{"id":"https://openalex.org/W4382010973","doi":"https://doi.org/10.1167/iovs.64.7.36","title":"Pressure Clamping During Ocular Perfusions Drives Nitric Oxide-Mediated Washout","display_name":"Pressure Clamping During Ocular Perfusions Drives Nitric Oxide-Mediated Washout","publication_year":2023,"publication_date":"2023-06-26","ids":{"openalex":"https://openalex.org/W4382010973","doi":"https://doi.org/10.1167/iovs.64.7.36","pmid":"https://pubmed.ncbi.nlm.nih.gov/37358489","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10297780"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.64.7.36","doi":"https://doi.org/10.1167/iovs.64.7.36","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.7.36","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938634/i1552-5783-64-7-36_1687518985.98684.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938634/i1552-5783-64-7-36_1687518985.98684.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034961694","display_name":"Ruth A. Kelly","orcid":"https://orcid.org/0000-0001-8041-4411","observed_orcids":["https://orcid.org/0000-0001-8041-4411"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth A. Kelly","raw_affiliation_strings":["Ophthalmology Department, Duke University, Durham, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Duke University, Durham, North Carolina, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030099699","display_name":"Fiona S. McDonnell","orcid":"https://orcid.org/0000-0001-7563-7258","observed_orcids":["https://orcid.org/0000-0001-7563-7258"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona S. McDonnell","raw_affiliation_strings":["Ophthalmology Department, Duke University, Durham, North Carolina, United States","Ophthalmology Department, University of Utah, Utah, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Duke University, Durham, North Carolina, United States","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Ophthalmology Department, University of Utah, Utah, United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042631236","display_name":"Michael Lucio De Ieso","orcid":"https://orcid.org/0000-0002-2402-4483","observed_orcids":["https://orcid.org/0000-0002-2402-4483"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. De Ieso","raw_affiliation_strings":["Ophthalmology Department, Duke University, Durham, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Duke University, Durham, North Carolina, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010652114","display_name":"Darryl R. Overby","orcid":"https://orcid.org/0000-0001-9894-7515","observed_orcids":["https://orcid.org/0000-0001-9894-7515"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Darryl R. Overby","raw_affiliation_strings":["Department of Bioengineering, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050561188","display_name":"William Daniel Stamer","orcid":"https://orcid.org/0000-0002-2504-8997","observed_orcids":["https://orcid.org/0000-0002-2504-8997"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. Daniel Stamer","raw_affiliation_strings":["Ophthalmology Department, Duke University, Durham, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Duke University, Durham, North Carolina, United States","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050561188"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":1.3811,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.78071102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"64","issue":"7","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9549999833106995},{"id":"https://openalex.org/keywords/aqueous-humor-outflow","display_name":"aqueous humor outflow","score":0.7839999794960022},{"id":"https://openalex.org/keywords/washout","display_name":"washout","score":0.5759999752044678},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.6539999842643738},{"id":"https://openalex.org/keywords/trabecular-meshwork","display_name":"trabecular meshwork","score":0.7979999780654907},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9319999814033508},{"id":"https://openalex.org/keywords/deta-no","display_name":"DETA/NO","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.7559999823570251},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.4860000014305115},{"id":"https://openalex.org/keywords/porcine-eyes","display_name":"porcine eyes","score":0.7250000238418579},{"id":"https://openalex.org/keywords/juxtacanalicular-tissue","display_name":"juxtacanalicular tissue","score":0.7149999737739563},{"id":"https://openalex.org/keywords/giant-vacuoles","display_name":"giant vacuoles","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C71839028","wikidata":"https://www.wikidata.org/wiki/Q7972627","display_name":"Washout","level":2,"score":0.8844467401504517},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5994910597801208},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.5664021968841553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5470401644706726},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.49301788210868835},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4543830156326294},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.425920695066452},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4166334569454193},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3742844760417938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32235994935035706},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26621121168136597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.256102591753006}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003250","descriptor_name":"Constriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014226","descriptor_name":"Triazenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.64.7.36","doi":"https://doi.org/10.1167/iovs.64.7.36","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.7.36","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938634/i1552-5783-64-7-36_1687518985.98684.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10297780","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10297780","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10297780/pdf/iovs-64-7-36.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},{"id":"pmid:37358489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37358489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1167/iovs.64.7.36","doi":"https://doi.org/10.1167/iovs.64.7.36","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.7.36","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938634/i1552-5783-64-7-36_1687518985.98684.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4302202594","display_name":null,"funder_award_id":"EY005722","funder_id":"https://openalex.org/F4320306811","funder_display_name":"Research to Prevent Blindness"},{"id":"https://openalex.org/G9000905508","display_name":"Center Core Grant for Vision Research","funder_award_id":"P30EY005722","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000910026","display_name":"eNOS-Dependent Mechanoregulation of Intraocular Pressure","funder_award_id":"R01EY022359","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382010973.pdf","grobid_xml":"https://content.openalex.org/works/W4382010973.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W20959426","https://openalex.org/W55079281","https://openalex.org/W68583292","https://openalex.org/W81321574","https://openalex.org/W155763689","https://openalex.org/W160367654","https://openalex.org/W173581656","https://openalex.org/W184584800","https://openalex.org/W200403761","https://openalex.org/W201268120","https://openalex.org/W373409248","https://openalex.org/W772204824","https://openalex.org/W1551787508","https://openalex.org/W1585342167","https://openalex.org/W1590106719","https://openalex.org/W1701831404","https://openalex.org/W1970323907","https://openalex.org/W1971337051","https://openalex.org/W1982878020","https://openalex.org/W1986864538","https://openalex.org/W1987670009","https://openalex.org/W1989266990","https://openalex.org/W2004111633","https://openalex.org/W2006932791","https://openalex.org/W2011358704","https://openalex.org/W2012761013","https://openalex.org/W2013951512","https://openalex.org/W2017160514","https://openalex.org/W2020156363","https://openalex.org/W2024215118","https://openalex.org/W2024413712","https://openalex.org/W2025563442","https://openalex.org/W2027140863","https://openalex.org/W2029346354","https://openalex.org/W2031049195","https://openalex.org/W2035684959","https://openalex.org/W2036115790","https://openalex.org/W2041304618","https://openalex.org/W2042277117","https://openalex.org/W2058593561","https://openalex.org/W2065004555","https://openalex.org/W2065579376","https://openalex.org/W2068616422","https://openalex.org/W2072121293","https://openalex.org/W2080348067","https://openalex.org/W2082516236","https://openalex.org/W2083989289","https://openalex.org/W2090678684","https://openalex.org/W2092846370","https://openalex.org/W2096078834","https://openalex.org/W2098539423","https://openalex.org/W2104959023","https://openalex.org/W2121378400","https://openalex.org/W2121872311","https://openalex.org/W2127306451","https://openalex.org/W2128017045","https://openalex.org/W2140344695","https://openalex.org/W2154994328","https://openalex.org/W2160292547","https://openalex.org/W2209001804","https://openalex.org/W2261980411","https://openalex.org/W2293614498","https://openalex.org/W2300332006","https://openalex.org/W2324535815","https://openalex.org/W2342196875","https://openalex.org/W2417257488","https://openalex.org/W2528113994","https://openalex.org/W2556991392","https://openalex.org/W2740776990","https://openalex.org/W2775248889","https://openalex.org/W2796165413","https://openalex.org/W2883367381","https://openalex.org/W2889488205","https://openalex.org/W2911383645","https://openalex.org/W3014285079","https://openalex.org/W3108678172","https://openalex.org/W3186535797","https://openalex.org/W4247684048","https://openalex.org/W4252436123","https://openalex.org/W4255515979","https://openalex.org/W6632883048"],"related_works":["https://openalex.org/W2057554731","https://openalex.org/W3118566702","https://openalex.org/W4399325036","https://openalex.org/W2209001804","https://openalex.org/W2883367381","https://openalex.org/W2054036613","https://openalex.org/W3122446695","https://openalex.org/W2589383340","https://openalex.org/W1038356595","https://openalex.org/W1973235785"],"abstract_inverted_index":{"Purpose:":[0],"The":[1],"aim":[2],"of":[3,41,44,59,129,181,205,218,242,262],"this":[4],"study":[5],"was":[6,69,96],"to":[7],"test":[8],"the":[9,45,80,103,189],"hypothesis":[10],"that":[11,21],"nitric":[12],"oxide":[13],"(NO)":[14],"mediates":[15],"a":[16,91,126,140,202],"pressure-dependent,":[17],"negative":[18],"feedback":[19],"loop":[20],"maintains":[22],"conventional":[23,114],"outflow":[24,115,144],"homeostasis":[25],"and":[26,48,79,85,102,107,118,163,184,245],"thus":[27],"IOP.":[28],"If":[29],"true,":[30],"holding":[31],"pressure":[32,58,266],"during":[33,260],"ocular":[34],"perfusions":[35,261],"will":[36],"result":[37],"in":[38,113,143,157,172,232],"uncontrolled":[39],"production":[40,255],"NO,":[42],"hyper-relaxation":[43],"trabecular":[46],"meshwork,":[47],"washout.":[49],"Methods:":[50],"Paired":[51],"porcine":[52],"eyes":[53,124,135,174,200,212,234,264],"were":[54,120],"perfused":[55,86,108,136],"at":[56],"constant":[57],"15":[60],"mm":[61],"Hg.":[62],"After":[63],"1":[64],"hour":[65],"acclimatization,":[66],"one":[67,94],"eye":[68,82,95],"exchanged":[70,97],"with":[71,83,98,105,137,154,161,166,226],"N5-[imino(nitroamino)methyl]-L-ornithine,":[72],"methyl":[73],"ester,":[74],"monohydrochloride":[75],"(L-NAME)":[76],"(50":[77],"\u00b5m)":[78],"contralateral":[81],"DBG,":[84],"for":[87,109,258],"3":[88,149],"hours.":[89],"In":[90],"separate":[92],"group,":[93],"DETA-NO":[99],"(100":[100],"nM)":[101],"other":[104],"DBG":[106],"30":[110],"minutes.":[111],"Changes":[112],"tissue":[116,186,247],"function":[117],"morphology":[119],"monitored.":[121],"Results:":[122],"Control":[123],"exhibited":[125],"washout":[127,203,216,259],"rate":[128,204,217],"15%":[130],"(P":[131,151,193,207,222,249],"=":[132,208],"0.0026),":[133],"whereas":[134,210],"L-NAME":[138],"showed":[139,201,213],"10%":[141],"decrease":[142],"facility":[145],"from":[146,188,220],"baseline":[147,221],"over":[148],"hours":[150],"<":[152,194,223,250],"0.01);":[153],"nitrite":[155],"levels":[156],"effluent":[158],"positively":[159],"correlating":[160],"time":[162],"facility.":[164],"Compared":[165,225],"L-NAME-treated":[167],"eyes,":[168,228],"significant":[169,229],"morphological":[170,230],"changes":[171,231],"control":[173,199,227],"included":[175,236],"increased":[176,215,237],"distal":[177,238],"vessel":[178,239],"size,":[179,240],"number":[180,241],"giant":[182,243],"vacuoles,":[183],"juxtacanalicular":[185,246],"separation":[187,248],"angular":[190],"aqueous":[191],"plexi":[192],"0.05).":[195,251],"For":[196],"30-minute":[197],"perfusions,":[198],"11%":[206],"0.075),":[209],"DETA-NO-treated":[211,233],"an":[214],"33%":[219],"0.005).":[224],"also":[235],"vacuoles":[244],"Conclusions:":[252],"Uncontrolled":[253],"NO":[254],"is":[256,267],"responsible":[257],"nonhuman":[263],"where":[265],"clamped.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-27T00:00:00"}
