{"id":"https://openalex.org/W4382010799","doi":"https://doi.org/10.22029/eir.2023.1755","title":"A Scoping Review on the Effects of Physical Exercise and Fitness on Peripheral Leukocyte Energy Metabolism in Humans","display_name":"A Scoping Review on the Effects of Physical Exercise and Fitness on Peripheral Leukocyte Energy Metabolism in Humans","publication_year":2026,"publication_date":"2026-07-15","ids":{"openalex":"https://openalex.org/W4382010799","doi":"https://doi.org/10.22029/eir.2023.1755","pmid":"https://pubmed.ncbi.nlm.nih.gov/37358364"},"language":"en","primary_location":{"id":"pmid:37358364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37358364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.22029/eir.2023.1755","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080172798","display_name":"Charles F. Hodgman","orcid":"https://orcid.org/0000-0002-7899-2084","observed_orcids":["https://orcid.org/0000-0002-7899-2084"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hodgman, CF","raw_affiliation_strings":["Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","University of Houston Department of Health and Human Performance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"University of Houston Department of Health and Human Performance","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001263732","display_name":"Rebekah M. Hunt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunt, RM","raw_affiliation_strings":["Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","University of Houston Department of Health and Human Performance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"University of Houston Department of Health and Human Performance","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074023271","display_name":"Justin C. Crane","orcid":"https://orcid.org/0000-0001-6144-4412","observed_orcids":["https://orcid.org/0000-0001-6144-4412"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crane, JC","raw_affiliation_strings":["Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","University of Houston Department of Health and Human Performance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"University of Houston Department of Health and Human Performance","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007318127","display_name":"Mahmoud T. Elzayat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elzayat, Mahmoud","raw_affiliation_strings":["Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","University of Houston Department of Health and Human Performance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"University of Houston Department of Health and Human Performance","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013300776","display_name":"Emily C. P. LaVoy","orcid":"https://orcid.org/0000-0002-9505-0144","observed_orcids":["https://orcid.org/0000-0002-9505-0144"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LaVoy, EC","raw_affiliation_strings":["Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","University of Houston Department of Health and Human Performance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Houston, Dept Hlth & Human Performance, Houston, TX USA","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"University of Houston Department of Health and Human Performance","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":3.4838,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.84448614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":null,"first_page":"54","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/physical-fitness","display_name":"physical fitness","score":0.9330000281333923},{"id":"https://openalex.org/keywords/acute-exercise","display_name":"acute exercise","score":0.7429999709129333},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immune-cell-metabolism","display_name":"immune cell metabolism","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.8399999737739563},{"id":"https://openalex.org/keywords/exercise-and-immunity","display_name":"exercise and immunity","score":0.597000002861023},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5793732404708862},{"id":"https://openalex.org/C117437137","wikidata":"https://www.wikidata.org/wiki/Q5038720","display_name":"Cardiorespiratory fitness","level":2,"score":0.552844762802124},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5179544687271118},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5130280256271362},{"id":"https://openalex.org/C171687745","wikidata":"https://www.wikidata.org/wiki/Q309252","display_name":"Physical fitness","level":2,"score":0.492107093334198},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.4854908287525177},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4612637162208557},{"id":"https://openalex.org/C133165541","wikidata":"https://www.wikidata.org/wiki/Q472094","display_name":"Exercise physiology","level":2,"score":0.45523905754089355},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.4278395175933838},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3678564429283142},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3138229548931122},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2929436266422272},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2906142771244049},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2263346016407013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21979591250419617}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:37358364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37358364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},{"id":"doi:10.22029/eir.2023.1755","doi":"https://doi.org/10.22029/eir.2023.1755","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2023.1755","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.22029/eir.2023.1755","doi":"https://doi.org/10.22029/eir.2023.1755","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2023.1755","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2604074349","https://openalex.org/W4399998499","https://openalex.org/W7000531436","https://openalex.org/W3019852809","https://openalex.org/W2547690040","https://openalex.org/W4294243579","https://openalex.org/W2033177701","https://openalex.org/W4398143136","https://openalex.org/W4285808818","https://openalex.org/W2070601439"],"abstract_inverted_index":{"Background:":[0],"Both":[1],"acute":[2,17,25,97,134,179,250],"and":[3,12,23,36,47,51,87,101,121,123,170,185,216,252,262,265,277,288,297],"chronic":[4,99,136],"exercise":[5,18,27,61,137,180,206,251,253,272,292],"have":[6,68],"profound":[7],"effects":[8,95,248,259,270],"on":[9,93,104,255],"systemic":[10,30,46],"metabolism":[11,50,55,108,153],"the":[13,71,94,117,146,183,241,247,258,269,285,294],"immune":[14,48,63,274,295],"system.":[15],"While":[16],"transiently":[19],"disturbs":[20],"energy":[21,107,152],"homeostasis":[22],"elicits":[24],"inflammation,":[26,35],"training":[28,207,232,254],"improves":[29],"metabolic":[31,214],"capacity,":[32],"lowers":[33],"basal":[34],"reduces":[37],"infection":[38],"risk.":[39],"Accordingly,":[40],"accumulating":[41],"evidence":[42,204],"indicates":[43],"links":[44],"between":[45,273],"cell":[49,222,275],"suggests":[52],"that":[53,132,205],"cellular":[54,213],"may":[56],"be":[57,299],"an":[58],"important":[59],"way":[60],"influences":[62,293],"function.":[64,217],"Yet,":[65],"no":[66],"reviews":[67],"systematically":[69],"surveyed":[70],"literature":[72,92,242],"in":[73,143,154,199,219,240,268],"this":[74,80],"area.":[75],"Aims:":[76],"The":[77],"aims":[78],"of":[79,91,96,109,150,187,221,249,260,271],"scoping":[81],"review":[82],"were":[83,114,130,158,228],"to":[84,145,193,283,301],"collect,":[85],"summarize,":[86],"provide":[88],"descriptive":[89],"analysis":[90],"exercise,":[98,100,264],"physical":[102,141,210],"fitness":[103,211],"peripheral":[105],"leukocyte":[106,151,188,256],"human":[110,155],"adults.":[111,156],"Methods:":[112],"Reports":[113],"retrieved":[115],"from":[116,160],"databases":[118],"Pubmed,":[119],"Scopus,":[120],"Embase":[122],"hierarchically":[124],"filtered":[125],"for":[126,172],"eligibility.":[127],"Eligible":[128],"reports":[129,162],"those":[131],"implemented":[133],"or":[135,139,148,209,225,233],"interventions,":[138],"assessed":[140],"fitness,":[142],"relation":[144],"regulation":[147,184,215,227],"function":[149,186,224],"Data":[157,202],"charted":[159],"eligible":[161],"by":[163,168],"two":[164],"independent":[165],"reviewers,":[166],"confirmed":[167],"conference,":[169],"organized":[171],"reporting.":[173],"Results":[174,177],"&":[175],"Conclusion:":[176],"suggest":[178],"can":[181,298],"influence":[182],"metabolism,":[189],"with":[190,234],"some":[191],"similarities":[192],"what":[194],"has":[195],"been":[196],"previously":[197],"documented":[198],"skeletal":[200],"muscle.":[201],"also":[203],"and/":[208],"alters":[212],"Improvements":[218],"markers":[220],"respiratory":[223],"mitochondrial":[226],"frequently":[229],"observed":[230],"following":[231],"greater":[235],"fitness.":[236],"However,":[237],"notable":[238],"gaps":[239,245,287],"remain.":[243],"These":[244],"include:":[246],"glycolysis,":[257],"resistance":[261],"concurrent":[263],"potential":[266],"differences":[267],"types":[276],"subsets.":[278],"Future":[279],"research":[280],"is":[281],"encouraged":[282],"fill":[284],"latter":[286],"further":[289],"delineate":[290],"how":[291],"system":[296],"used":[300],"support":[302],"overall":[303],"health.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-06-27T00:00:00"}