{"id":"https://openalex.org/W4382009184","doi":"https://doi.org/10.32388/cr1jid","title":"Network Neuroscience and Translational Medicine for Understanding Mental Health: The example of Post-traumatic Stress Disorder","display_name":"Network Neuroscience and Translational Medicine for Understanding Mental Health: The example of Post-traumatic Stress Disorder","publication_year":2023,"publication_date":"2023-05-09","ids":{"openalex":"https://openalex.org/W4382009184","doi":"https://doi.org/10.32388/cr1jid"},"language":"en","primary_location":{"id":"doi:10.32388/cr1jid","doi":"https://doi.org/10.32388/cr1jid","is_oa":true,"landing_page_url":"https://doi.org/10.32388/cr1jid","pdf_url":"https://www.qeios.com/read/CR1JID/pdf","source":{"id":"https://openalex.org/S4210177074","display_name":"Qeios","issn_l":"2632-3834","issn":["2632-3834"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Qeios","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.qeios.com/read/CR1JID/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090482038","display_name":"Carl F. Weems","orcid":"https://orcid.org/0000-0001-9214-3401","observed_orcids":["https://orcid.org/0000-0001-9214-3401"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carl F. Weems","raw_affiliation_strings":["Iowa State University"],"raw_orcid":"https://orcid.org/0000-0001-9214-3401","affiliations":[{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090482038"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/network-neuroscience","display_name":"network neuroscience","score":0.9570000171661377},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.8870000243186951},{"id":"https://openalex.org/keywords/case-control-study","display_name":"case-control study","score":0.5550000071525574},{"id":"https://openalex.org/keywords/symptom-heterogeneity","display_name":"symptom heterogeneity","score":0.5460000038146973},{"id":"https://openalex.org/keywords/emotion-regulation","display_name":"emotion regulation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/brain-network-models","display_name":"brain network models","score":0.5680000185966492},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.7409999966621399},{"id":"https://openalex.org/keywords/translational-neuroscience","display_name":"translational neuroscience","score":0.621999979019165},{"id":"https://openalex.org/keywords/diagnostic-criteria","display_name":"diagnostic criteria","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6031039357185364},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6011964678764343},{"id":"https://openalex.org/C2776674806","wikidata":"https://www.wikidata.org/wiki/Q12135","display_name":"Mental illness","level":3,"score":0.5358995199203491},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.5181728601455688},{"id":"https://openalex.org/C2081992","wikidata":"https://www.wikidata.org/wiki/Q5133838","display_name":"Clinical neuroscience","level":3,"score":0.4877663254737854},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.4766814708709717},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.451452374458313},{"id":"https://openalex.org/C17289045","wikidata":"https://www.wikidata.org/wiki/Q1138951","display_name":"Cognitive neuroscience","level":3,"score":0.45076972246170044},{"id":"https://openalex.org/C2778159538","wikidata":"https://www.wikidata.org/wiki/Q16920843","display_name":"Traumatic stress","level":2,"score":0.42903709411621094},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3962787687778473},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3095870614051819},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.25711190700531006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25215792655944824},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1503685712814331},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09678667783737183},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32388/cr1jid","doi":"https://doi.org/10.32388/cr1jid","is_oa":true,"landing_page_url":"https://doi.org/10.32388/cr1jid","pdf_url":"https://www.qeios.com/read/CR1JID/pdf","source":{"id":"https://openalex.org/S4210177074","display_name":"Qeios","issn_l":"2632-3834","issn":["2632-3834"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Qeios","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.32388/cr1jid","doi":"https://doi.org/10.32388/cr1jid","is_oa":true,"landing_page_url":"https://doi.org/10.32388/cr1jid","pdf_url":"https://www.qeios.com/read/CR1JID/pdf","source":{"id":"https://openalex.org/S4210177074","display_name":"Qeios","issn_l":"2632-3834","issn":["2632-3834"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Qeios","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382009184.pdf","grobid_xml":"https://content.openalex.org/works/W4382009184.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1990121190","https://openalex.org/W2005933475","https://openalex.org/W2007081717","https://openalex.org/W2010220571","https://openalex.org/W2025930196","https://openalex.org/W2315685001","https://openalex.org/W2559883979","https://openalex.org/W2621873218","https://openalex.org/W2625092417","https://openalex.org/W2756085351","https://openalex.org/W2801553051","https://openalex.org/W2898451972","https://openalex.org/W2922371870","https://openalex.org/W3005948235","https://openalex.org/W3006325126","https://openalex.org/W3026888467","https://openalex.org/W3032615788","https://openalex.org/W3210518497","https://openalex.org/W4247665917","https://openalex.org/W4302287466"],"related_works":["https://openalex.org/W4377287622","https://openalex.org/W2772281117","https://openalex.org/W2159812249","https://openalex.org/W3036743429","https://openalex.org/W3217055850","https://openalex.org/W4408745582","https://openalex.org/W3006325126","https://openalex.org/W6931519585","https://openalex.org/W4383302788","https://openalex.org/W2756085351"],"abstract_inverted_index":{"Translational":[0],"network":[1,4,176],"neuroscience":[2,21,81,177],"and":[3,92,103,166],"models":[5,104],"have":[6],"the":[7,15,33,43,46,71,77,97,118,130,173],"potential":[8,174],"to":[9,48,69,83,88,145,171],"change":[10],"fundamentally":[11],"our":[12],"understanding":[13,51],"of":[14,17,36,42,79,105,112,120,132,163,175],"nature":[16],"mental":[18,24,113,139,179],"illness.":[19],"Network":[20],"suggests":[22,136],"that":[23,137],"pathology-linked":[25],"systems":[26,135],"such":[27],"as":[28],"emotion":[29],"regulation":[30],"derive":[31],"from":[32],"synchronized":[34],"activation":[35],"multiple,":[37],"sometimes":[38],"regionally":[39],"disparate":[40],"areas":[41],"brain.":[44],"While":[45],"methods":[47,67,87],"actualize":[49,89,172],"this":[50,90],"are":[52],"emerging,":[53],"case":[54,85],"(e.g.,":[55,64],"those":[56],"who":[57],"meet":[58],"criteria":[59,123],"for":[60,178],"a":[61,94,138],"disorder)":[62],"control":[63,86],"\u201chealthy\u201d":[65],"participants)":[66],"continue":[68],"dominate":[70],"literature.":[72],"Here":[73],"I":[74],"illustrate,":[75],"why":[76],"field":[78],"translational":[80],"has":[82],"abandon":[84],"potential,":[91],"provide":[93],"perspective":[95],"on":[96],"path":[98],"forward":[99],"using":[100],"recent":[101],"research":[102],"posttraumatic":[106],"stress":[107],"disorder":[108,140],"(PTSD).":[109],"The":[110],"heterogeneity":[111],"illness":[114],"-":[115,127],"just":[116],"in":[117],"presentation":[119],"meeting":[121],"diagnostic":[122],"within":[124],"specific":[125],"disorders":[126,180],"combined":[128],"with":[129],"complexity":[131],"human":[133],"brain":[134],"cannot":[141],"be":[142,169],"directly":[143],"mapped":[144],"any":[146],"one":[147],"individual":[148],"region":[149],"or":[150],"even":[151],"multiple":[152],"regions.":[153],"Fine":[154],"grained":[155],"(symptom":[156],"level),":[157],"well-developed":[158],"(psychometrically":[159],"sound),":[160],"continuous":[161],"measures":[162],"symptom":[164],"expression":[165],"intensity":[167],"will":[168],"critical":[170],"like":[181],"PTSD.":[182]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-06T09:10:53.072986","created_date":"2023-06-27T00:00:00"}