://openalex.org/W2001568034","https://openalex.org/W2002226709","https://openalex.org/W2002295098","https://openalex.org/W2003612099","https://openalex.org/W2004582874","https://openalex.org/W2007154749","https://openalex.org/W2007486805","https://openalex.org/W2007527212","https://openalex.org/W2007717823","https://openalex.org/W2009886463","https://openalex.org/W2010140657","https://openalex.org/W2010895424","https://openalex.org/W2011647937","https://openalex.org/W2011872098","https://openalex.org/W2011934557","https://openalex.org/W2012137033","https://openalex.org/W2016015510","https://openalex.org/W2016366885","https://openalex.org/W2017011351","https://openalex.org/W2017578566","https://openalex.org/W2018062124","https://openalex.org/W2019665485","https://openalex.org/W2019717203","https://openalex.org/W2019973807","https://openalex.org/W2021537613","https://openalex.org/W2021892283","https://openalex.org/W2024851295","https://openalex.org/W2025176940","https://openalex.org/W2027519382","https://openalex.org/W2028874440","https://openalex.org/W2030610610","https://openalex.org/W2030817984","https://openalex.org/W2031149113","https://openalex.org/W2031846075","https://openalex.org/W2032150904","https://openalex.org/W2032319170","https://openalex.org/W2033429522","https://openalex.org/W2033437499","https://openalex.org/W2033823674","https://openalex.org/W2035016947","https://openalex.org/W2035816889","https://openalex.org/W2037094605","https://openalex.org/W2037270771","https://openalex.org/W2037341437","https://openalex.org/W2037590835","https://openalex.org/W2038375379","https://openalex.org/W2039890062","https://openalex.org/W2039999119","https://openalex.org/W2040143421","https://openalex.org/W2040612932","https://openalex.org/W2040692229","https://openalex.org/W2041103188","https://openalex.org/W2041139404","https://openalex.org/W2043129813","https://openalex.org/W2044318948","https://openalex.org/W2045315353","https://openalex.org/W2045619830","https://openalex.org/W2046449500","https://openalex.org/W2046770965","https://openalex.org/W2046976278","https://openalex.org/W2048498664","https://openalex.org/W2051408525","https://openalex.org/W2051591857","https://openalex.org/W2052347239","https://openalex.org/W2053044426","https://openalex.org/W2053073281","https://openalex.org/W2053181794","https://openalex.org/W2053871565","https://openalex.org/W2054264938","https://openalex.org/W2055409036","https://openalex.org/W2055759350","https://openalex.org/W2056040807","https://openalex.org/W2056085420","https://openalex.org/W2057106513","https://openalex.org/W2057816478","https://openalex.org/W2057938901","https://openalex.org/W2058342085","https://openalex.org/W2059215626","https://openalex.org/W2060460124","https://openalex.org/W2060607801","https://openalex.org/W2061417808","https://openalex.org/W2061864595","https://openalex.org/W2062412316","https://openalex.org/W2062470598","https://openalex.org/W2062933320","https://openalex.org/W2063937428","https://openalex.org/W2064707735","https://openalex.org/W2066768833","https://openalex.org/W2066805219","https://openalex.org/W2066917089","https://openalex.org/W2067677059","https://openalex.org/W2070098406","https://openalex.org/W2070206952","https://openalex.org/W2070732456","https://openalex.org/W2073249718","https://openalex.org/W2073926725","https://openalex.org/W2075342501","https://openalex.org/W2076103389","https://openalex.org/W2076641946","https://openalex.org/W2078920527","https://openalex.org/W2079386976","https://openalex.org/W2081359005","https://openalex.org/W2081458493","https://openalex.org/W2084697100","https://openalex.org/W2084744450","https://openalex.org/W2086024671","https://openalex.org/W2086222405","https://openalex.org/W2086462010","https://openalex.org/W2086524655","https://openalex.org/W2086528604","https://openalex.org/W2088024537","https://openalex.org/W2089119460","https://openalex.org/W2089202931","https://openalex.org/W2090063543","https://openalex.org/W2090224663","https://openalex.org/W2091087465","https://openalex.org/W2091277139","https://openalex.org/W2091671727","https://openalex.org/W2092045274","https://openalex.org/W2093157345","https://openalex.org/W2094091679","https://openalex.org/W2094941511","https://openalex.org/W2095659152","https://openalex.org/W2096286606","https://openalex.org/W2099905857","https://openalex.org/W2102106861","https://openalex.org/W2102469588","https://openalex.org/W2102785858","https://openalex.org/W2103116278","https://openalex.org/W2103845188","https://openalex.org/W2105283833","https://openalex.org/W2106061083","https://openalex.org/W2106183132","https://openalex.org/W2106694937","https://openalex.org/W2107368610","https://openalex.org/W2107752044","https://openalex.org/W2108090841","https://openalex.org/W2108107722","https://openalex.org/W2108360575","https://openalex.org/W2109069233","https://openalex.org/W2111352469","https://openalex.org/W2112031005","https://openalex.org/W2112632255","https://openalex.org/W2112669923","https://openalex.org/W2112759538","https://openalex.org/W2113824754","https://openalex.org/W2114597116","https://openalex.org/W2114859236","https://openalex.org/W2115177689","https://openalex.org/W2115514333","https://openalex.org/W2117011155","https://openalex.org/W2118688616","https://openalex.org/W2119296435","https://openalex.org/W2119913660","https://openalex.org/W2120692492","https://openalex.org/W2121570370","https://openalex.org/W2121914083","https://openalex.org/W2122687475","https://openalex.org/W2124593509","https://openalex.org/W2124615340","https://openalex.org/W2126847200","https://openalex.org/W2127063807","https://openalex.org/W2127847687","https://openalex.org/W2127958304","https://openalex.org/W2129438003","https://openalex.org/W2130016382","https://openalex.org/W2131085646","https://openalex.org/W2131426434","https://openalex.org/W2131622156","https://openalex.org/W2131840335","https://openalex.org/W2132961868","https://openalex.org/W2133422448","https://openalex.org/W2133706171","https://openalex.org/W2136494273","https://openalex.org/W2136776926","https://openalex.org/W2137035181","https://openalex.org/W2139277690","https://openalex.org/W2139351004","https://openalex.org/W2139798972","https://openalex.org/W2140079333","https://openalex.org/W2140439371","https://openalex.org/W2140699761","https://openalex.org/W2141956267","https://openalex.org/W2143146488","https://openalex.org/W2144178804","https://openalex.org/W2144810749","https://openalex.org/W2145158439","https://openalex.org/W2146238817","https://openalex.org/W2146415848","https://openalex.org/W2146797307","https://openalex.org/W2146966453","https://openalex.org/W2152435464","https://openalex.org/W2153191047","https://openalex.org/W2154119553","https://openalex.org/W2154267159","https://openalex.org/W2154574841","https://openalex.org/W2157815953","https://openalex.org/W2158062662","https://openalex.org/W2158465207","https://openalex.org/W2158612356","https://openalex.org/W2159480841","https://openalex.org/W2159868923","https://openalex.org/W2160080742","https://openalex.org/W2160870282","https://openalex.org/W2162051951","https://openalex.org/W2162897583","https://openalex.org/W2165912352","https://openalex.org/W2166142060","https://openalex.org/W2168724512","https://openalex.org/W2169041822","https://openalex.org/W2169894356","https://openalex.org/W2170781174","https://openalex.org/W2186765149","https://openalex.org/W2188563156","https://openalex.org/W2207728941","https://openalex.org/W2274254314","https://openalex.org/W2277857269","https://openalex.org/W2286797029","https://openalex.org/W2289246341","https://openalex.org/W2312854189","https://openalex.org/W2327833169","https://openalex.org/W2332282497","https://openalex.org/W2348229247","https://openalex.org/W2396804493","https://openalex.org/W2401659433","https://openalex.org/W2403507619","https://openalex.org/W2405221408","https://openalex.org/W2426404685","https://openalex.org/W2467091785","https://openalex.org/W2517054293","https://openalex.org/W2521958286","https://openalex.org/W2523564199","https://openalex.org/W2523671317","https://openalex.org/W2536126966","https://openalex.org/W2556357555","https://openalex.org/W2558991743","https://openalex.org/W2591567957","https://openalex.org/W2592226915","https://openalex.org/W2605493286","https://openalex.org/W2606513998","https://openalex.org/W2609051652","https://openalex.org/W2687757105","https://openalex.org/W2737880705","https://openalex.org/W2740884150","https://openalex.org/W2759497355","https://openalex.org/W2762054879","https://openalex.org/W2773300145","https://openalex.org/W2775794300","https://openalex.org/W2783761735","https://openalex.org/W2787707131","https://openalex.org/W2805369292","https://openalex.org/W2809679140","https://openalex.org/W2897376095","https://openalex.org/W2909977372","https://openalex.org/W2921967571","https://openalex.org/W2934910841","https://openalex.org/W2940388007","https://openalex.org/W2945824290","https://openalex.org/W2952892773","https://openalex.org/W2969632049","https://openalex.org/W2979459757","https://openalex.org/W2980950801","https://openalex.org/W2993862932","https://openalex.org/W3011781546","https://openalex.org/W3012090404","https://openalex.org/W3028054079","https://openalex.org/W3032349611","https://openalex.org/W3080449802","https://openalex.org/W3091243730","https://openalex.org/W3157667796","https://openalex.org/W4220818840","https://openalex.org/W4238567307"],"related_works":["https://openalex.org/W2012652496","https://openalex.org/W60248607","https://openalex.org/W2605493286","https://openalex.org/W2037637732","https://openalex.org/W2075740571","https://openalex.org/W2056233962","https://openalex.org/W2899043265","https://openalex.org/W2909835632","https://openalex.org/W2124464501","https://openalex.org/W5722764"],"abstract_inverted_index":{"The":[0,15],"incidence":[1],"of":[2,43,46,51,66,118,140,161,180,188,191,211],"obesity,":[3],"insulin":[4,33,47,72,93,162,193],"resistance,":[5],"and":[6,58,84,109,124,129,147,166,174,195,205,215],"type":[7],"II":[8],"diabetes":[9],"(T2DM)":[10],"continues":[11,95],"to":[12,40,61,74,77,96,102,107,151],"rise":[13],"worldwide.":[14],"liver":[16,37,54,76,135],"is":[17,38,113,149],"a":[18,138,186],"central":[19],"insulin-responsive":[20],"metabolic":[21,26,64,119,181],"organ":[22],"that":[23],"governs":[24],"whole-body":[25],"homeostasis.":[27],"Therefore,":[28,157],"defining":[29],"the":[30,36,44,53,63,67,75,116,159,178,189,216],"mechanisms":[31],"underlying":[32],"action":[34],"in":[35,153,208],"essential":[39],"our":[41,209],"understanding":[42,158,210],"pathogenesis":[45],"resistance.":[48],"During":[49],"periods":[50],"fasting,":[52],"catabolizes":[55],"fatty":[56,134,143],"acids":[57],"stored":[59],"glycogen":[60],"meet":[62],"demands":[65],"body.":[68],"In":[69,86],"postprandial":[70],"conditions,":[71],"signals":[73],"store":[78],"excess":[79],"nutrients":[80],"into":[81,172],"triglycerides,":[82],"cholesterol,":[83],"glycogen.":[85],"insulin-resistant":[87,219],"states,":[88],"such":[89,121],"as":[90,122],"T2DM,":[91],"hepatic":[92,192,212],"signaling":[94,163,194],"promote":[97],"lipid":[98,155,196,213],"synthesis":[99],"but":[100],"fails":[101],"suppress":[103],"glucose":[104],"production,":[105],"leading":[106],"hypertriglyceridemia":[108],"hyperglycemia.":[110],"Insulin":[111],"resistance":[112],"associated":[114],"with":[115],"development":[117],"disorders":[120],"cardiovascular":[123],"kidney":[125],"disease,":[126],"atherosclerosis,":[127],"stroke,":[128],"cancer.":[130],"Of":[131],"note,":[132],"nonalcoholic":[133],"disease":[136],"(NAFLD),":[137],"spectrum":[139],"diseases":[141],"encompassing":[142],"liver,":[144],"inflammation,":[145],"fibrosis,":[146],"cirrhosis,":[148],"linked":[150],"abnormalities":[152],"insulin-mediated":[154],"metabolism.":[156],"role":[160],"under":[164,218],"normal":[165],"pathologic":[167],"states":[168],"may":[169],"provide":[170,185],"insights":[171],"preventative":[173],"therapeutic":[175],"opportunities":[176],"for":[177],"treatment":[179],"diseases.":[182],"Here,":[183],"we":[184],"review":[187],"field":[190],"regulation,":[197],"including":[198],"providing":[199],"historical":[200],"context,":[201],"detailed":[202],"molecular":[203],"mechanisms,":[204],"address":[206],"gaps":[207],"regulation":[214],"derangements":[217],"conditions.":[220],"\u00a9":[221],"2023":[222],"American":[223],"Physiological":[224],"Society.":[225],"Compr":[226],"Physiol":[227],"13:4785-4809,":[228],"2023.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-06-27T00:00:00"}
